ライフサイエンスコーパス: claustrum

1 ces send projections only to the ipsilateral claustrum.

2 stral cells, enabling a clear delineation of claustrum.

3 the contralateral neostriatum, thalamus, and claustrum.

4 right frontoparietal cortex and in the left claustrum.

5 key cerebral cortex (layers I-II) and in the claustrum.

6 s area, superior temporal gyrus, insula, and claustrum.

7 a perisylvian division travelling within the claustrum.

8 trosplenial and perirhinal cortices, and the claustrum.

9 striatum, lateral neocortex, or endopiriform claustrum.

10 layer 6, suggesting that they project to the claustrum.

11 ore intrinsic excitatory connectivity of the claustrum.

12 d and more evenly distributed throughout the claustrum.

13 , the ventral pulvinar nucleus (Pv), and the claustrum.

14 , and hypocretin (Hcrt) in the region of the claustrum.

15 tivity between a given cortical area and the claustrum.

16 located in the posterior-ventral part of the claustrum.

17 zation of these projections within the mouse claustrum.

18 projections to either ipsi- or contralateral claustrum.

19 supporting a core/shell organization of the claustrum.

20 o contribute to broad integration within the claustrum.

21 o determine the cellular organization of the claustrum.

22 (0.94 +/- 0.08 mum(2) ), intermediate in the claustrum (0.34 +/- 0.02 mum(2) ), and smallest in the d

23 common in the Pv (39%), intermediate in the claustrum (15%), and least common in the dLGN (12%).

24 Significance statement: The function of the claustrum, a brain nucleus found in mammals, remains poo

25 reas of the neocortex are connected with the claustrum, a nucleus located between the neocortex and t

26 The claustrum, a poorly understood subcortical structure loc

27 hat recurrent excitatory circuits within the claustrum alone are unlikely to integrate across multipl

28 the bed nucleus of the stria terminalis, the claustrum (alpha1G), the olfactory tubercles (alpha1H an

29 The entire claustrum also receives a serotonergic input.

30 Tracer injections in the claustrum also revealed hundreds of labeled neurons thro

31 anterior and middle cingulate gyrus, insula/claustrum, amygdala/periamygdala, lingual and middle tem

32 nal capsule and the surrounding gray matter (claustrum and amygdala).

33 frontal eye fields, dysfunctional pulvinar, claustrum and amygdaloid subnuclei of the amygdala, the

34 the piriform lobe, such as the endopiriform claustrum and basolateral amygdala.

35 Latexin was detected in the claustrum and dorsal endopiriform nucleus, but not in co

36 ibited highly concentrated expression in the claustrum and endopiriform nucleus, as well as in a subp

37 the interhemispheric connections between the claustrum and primary motor (MI) cortex, anterograde tra

38 reased relative [14C]AA incorporation in the claustrum and pyramidal cell layer of the hippocampus co

39 enetic unit gives rise to the insular cortex/claustrum and should therefore be considered a most vent

40 MC regions also receive projections from the claustrum and the basal forebrain and project to the cau

41 The connections between the claustrum and the cortex in mouse are systematically inv

42 regulation of the communication between the claustrum and the cortical modalities.

43 nectivity with the right ventral putamen and claustrum and the temporoparietal junction.

44 terior insula" that may arise, in part, from claustrum and/or peri-insular projections to the anterio

45 veral subcortical regions (external capsule, claustrum, and amygdala).

46 three subcortical structures (the pulvinar, claustrum, and amygdala).

47 pic organizations have been described in the claustrum, and anatomical studies in cats, monkeys, and

48 parvalbumin-positive interneurons within the claustrum, and cortical afferents is also consistent wit

49 x, alpha5 mRNA was detected in the subplate, claustrum, and endopiriform nucleus at embryonic day 18

50 nally comparable to the mammalian neocortex, claustrum, and pallial amygdala (all of which derive fro

51 by the hypothalamus and basal forebrain, the claustrum, and the brainstem.

52 ons of the pulvinar, two subdivisions of the claustrum, and the interlaminar portions of the lateral

53 IPCG bilaterally, the right anterior insula/claustrum, and the left cerebellum.

54 n involving the ventral lateral putamen, the claustrum, and the white matter underneath the frontal l

55 Thus, the gene set required for the claustrum appears to be broadly conserved across species

56 ent sizes in bat claustrum compared with rat claustrum are consistent with events occurring in popula

57 ogical data suggested that most cells in the claustrum are large neurons that both receive cortical i

58 eral claustrum, but those to the ipsilateral claustrum are less numerous.

59 trinsic and extrinsic connections of the rat claustrum are structured for rapid, interhemispheric tra

60 ingled populations of labeled neurons in the claustrum, as well as many double-labeled neurons.

61 ital, and perirhinal cortices as well as the claustrum, basal forebrain, thalamus, epithalamus, hypot

62 y and the three-dimensional structure of the claustrum based on a variety of molecular and anatomical

63 OS expression increased significantly in the claustrum, bed nucleus of the stria terminalis, medial p

64 sends dense projections to the contralateral claustrum, but those to the ipsilateral claustrum are le

65 as a very early developmental marker of the claustrum (CL) proper in the mouse.

66 re we show that the principal neurons of the claustrum, claustrocortical (ClaC) projection neurons, r

67 efrontal cortex), emotional aspects of pain (claustrum, closely connected to amygdala) and motor cont

68 The smaller event sizes in bat claustrum compared with rat claustrum are consistent wit

69 nd dorsal-ventral topographic arrangement of claustrum connections and clear rostral-caudal topograph

70 cortex is at the extreme caudal limit of the claustrum, consistent with classical definitions of insu

71 The claustrum contains a significant projection by MCH axons

72 Carollia's claustrum contains cells whose intrinsic connectivity an

73 cal areas and should be considered part of a claustrum-DEn complex.

74 dicate that the synaptic organization of the claustrum does not correspond to a driver/modulator fram

75 ubercle, nucleus accumbens, caudate-putamen, claustrum, dorsal endopiriform nucleus, and cingulate co

76 The claustrum/endopiriform nucleus is a unique structure tha

77 Tmem163 genes were both concentrated in the claustrum/endopiriform nucleus, as reported in mice, but

78 GNG2 was expressed strongly in the claustrum/endopiriform nucleus, but was abundant across

79 ion in the upper layers (layers 2-4) and the claustrum/endopiriform nucleus.

80 ation histochemistry was performed for such "claustrum-enriched" genes in the marmoset brain.

81 ense, widespread connections from the dorsal claustrum, extending along its entire rostral-caudal len

82 together are a ventromedial extension of the claustrum for major regions of the temporal and frontal

83 The claustrum has been the subject of intense research inter

84 Our quantitative results show that the claustrum has strong reciprocal and bilateral connection

85 (DEn), which lies immediately ventral to the claustrum, has connections with limbic cortical areas an

86 By showing that DEn and claustrum have parallel sets of connections, these resul

87 ditioned stimulus, suggesting a role for the claustrum in associative learning.

88 cussed mainly with regard to the role of the claustrum in cognitive functions and that of MCH in REM

89 t with more recent proposals implicating the claustrum in detecting sensory novelty or in amplifying

90 isphere, whereas wSI does not project to the claustrum in either hemisphere.

91 late cortex and orbitofrontal cortex) to the claustrum in mice.

92 The role of the claustrum in Pavlovian heart rate (HR) conditioning was

93 The role of the claustrum in processing limbic information, however, is

94 showed that wMI projects most densely to the claustrum in the contralateral hemisphere, whereas wSI d

95 Each class was found throughout the entire claustrum, in all functionally defined subdivisions.

96 We find that the claustrum, in turn, sends widespread projections prefere

97 rphanol produced a bilateral deactivation of claustrum, insula, and putamen, areas activated during i

98 oming-specific interactions within the right claustrum/insula extending inferiorly into the amygdala

99 whereas auditory-specific imagery recruited claustrum/insula.

100 in the ipsilateral hemisphere including the claustrum, insular and perirhinal cortices; (4) unexpect

101 atomical tracers to map projections from the claustrum-insular region to the medial prefrontal and an

102 atomical data, it has been proposed that the claustrum integrates activity across sensory modalities.

103 Recent evidence indicates that the rat claustrum interconnects the motor cortical areas in both

104 c region, stria terminalis, medial amygdala, claustrum, internal capsule, and globus pallidus.

105 The function of the claustrum is a fundamental issue in neuroscience.

106 The claustrum is a gray-matter structure that underlies neoc

107 The claustrum is a small, elongated nucleus close to the ext

108 The claustrum is a subcortical structure reciprocally and to

109 The claustrum is a telencephalic gray matter structure with

110 The claustrum is an intriguing brain structure, featuring th

111 The claustrum is connected with the cerebral cortex.

112 In lower mammals, the claustrum is directly adjacent to neocortex, making the

113 The claustrum is made up of distinct deep (subplate-like) an

114 al, and functional studies indicate that the claustrum is most highly interconnected with prefrontal

115 Anatomical data indicate that the rat claustrum is part of an interhemispheric circuit that co

116 We have previously shown that the claustrum is part of an interhemispheric circuit that in

117 Although the rodent claustrum is probably involved in the interhemispheric c

118 The overall size of claustrum, its pronounced vascularity, and its more comp

119 ation signal was also seen in the neocortex, claustrum, lateral amygdala, ventral cochlear nucleus, r

120 led neurons were abundant in the allocortex, claustrum, lateral septum, bed nucleus of the stria term

121 ulum of the hippocampus, dorsal tenia tecta, claustrum, lateral septum, dorsal striatum, nucleus accu

122 inent in the neocortex endopiriform nucleus, claustrum, lateral septum, ventral forebrain, hypothalam

123 in the right subinsular region including the claustrum, left caudate and putamen, right middle occipi

124 rminals, suggesting that many neurons of the claustrum make extensive intraclaustral connections.

125 lfactory bulb, the endopiriform nucleus, the claustrum, many parts of retrohippocampal allocortex, an

126 This connectivity pattern suggests that the claustrum may preferentially subserve executive function

127 The possibility that the claustrum might mediate a more "global" function has bee

128 eased as a function of processing hierarchy; claustrum neurons projecting to primary sensory cortices

129 In the claustrum, non-GABAergic terminals (0.34 +/- 0.01 mum(2)

130 ere the medial striatum, olfactory tubercle, claustrum, nucleus accumbens, septum, substantia innomin

131 g around retrogradely labeled neurons in the claustrum of both hemispheres.

132 e-dependent subjects and the lateral putamen/claustrum of control subjects were observed at a weaker

133 he MI-Fp region has few connections with the claustrum of either hemisphere, both whisker regions pro

134 forepaw region sends few projections to the claustrum of either hemisphere.

135 substrate for information processing in the claustrum of the cat by analyzing the patterns of immuno

136 amidal neurons, the endopiriform nucleus and claustrum of the insular cortex, the globus pallidus, th

137 Studies on gene expression in the developing claustrum of the mouse have clarified the relationships

138 ntiated parts of the traditional cortex, the claustrum, or the striatum, and these parts belong to fo

139 ft caudate nucleus and right lateral putamen/claustrum (p < 0.05, determined by threshold-free cluste

140 nections, these results suggest that DEn and claustrum perform similar functions in processing limbic

141 ons of Y1 immunoreactivity were found in the claustrum, piriform cortex (superficial layer), arcuate

142 so consistent with recent proposals that the claustrum plays a role in detecting salient stimuli or a

143 Carollia claustrum possesses intrinsic excitatory connectivity su

144 The cells of the claustrum primordium express Nr4a2; they are formed in c

145 positive) are formed in the deep part of the claustrum primordium in the lateral pallium, but they mi

146 The present results suggest that the claustrum projections may help coordinate the activity o

147 This indicates that the same part of the claustrum projects to the whisker representations in bot

148 rified the relationships and identity of the claustrum proper and related endopiriform nuclei.

149 rior parietal lobule, and hippocampus; right claustrum/putamen, lateral prefrontal gyrus, and middle

150 d with increased activity in the ipsilateral claustrum (r = 0.51, P < 0.05), cerebellum (r = 0.43, P

151 reciprocal connections with the pulvinar and claustrum; received afferents from the locus coeruleus,

152 Other FEF connections were with the claustrum, reticular nucleus, zona incerta, lateral post

153 neus, right anterior cingulate cortex, right claustrum, right middle and inferior frontal gyri, and r

154 d function that will permit unique access to claustrum's processing capabilities.

155 Hence, the claustrum should not be universally regarded as an integ

156 In addition, EphA5 protein was found in the claustrum, stria terminalis, barrel cortex, and striatal

157 Instead, the circuitry of the claustrum suggests an integration of convergent cortical

158 nial cortices; CA1/subiculum of hippocampus; claustrum, tania tecta, lateral septum, substantia innom

159 uced more labeled neurons in the ipsilateral claustrum than retrograde tracer injections in the MI-Re

160 send denser projections to the contralateral claustrum than to the ipsilateral one.

161 substrate for information processing in the claustrum that may allow integration of information acro

162 en retrograde tracers were injected into the claustrum, the highest density of labeled neurons in MI

163 ical areas send bilateral projections to the claustrum, the majority being denser on the ipsilateral

164 distribution of neurons projecting from the claustrum to these areas.

165 hich are Nr4a2-negative, migrate through the claustrum toward the pial surface to form layers (2-6a)

166 iate cortex projections to the dLGN, Pv, and claustrum, using anterograde tracing and electron micros

167 overlap of labeled terminals and soma in the claustrum was greatest when both tracers were injected i

168 To provide clues to the function of the claustrum, we compare the synaptic arrangements of stria

169 Given its proportionately large claustrum, we hypothesized that the short-tailed fruit b

170 ilar patterns of cortical connections as the claustrum, we used anterograde and retrograde tracing te

171 The largest terminals in the claustrum were GABAergic (0.51 +/- 0.02 mum(2) ), and th

172 Many neurons in the claustrum were surrounded by parvalbumin, calretinin, GA

173 rojections to the neostriatum, thalamus, and claustrum when the whisker regions were injected, but no

174 projections from the sensory cortices to the claustrum, whereas frontal inputs are more extensive and

175 nt and restricted in distribution across the claustrum, whereas neurons projecting to the cingulate c

176 l inputs from a posterior-dorsal part of the claustrum, which has been previously reported to project

177 input from an anterior-ventral region of the claustrum, which has been reported to project to the vis

178 ncepts is the reciprocal connectivity of the claustrum with most, if not all, areas of the cortex.

179 tudy was to elucidate the connections of the claustrum with respect to the whisker representations in

180 ial strip located in the rostral half of the claustrum, with a second, smaller patch of cells in the

181 nterpreted to imply a relay function for the claustrum, with information from different functional co

182 whisker regions project to the contralateral claustrum, with those from the MI-RW region being denser