ライフサイエンスコーパス: clathrin adaptor

1 s of CD4 by linking the receptor to the AP-2 clathrin adaptor.

2 teins, at a site overlapping that for AP2, a clathrin adaptor.

3 Ced-6 thus operates in vivo as a clathrin adaptor.

4 plex and endosomal compartments and recruits clathrin adaptors.

5 oated vesicles, the motifs are recognized by clathrin adaptors.

6 mblies on membranes that display five unique clathrin adaptors.

7 y to down-regulate CD4 and to associate with clathrin adaptors.

8 acking the adaptor protein 1 (AP-1) and AP-2 clathrin adaptors.

9 ated BIG1/2 then activates ARFs that recruit clathrin adaptors.

10 h ArfGAP3 regulates Golgi association of GGA clathrin adaptors.

11 are a family of ubiquitin-binding, endocytic clathrin adaptors.

12 res an ExxxLL motif predicted to recruit the clathrin adaptor, Adaptor protein 2 (AP2).

13 e SNARE VAMP7 is directly mediated by Hrb, a clathrin adaptor and ArfGAP.

14 Clathrin adaptor and COP-I coatomer subunits, which func

15 GFP) fusion, CD28 co-localizes with the AP-2 clathrin adaptor and Nef-GFP.

16 ng drug nystatin, and is independent of AP-2 clathrin adaptor and two putative GLUT4 endocytic motifs

17 to target the endocytic machinery, including clathrin adaptors and dynamin 2, to focal adhesion sites

18 identified the interaction between monomeric clathrin adaptors and endocytic scaffold proteins as a c

19 ctions with both ENT1 and ENT2, and that the clathrin adaptors and Sla2p together regulate the actin

20 hanism involving MTs, clathrin, and specific clathrin adaptors and that direct endocytosis of integri

21 Because the recruitment of clathrin adaptors and their cargoes to the TGN is mediat

22 which is related to the adaptor protein (AP) clathrin adaptors, and the cargo-binding alphabeta'epsil

23 l. show that a close interaction between the clathrin adaptor AP-1 and a kinesin motor KIF13A is esse

24 ium-specific (AP-1B) forms of the tetrameric clathrin adaptor AP-1 are capable of carrying out basola

25 dentified the medium subunit (micro1) of the clathrin adaptor AP-1 as a top hit.

26 Indeed, we have found that Eps15 and the TGN clathrin adaptor AP-1 coimmunoprecipitate from rat liver

27 We found that the clathrin adaptor AP-1 complex mu1 subunit UNC-101 functi

28 ases Golgi PI(4)P, blocks the recruitment of clathrin adaptor AP-1 complexes to the Golgi, and inhibi

29 ily with homology to the "ear" domain of the clathrin adaptor AP-1 gamma subunit.

30 PACS-1 connects the clathrin adaptor AP-1 to acidic cluster sorting motifs c

31 in needed for vesicle tethering binds to the clathrin adaptor AP-1, and cells depleted of GCC185 accu

32 ructures also contained the Golgi-associated clathrin adaptor AP-1, suggesting that they were Golgi-d

33 of the proteins by the sigma1 subunit of the clathrin adaptor AP-1.

34 emonstrate a distinct role of the ubiquitous clathrin adaptor AP-1A in basolateral protein sorting.

35 Clathrin and the epithelial-specific clathrin adaptor AP-1B mediate basolateral trafficking i

36 brane (PM) utilizing the epithelial-specific clathrin adaptor AP-1B.

37 ch is facilitated by the epithelial-specific clathrin adaptor AP-1B.

38 ing mediated by the epithelial cell specific clathrin adaptor AP-1B.

39 a dual interaction of synaptotagmin with the clathrin adaptor AP-2 plays a key physiological role in

40 hat DPY-23, the C. elegans mu subunit of the clathrin adaptor AP-2 that mediates the endocytosis of m

41 the sequential binding of beta-arrestin, the clathrin adaptor AP-2, and clathrin.

42 a its direct interactions with clathrin, the clathrin adaptor AP-2, and Eps15.

43 eolar macrophages (AMs): 1) Abs to clathrin, clathrin adaptor AP-2, and hsc70, and 2) amantadine.

44 raction with the medium subunit (mu2) of the clathrin adaptor AP-2, but how they guide new and recycl

45 otif YEKL, which is the binding site for the clathrin adaptor AP-2.

46 , bind to the beta(2)-adaptin subunit of the clathrin adaptor AP-2.

47 ntain binding sites for clathrin and for the clathrin adaptor AP-2.

48 the same domain also binds clathrin and the clathrin adaptor AP-2.

49 f Eps15 and the alpha-adaptin subunit of the clathrin adaptor AP-2.

50 nteract through this central region with the clathrin adaptor AP-2.

51 cruits clathrin in a manner dependent on the clathrin adaptor AP-2.

52 (Dvl2) and micro2-adaptin, a subunit of the clathrin adaptor AP-2; this interaction is required to e

53 The clathrin adaptors AP-1 and AP-2 bind cargo proteins via

54 ntributes to the association of SIV Nef with clathrin adaptors AP-1 and AP-2.

55 phosphatase 1 regulatory subunit 9b) and the clathrin adaptors AP-1 and AP-2.

56 We conclude that the clathrin adaptors AP-1, Ent3p, Ent5p, and the Ggas coope

57 n the medium subunits (mu1A and mu1B) of the clathrin adaptors AP-1A and AP-1B.

58 rin and TGN38 were readily recognized by the clathrin adaptor, AP-2.

59 with the absence of the epithelial-specific clathrin adaptor AP1B.

60 The clathrin adaptor AP2 (adaptor protein complex-2) is crit

61 Additionally, we identified the clathrin adaptor AP2 as an interacting partner of a prev

62 The prototypical clathrin adaptor AP2 mediates cargo recruitment, maturat

63 ing of the COPI subunit betaCOP based on the clathrin adaptor AP2 suggested that the betaCOP C termin

64 cilitates BUBR1-dependent recruitment of the clathrin adaptor AP2 to IR.

65 binding and recruits beta-arrestins and the clathrin adaptor AP2 to trigger PC1 internalization.

66 unmasks a basic patch-binding motif for the clathrin adaptor AP2, enhancing the endocytosis of selec

67 il of GluN3A and mediates its binding to the clathrin adaptor AP2.

68 in at the trans-Golgi network as well as the clathrin adaptors AP2 and AP1 in clathrin-coated pits at

69 tro binding studies confirmed binding to the clathrin adaptors AP2, EPS15, and amphiphysin 2/Bin1.

70 regulated by receptor interactions with the clathrin-adaptor AP2, but the molecular determinants of

71 proteins that resemble the four subunits of clathrin adaptors (APs), with highest sequence similarit

72 ing RNAi further provides evidence that both clathrin adaptors are important for trafficking of ATP7A

73 Clathrin adaptors are key factors in clathrin-coated ves

74 GGAs, a class of monomeric clathrin adaptors, are involved in the sorting of cargo

75 Pan1p shares homology with the mammalian clathrin adaptor-associated protein, eps15.

76 nding is competed by the binding of the AP-2 clathrin adaptor at (and near) residues 24-29 but not by

77 alization and then partial relocalization of clathrin adaptors at the trans-Golgi network and endosom

78 They have all the properties of clathrin adaptors, because they can both bind to clathri

79 helical receptors in coated pits employs the clathrin adaptor beta-arrestin proteins.

80 that disrupt the constitutively strong AP-2 clathrin adaptor binding element located in the N-termin

81 Here, we show that AP2, a clathrin adaptor, binds directly to a tyrosine-based mot

82 directly to soluble clathrin trimers and to clathrin adaptors by a mode involving the independently

83 expressed, PtdIns4,5P(2)-binding, endocytic clathrin adaptor CALM/PICALM.

84 Vs are clathrin and the two cargo-selecting, clathrin adaptors, CALM and AP2.

85 , demonstrating that unstructured regions of clathrin adaptors can select cargo.

86 hat the GTP-binding protein, Arfrp1, and the clathrin adaptor complex 1 (AP-1) are required for Vangl

87 In cells deficient for both the clathrin adaptor complex 1 and Chs6p, where Chs3p is tra

88 d in cells depleted of clathrin or its major clathrin adaptor complex 2 (AP-2), a phenotype mimicked

89 eraction between the mu2 subunit of the AP-2 clathrin adaptor complex and ITIM tyrosine residues in t

90 e trans-Golgi network and endosomes, linking clathrin adaptor complex AP-1 and the Rab GTPase Ypt31p.

91 In this study, we demonstrate binding of the clathrin adaptor complex AP-1 with the GVYVKM motif of t

92 work (TGN) and endosomes that depends on the clathrin adaptor complex AP-1.

93 The epithelial cell-specific clathrin adaptor complex AP-1B facilitates the sorting o

94 Recent findings of Eps15 association with clathrin adaptor complex AP-2 and its localization in cl

95 -fluorescent-protein-tagged beta2 subunit of clathrin adaptor complex AP-2 revealed that EGFR mutants

96 sine phosphorylation of the beta2 subunit of clathrin adaptor complex AP-2 was detected in three type

97 itination of the receptor kinase domain, the clathrin adaptor complex AP-2, the Grb2 adaptor protein,

98 of its association with the plasma membrane clathrin adaptor complex AP-2.

99 ell surface co-receptor CD4 by hijacking the clathrin adaptor complex AP-2.

100 s with the mu-subunits of plant or mammalian clathrin adaptor complex AP1 and plant AP4 but not that

101 The clathrin adaptor complex AP2 is thought to be an obligat

102 Here we show that AP2, a clathrin adaptor complex important for endocytosis, asso

103 The AP-1B clathrin adaptor complex is responsible for the polarize

104 The AP2 clathrin adaptor complex links protein cargo to the endo

105 n exocyst component, Apm1p, a subunit of the clathrin adaptor complex or For3p, an actin-polymerizing

106 The AP-2 clathrin adaptor complex oversees endocytic cargo select

107 The AP-1B clathrin adaptor complex plays a key role in the recogni

108 We have identified a novel form of the AP-1 clathrin adaptor complex that contains as one of its sub

109 AP-1 is a clathrin adaptor complex that sorts cargo between the tr

110 BLOC-1 and BLOC-2, together with the AP-3 clathrin adaptor complex, act at early endosomes to sort

111 424)YDSI, which interacts with the endocytic clathrin adaptor complex, AP-2, and is required for its

112 xocytosis and as a membrane receptor for the clathrin adaptor complex, AP-2, during endocytosis.

113 tail of the AMPAR GluR2 subunit with the AP2 clathrin adaptor complex.

114 UNC-101 encodes a mu1 subunit of the AP-1 clathrin adaptor complex.

115 s, providing further evidence that AP-1 is a clathrin adaptor complex.

116 AP-1, the TGN (trans-Golgi network)-specific clathrin adaptor complex.

117 membrane-facing in the open form of the AP2 clathrin adaptor complex.

118 two isoforms of the mu1 subunit of the AP-1 clathrin adaptor complex: the ubiquitous mu1A and the ep

119 asolateral sorting may not be related to the clathrin-adaptor complex pathway, as is the case for man

120 n also impairs the dynamics of intracellular clathrin/adaptor complex 1 (AP-1)- or GGA (Golgi-localiz

121 cifically to the beta-adaptin subunit of the clathrin adaptor complexes AP-1 and AP-2, which are resp

122 e loop of Nef, which mediates binding to the clathrin adaptor complexes AP-1, AP-2, and AP-3.

123 sequences and the medium chain and endocytic clathrin adaptor complexes have been shown by protein-pr

124 Arf is also required with coatomer-related clathrin adaptor complexes to bud vesicles from the tran

125 istal C termini and that these interact with clathrin adaptor complexes with differing affinities.

126 sm to diversify the functional repertoire of clathrin adaptor complexes.

127 Most epithelial cells contain two AP-1 clathrin adaptor complexes.

128 CD4 downregulation and for interaction with clathrin adaptor complexes.

129 athrin accessory proteins that interact with clathrin adaptor complexes.

130 al cells coexpress two almost identical AP-1 clathrin adaptor complexes: the ubiquitously expressed A

131 We assess the role of clathrin, adaptor complexes, lipid rafts, and Rab22a in

132 , including clathrin itself, the alternative clathrin-adaptor Dab2, dynamin, myosin-VI, and actin are

133 ain structure that serves as an unusual AP-1 clathrin adaptor-dependent Golgi export signal in one Ki

134 The AP-2 clathrin adaptor differs fundamentally from the related

135 Our study illustrates how two clathrin adaptors direct basolateral trafficking of a pl

136 dileucine signal binds to the endocytic AP-2 clathrin adaptor directly.

137 Heterotetrameric clathrin adaptors directly link the clathrin coat with c

138 Clathrin adaptors display diversity in both the type and

139 domain of the mouse SNARE Vti1b by the human clathrin adaptor epsinR (EPNR, also known as CLINT1).

140 Upon glucose withdrawal, clathrin adaptors exhibit a biphasic change in localizat

141 ant, support the notion that AP-2 is the key clathrin adaptor for the downregulation of CD4 by Nef, a

142 s, and they suggest that AP-2 functions as a clathrin adaptor for the endocytosis of diverse classes

143 rated that epsin links ubiquitinated ENaC to clathrin adaptors for clathrin-mediated endocytosis.

144 as been proposed that betaarrestins serve as clathrin adaptors for the GPCR family by linking these r

145 Interestingly, Dab2, an accessory clathrin adaptor found earlier to be important for GJ en

146 omes and led to the loss of some but not all clathrin adaptors from the Golgi membrane.

147 AGAPs bind to clathrin adaptors, function in post Golgi membrane traff

148 ffect of inhibiting CCV budding by using the clathrin adaptor GGA (Golgi-associated, gamma-ear-contai

149 important roles in recruitment of two major clathrin adaptors, Gga (Golgi-localized, gamma-adaptin e

150 We conclude that clathrin adaptor GGA1 is a clathrin assembly protein, bu

151 Here, we report that the clathrin adaptor Gga2 and ubiquitination by the Rsp5 ubi

152 ery of a new autoregulatory motif within the clathrin adaptor Gga2 that drives synergistic binding of

153 Both proteins interact with the monomeric clathrin adaptor Gga2p, but Ent5p also interacts with th

154 Clathrin adaptors have the highest capability for moonli

155 This study reveals a novel role for the AP2 clathrin adaptor in promoting the abundance of GluRs at

156 onal codependence between Drs2p and the AP-1 clathrin adaptor in protein sorting at the TGN and early

157 n complex AP2, beta-arrestin1 functions as a clathrin adaptor in receptor endocytosis which is regula

158 Here we report that Ent5, an endosomal clathrin adaptor in Saccharomyces cerevisiae, regulates

159 ion of PAR1, suggesting a function for other clathrin adaptors in this process.

160 ate that the GGAs, a family of Arf-dependent clathrin adaptors involved in selection of TGN cargo, in

161 sphatase (ALP) to the vacuole depends on the clathrin adaptor-like complex AP-3, but does not depend

162 A novel clathrin adaptor-like complex, adaptor protein (AP)-3, h

163 ntly in the plasma membrane, binds endocytic clathrin adaptors, many of their accessory factors, and

164 onal calcium sensor protein hippocalcin, the clathrin adaptor molecule AP2, the postsynaptic density

165 re, we found that ROMK bound directly to the clathrin adaptor molecule autosomal recessive hyperchole

166 these factors, we mutagenized the quadruple clathrin adaptor mutant strain and selected cells that w

167 e depends on the function of three monomeric clathrin adaptors named GGAs.

168 did not provide a docking site for the AP-2 clathrin adaptor, nor did it potentiate receptor interna

169 ated knockdown of either alpha adaptin (AP-2 clathrin adaptor) or clathrin heavy chain, revealing tha

170 gamma also interacts with the mu subunits of clathrin adaptor protein (AP) complexes and acts as a si

171 sorting motifs like those recognized by the clathrin adaptor protein (AP) complexes AP1, AP2, and AP

172 Isolated clathrin adaptor protein (AP) preparations are known to

173 kinase (GAK) are host kinases that regulate clathrin adaptor protein (AP)-mediated trafficking in th

174 oach to identify direct interactions between clathrin adaptor protein (AP)1 complexes and small GTPas

175 NR2B subunit--the PDZ binding domain and the clathrin adaptor protein (AP-2) binding motif--in the sy

176 In this study, we report that the clathrin adaptor protein 1 (AP-1) complex, although disp

177 tor Gga2p, but Ent5p also interacts with the clathrin adaptor protein 1 (AP-1) complex, which facilit

178 lass I (MHC-I) trafficking by recruiting the clathrin adaptor protein 1 (AP-1) to the MHC-I cytoplasm

179 of viable, null mutations in subunits of the clathrin adaptor protein 2 (AP2) complex in Caenorhabdit

180 -ethylmaleimide-sensitive fusion protein-AP2-clathrin adaptor protein 2 inhibitory peptide pep2m occl

181 e evasion strategies to demonstrate that the clathrin adaptor protein adaptor protein 1 (AP-1) is nec

182 precipitates containing Src and dynamin, the clathrin adaptor protein alpha-adaptin was also found.

183 The GGAs colocalize in vivo with the clathrin adaptor protein AP-1 and bind to AP-1 in vitro,

184 ng a protein-protein interaction between the clathrin adaptor protein AP-1 and the MHC-I cytoplasmic

185 tosis is initiated by the recruitment of the clathrin adaptor protein AP-2 to the plasma membrane whe

186 During endocytosis, clathrin and the clathrin adaptor protein AP-2, assisted by a variety of

187 ssociation of the chimeric receptor with the clathrin adaptor protein AP-2, involved in endocytosis,

188 We recently demonstrated that removal of the clathrin adaptor protein AP-2, the key protein thought t

189 ts with the clathrin terminal domain and the clathrin adaptor protein AP-2.

190 transporter recycles by interacting with the clathrin adaptor protein AP-2.

191 is is thought to involve the activity of the clathrin adaptor protein AP180.

192 ) receptor (LDLR) in coated pits employs the clathrin adaptor protein ARH.

193 e proteins, whose sorting is mediated by the clathrin adaptor protein complex (AP) AP-1B.

194 Disruption of the clathrin adaptor protein complex 1 (AP-1) restores Chs3p

195 Disruption of the clathrin adaptor protein complex 1 (AP-1) restores Fus1p

196 BST2 cytoplasmic domains and the core of the clathrin adaptor protein complex 1 (AP1).

197 etwork area, whereas the localization of the clathrin adaptor protein complex 1 in the trans-Golgi ne

198 ors, PAR1 internalization is mediated by the clathrin adaptor protein complex 2 (AP-2) and epsin-1, r

199 The endosomal clathrin adaptor protein complex AP-1 is a key cellular

200 interactions between the mu2 subunit of the clathrin adaptor protein complex AP-2 and tyrosine-based

201 eraction with beta-adaptin, a subunit of the clathrin adaptor protein complex AP-2.

202 constitutive association with the endocytic clathrin adaptor protein complex, AP-2, strongly suggest

203 odamine conjugate and a fluorescently tagged clathrin adaptor protein complex, AP-2.

204 ntracellular loop of PAR4 and found that the clathrin adaptor protein complex-2 (AP-2) is important f

205 ation of unactivated PAR1 is mediated by the clathrin adaptor protein complex-2 (AP-2), where the mu2

206 ation of unactivated PAR1 is mediated by the clathrin adaptor protein complex-2 (AP-2), which binds t

207 nd in complex with AP-2, the plasma membrane clathrin adaptor protein complex.

208 b-like GTPase domain, was shown to bind both clathrin adaptor protein complexes, indicating a role in

209 on between their GluR2 subunits and AP2, the clathrin adaptor protein required for endocytosis.

210 ion factor-binding protein 3), a multidomain clathrin adaptor protein that sorts cargo proteins at th

211 Moreover the clathrin adaptor protein, AP-2, necessary for TfR intern

212 n, it potently stimulates the ability of the clathrin adaptor protein, AP180, to assemble clathrin at

213 pecific Yxxvarphi-type-binding motif for the clathrin adaptor protein, AP2, which is located within a

214 A similar clathrin adaptor protein, epsinR, exists in humans.

215 AP-2, the heterotetrameric clathrin adaptor protein, has been demonstrated to media

216 3S408/9A), which have reduced binding to the clathrin adaptor protein-2, a critical regulator of GABA

217 they display rapid movement, colocalize with clathrin, adaptor protein complex 1 (AP-1), and TGN46, b

218 ssing a dominant-negative mu2-subunit of the clathrin-adaptor protein AP-2.

219 n homologous to the mammalian brain-specific clathrin-adaptor protein AP180.

220 is initiated by the controlled assembly of a clathrin-adaptor protein coat on the cytosolic surface o

221 membrane in cells lacking Gga2p, a monomeric clathrin-adaptor protein involved in vesicular transport

222 Here we show that clathrin/adaptor protein 1 (AP-1)-dependent intestinal a

223 coats (e.g., coat protein complex I, II, and clathrin/adaptor protein complex), the exomer does not f

224 ciation of alpha-arrestins with clathrin and clathrin adaptor proteins (AP) and show that Aly1 and Al

225 In addition, shRNA-mediated knockdown of clathrin adaptor proteins AP-1 and AP-2 shows that the C

226 ) and LL, that are important for binding the clathrin adaptor proteins AP-1 and AP-2in vitro Surprisi

227 association between the delta subunits with clathrin adaptor proteins AP2-mu2 revealed by coimmunopr

228 we predicted that Eps15 might associate with clathrin adaptor proteins at the TGN and thereby mediate

229 ) are a highly conserved family of monomeric clathrin adaptor proteins implicated in clathrin-mediate

230 The role of clathrin adaptor proteins in sorting cargo in the biosyn

231 erged that beta-arrestins are more than just clathrin adaptor proteins involved in turning off recept

232 The GGAs are a family of clathrin adaptor proteins involved in vesicular transpor

233 sma membrane through interactions with other clathrin adaptor proteins such as AP-2.

234 key regulator of the recruitment of the GGA clathrin adaptor proteins to the TGN and that PI4P has a

235 and co-immunoprecipitate with both epsin and clathrin adaptor proteins, and epsin, as expected, co-im

236 id sequences that serve as binding sites for clathrin adaptor proteins.

237 sin, as expected, co-immunoprecipitates with clathrin adaptor proteins.

238 hat lack cytoplasmic sequences recognized by clathrin adaptor proteins.

239 osis, beta-secretase 1, and interaction with clathrin adaptor proteins.

240 es the canonical motif for interactions with clathrin adaptor proteins.

241 are structurally conserved between COPI and clathrin/adaptor proteins.

242 e examined the role of a potential dileucine clathrin adaptor recognition motif [DE]XXXL[LI] embedded

243 In CME, plasma membrane-binding clathrin adaptors recruit and polymerize clathrin to for

244 AP-1 is a clathrin adaptor recruited to the trans-Golgi Network wh

245 ive internalization and specifies a distinct clathrin adaptor requirement for activated receptor inte

246 Experiments employing a mutated clathrin adaptor reveal distinct mechanisms for sorting

247 ansitions from early to late events and that clathrin adaptor/scaffold protein interaction is essenti

248 DR-proximal initiator caspases cleaved the clathrin adaptor subunit AP2alpha between functionally d

249 scernible Golgi apparatus, the presence of a clathrin-adaptor system suggests that this parasite poss

250 that L1 associates in rat brain with AP-2, a clathrin adaptor that captures plasma membrane proteins

251 nd biochemically stable complex with Sla1, a clathrin adaptor that inhibits Las17 activity.

252 To function, clathrin requires clathrin adaptors that link it to transmembrane protein

253 ng, ARF-binding (GGA) proteins are monomeric clathrin adaptors that mediate the sorting of cargo at t

254 osylation factor)-binding (GGA) proteins are clathrin adaptors that mediate the sorting of transmembr

255 ng, Arf-binding (GGA) proteins are monomeric clathrin adaptors that mediate the sorting of transmembr

256 eficiency virus (SIV) bind the AP-1 and AP-2 clathrin adaptors to downmodulate the expression of CD4

257 s, whereas BIG1 and BIG2 recruit AP1 and GGA clathrin adaptors to the trans-Golgi network (TGN) and e

258 4,5)-bisphosphate [PI(4,5)P2] with endocytic clathrin adaptors, whereas functional studies using cell

259 the GGA or adaptor protein 1 (AP-1) type of clathrin adaptors, which are thought to function in TGN

260 sin is an evolutionarily conserved endocytic clathrin adaptor whose most critical function(s) in clat

261 ain lacking the genes encoding the candidate clathrin adaptors Yap1801p, Yap1802p, and Ent2p and cont