ライフサイエンスコーパス: classically

1 ation problems more rapidly than is possible classically.

2 Pex3 is classically a docking protein for other proteins that af

3 e report an alternative situation: a system, classically a liquid, freezes in the clean limit into a

4 ow those bounds may be pushed beyond what is classically achievable, by suitably tailoring the enviro

5 BAR501 shifted intestinal macrophages from a classically activated (CD11b(+), CCR7(+), F4/80(-)) to a

6 Classically activated (M1) macrophages are known to play

7 ossess higher phagocytic activities and that classically activated (M1) macrophages exhibit greater p

8 and cell-to-cell interactions allowing human classically activated (M1) macrophages, but not resting

9 crosis factor alpha (tnfa), a key feature of classically activated (M1) macrophages, express fluoresc

10 significantly decreases CNS accumulation of classically activated (M1) monocyte-derived macrophages

11 BMMPhi differentiated to promote a classically activated (M1) phenotype released more IL-1b

12 T3-induced macrophages displayed a classically activated (M1) signature.

13 , locally proliferating macrophages were not classically activated (M1), but they exhibited a rather

14 typic switch in macrophage activation from a classically activated (pro-inflammatory; M1/CAM) toward

15 increased infiltration and proinflammatory (classically activated [M1]) polarization of macrophages

16 Although they are classically activated by immunoglobulin (Ig)E antibodies

17 STAT3 is a transcription factor classically activated by specific tyrosine 705 phosphory

18 cific 6 and Protein S, were downregulated in classically activated cells.

19 and TTBK1/JNPL3 mice showed accumulation of classically activated infiltrating peripheral monocytes.

20 ow that iNOS-deficient mice display enhanced classically activated M1 macrophage polarization without

21 and the two major functional phenotypes are classically activated M1 phenotype showing pro-inflammat

22 Classically activated M1-Mvarphi gene promoters, includi

23 for determination of phagocytic activity and classically activated macrophage (M1)-alternatively acti

24 ) macrophages displayed higher expression of classically activated macrophage markers.

25 and prolongs the antimicrobial state of the classically activated macrophage.

26 macrophages while leaving the generation of classically activated macrophages (M1) intact.

27 Classically activated macrophages (M1) secrete proinflam

28 in WAT (a dramatic reduction in inflammatory classically activated macrophages [M1] and expansion in

29 R1 gene ablation enhanced the recruitment of classically activated macrophages in the colonic lamina

30 tification of two major polarization states: classically activated macrophages or M1, induced by IFN-

31 ulated the Th1-stimulatory cytokine IL-12 in classically activated macrophages, whereas in alternativ

32 ng a pivotal inhibitory role for stathmin in classically activated macrophages.

33 toreactive T cells and reduced CNS influx of classically activated monocytes/macrophages.

34 Classically activated Mphis predominate initially (as th

35 strocytes, which we termed A1, is induced by classically activated neuroinflammatory microglia.

36 tle is known about the relative roles of M1 (classically activated or polarized) and M2 (alternativel

37 tching of macrophages from a more protective classically activated phenotype to a more permissive alt

38 ing basal conditions and markedly reduced in classically activated polarized cells.

39 The classically activated response in turn helps in presenti

40 PS) polarizes macrophages toward the M1, or "classically activated" phenotype that participates in de

41 ly increased in number and are predominantly classically activated, M1-like, and promote inflammation

42 ited reduced proinflammatory M1 markers when classically activated.

43 ntracellularly unless the macrophages become classically activated.

44 arginase-1 activities, suggesting a dominant classically activated/M1 macrophage response.

45 Classically AD has been viewed as a neurodegenerative di

46 s of circulating chromogranin A (CgA, CHGA), classically an antiangiogenic protein, can activate late

47 ata collected through standard bioassays are classically analyzed by regression in order to fit expos

48 We found that both in classically and alternatively polarized macrophages, NFA

49 Both classically and non-classically restricted cytotoxic CD8

50 Phenotypic differences between classically and nonclassically affected patients are evi

51 The definition of severe aortic stenosis has classically and retrospectively been based on the natura

52 ctronics when the radiation field is treated classically, and that differences between the toolboxes

53 TOT classically antagonizes estradiol (E2) -dependent breast

54 form of short-chain fatty acid (SCFA), acts classically as a potent anti-angiogenic agent in tumour

55 mesencephalic boundaries through a mechanism classically ascribed to their transcriptional functions.

56 cted compounds, mainly low abundant species, classically assigned by using only the mass spectrometri

57 he obvious cognitive/behavioral interruption classically associated with absence seizures or CPSs in

58 The renin gene, although classically associated with expression in the kidney, is

59 odest modulations of the two main components classically associated with face processing (P100 and N1

60 Asthma and atopy, classically associated with hyper-activation of the T he

61 gh levels of glycosylation profiles that are classically associated with immature intracellular prote

62 beta-Catenin activation has been classically associated with increased IEC proliferation.

63 nteractions and into how components that are classically associated with inflammation can differentia

64 tors (TLR) are pattern recognition receptors classically associated with innate immunity but more rec

65 Mutations in CLN3 are classically associated with juvenile neuronal ceroid lip

66 They carry sound and heat, but are not classically associated with magnetism.

67 Activation markers classically associated with peptide presentation to and

68 Activated STAT proteins, classically associated with tyrosine phosphorylation, su

69 Host-parasite theory has classically assumed fluctuations either occur between hi

70 Surprisingly, although D2Rs are classically assumed to signal through Gi/o-coupled G-pro

71 , that the landscape is much rougher than is classically assumed.

72 Classically, asthma has been described as a Th2-associat

73 This operation is classically attributed to an increase in GABAergic synap

74 atric and cognitive deficits with the latter classically attributed to disruption of frontostriatal n

75 Deficits following stroke are classically attributed to focal damage, but recent evide

76 PHH is classically attributed to primary impairments in CSF rea

77 of fast azadiene cycloaddition reactivity is classically attributed to the inverse frontier molecular

78 han the Gi/o-associated mechanisms that have classically been ascribed to D2Rs.SIGNIFICANCE STATEMENT

79 cells, the defining feature of EAEC that has classically been associated with virulence.

80 Although this diagnosis has classically been based on radiological findings, we esta

81 Peripheral components of the ER have classically been described as comprising both tubules an

82 de that receives strongest illumination, has classically been explained as an adaptation for camoufla

83 he terrestrial realm, resource depletion has classically been related to accessibility through road n

84 l protein without catalytic function and has classically been termed as pseudo-enzymes.

85 owing due to illumination, and has therefore classically been thought of as an adaptation for visual

86 ate levels in the early phase of sepsis have classically been thought to be related to tissue hypoxia

87 It is classically believed that site-specific fibroblasts in t

88 Classically, bloom response to horizontal stirring is re

89 y (SD) is a mucohemorrhagic colitis of swine classically caused by infection with the intestinal spir

90 opathy (CIDP) is an inflammatory neuropathy, classically characterised by a slowly progressive onset

91 Seizures are classically characterized as the expression of hypersync

92 urotoxic syndrome of cerebral vasoregulation classically characterized by bilaterally symmetrical par

93 me is a rare, recessively inherited disorder classically characterized by high myopia, retinal detach

94 Classically Class IB phosphoinositide 3-kinase (PI3Kgamm

95 eters are iterated to self-consistency via a classically computed feedback loop where quantum gate er

96 insic amygdala networks in the regulation of classically conditioned defensive behaviors, commonly kn

97 site model of learning during acquisition of classically conditioned eyeblinks.

98 he acquisition, retention, and extinction of classically conditioned fear responses.

99 with studies using cocaine, STs approached a classically conditioned opioid cue more readily than GTs

100 timations, and linkage studies in humans are classically conducted through genome-wide single-nucleot

101 Classically considered "nonenveloped," recent studies sh

102 of the innate immune system, neutrophils are classically considered a homogenous population of termin

103 The motor cortex (M1) is classically considered an agranular area, lacking a dist

104 Many agonists and antagonists classically considered as being beta3-selective actually

105 ese studies demonstrate that amides, despite classically considered inert substrates, can be harnesse

106 low-level visual discriminations [1] and is classically considered outside of neural systems that su

107 Phosphatases are classically considered to be promiscuous, acting on tens

108 These anticholinesterase compounds are classically considered to cause an acute cholinergic syn

109 ctivation of the pathway by which insulin is classically considered to regulate DNL.

110 al materials, band bending and alignment are classically controlled by differences in electrochemical

111 the state of the system to a suitable set of classically correlated states is considered.

112 However, roles for classically cytoplasmic proteins in the nucleus are begi

113 zed that SWDs are not always associated with classically defined absence seizures or CPSs.

114 CXCL5 is classically defined as a proinflammatory chemokine, but

115 Classically defined as a serine/threonine kinase, BIK1 i

116 in patients with mutations in Scn1b, a gene classically defined as ancillary to the Na(+) channel al

117 in patients with mutations in Scn1b, a gene classically defined as ancillary to the Na(+) channel al

118 in patients with mutations in Scn1b, a gene classically defined as ancillary to the Na+ channel alph

119 the retinoblastoma (Rb) protein in a manner classically defined as inactivation, human cytomegalovir

120 inhibitors are low molecular weight proteins classically defined as serine protease inhibitors.

121 Homeosis is classically defined as the transformation of one body pa

122 ssing RGCs lacked GABA labeling and included classically defined as well as recently identified types

123 -11,600 y ago) in the Northern Hemisphere is classically defined by abrupt cooling and renewed glacia

124 hough the medial prefrontal cortex (mPFC) is classically defined by its reciprocal connections with t

125 Pulmonary sarcoidosis is classically defined by T-helper (Th) cell type 1 inflamm

126 Ihog spatial discontinuity may contribute to classically defined cell segregation and lineage restric

127 Using this cartography, classically defined cognitive systems can be categorized

128 These tools enable us to demonstrate that classically defined cognitive systems-including visual,

129 genes and became demethylated at the loci of classically defined effector molecules.

130 umber of long-lived progenitors, rather than classically defined haematopoietic stem cells, are the m

131 escent cells in G0 Surprisingly, the loss of classically defined HSCs did not affect mouse viability,

132 Thus, classically defined HSCs maintain immune cell developmen

133 maximal flux is different compared with the classically defined kcat.

134 -sensitive regions, especially compared with classically defined multisensory regions in temporal ass

135 al agonism, and unmasks molecular actions of classically defined partial agonists.

136 suggests increasingly complex coupling among classically defined pathways.

137 re, causing Streptomyces to deviate from its classically-defined life cycle.

138 ns and cephalosporins are synthesized from a classically derived non-ribosomal peptide synthetase tri

139 clear cells from patients with ABPA with the classically described A. fumigatus allergens Aspf1, Aspf

140 Immune responses were not limited to the classically described A. fumigatus allergens.

141 Botulism is classically described as a bilateral, symmetric, descend

142 Sciatica has been classically described as pain in the back and hip with r

143 racterized by yellow-white spots, which were classically described as subretinal.

144 ypes that are partially consistent with both classically described dopaminergic and non-dopaminergic

145 commissure, lack the disconnection syndrome classically described in callosotomized patients?

146 ng with dermal hyperneury, cutaneous lesions classically described in MEN 2B syndrome, and 1 relative

147 Chronic actinic dermatitis (CAD) is classically described in older, white men, although incr

148 on collaterals and more generally to that of classically described STN neurons.

149 Atypical hemolytic uremic syndrome (aHUS) is classically described to result from a dysregulation of

150 l AngII exhibited a marked sodium intake, as classically described.

151 s is a key feature of airway remodeling that classically distinguishes severe from nonsevere asthma.

152 Tuberculosis is classically divided into states of latent infection and

153 Muscle tissues are classically divided into two major types, depending on t

154 We then calculated tau as is classically done using the isotopic signals of evaporati

155 Classically, during viral infection, the presence of for

156 alized or systemic allergic reaction that is classically elicited by antigen crosslinking of antigen-

157 Classically, enteropathy has been identified histopathol

158 Classically, Epac1 is thought to exert its effects throu

159 thological overlap is emerging, blurring the classically established boundaries.

160 displays intermediate features lying between classically excitatory and inhibitory endings; and (3) i

161 s (10 to 300 kelvin) are consistent with the classically expected behavior of the magnetic fluctuatio

162 This observation is classically explained by the assumption of a reduced bar

163 While classically expressed by neutrophils and macrophages, CD

164 ed protein 4 (CTLA-4; an inhibitory molecule classically expressed on T cells) is now reported at an

165 Compared to classically fabricated nanowires, the TFT nanoribbon sen

166 s.SIGNIFICANCE STATEMENT Parkinson's disease classically first becomes manifest in one hemibody befor

167 e development of bioorthogonal reactions has classically focused on bond-forming ligation reactions.

168 Atherosclerosis research has classically followed 2 intertwining lines of investigati

169 In this regime, classically forbidden detection of completely unpolarize

170 LTA4H classically functions in the generation of pro-inflammat

171 Classically, G protein-coupled receptor (GPCR) stimulati

172 ioral role, the upper three layers have been classically grouped together as the superficial layers a

173 omenon, known as glomerular hyperfiltration, classically has been hypothesized to predispose to irrev

174 th uniformly poor prognosis, exemplifies the classically held view of stepwise cancer development.

175 Classically, hormones elicit specific cellular responses

176 Two basal ganglia pathways have been classically hypothesized to regulate this process via op

177 These variants have been classically identified as antibiotic-resistant forms in

178 t variants of common bacteria that have been classically identified as antibiotic-resistant variants

179 C state and report that these TAS, which are classically implicated in persister cell formation, are

180 In the model, the nuclei move classically in a fully quantum potential created by elec

181 and interferon regulatory factor 3 (IRF-3), classically inducing IFNbeta production.

182 hysical constraints frame the -1/4 power law classically inferred from allometry of animal metabolic

183 the results of such simulations also becomes classically intractable as system sizes increase.

184 sults also offer the potential of developing classically intractable simulations with currently acces

185 ere central, deep or large, non-Nocardia, or classically invasive Pseudomonas aeruginosa; for patient

186 The Galphas subunit is classically involved in the signal transduction of G pro

187 (mainly carotid arteries) arterial beds are classically involved; involvement of visceral arteries i

188 s sandwiched between the electrodes, whereas classically it should be unchanged.

189 Classically, it has been hypothesized that reach-to-gras

190 amounts of cysteinyl leukotrienes (cysLTs), classically known as a slow reactive substance of anaphy

191 Eosinophils are classically known as proinflammatory cells, as they are

192 , while matrix metalloproteinases (MMPs) are classically known as significant enhancers of cancer cel

193 R (PKR) is another host non-self RNA sensor classically known for its vRNA recognition activity.

194 ented independently by the G protein complex classically known for orienting the mitotic spindle.

195 Dopamine neurons are classically known to modulate locomotion indirectly thro

196 Classically, late transition-metal organometallic compou

197 species regulate longevity through a pathway classically linked to apoptosis.

198 Although ZEB1 is classically linked to epithelial-mesenchymal transition

199 The endoplasmic reticulum (ER) is classically linked to metabolic homeostasis via the acti

200 Thus, these molecules display more classically liquid-crystalline self-assembly behavior wh

201 Although being classically located inside the liver parenchyma, hemangi

202 We generated classically (M1) and alternatively (M2) polarized macrop

203 This potential classically manifests as a negative deflection in medial

204 Esophageal motility disturbance classically manifests as a reduced lower esophageal sphi

205 disease is a nonlysosomal glycogenosis that classically manifests with exercise-induced pain from ch

206 reted rather narrowly in the literature when classically measured in one-dimension.

207 k, to directly assess how trait optimism, as classically measured using self-report questionnaires, i

208 (ERalpha) activation functions AF-1 and AF-2 classically mediate gene transcription in response to es

209 Thus, instead of classically mediating the kinase arm, PI3Kgamma inhibits

210 anocytic nevi with extra-cutaneous features, classically melanotic cells within the central nervous s

211 st responses were identified as conventional classically MHC I restricted, and we found no evidence f

212 Classically, microtubules have been considered secondary

213 difficult in the case of amyloidosis, which classically mimics HCM.

214 Classically, models of this process are based on the Fis

215 Fcgamma receptors (FcgammaRs) classically modulate intracellular signaling on binding

216 icutes and the Halanaerobiales belong to the classically monoderm Firmicutes, but possess outer membr

217 Classically, most BC types are thought to contact all co

218 Classically, natural killer (NK) cells have been defined

219 Classically, neural adaptation refers to a reduction in

220 Classically, NF-kappaB activity is limited by cytoplasmi

221 s) found in crystallization drops that would classically not be considered as "hits." We found that p

222 e (GL-1) and glucosylsphingosine (LysoGL-1), classically noted within the lysosomes of mononuclear ph

223 al a cortical physiological signature of the classically observed inverted-U relationship between tas

224 ctions occur via an associative mechanism as classically observed with transition metal complexes.

225 Classically one expects an AFM tip interacting with a ce

226 However, the requirement for either classically or alternatively activated macrophages for P

227 Classically, P(open) is regulated by a calcium-sensitive

228 Autoimmune diseases classically present with a complex etiology in which dif

229 OPA-responsive dystonia, a rare disease that classically presents in childhood with generalized dysto

230 ually arises after 32 weeks of gestation and classically presents with hypertension and proteinuria.

231 Classically, promoters and enhancers are considered sepa

232 ther than through the inhibitory receptor as classically proposed.

233 and invertebrate species, with four species classically recognized as human parasites: Dientamoeba f

234 r influenza A virus evolution, including its classically recognized role in the emergence of genetica

235 Mac-1 (CD11b/CD18) is a beta2 integrin classically regarded as a pro-inflammatory molecule beca

236 ttern of limb development; both are features classically regarded as unique to urodeles.

237 tivated protein kinase (AMPK), a kinase that classically regulates cellular energy homeostasis.

238 assessment and imaging of the notochord has classically relied on histological techniques, which int

239 Exploration of developmental mechanisms classically relies on analysis of pattern regularities.

240 Nowadays, analytical strategies classically rely on sensitive immunological assays, but

241 Cryptosporidiosis is classically reported in patients with acquired immunodef

242 the patient's constellation of symptoms are classically representative of major depression, the pati

243 Pancreatic ductal adenocarcinoma (PDA) is classically resistant to immunotherapy and lacks baselin

244 d runoff on the expression of genes that are classically responsive to contaminant exposures, as well

245 Both classically and non-classically restricted cytotoxic CD8(+) T cells are impo

246 different integrins, and in addition to its classically secreted form, an intracellular form of oste

247 It is classically seen as the most heterogeneous region of the

248 Myxomatous mitral valve with prolapse are classically seen with abnormal leaflet apposition during

249 Classically, senescence, particularly in human cells, in

250 Classically, sensory deprivation first drives rapid Hebb

251 Janus kinases (JAKs) classically signal by activating STAT transcription fact

252 ough a series of classic collisions, whereas classically simulated rotational-energy dissipation is s

253 argeting both voltage-gated Ca(2+) channels, classically studied for neurodegenerative diseases, and

254 oxidase (Nox) family of enzymes, which were classically studied for their roles in phagocytic immune

255 differentially regulated in B. subtilis from classically studied Gram-negative flagellar systems and

256 ventricle in addition to the left ventricle classically studied.

257 Glucagon levels are classically suppressed after glucose challenge.

258 Classically, TD learning imparts value to features that

259 elated potentials (ERPs), specifically those classically termed feedback-related negativity, are modu

260 Classically the immunological 'Big Bang' of adaptive imm

261 Classically, the 3 pillars of atrial fibrillation (AF) m

262 Classically, the CD56dim NK cell subset is thought to me

263 Classically, the congenital myopathies are defined by sk

264 erning numerous embryonic tissues including, classically, the developing limb bud where it controls d

265 Classically, the diatom biotic indices are based on the

266 Classically, the interaction between NP and viral RNA (v

267 Classically, the NLRP3 inflammasome in murine macrophage

268 Classically, the recycling of internalized receptors is

269 duced burden of deleterious variation due to classically theorized 'genetic purging'.

270 Classically, this critical examination can be either int

271 Classically, this process is driven by the Nernst effect

272 Classically, this reaction is performed with an electrop

273 onment (proteases, allergens, and injury) is classically thought of as a principal contributor to bar

274 Human perceptual learning is classically thought to be highly specific to trained sti

275 In bacteria, protein phosphorylation was classically thought to be mediated exclusively by histid

276 Although classically thought to be primarily a nosocomial infecti

277 Arcuate nucleus (AN) neurons are classically thought to be responsible for hypothalamic g

278 Language is classically thought to be supported by perisylvian corti

279 ndoderm [9-12], while gnathostome gills were classically thought to derive from ectoderm [10, 13].

280 neuron models, we show how currents that are classically thought to permit low firing rates can parad

281 eritoneum (ascites) of nephrotic patients is classically thought to stem from the prevailing low plas

282 Cytokines are classically thought to stimulate downstream signaling pa

283 e outer plexiform layer is more complex than classically thought.

284 as a result of previous antigenic exposures, classically through previous transplantation, pregnancy,

285 Classically, transverse myelitis and acute disseminated

286 Classically, two stimuli have been used to trigger a bei

287 y actions via the GC receptor (GR), which is classically understood to function as a nuclear transcri

288 with BH3 was examined experimentally, and a classically unexpected trend is that the selectivity inc

289 the isolated populations showed that several classically used exosome markers, like major histocompat

290 s, including the standard disposable inserts classically used in HR-MAS NMR-based metabolomics.

291 and allows analysis of the patterns by tools classically used to analyze 2D patterns.

292 that TbRP2 is detected by YL1/2, an antibody classically used to detect alpha-tubulin.

293 However, the conditions classically used to elicit USV vary greatly with the ani

294 mouse strains, that is, BALB/c and C57BL/6, classically used to study mycobacterial infection, and F

295 The hippocampal CA3 region is classically viewed as a homogeneous autoassociative netw

296 Although classically viewed as a type 2-regulated disease, type 1

297 Although they are classically viewed as continuously recirculating through

298 genic transcription factors, which have been classically viewed as intractable targets using small-mo

299 Lysosomes are classically viewed as vesicular structures to which carg

300 ic nucleus locus ceruleus (LC) is associated classically with arousal and attention.