ライフサイエンスコーパス: clathrin heavy chain

1 n of epsin 1 with the terminal domain of the clathrin heavy chain.

2 ubunit with the amino-terminal domain of the clathrin heavy chain.

3 55 kDa N-terminal fragment from the 190 kDa clathrin heavy chain.

4 as a domain with resemblance to a region of clathrin heavy chain.

5 odes the last 654 amino acid residues of the clathrin heavy chain.

6 ferrin receptors (TfRs) and negative for the clathrin heavy chain.

7 ricarboxylate transport protein and a bovine clathrin heavy chain.

8 length CvpA interacted with AP2 subunits and clathrin heavy chain.

9 the regulatory clathrin light chain bound to clathrin heavy chain.

10 nal region of OCRL, but not of INPP5B, binds clathrin heavy chain.

11 with a small interfering RNA specific to the clathrin heavy chain.

12 essory proteins, most of which interact with clathrin heavy chain.

13 dle directly by the amino-terminal domain of clathrin heavy chain.

14 g human cancers that involve gene fusions of clathrin heavy chain.

15 reduced in a chicken B cell line depleted of clathrin heavy chain.

16 ) in ARH and to the N-terminal domain of the clathrin heavy chain.

17 in combination with a temperature-sensitive clathrin heavy chain.

18 that also bind to the terminal domain of the clathrin heavy chain.

19 nd altered the intracellular distribution of clathrin heavy chains.

20 protein zeta/delta, annexin A1/A3/A4/A5/A6, clathrin heavy chain 1, glyceraldehyde-3-phosphate dehyd

21 per, we report that RNAi depletion of CHC17 (clathrin heavy chain 17) clathrin, but not the CHC22 cla

22 Clathrin heavy chain 22 (CHC22) is an isoform of the wel

23 s an isoform of the well-characterized CHC17 clathrin heavy chain, a coat component of vesicles that

24 The clathrin heavy chain accesses the same contact surface o

25 The C-terminal part of CALM binds clathrin heavy chain, although the full-length protein e

26 ntaining alpha-solenoids related to those of clathrin heavy chain and COPI subunits.

27 AP-2 interacts with the clathrin heavy chain and cytoplasmic domains of receptor

28 Among them, we identified clathrin heavy chain and dynamin 1 as potential candidat

29 The knock-downs of clathrin heavy chain and dynamin produced maximal inhibi

30 We found that LdRab5b interacts with clathrin heavy chain and hemoglobin receptor.

31 e the binding site to residues 89-100 of the clathrin heavy chain and indicate that residues 1-100 ca

32 studies have shown that ACK1 interacts with clathrin heavy chain and is involved in clathrin-coated

33 ion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecul

34 T40 to inactivate the endogenous alleles for clathrin heavy chain and replace them with human clathri

35 preference for light chains associated with clathrin heavy chain and show that Hip1R stimulation of

36 nvolves amino acid residues 1315-1557 of the clathrin heavy chain and the carboxy, but not the amino-

37 athrin-coated vesicles at the TGN (the Chc1p clathrin heavy chain and the Vps1p dynamin homolog) and

38 ight chains to alter the conformation of the clathrin heavy chain and thereby regulates assembly.

39 n assembles into triskelia composed of three clathrin heavy chains and associated clathrin light chai

40 Vesicular structures containing both clathrin heavy chains and PtdIns(4,5)P2 are revealed imm

41 CD63, clathrin heavy chain, and beta-adaptin mRNAs, all of whi

42 However, LdRab5a failed to interact with the clathrin heavy chain, and interaction with hemoglobin re

43 receptor causes rapid phosphorylation of the clathrin heavy chain at tyrosine 1477, which lies in a d

44 2 and promotes binding of beta-arrestin 2 to clathrin heavy chain/beta-adaptin, thereby accelerating

45 Further more, A1AT associated with clathrin heavy chains, but not with caveolin-1 in the pl

46 We trace most of the 1,675-residue clathrin heavy chain by fitting known crystal structures

47 Reduced expression of the clathrin heavy chain by HCV prevents ENT1 recycling to t

48 cDNA selection protocol, we isolated a novel clathrin heavy chain cDNA (CLTD) from the VCFS/DGS minim

49 naling involves inducible phosphorylation of clathrin heavy chain (CHC) in both CD4+ and CD8+ human T

50 The clathrin heavy chain (CHC) is the major structural prote

51 individualization complex in a male-sterile clathrin heavy chain (Chc) mutant is observed to be redu

52 Like partial loss-of-function Clathrin heavy chain (Chc) mutants, aux mutant males are

53 edistributed the adaptor protein AP2 and the clathrin heavy chain (CHC) to surface membranes.

54 Clathrin heavy chain (Chc), a major constituent of coate

55 exhibited increased association of Egfr with clathrin heavy chain (CHC), Gab1, and p85alpha, the regu

56 The ubiquitous clathrin heavy chain (CHC), the main component of clathr

57 stmitotic Golgi reassembly that requires the clathrin heavy chain (CHC).

58 , composed of clathrin light chain (Clc) and clathrin heavy chain (Chc).

59 nduced phagocytosis requires GULP binding to clathrin heavy chain (CHC).

60 Here, we report that clathrin heavy chain (CHC-1), a membrane coat protein we

61 ull allele is also synthetically lethal with clathrin heavy chain (chc1) temperature-sensitive allele

62 In humans, there are two isoforms each of clathrin heavy chain (CHC17 and CHC22) and light chain (

63 tion and function compared with conventional clathrin heavy chain (CHC17), encoded on chromosome 17.

64 was shown to bind to two proteins, including clathrin heavy chain, Chc1p.

65 The muscle isoform of clathrin heavy chain, CHC22, has 85% sequence identity t

66 We examined clathrin heavy chain (ClaH-GFP) which localized to three

67 elium cell line revealed important roles for clathrin heavy chain (clathrin) in endocytosis, secretio

68 c1p displayed no defects in Clc1p binding to clathrin heavy chain, clathrin trimer stability, sorting

69 hal screen identified DRS2/SWA3 along with a clathrin heavy-chain conditional allele (chc1-5/swa5-1)

70 The clathrin heavy chains continue inwards under the vertice

71 In the current study, fusion of ALK with the clathrin heavy chain (CTLC) gene localized to 17q23 was

72 uppressors that can rescue lethal strains of clathrin heavy chain-deficient yeast (Chc - scd1-i) to v

73 otillin had no effect on ATP7A localization, clathrin heavy chain depletion or expression of AP180 do

74 ntigen 1) and clathrin-mediated endocytosis (clathrin heavy chain) during entry into RFs.

75 shed roles in clathrin-mediated endocytosis (clathrin heavy chain, dynamin-2, heat shock 70-kDa prote

76 as well as treatment with Torin 1, degrades clathrin heavy chain expression in a hepatoma cell line.

77 ly 70% in B cells conditionally deficient in clathrin heavy chain expression.

78 , to inhibit endocytic pathways regulated by clathrin heavy chain, flotillin-1, caveolin-1, dynamin-2

79 concept by demonstrating that acute loss of clathrin heavy chain function in the fly eye leads to sy

80 An interesting characteristic of the yeast clathrin heavy chain gene (CHC1) is that in some strains

81 m and site-directed mutagenesis of the yeast clathrin heavy chain gene (CHC1) to characterize regions

82 hat carry a multicopy plasmid containing the clathrin heavy chain gene (CHC1), resulting in levels of

83 is a new temperature-sensitive allele of the clathrin heavy chain gene (chc1-5), which carries a fram

84 d with a temperature-sensitive allele of the clathrin heavy chain gene (chc1-521) in Saccharomyces ce

85 An exon representing a novel clathrin heavy chain gene (CLTCL) was isolated during ge

86 not identical to the ubiquitously expressed clathrin heavy chain gene.

87 rrying a temperature-sensitive allele of the clathrin heavy chain gene.

88 We report the cloning of a novel clathrin heavy-chain gene (CLTC)-TFE3 gene fusion result

89 In contrast, inactivation of the clathrin heavy-chain gene CHC1 results in transport of K

90 genetics, we sequenced parts of two unlinked clathrin heavy chain genes (CLTC and CLTCL1).

91 id sequence of this gene product to those of clathrin heavy chain genes of other species.

92 alpha(q) on Kir4.1, whereas knockdown of the clathrin heavy chain had no effect.

93 recruitment to membranes is mediated by the clathrin heavy chain (HC) N-terminal domain (TD), which

94 LC binding to clathrin heavy chain (HC) was characterized by genetic a

95 hVam6p binds through its clathrin heavy chain homology domain to a unique region

96 We investigate how the deletion of clathrin heavy chain impairs the dynamics and the morpho

97 STAT3 was constitutively associated with clathrin heavy chain in membrane and in the 1- to 2-MDa

98 ane is significantly less than the number of clathrin heavy chains in the assembly.

99 was strongly inhibited by siRNA depletion of clathrin heavy chain, indicating that CAT-1-HA-GFP inter

100 amin, or a dominant-negative hub fragment of clathrin heavy chain, indicating that it is mediated by

101 n triskelia but not the N-terminal domain of clathrin heavy chain, indicating that stabilization of k

102 coimmunoprecipitation demonstrated that the clathrin heavy chain is the major binding partner of CAL

103 ntracellular trafficking, and in humans, the clathrin heavy-chain isoform CHC22 is highly expressed i

104 A triskelion comprises three clathrin heavy chains joined at their C-termini, extendi

105 romised if clathrin levels fall by 20% after clathrin heavy chain knock down using RNAi.

106 Clathrin heavy chain knockdown and dileucine mutation of

107 anslocation and shown that it interrupts the clathrin heavy chain-like gene (CLTCL) within the MDGCR.

108 to the cytokinesis failure of Dictyostelium clathrin heavy-chain mutants.

109 -NT in yeast suppresses endocytic defects of clathrin heavy-chain mutants.

110 Combination of suppressor mutations with a clathrin heavy chain mutation (chc1-ts) confers no synth

111 when combined with a conditional mutation in clathrin heavy chain or deletion of GGA genes, accentuat

112 r annexins I, II, IV, and VI; alpha-adaptin; clathrin heavy chain; or beta-coatomer protein.

113 ssense mutation in CLTCL1 encoding the CHC22 clathrin heavy chain, p.E330K, which we demonstrate to h

114 ly kinase activity is required for inducible clathrin heavy chain phosphorylation, BCR colocalization

115 ,210-1,516 involved in mediating spontaneous clathrin heavy-chain polymerization and light-chain asso

116 other fundamental cellular processes (e.g., clathrin heavy-chain polypeptide, culreticulin, and Ras-

117 ion at a site at the N-terminal hooks of the clathrin heavy chains, presumably via the J domain of C5

118 re involved and deletion analysis mapped the clathrin heavy-chain regions participating in their form

119 and that its self-assembly is mediated by a clathrin heavy chain repeat domain in the middle of the

120 Both the CNH and clathrin heavy chain repeat domains are required for ind

121 conserved N-terminal domain and a C-terminal clathrin heavy-chain repeat (CHCR) domain.

122 ptor protein complex) interaction domain and clathrin heavy-chain repeat domain are required for prot

123 predicted protein contains six WD repeats, a clathrin heavy-chain repeat, and three transmembrane dom

124 lso shares structural features with HEAT and clathrin heavy chain repeats.

125 ith an inducible short hairpin RNA targeting clathrin heavy chain, resulting in approximately 85% pro

126 in cells expressing a temperature-sensitive clathrin heavy chain results in accentuated growth and a

127 her alpha adaptin (AP-2 clathrin adaptor) or clathrin heavy chain, revealing that Kir2.3 is internali

128 hree-dimensional framework for understanding clathrin heavy-chain self-assembly, light-chain binding

129 Knockdown of endogenous clathrin heavy chain showed that the Golgi apparatus fai

130 rimeric CHC22 protein does not interact with clathrin heavy chain subunits nor bind significantly to

131 s of clathrin-coated membranes, we expressed clathrin heavy chain tagged with green fluorescent prote

132 ity correlates with expression levels of the clathrin heavy chain TbCLH, and additional evidence sugg

133 bind weakly to the N-terminal domain of the clathrin heavy chain (TD).

134 uted to direct interaction of kindlin-2 with clathrin heavy chain, thereby controlling endocytosis an

135 have found that ACK2 directly interacts with clathrin heavy chain through a clathrin-binding motif th

136 rence to knock down the AP-2 mu2 subunit and clathrin heavy chain to undetectable levels in HeLaM cel

137 ty salt bridges which would otherwise induce clathrin heavy chains to assemble at physiological pH.

138 Depletion of clathrin heavy chain using RNA interference prolonged mi

139 After inactivation of clathrin heavy chain, vacuolar protease-dependent degrad

140 We present evidence for two clathrin heavy chain variants in the photoreceptor termi

141 centrated at clathrin-coated pits, and binds clathrin heavy chain via two clathrin boxes.

142 r ros sequences identified cellular RNA 7SL, clathrin heavy chain, visinin-like protein-1, and three

143 he vertex may correspond to the C-termini of clathrin heavy chains which form a protrusion on free tr

144 assembly of recombinant hub fragments of the clathrin heavy chain, which bind clathrin light-chain su

145 The amino-terminal domain of the clathrin heavy chain, which folds into a seven-bladed be

146 ankyrin(R) binds to the N-terminal domain of clathrin heavy chain with high affinity.