ライフサイエンスコーパス: claudin-3

1 involving increased inflammation and loss of claudin-3.

2 udin-19 mRNA was 25 times more abundant than claudin-3.

3 site at amino acid 192 in the C terminus of claudin-3.

4 nd diminished junctional immunoreactivity of claudin-3.

5 d downregulated expression of genes encoding claudin 3, 4, and 7 and the luminal marker, cytokeratin

6 Claudin 3, a tight junction protein, is transiently inco

7 regimen, a novel and tissue-specific role of claudin-3, a tight junction integral protein, in inhibit

8 Loss of claudin-3 also predicted poor patient survival.

9 5 only in junctions of acinar cells, whereas claudin 3 and 4 are in both.

10 EB1, S100A8, amyloid beta precursor protein, claudin 3 and cadherin 1 (downregulated in MDA-MB-231) w

11 whereas the expression of 194 genes, such as claudin 3 and cell adhesion molecule 1, is significantly

12 family, and low to absent expression of both claudin 3 and E-cadherin.

13 junction (TJ) proteins in the ileum revealed claudin 3 and occludin expression to be increased overal

14 Claudin-3 and -4 are frequently overexpressed in ovarian

15 Here, we showed that claudin-3 and -4 can be phosphorylated in ovarian cancer

16 presence of the high-affinity CPE receptors claudin-3 and -4 in both organs of rabbits, consistent w

17 present surface or secreted proteins such as claudin-3 and -4, HE4, mucin-1, epithelial cellular adhe

18 ptors on intestinal epithelial cells include claudin-3 and -4, members of a large family of tight jun

19 ity association of the PDZ domain of nNOS to claudin-3 and claudin-14, two tight junction tetraspan m

20 In particular, claudin-3 and claudin-4 are frequently overexpressed in

21 However, claudin-3 and claudin-4 are the only family members capa

22 nterfering RNA (siRNA)-mediated knockdown of claudin-3 and claudin-4 expression in ovarian cancer cel

23 ely in breast cancer cells, correlating with claudin-3 and claudin-4 expression.

24 current ovarian tumors were found to express claudin-3 and claudin-4 genes at significantly higher le

25 profiling, we and others have recently found claudin-3 and claudin-4 genes to be highly expressed in

26 (CNS) revealed low or undetectable levels of claudin-3 and claudin-4 in all regions tested by Western

27 tudy was designed to study the expression of claudin-3 and claudin-4 in human prostate tissue as pote

28 Our previous studies have revealed that claudin-3 and claudin-4 proteins are highly overexpresse

29 In contrast, expression of claudin-3 and claudin-4 was absent in adjacent normal br

30 issue Northern blot analysis, mRNAs for both claudin-3 and claudin-4 were expressed at high levels in

31 By immunohistochemical analysis, claudin-3 and claudin-4 were expressed frequently in met

32 We found that although claudin-3 and claudin-4 were heteromerically compatible

33 estroy cancer cells expressing CPE receptors claudin-3 and claudin-4.

34 E) cells constitutively expressing wild-type claudin-3 and claudin-4.

35 ession of TJ proteins ZO-1, JAM-2, Occludin, Claudin-3 and Claudin-5, using in vitro cultures of the

36 y we investigated the level of expression of claudin-3 and/or claudin-4 in chemotherapy-naive and che

37 The abundance of claudins-3 and -5 remained unchanged.

38 Rvp.1 (claudin-3) and CPE-R (claudin-4) are members of a larger

39 s 8, 18, and 19, CD133/1, telomerase, CD44H, claudin 3, and albumin (weakly).

40 e tight-junction molecules zona occludens-1, claudin 3, and claudin 5 and other pathways critically i

41 e able to heterotypically bind to claudin-1, claudin-3, and claudin-5.

42 blots revealed that expression of Claudin-7, Claudin-3, and Occludin, critical proteins that regulate

43 Although glucose transporter 1, claudin-3, and plasmalemma vesicular-associated protein

44 helial cells, in which zonal occludens-1 and claudin-3, apical tight-junction proteins, are mislocali

45 Overall, these novel findings identify claudin-3 as a therapeutic target for inhibiting overact

46 Claudin-3, claudin-10, and claudin-19 were detected in R

47 ts were unexplained by effects on claudin-2, claudin-3, claudin-19, occludin, and ZO-1, but changes i

48 audins expressed by the alveolar epithelium, claudin-3, claudin-4, and claudin-18 are the most promin

49 hrough immunohistochemical analysis of ApoJ, claudin-3, claudin-4, and epithelial cellular adhesion m

50 pression of other tight junctional proteins (claudin-3, claudin-4, claudin-5, occludin, and ZO-1) and

51 Claudin-3 (CLDN3) and claudin-4 (CLDN4) are the major st

52 Claudin-3 (CLDN3) is a tight junction protein that is ov

53 ered intestinal morphology, and dysregulated claudin-3 crypt expression.

54 , which were heterotypically compatible with claudin-3, did not heterotypically bind to claudin-4.

55 tercellular junctional proteins (e.g., ZO-1, claudin-3, E-cadherin) and the subapical cytoskeletal/mi

56 nal barrier function maturation by promoting claudin 3 expression.

57 ibit impaired barrier function and decreased claudin 3 expression.

58 es intestinal barrier maturation and induces claudin 3 expression.

59 e findings however contrasted an upregulated claudin-3 expression in other cancer types and implicate

60 The persistent high level of claudin-3 expression in prostate adenocarcinoma and func

61 ases in the distribution of occludin but not claudin-3 in the B, EF, and B+EF groups.

62 from periportal to pericentral hepatocytes, claudin 3 is uniformly expressed, claudin 4 is absent, a

63 nstructs demonstrated that the C terminus of claudin-3 is an excellent substrate for cAMP-dependent p

64 Claudin-3 loss also upregulated the gp130/IL6/Stat3 sign

65 c and pharmacological studies confirmed that claudin-3 loss induces Wnt/beta-catenin activation, whic

66 Claudin-3-/- mice revealed dedifferentiated and leaky co

67 ndent manner, differentiated colon cancer in claudin-3-/- mice versus WT-mice.

68 nding normal glandular tissue, expression of claudin-3 mRNA remained high in the epithelium of prosta

69 Our results suggest that claudin-3 phosphorylation by PKA, a kinase frequently ac

70 e blood-testis barrier to biotin, suggesting claudin 3 regulates the movement of small molecules acro

71 stinal tight junction proteins, occludin and claudin-3, showed decreases in the distribution of occlu

72 on in the first extracellular loop domain of claudin-3 to convert Asn(44) to the corresponding amino

73 In normal prostate tissue, expression of claudin-3 was localized exclusively within acinar epithe

74 icated by loss of the tight junction protein claudin-3 was not observed during acute infection despit

75 Claudin-3 was reduced in LSI animals with severe intesti

76 e first EL domain or the second EL domain of claudin-3 were able to heterotypically bind to claudin-1

77 ion in the ileum, VE-cadherin, occludin, and claudin-3, Western blot analyses were conducted.

78 n Sertoli cells, regulates the expression of claudin 3, which encodes a transient component of newly

79 caused a loss of the tight junction protein claudin-3, which was ameliorated by genetic ablation of