ライフサイエンスコーパス: clearance

1 ary outcome was measured GFR (iohexol plasma clearance).

2 to achieve a desired Css,avg and creatinine clearance.

3 predictors for viral decline and subsequent clearance.

4 components for host-cell mediated bacterial clearance.

5 of Leishmania which may contribute to their clearance.

6 the airways was associated with early viral clearance.

7 -2 upregulation drives diarrhea and pathogen clearance.

8 ng alters neither inflammation nor bacterial clearance.

9 recurrent infection and participate in viral clearance.

10 ects against enzymatic degradation and renal clearance.

11 f IL-6 and TNF-alpha, and impaired bacterial clearance.

12 effects of therapeutic improvement of mucus clearance.

13 d typically experience lifelong asymptomatic clearance.

14 airway surface liquid volume and mucociliary clearance.

15 ng inflammation and enhancing alveolar fluid clearance.

16 xpanded and forest burning was used for land clearance.

17 educes plasma uridine levels through biliary clearance.

18 nization, infection initiation, and eventual clearance.

19 stitial space provides a mechanism for waste clearance.

20 or disease due to inefficient myelin debris clearance.

21 on and improve microglial-mediated alpha-syn clearance.

22 on for efficient tumor penetration and rapid clearance.

23 of amyloid beta (Abeta) or to promote Abeta clearance.

24 l recruitment, leading to enhanced bacterial clearance.

25 with significantly improved microbiological clearance.

26 nobiotic processing genes, and enhanced drug clearance.

27 ommunities that are highly resistant to host clearance.

28 or affecting tracer uptake, specificity, and clearance.

29 e-establishment of EZH2 expression and blast clearance.

30 ether anti-PD-1 Ab treatment improves fungal clearance.

31 es highly sensitive tracers with rapid blood clearance.

32 ter reservoirs may be required for long-term clearance.

33 ent in medaka, along with delayed neutrophil clearance.

34 BR/08, but did not result in complete virus clearance.

35 onses are weak and thus rarely lead to viral clearance.

36 14 adult critically-ill patients (creatinine clearance 0-236mL/min; 29 receiving renal replacement th

37 itive participants (540 with spontaneous HCV clearance, 1294 untreated HCV RNA positive, 345 treated

38 For GNI, the time to microbiologic clearance (51.13 versus 34.51 h; P < 0.001), the hospita

39 a under the curve (AUC) (33mugh/mL) and high clearance (916mL/h/kg) and lower volume of distribution

40 ly, we demonstrated that reduced mucociliary clearance, a characteristic feature of asthma, produces

41 DeltaF508 mice demonstrated impaired viral clearance, a slower type I interferon response and delay

42 mGFR was measured using plasma isotope clearance according to a technique validated in patients

43 of Ncad by Ecad+ cells increased mesothelial clearance activity but was not sufficient to induce matr

44 n of antigen levels with parasitemia and its clearance after drug treatment.

45 tion titers, CTL activity, and earlier virus clearance after homologous and heterosubtypic [A/Philipp

46 P < .01), including 3 patients with complete clearance, although not statistically significant (P = .

47 rrent Abeta suppression could enhance plaque clearance and could improve pathologic outcomes in mice

48 tence of T-cell activation well beyond viral clearance and detect EBOV-specific T cells.

49 GALC mutant mice have reduced myelin debris clearance and diminished remyelination after a demyelina

50 BB with agonist antibodies can lead to tumor clearance and durable antitumor immunity.

51 proinflammatory cytokines impaired bacterial clearance and eliminated host protection conferred by Ga

52 We propose that a combination of failed clearance and exaggerated release of glutamate by glial

53 autophagy deficiency did not affect glucose clearance and exercise capacity in lean adult mice.

54 l functions of its host cell to avoid immune clearance and gain access to nutritional resources.

55 in this precise window accelerated parasite clearance and generated species-transcending immunity to

56 d C2Am derivative showed predominantly renal clearance and high specificity and sensitivity for detec

57 ptide to obese C57BL/6 mice improved glucose clearance and insulin sensitivity.

58 ectomized rats also led to higher creatinine clearance and lower plasma calcium levels but did not re

59 Finally, we show that both actin clearance and recovery correlated with synaptic phosphat

60 evant model of HBV infection to study immune clearance and test therapeutic and curative approaches.

61 E in cancer cells significantly affects drug clearance and the onset of drug resistance.

62 ndicate that Eld recipients have a lower TAC clearance and therefore need a lower TAC dose than young

63 withdrew from the AQ-13 group after parasite clearance and three were lost to follow-up.

64 Body weight influenced clearance and volume parameters significantly, resulting

65 CD8(+) T cells are important for viral clearance, and although often ineffective in neonates th

66 ns among glucosylceramide, protein aggregate clearance, and autophagy.

67 elations between log D, solubility, in vitro clearance, and plasma protein binding also hold in trans

68 ing mucus dehydration, decreased mucociliary clearance, and recurrent acute bacterial infections.

69 ong-range promoter-Ebeta looping, nucleosome clearance, and robust transcription throughout the Tcrb

70 combinations on hyperinflation, mucociliary clearance, and symptom severity may all contribute to de

71 such as poor enzymatic stability, rapid body clearance, and unwanted immunostimulation.

72 n was observed for 12-hour values of lactate clearance (area under the curve = 0.839; 95% CI, 0.751-0

73 gests therapeutic improvement of mucociliary clearance as a novel treatment strategy for children wit

74 Surprisingly, renal creatinine clearance as estimated from mass, age, and plasma creati

75 in macrophages, identify reduced cholesterol clearance as the primary macrophage defect driving PAP p

76 NETs promote pathogen clearance but also can lead to thrombosis; the pathways

77 This promoted myelin clearance but led to abnormalities in nonmyelinating and

78 y enhanced T cell responses to promote viral clearance, but increased IL-22 in vivo decreased T cell

79 sent in the phagosome and enhances bacterial clearance by differential regulation of lysosomal acidif

80 lso by mounting effector responses for their clearance by extracellular means.

81 increased secretion and/or decreased insulin clearance by liver or other tissues.

82 and phagocytic activity, enhancing parasite clearance by macrophages and neutrophils.

83 Rapid viral clearance by pegIFNalpha was confirmed in HEV gt1, but n

84 Further, INAVA enhanced bacterial clearance by regulating reactive oxygen, reactive nitrog

85 that decreasing CysC would facilitate Abeta clearance by relieving CatB inhibition.

86 ought to test the significance of phagocytic clearance by resident and recruited phagocytes after myo

87 ls, which indicates LegC4 augments bacterial clearance by the host immune system.

88 Salmonellae establish infection and avoid clearance by the immune system by mechanisms that are no

89 To avoid clearance by the spleen, red blood cells infected with t

90 to quantify manganese and gadolinium plasma clearance by using inductively coupled plasma mass spect

91 to impair tissue function, and their genetic clearance can delay features of aging.

92 was concluded that splenic malaria parasite clearance capacity was readily exceeded, resulting in th

93 and promoted neovascularization, neutrophil clearance, cardiomyocyte proliferation and scar resoluti

94 to assess the effect of CBF and radiotracer clearance changes on SUVRs and noninvasive kinetic model

95 The estimated in vitro intrinsic clearance (Clint) of TBECH mixture was slower (P < 0.05)

96 Estimated creatinine clearance (Cockcroft-Gault) from baseline out to 6 addit

97 ces elongated hyphae resistant to phagocytic clearance compelling alternative neutrophil effector mec

98 Estimated renal creatinine clearance correlated with the extent of activated BAT in

99 ) did not change MAP, HR, RBF, or creatinine clearance (CrCl) in SD rats (n = 7).

100 Mucociliary clearance, driven by the engine of ciliary beating, is t

101 NO, on the level of parasitemia and parasite clearance during acute babesiosis.

102 d animals showed slightly improved bacterial clearance during the bacteremic stage compared with cont

103 Clearance estimate (as a continuous variable) showed a h

104 Interestingly, in vivo clearance experiments in dual VWF(-/-)/Asgr1(-/-) mice d

105 f the carrier in the body showed an enhanced clearance for the acid-degradable carrier, even after mu

106 e Xpert MRSA NxG assay recently received FDA clearance for the direct detection of MRSA from nasal sw

107 ging and biodistribution studies showed fast clearance from blood and major accumulation in the kidne

108 dose of TETS and to monitor kinetics of TETS clearance from blood over a short period of time.

109 per cubic centimeter at 40-60 min and rapid clearance from blood to kidney and bladder.

110 igh relaxivity, unappreciable sedimentation, clearance from circulation and no overt toxicity.

111 er tumor uptake and faster and more complete clearance from circulation.

112 nt mice increased the efficiency of bacteria clearance from the FRT while reducing tissue-associated

113 These results suggest that CR3 limits Abeta clearance from the ISF, illustrating a novel role for CR

114 arge microparticles demonstrating negligible clearance from the local tissue 24h after delivery ex vi

115 d in E-Syts KO cells, delayed diacylglycerol clearance from the PM and impaired Ca(2+)-triggered phos

116 ime did not reach significantly different AK clearance from the sham control.

117 The PRECISE-DAPT score (age, creatinine clearance, haemoglobin, white-blood-cell count, and prev

118 l (HCV) load decline followed by spontaneous clearance has been previously described.

119 The association of EVD outbreaks with forest clearance has been suggested previously but many aspects

120 stimated hepatic versus extrahepatic insulin clearance in 29 EA and 18 AA healthy women.

121 g new receptor targets to stimulate improved clearance in airway diseases, such as cystic fibrosis an

122 the delayed phase of intracellular bacterial clearance in COPD.

123 measured in millimeters estimated for tumor clearance in each quadrant based on HRCM-RV findings wer

124 , H3N2, and H5N1 strains, and improved viral clearance in ferrets.

125 ate that RAB2A is required for autophagosome clearance in human breast cancer cells.

126 rate that GM-CSF is required for cholesterol clearance in macrophages, identify reduced cholesterol c

127 sponse in the spleen, and enhanced bacterial clearance in multiple peripheral organs.

128 e response is associated with impaired viral clearance in Nlrc5(-/-) mice.

129 previous clinical reports of increased drug clearance in patients with untreated diabetes.

130 ibution of basophils to S. venezuelensis egg clearance in primary infections.

131 d drug exposure, allowing for fine-tuning of clearance in response to specific conditions, and here w

132 try across the blood-brain barrier and virus clearance in the absence of overt sequelae.

133 boratory has previously reported that myelin clearance in the injured sciatic nerve proceeds unhinder

134 ught to determine the role of impaired mucus clearance in the pathogenesis of allergen-induced type 2

135 test showed major improvement of the glucose clearance in the scaffold groups compared to diabetic co

136 penia due to a markedly accelerated platelet clearance in the spleen.

137 4; 95% CI, 1.4 to 9.4; P = 0.0085), and lung clearance index based on lung volume turnover required t

138 volume in 1 s (FEV1) of 70 or more, and lung clearance index2.5 (LCI2.5) of 7.5 or more at screening

139 e osmolyte excretion, but reduced free-water clearance, indicating endogenous free water accrual by u

140 The faster glutamate clearance induced by PAR1 activation leads to short- and

141 n glycemia were not identified following HCV clearance irrespective of HIV, diabetes, or fibrosis sta

142 However, we demonstrate that this clearance is nearly identical in WT and Ccr2(-/-) mice,

143 High estimated clearance is significantly associated with increased ris

144 ent due to a larger reduction in the rate of clearance (k2=0.291+/-0.030s(-1) versus 0.747+/-0.24s(-1

145 ulated marrow stromal cells into mice delays clearance kinetics and sustains donor-derived soluble fa

146 In-PSMA-I&T, (99m)Tc-PSMA-I&S showed delayed clearance kinetics but identical uptake in PSMA-positive

147 and flagella govern respiratory mucociliary clearance, laterality determination and the transport of

148 effects on plasma lipid levels, triglyceride clearance, liver triglyceride content, insulin sensitivi

149 Tumor clearance <1.0 or <1.5 mm was an independent determinant

150 t center, including estimating equations and clearance measurements.

151 atterns are modulated by both production and clearance mechanisms active in sleep-wake cycles and tha

152 that ostensibly allows the organism to evade clearance mechanisms and establish chronic infection.

153 In knockout mice, clearance mechanisms are identified for nanoparticles wi

154 trol of neurotransmission, but neuronal acid clearance mechanisms remain poorly understood.

155 priori knowledge of carrier degradation and clearance mechanisms.

156 of the CNS and are responsible for glutamate clearance, metabolic support, response to injury, and re

157 of IFN activation, while important for viral clearance, modify the host proinflammatory responses thr

158 Estimated total body clearance normalized by dose and weight was lower in the

159 Rapid sediment clearance occurred that was potentially aided by mucus p

160 LOF alleles were less likely to report skin clearance (odds ratio [OR], 0.20; 95% CI, 0.07-0.55) and

161 Maternofetal clearance of (14)C-MeAIB and (3)H-taurine was reduced an

162 in the kidneys, indicating substantial renal clearance of (18)F-FCP.

163 apeutic approaches have been limited by poor clearance of a core AD lesion, cerebral amyloid angiopat

164 macrophages prevents M2 differentiation and clearance of a parasitic helminth infection in mice, and

165 Rapid clearance of acid loads is necessary to maintain control

166 , these conjugates promote rapid proteasomal clearance of aggregation-prone proteins.

167 tion inhibitors, we demonstrated that normal clearance of alpha-synuclein was re-established, aggrega

168 F(-/-)/Asgr1(-/-) mice demonstrated enhanced clearance of alpha2-3Neu-VWF even in the absence of the

169 The total cardiac clearance of amitriptyline was calculated as 0.316 L/h.

170 interest, thereby allowing the retention or clearance of an agent to be quantified.

171 excessive cell death, coupled with impaired clearance of apoptotic cells, have been implicated as ca

172 A key cause of plaque necrosis is defective clearance of apoptotic cells, or efferocytosis, by lesio

173 Phagocytic clearance of apoptotic germ cells by Sertoli cells is vi

174 While Bai1 overexpression rescues clearance of apoptotic germ cells in the testes of Mertk

175 The composite primary outcome was clearance of asexual parasites and fever by day 7, and a

176 6 months before enrolment and had creatinine clearance of at least 50 mL/min.

177 drug-resistant wound infections demonstrated clearance of bacteria and wound healing following repeat

178 EL, which thus has therapeutic potential for clearance of bacterial infections.

179 or VWF that significantly contributes to the clearance of both wild-type and hyposialylated VWF.

180 the joint but also contributes to subsequent clearance of Brucella and resolution of inflammation.

181 lian target of rapamycin, enhanced lysosomal clearance of C99.

182 scovery of cellular immunity, the phagocytic clearance of cellular debris has been considered an inte

183 diffusion from the surrounding snow and the clearance of CO2 by diffusion and absorption.

184 Recent studies have demonstrated that plasma clearance of cortisol is markedly reduced during critica

185 t a Th2 environment associated with impaired clearance of cryptococci while high IL-7 levels may refl

186 e ubiquitin-directed AAA-ATPase, p97, in the clearance of damaged lysosomes by autophagy.

187 y-mediated PINK1 overexpression promotes the clearance of damaged mitochondria by augmenting autophag

188 MTORC1 may specifically regulate autophagic clearance of damaged mitochondria.

189 ulate two synergistic processes required for clearance of damaged mitochondria: (i) general autophagy

190 ceptor that regulates the detoxification and clearance of drugs and foreign compounds from the liver.

191 ges, where LAP has instrumental roles in the clearance of extracellular particles including apoptotic

192 he nasopharyngeal mucosa in association with clearance of FMDV.

193 less well studied, although it is key in the clearance of fungal pathogens.

194 that coinfection with H. influenzae promoted clearance of H. parainfluenzae from biofilm communities

195 ype 1 (HIV-1)-specific immunity and increase clearance of HIV-1-expressing cells.

196 maintenance of striatal excitatory synapses, clearance of Htt aggregates and preserves body mass comp

197 CCL3 plays a significant role in the clearance of infection and resolution of inflammation an

198 were the sole mechanism responsible for the clearance of infections.

199 l and unravel a mechanism of Nur77-dependent clearance of inflamed mitochondria to alleviate inflamma

200 Our data support that impaired clearance of inhaled allergens triggering IL-13 producti

201 y, which accelerated the molecular aging and clearance of intestinal alkaline phosphatase (IAP).

202 specialized form of autophagy that mediates clearance of intracellular pathogens.

203 d 5XFAD mice with bexarotene resulted in the clearance of intraneuronal amyloid deposits.

204 racellular traps (NETs) are critical for the clearance of large pathogens and are also implicated in

205 miR-430 is crucial for the clearance of maternal mRNA during maternal zygotic trans

206 Activation of the pathway contributes to the clearance of megakaryocytes following platelet shedding

207 hange (ionic etching), and facilitates renal clearance of metal ions released from the quantum dots.

208 s, which promote resolution of inflammation, clearance of microbes, reduction of pain, and promotion

209 ed degradation (ERAD) is responsible for the clearance of misfolded pro-arginine vasopressin (proAVP)

210 Macrophage death did not result in clearance of Mtb.

211 of robust pulmonary intravascular macrophage clearance of nanoparticles in mediating adverse cardiopu

212 ein receptor plays a predominant role in the clearance of nanoparticles, irrespective of poly(ethylen

213 upon acute sterile injuries is necessary for clearance of necrotic debris and for coordination of tis

214 Defective clearance of necrotic tissue interferes with amelioratio

215 y to support US Food and Drug Administration clearance of new diagnostic tests by promoting research

216 ASAQ presented faster clearance of parasitaemia and fever.

217 ite sequestration to host organs, phagocytic clearance of parasites, and regulation of immunity.

218 ced mitophagy in mammalian cells and for the clearance of paternal mitochondria after embryonic ferti

219 Time to clearance of pathogens is probably critical to outcome i

220 tosis in mediating immunity to infection and clearance of pathogens.

221 killing of tumor cells in vitro and enhanced clearance of PD-L1+ tumor xenografts in vivo.

222 gic and lymphoid disease may occur following clearance of peripheral virus in ZIKV-infected individua

223 Further, feeding-induced clearance of plasma uridine improves glucose metabolism.

224 We suggest that asymmetric clearance of pluripotency regulators may represent an im

225 e in IL-5-positive cells, but did not impact clearance of Pneumocystis infection.

226 cute and chronic inhibition of the molecular clearance of protein products resulting in a buildup of

227 degradation process that is involved in the clearance of proteins and damaged organelles to maintain

228 enting with intralysosomal storage, enhances clearance of proteolipid aggregates, reduces neuropathol

229 ecause transgenic mice demonstrated impaired clearance of pulmonary bacteria and increased neutrophil

230 Here we report that the pharmacokinetics and clearance of renal clearable gold nanoparticles (GS-AuNP

231 hages, natural killer cells) associated with clearance of senescent tumors.

232 he retinal pigmented epithelium (RPE) is the clearance of shed photoreceptor outer segments (POS) thr

233 route for 5 days and displayed >91 and >93% clearance of splenic and liver parasitic burden, respect

234 Increased clearance of sTyro3 and sMer was associated with loss of

235 In addition, rapid clearance of the BiSAb.IL-6 complex was observed in mice

236 CDK6, in neutrophils, is required for clearance of the fungal pathogen Candida albicans.

237 microbe are complex, ultimately resulting in clearance of the microbe, stable colonization of the hos

238 response, which led to a 2-day delay in the clearance of the virus from older hosts in the sublethal

239 a network of interactions leading to either clearance of the virus or death of the host, depending o

240 not only neutralize but also actively drive clearance of their soluble antigens.

241 f the liver in mice confirmed that the rapid clearance of these large immune complexes was associated

242 asminogen activator every 8 hours until clot clearance of third and fourth ventricles) or a combined

243 ined treatment approach of IVF and-upon clot clearance of third and fourth ventricles-subsequent plac

244 esults demonstrate that enhancing endogenous clearance of tumor cell debris is a new therapeutic targ

245 Effective clearance of virally infected cells requires the sequent

246 le to sexually transmit for months after the clearance of viremia, ZIKV must establish infection in t

247 essels and must rely on other mechanisms for clearance of waste products, including amyloid [Formula:

248 owing for characterization of the growth and clearance of ZIKV within individual macaques.

249 Clearances of intrahepatic cccDNA and/or HBsAg are criti

250 ine (PS) and examined the effect of platelet clearance on procoagulant activity (PCA) in sepsis.

251 possible additional role in hepatic insulin clearance or insulin processing.

252 o an excellent response on average (76%-100% clearance) (P < .001).

253 a virus RNA load in seminal fluid, including clearance parameters.

254 Increased activity of protein clearance pathways in the cardiomyocyte, such as proteas

255 logy, leads to the activation of alternative clearance pathways including Golgi membrane-associated a

256 The contribution of P450 3A5 to these clearance pathways varies between individuals owing to g

257 s of lower concentrations in high versus low clearance patients.

258 actors for PD, indicating that disrupted GSL clearance plays a key role in alpha-syn aggregation.

259 the expression of many genes within this AC clearance program.

260 The slow clearance rate in men (based on 6 months' follow-up) was

261 To explain why parasite clearance rates were not faster with split dose regimens

262 min after agent administration by examining clearance rates.

263 human immunity is the primary determinant of clearance rates.

264 de receptor 2) and not the G-protein-coupled clearance receptor NPR3 (natriuretic peptide receptor 3)

265 Despite the delayed clearance, rechallenged C. muridarum-infected mice were

266 improving airway surface hydration and mucus clearance, reduced allergen-induced inflammation in Scnn

267 Some hydroxamic acids display a high plasma clearance resulting in poor in vivo activity, though the

268 ry cell populations involved in beta-amyloid clearance.SIGNIFICANCE STATEMENT Mounting evidence suppo

269 ollowing liver transporters involved in drug clearance: SLC10A1, SLC22A1, SLC22A7, SLC47A1, SLCO1B1,

270 fforts to develop latency reversal and viral clearance strategies to eradicate established HIV infect

271 ed that 1B6 displayed a rapid dose-dependent clearance (t(1/2) 10-60 h) in contrast to 1F11, which pr

272 osa died earlier and showed slower bacterial clearance than males (P < 0.0001).

273 ium-hydrogen antiporter 3, and lower lithium clearance than WT mice.

274 Polymethine-dye clearance thereby allows sensitive point-of-care assessm

275 CFTR trafficking could enhance P. aeruginosa clearance through activating the tumor suppressor PTEN.

276 d MZ B cells regulate systemic S. pneumoniae clearance through complementary mechanisms.

277 causes enhanced von Willebrand factor (VWF) clearance through the Ashwell-Morrell receptor (AMR).

278 g in the PD-L1-rich spleen, with rapid blood clearance through the kidneys and bladder.

279 FICANCE STATEMENT Impairment of brain solute clearance through the recently described glymphatic syst

280 The median parasite clearance time was 24 hours in both the arms.

281 time (HTST) treatment, a commonly used viral clearance upstream strategy.

282 genomic variants underlying HCV spontaneous clearance using ImmunoChip in European and African ances

283 ly actionable pathway that controls cellular clearance via Akt modulation of transcription factor EB

284 oing coat replacement are only vulnerable to clearance via early IgM antibodies for a limited time.

285 e in both tumor immunosurveillance and viral clearance via their effector functions.

286 nfection spontaneously, the likelihood of re-clearance was 49% lower (aHR: 0.51, 95% CI: 0.27-0.94) w

287 For the 20-minute incubation arm, average AK clearance was 76% vs 58% on the sham side (P < .01), inc

288 Coincident virologic clearance was confirmed by in situ hybridization and a f

289 By comparison, insulin clearance was not affected by cold exposure or phentolam

290 ation of prolonged antivirals beyond initial clearance was not associated with a reduced risk of recu

291 In contrast, extrahepatic insulin clearance was not lower in AAs than in EAs.

292 Mucociliary clearance was slowed 4 hours postchallenge in the placeb

293 parasites in the circulation, that parasite clearance was therefore an unreliable measure of drug ef

294 ty (2.7-18.6 GBq) based on whole-body/-blood clearance (WB/BC) dosimetry at Memorial Sloan Kettering

295 mally resistant to TMEV infection with viral clearance, we have previously demonstrated that RORgamma

296 ytogenetics demonstrated the fastest disease clearance, whereas patients with high-risk genetics and

297 y that septic patients have impaired insulin clearance, which could increase their susceptibility to

298 )-bound CXCL10, resulting in target-mediated clearance, which was corroborated using CXCL10-deficient

299 course of infection, by improving bacterial clearance while limiting inflammation.

300 tumor recurrence and occurrence after viral clearance with DAA agents.