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1 ne 256, and an intact actin cytoskeleton and clathrin coated pit.
2 centration upon Wnt-induced recruitment into clathrin-coated pits.
3 of endothelial cells but is internalized in clathrin-coated pits.
4 is not necessary for its internalization by clathrin-coated pits.
5 or clathrin, the major structural protein of clathrin-coated pits.
6 targets the proteins for internalization via clathrin-coated pits.
7 itionally been viewed as being initiated via clathrin-coated pits.
8 ed together with transferrin receptor and to clathrin-coated pits.
9 ted signaling molecules, and the presence of clathrin-coated pits.
10 d to be internalized rapidly, likely through clathrin-coated pits.
11 n levels, and are distinct from caveolae and clathrin-coated pits.
12 ired for ARH-associated LDLR clustering into clathrin-coated pits.
13 ell as association of adaptor protein-2 with clathrin-coated pits.
14 Nef down-regulates CD4 by linking CD4 to clathrin-coated pits.
15 we observe that SNX9 partially localizes to clathrin-coated pits.
16 namin might guide or insert the complex into clathrin-coated pits.
17 o in mammalian cells, they are excluded from clathrin-coated pits.
18 any proteins, including beta-arrestin-2 with clathrin-coated pits.
19 two processes promote endocytosis of Smo in clathrin-coated pits.
20 , and not in assembly of functionally active clathrin-coated pits.
21 usly that PSMA undergoes internalization via clathrin-coated pits.
22 hat have been implicated in the formation of clathrin-coated pits.
23 ling through spatial segregation of a GAP in clathrin-coated pits.
24 arized cells but are prevented from entering clathrin-coated pits.
25 nitial steps of EGFR internalization through clathrin-coated pits.
26 -mediated phosphorylation directs it through clathrin-coated pits.
27 in, suggesting that endocytosis occurred via clathrin-coated pits.
28 receptor desensitization and endocytosis via clathrin-coated pits.
29 role in mediating arrestin interaction with clathrin-coated pits.
30 ing the recruitment of the receptor/cargo to clathrin-coated pits.
31 est detectable endocytic vesicles arise from clathrin-coated pits.
32 e channel that undergoes endocytosis through clathrin-coated pits.
33 rtonic medium, suggesting the involvement of clathrin-coated pits.
34 hese kinases in EGFR internalization through clathrin-coated pits.
35 an chemoattractant receptors internalize via clathrin-coated pits.
36 initiates redistribution of occupied uPAR to clathrin-coated pits.
37 ndocytosis of G protein-coupled receptors by clathrin-coated pits.
38 go rapid, agonist-induced internalization by clathrin-coated pits.
39 roofed' cells showed that Hip1R localizes to clathrin-coated pits.
40 ependent pathway for internalization through clathrin-coated pits.
41 es internalization of the sst2A receptor via clathrin-coated pits.
42 teins entering the endocytic pathway through clathrin-coated pits.
43 clathrin binding motif are still targeted to clathrin-coated pits.
44 naptotagmin fragment had a reduced number of clathrin-coated pits.
45 in the cell cytosol and primes it to reform clathrin-coated pits.
46 targeting of beta(2)-adrenergic receptor to clathrin-coated pits.
47 ological role in the nucleation of endocytic clathrin-coated pits.
48 min I-dependent process that likely involves clathrin-coated pits.
49 olocalize with alpha-adaptin, a component of clathrin-coated pits.
50 soproterenol and colocalizes with beta2AR in clathrin-coated pits.
51 itosis due to a block in the invagination of clathrin-coated pits.
52 n ECs (HUVECs), increasing NP uptake through clathrin-coated pits.
53 cludes the agonist-occupied receptors to the clathrin-coated pits.
54 n adaptor incorporation into plasma membrane clathrin-coated pits.
55 d occurs independently of internalization by clathrin-coated pits.
56 at leads to invagination and then fission of clathrin-coated pits.
57 h syndrome protein (WASP) assembles actin at clathrin-coated pits.
58 s intracellularly into EEA-1+ endosomes from clathrin-coated pits.
59 g that CAT-1-HA-GFP internalization requires clathrin-coated pits.
60 xclusion of bulky extracellular domains from clathrin-coated pits.
61 or-dependent redistribution of arrestin2L to clathrin-coated pits.
62 nner vesicles/tubules and exocytosis through clathrin-coated pits.
63 acterized mechanism for endocytosis involves clathrin-coated pits [1], but evidence has accumulated f
64 raphy to investigate the massive increase in clathrin-coated pit abundance that is selectively observ
65 ing or in the ability to target receptors to clathrin-coated pits, acted as dominant negative inhibit
66 apse leads to a block in the invagination of clathrin-coated pits adjacent to the active zone and the
68 of these long plasmalemmal invaginations had clathrin-coated pits along their cytoplasmic surface.
69 s believed to contribute to the formation of clathrin-coated pits, although the specific components t
72 tiate the endocytosis of these receptors via clathrin coated-pits and interact directly with clathrin
73 which the GAK was disrupted showed a lack of clathrin-coated pits and a complete block in clathrin-me
74 that results in an accumulation of arrested clathrin-coated pits and a greatly reduced synaptic vesi
75 e clathrin-mediated endocytosis with shallow clathrin-coated pits and a strong reduction in the inter
77 ells it colocalizes with clathrin and AP2 in clathrin-coated pits and at the leading edge of migratin
78 show that OCRL visits late-stage, endocytic clathrin-coated pits and binds the Rab5 effector APPL1 o
79 es scission from the plasma membrane of both clathrin-coated pits and caveolae during distinct endocy
80 ls through receptor-mediated endocytosis via clathrin-coated pits and caveolae, that actin filaments
82 als, these peptides inhibit the formation of clathrin-coated pits and coated vesicles during synaptic
83 tic adaptor, which is highly concentrated at clathrin-coated pits and coordinates acquisition of bila
86 mplex, which were concentrated at late-stage clathrin-coated pits and in lamellipodia, also dissociat
88 demonstrate that E-selectin clusters in both clathrin-coated pits and lipid rafts of endothelial cell
89 as to test whether cortactin associates with clathrin-coated pits and participates in receptor-mediat
90 least two distinct endocytic pathways (i.e., clathrin-coated pits and plasma membrane lipid rafts) th
91 ation by a process involving endocytosis via clathrin-coated pits and subsequent sorting to lysosomes
92 in-coupled receptors for internalization via clathrin-coated pits and that its endocytic function is
93 hat ADAM17 is constitutively internalised by clathrin-coated pits and that physiological stimulators
95 per-resolution images of living cells, using clathrin-coated pits and the transferrin cargo as model
96 docytic trafficking; it is recruited to both clathrin-coated pits and to ensuing uncoated endocytic v
97 , a membrane protein that is endocytosed via clathrin-coated pits and traffics through the acidic end
98 ies showed FcRY-mediated internalization via clathrin-coated pits and transport involving early and r
99 in 1 related (Hip1R) is a novel component of clathrin-coated pits and vesicles and is a mammalian hom
100 hese data show that mHip1R is a component of clathrin-coated pits and vesicles and suggest that it mi
102 st component Sec5 is unexpectedly present in clathrin-coated pits and vesicles at the plasma membrane
103 amin-1 (K44A), and MUC1 was observed in both clathrin-coated pits and vesicles by immunoelectron micr
104 wed that virus particles concentrated within clathrin-coated pits and vesicles early in the uptake pr
108 nduced a selective increase in unconstricted clathrin-coated pits and, in the case of swinholide, an
110 PS15, a protein required for the assembly of clathrin-coated pits, and DN PAK-1, an obligate mediator
111 molecules from the plasma membrane, through clathrin-coated pits, and into the cell for lysosomal de
112 Triad3A associates with Arc, localizes to clathrin-coated pits, and is associated with endocytic s
113 oenvironments, three-dimensional tracking of clathrin-coated pits, and long-term imaging spanning >10
114 Lp(a) internalization was also dependent on clathrin-coated pits, and Lp(a) was targeted for lysosom
115 ysically interacts with AP-2, is enriched on clathrin-coated pits, and requires clathrin but not RAB-
116 h respect to G proteins, internalization via clathrin-coated pits, and signaling via a growing list o
117 AP-2 complex responsible for the assembly of clathrin-coated pits, and that AP50 is essential for fun
118 at BKV entered into HRPTEC via caveolae, not clathrin-coated pits, and that BKV is maximally associat
119 ceptors are most likely internalized through clathrin-coated pits, and then returned to the plasma me
120 t likely to be internalized independently of clathrin-coated pits, and there is evidence to suggest t
121 alized with clathrin and other components of clathrin-coated pits, AP-2 did not seem to be present in
125 eptor signaling, in cells in which endocytic clathrin-coated pits are frozen at a deeply invaginated
127 ompartment provides additional evidence that clathrin-coated pits are the predominant pathway for end
129 1 and inducing GLUT1 internalization through clathrin-coated pits, as well as indirectly, by reducing
131 issive Vero cells is slow, is independent of clathrin-coated-pit assembly, is dependent on an intact
134 f ARF6 leads to an increase in the number of clathrin-coated pits at the apical plasma membrane.
135 Recent studies suggest that the mobility of clathrin-coated pits at the cell surface are restricted
139 well as the clathrin adaptors AP2 and AP1 in clathrin-coated pits at the plasma membrane and trans-Go
140 overy after photobleaching, that clathrin in clathrin-coated pits at the plasma membrane exchanges wi
141 2 proteins with membranes, and the number of clathrin-coated pits at the plasma membrane increased wh
142 catalyzes the scission of deeply invaginated clathrin-coated pits at the plasma membrane, but the mec
146 pha subunit showed defective localization to clathrin-coated pits; at high expression levels, the app
147 onstruct of EPS15, an essential component of clathrin-coated pits, blocked the entry of RRV into RFs.
148 out significantly affecting the structure of clathrin-coated pits, both clathrin and AP2 at the plasm
151 that undergo agonist-induced endocytosis via clathrin-coated pits but differ significantly in their p
152 idly, beta-arrestin directs the receptors to clathrin-coated pits but does not internalize with them.
153 rpromazine HCl, which blocks endocytosis via clathrin-coated pits, but not by nystatin and cholera to
154 bound clathrin is a fundamental property of clathrin-coated pits, but not clathrin baskets, and may
155 sion by forming a collar around the necks of clathrin-coated pits, but the specific structural intera
156 he transferrin receptor is incorporated into clathrin-coated pits by associating, via tyrosine-based
158 ns can be marked as cargo for inclusion into clathrin-coated pits by common internalization signals (
160 or protein 2 (AP2) complexes, which initiate clathrin-coated pit (CCP) assembly, are activated by con
165 This corresponded to a decreased rate of clathrin-coated pit (CCP) initiation and increased lifet
166 DEO ABSTRACT: Some endocytic cargoes control clathrin-coated pit (CCP) maturation, but it is not know
169 pithelium (PTE), where it is concentrated in clathrin-coated pits (CCPs) and vesicles in the brush bo
171 Classical CME proceeds via the formation of clathrin-coated pits (CCPs) at the plasma membrane, whic
173 ns (EAPs) mediate assembly and maturation of clathrin-coated pits (CCPs) into cargo-containing vesicl
175 es of the observed heterogeneous dynamics of clathrin-coated pits (CCPs) might be the different cargo
176 rgo receptors, either recruiting cargos into clathrin-coated pits (CCPs) or initiating clathrin-coat
177 ntrol its fate by regulating the dynamics of clathrin-coated pits (CCPs) that mediate their internali
178 ing structures at the plasma membrane termed clathrin-coated pits (CCPs) that mediate vesicle formati
179 substantial increase in the ratio of "open" clathrin-coated pits (CCPs) to "necked"/"closed" CCVs an
180 composition of the lifetime distributions of clathrin-coated pits (CCPs) to measure independent aspec
181 P(2) levels and is concentrated at endocytic clathrin-coated pits (CCPs) via interactions with the sc
183 cargos are known to accumulate into maturing clathrin-coated pits (CCPs), whether and how cargo recru
187 itions that markedly affect the structure of clathrin-coated pits, clathrin exchange was blocked but
188 thrin interactor, is recruited to late-stage clathrin-coated pits, clinical manifestations have been
189 )P(2) breakdown on the dynamics of endocytic clathrin-coated pit components and of the actin regulato
190 participates initially in the maturation of clathrin-coated pits during early stages of synaptic ves
194 synthesis and its metabolic processing, the clathrin-coated pit endocytosis pathway, and the ubiquit
196 f megalin, ARH and megalin are first seen in clathrin coated pits followed by sequential localization
197 on, mediated by endocytosis of receptors via clathrin-coated pits followed by sorting to lysosomes, h
202 results suggest a role for synaptojanin 2 in clathrin-coated pit formation and imply that lipid hydro
203 athrin-binding domain of AP180, which blocks clathrin-coated pit formation but not clathrin-independe
204 nodansylcadaverine (MDC), which both inhibit clathrin-coated pit formation, resulted in decreased inv
205 could be blocked by conditions that prevent clathrin-coated pit formation, suggesting that heregulin
206 PARs is blocked by biochemical inhibition of clathrin-coated pit function or overexpression of a domi
209 ntry that is low-pH dependent occurs through clathrin-coated pits in a manner similar to wild-type vi
211 is generally believed that the formation of clathrin-coated pits in epithelial cells occurs randomly
212 y ligands, MORs are rapidly internalized via clathrin-coated pits in heterologous cells and dissociat
213 -) mice are overtly normal, but have reduced clathrin-coated pits in kidney proximal tubule cells and
218 n-dependent internalization, indicating that clathrin-coated pits, in concert with mechanisms depende
219 embrane invaginations accumulated, capped by clathrin-coated pits, in synapses of dynamin 1-knockout
220 st partially defined by the cytoskeleton and clathrin-coated pits, in which receptors and G proteins
221 ith lipid rafts, the actin cytoskeleton, and clathrin-coated pits influences B cell signaling and ant
224 crose, which have been reported to transform clathrin-coated pits into clathrin cages just below the
229 ocalization of the SNX9.dynamin-2 complex to clathrin-coated pits is blocked by interactions with the
230 the mechanisms by which the invagination of clathrin-coated pits is blocked in mitosis and their sti
231 alization of G protein-coupled receptors via clathrin-coated pits is dependent on the adaptor protein
232 receptor-mediated cholesterol uptake through clathrin-coated pits is now well understood, the molecul
233 suggests a mechanism by which nucleation of clathrin-coated pits is stimulated by the loading of car
236 d capsids laterally diffused into assembling clathrin-coated pits less than 30 s after attachment.
239 transporter that is a critical component of clathrin-coated pit-mediated endocytosis, as well as in
241 after a 4 h chase and became undetectable if clathrin-coated pit-mediated trafficking was blocked wit
242 Both immature and mature DCs are capable of clathrin-coated pit-mediated uptake of SIV, supporting t
244 ntly, ligand-bound EGFR is incorporated into clathrin-coated pits--membrane structures containing cla
245 )P(3) biosensors, disappearance of endocytic clathrin-coated pits, nearly complete inhibition of KCNQ
247 of PP1, suggesting that entry of c-Kit into clathrin-coated pits occurs independently of Src family
249 rin receptors are delivered selectively from clathrin-coated pits on the plasma membrane into a speci
250 e ESCRT-0 complex accumulates at a subset of clathrin-coated pits on the surface of human cells.
253 oma cells, which mediate endocytosis via the clathrin-coated pit pathway and are almost completely in
254 ernalizes desialylated glycoproteins via the clathrin-coated pit pathway and mediates their delivery
255 receptors that are internalized through the clathrin-coated pit pathway in a beta-arrestin- and dyna
261 ctly couple TGF-beta receptors to AP2 and to clathrin-coated pits, providing the first in vivo eviden
262 opinocytosis (or phagocytosis), formation of clathrin-coated pits (receptor mediated), and penetratio
263 many chemokine receptors internalize through clathrin-coated pits, regulation of the receptor traffic
264 n thought to coordinate cargo selection into clathrin-coated pits, results in a significant impairmen
265 sis of transmembrane receptors requires that clathrin-coated pits retain the receptors long enough to
266 ocal activity, and axonal boutons containing clathrin-coated pits showed a more pronounced decrease i
267 decreased the recruitment of P-selectin into clathrin-coated pits, slowed the internalization of P-se
268 erized, and it remains controversial whether clathrin-coated pits specialize to internalize particula
269 e involvement of adaptor proteins present in clathrin-coated pits, such as epsin, Eps15 (epidermal gr
270 with EGF-R, but with CD71, which is found in clathrin-coated pits, suggesting that integration of tre
272 transient burst of EGFP-SNX9 recruitment to clathrin-coated pits that occurs during the late stages
273 y of auxilin is required for constriction of clathrin-coated pits, the same early step in endocytosis
275 egulated by dynamin-dependent endocytosis in clathrin-coated pits through its cytoplasmic domain.
276 indings reveal a link between progression of clathrin-coated pits to endocytic vesicles and an activa
277 ycling, and hence in oocytes is recruited to clathrin-coated pits to facilitate the rapid recycling o
278 , these findings indicate that BRAG2 acts at clathrin-coated pits to promote integrin internalization
279 m of Eps15 that is an essential component of clathrin-coated pits, to investigate the extent and impo
281 endocytosis of ligand-receptor complexes via clathrin-coated pits, trafficking of the internalized li
283 tor protein to be identified associated with clathrin-coated pits/vesicles and shown to modulate clat
284 rin-mediated endocytosis and associates with clathrin-coated pits/vesicles at the plasma membrane.
285 t myosin VI associates and co-localizes with clathrin-coated pits/vesicles by its C-terminal tail.
286 on BL-3 cells, LKT moves to lipid rafts and clathrin-coated pits via a dynamic process that results
287 ntrast to INPP5B visits late stage endocytic clathrin-coated pits, was earlier shown to contain anoth
288 e for activated PAR1 internalization through clathrin-coated pits we examined the function of a highl
289 D1A, which encodes a protein associated with clathrin-coated pits where cell-surface receptors reside
291 ed mechanism for 7TMR internalization is via clathrin-coated pits, where clathrin and adaptor protein
292 Activated PAR1 was rapidly recruited to clathrin-coated pits, where it colocalized with transfer
293 ns in a complex with the GTPase dynamin-2 at clathrin-coated pits, where it provokes fission of vesic
294 accumulate at the base of arrested endocytic clathrin-coated pits, where they support the growth of d
295 e it is internalized, P-selectin clusters in clathrin-coated pits, which enhances its ability to supp
296 -coated vesicles and an increase in U-shaped clathrin-coated pits, which may result from sequestratio
298 toplasmic domain of E-selectin or disrupting clathrin-coated pits with hypertonic medium blocked inte
299 clathrin triskelions to the edges of growing clathrin-coated pits with very little exchange occurring
300 endocytic defect included an accumulation of clathrin-coated pits with wide necks, as previously obse
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