ライフサイエンスコーパス: clearing

1 ations of LkCa 15 that probe within the disk clearing.

2 ions from food production and to global land clearing.

3 om physical drivers or catastrophic ecospace clearing.

4 rical woody alien plant densities 30 y after clearing.

5 ortionately impacted by these linear habitat clearings.

6 We combined tissue clearing, 3D-immunofluorescence, and electron tomography

7 egulates serotoninergic neurotransmission by clearing 5-HT released into the synaptic space.

8 RAS40 phosphorylations play crucial roles in clearing aberrant proteins that accumulate due to mTORC1

9 A critical protein for clearing Abeta across the blood-brain barrier is the eff

10 While successful in clearing Abeta and improving cognition in mice, anti-Abe

11 o the brain is insufficient in substantially clearing Abeta burden and suggest that specific addition

12 poproteins are less effective at binding and clearing Abeta, and LD Abeta peptides are more toxic to

13 sts examining ET patency confirmed a reduced clearing ability in the heterozygous mice.

14 esses haematopoietic stem-cell metabolism by clearing active, healthy mitochondria to maintain quiesc

15 olar concentrations in vitro, have aggregate-clearing activity in a cellular model of Huntington's di

16 Piperaquine possesses rapid parasite-clearing activity, but monotherapy is followed by the ap

17 The use of a clearing agent led to a doubling of the tetrazine tumor

18 e present a new, convenient, aqueous optical clearing agent, termed UbasM: Urea-Based Amino-Sugar Mix

19 Here we developed 2 tetrazine-functionalized clearing agents that enable rapid reaction with and remo

20 using the appropriate temperature for tissue clearing, all of which contributed to the superiority of

21 results show that macrophages are capable of clearing alphaS, but that high levels of exogenous or en

22 Even as the sole fidelity pathway for clearing amino acid selection errors in the pathogenic M

23 ieved to be ineffective at phagocytosing and clearing amyloid-beta (Abeta), a major pathological hall

24 T cells play a critical role in clearing an acute RSV infection, as well as contributing

25 The probability of clearing an oncogenic HPV infection was 30% higher among

26 dentify the immune cells that participate in clearing an oncolytic infection in glioma, we used flow

27 lysin (NEP) was found, whereas various Abeta-clearing and -degrading proteins were unchanged.

28 nd its progeny in situ, combined with tissue clearing and 3D imaging.

29 In addition, to enable clearing and 3D tissue imaging with light microscopy met

30 Here, we use optical tissue clearing and a TAM-targeting injectable fluorescent nano

31 Results indicate that forest clearing and climate are significant driving factors of

32 ween 2002 and 2005 on contemporaneous forest clearing and disturbance.

33 and timing of colonoscopy for perioperative clearing and for postoperative prevention of metachronou

34 forts to increase crop yields, minimize land clearing and habitat fragmentation, and protect natural

35 ing of cleared tissues, thus enabling tissue clearing and imaging in a wide variety of settings.

36 DS)-based clearing protocol for the chemical clearing and imaging of brain tissue containing transgen

37 nt release in situ), a method for whole-body clearing and immunolabeling.

38 ty technique), a protocol for passive tissue clearing and immunostaining of intact organs; RIMS (refr

39 missions from fires associated with land use clearing and land management on the Indonesian island of

40 Fires are the predominant method of clearing and managing land for more intensive uses, and

41 Recent developments in optical tissue clearing and microscopic imaging have advanced three-dim

42 calised historical disturbances such as land clearing and overfishing remains unresolved.

43 ltural greenhouse gas emissions, reduce land clearing and resultant species extinctions, and help pre

44 set of tissue fixation-embedding, detergent-clearing and staining protocols that can be used to tran

45 Clearing and subsequent 3D reconstruction of entire orga

46 lution without labeling by leveraging tissue clearing and the scattering contrast of optical frequenc

47 en, as was previously found for women: "slow-clearing" and "fast-clearing." Only 68% (57%-78%) (poste

48 d rapid immunofluorescence staining, optical clearing, and confocal microscope imaging.

49 rabidopsis thaliana are stunted growth, vein clearing, and leaf chloroses.

50 or sonication treatment, antibody staining, clearing, and mounting.

51 d and optimized antibody penetration, tissue clearing, and triple-color illumination to create a meth

52 activate Pak4, which in turn activates NMII, clearing apical junctions.

53 Given the importance of clearing apoptotic cell debris to prevent inappropriate

54 Mer) signaling maintains immune tolerance by clearing apoptotic cells (ACs) and inducing immunoregula

55 Defects in clearing apoptotic debris disrupt tissue and immunologic

56 uction that exploited natural mechanisms for clearing apoptotic debris, we show that antigen-decorate

57 rbulent flow forms in the tube and a zone of clearing appears below the air-liquid interface just bef

58 Here, we developed a sample clearing approach for FISH measurements.

59 ouse brain using this matrix-imprinting and -clearing approach.

60 Unfortunately, existing optical clearing approaches present a compromise between maximiz

61 ndogenous fluorescent reporter where typical clearing approaches render such structures difficult to

62 d, which is 20x faster than current passive clearing approaches.

63 es or infrared sources detected within their clearings, as in the case of LkCa 15.

64 sed combination therapy is very effective in clearing asexual stages of malaria and reduces gametocyt

65 demonstrate a high-speed approach, termed as Clearing Assisted Scattering Tomography (CAST), where in

66 ions to take one of 1, 2, or 3 courses, each clearing at a different rate.

67 m 2007 to 2013, despite extensive vegetation clearing at farm field margins.

68 tein receptor (LDLR) plays a pivotal role in clearing atherogenic circulating low-density lipoprotein

69 res both altering the transcription rate and clearing away the existing mRNA through degradation, a p

70 ybrids play dual protective roles by rapidly clearing bacteria and presenting bacterial antigens to C

71 The liver plays a central role in clearing bacteria from the bloodstream.

72 innate immune functions that are critical in clearing bacterial infections.

73 FP fluorescence in CST-YFP mice is faint for clearing-based 3D imaging in comparison with fluorescenc

74 ition disks, protoplanetary disks with inner clearings best explained by the influence of accreting p

75 it is clear that macrophages are capable of clearing Borrelia spirochetes and exhausted neutrophils;

76 raints in crossing biological membranes, and clearing by enterohepatic circulation.

77 Our results indicate that titling reduces clearing by more than three-quarters and forest disturba

78 chicken and shows antibody is ineffective in clearing C. jejuni from the ceca within the production l

79 ophages or dendritic cells, were impaired in clearing C. rodentium.

80 Microglia lose their amyloid-beta-clearing capabilities with age and as AD progresses.

81 rogeneous cell population with greater Abeta-clearing capabilities.

82 ches present a compromise between maximizing clearing capability, the preservation of fluorescent pro

83 to enteric pathogens, but capable of rapidly clearing causative and coinfecting pathogens.

84 proportion of patients with complete corneal clearing (CCC; 100%) at week 8 was greatest with tofacit

85 Clearing cellular debris after brain injury represents a

86 n cell division, co-ordinating division with clearing chromosomal DNA from the site of septation and

87 ein receptor (LDLR) pathway is essential for clearing circulating LDL cholesterol (LDL-C).

88 facilitate early treatment of metastasis by clearing circulating tumor cells from vasculature.

89 Combining rabies-virus tracing, optical clearing (CLARITY), and whole-brain light-sheet imaging,

90 ng lamin A on the inner nuclear membrane and clearing clogged translocons on the endoplasmic reticulu

91 P) over the first three growing seasons post-clearing, coincident with large and relatively stable ne

92 All patients underwent clearing colonoscopy with removal of all polyps >/=3 mm.

93 antigen "bystander" tumors while efficiently clearing combinatorial antigen "disease" tumors.

94 li that combines immunofluorescence, optical clearing, confocal microscopy, and three-dimensional ana

95 ive to engage in the required investments in clearing, cultivation, animal tending, and storage.

96 ophen (APAP)-induced liver injury in mice by clearing damaged mitochondria.

97 e and elevation of Trem2, both necessary for clearing damaged myelin, were markedly reduced in GALC +

98 Autophagy is an essential mechanism for clearing damaged organelles and proteins within the cell

99 m tissue regeneration and synapse pruning to clearing debris and controlling tumor cell progression.

100 than hemocytes are the primary phagocytes in clearing degenerating dendrites.

101 s', most likely resulting from using fire to clearing dense pastures and forests for reclaiming.

102 icated the lymphatic system was effective in clearing deposited plutonium from the lung tissues.

103 ly during the first 20 years following stand-clearing disturbance, with slower accumulation following

104 pha-deficient mice showed in vivo defects in clearing dying cells, which led to multiple organ damage

105 ibe the specificity and amyloid beta (Abeta)-clearing effect of a catabody construct engineered from

106 er effect was 25 times greater than the land clearing effect, the often cited culprit of malaria in t

107 ated the anti-inflammatory and autophagosome-clearing effects of IDR-1018, as did a chemical inhibito

108 oxicological problems while maintaining iron clearing efficacy and has led to three ligands being eva

109 tive lipid extraction, resulting in enhanced clearing efficiency and sample integrity.

110 t restoring alpha-l-iduronidase activity and clearing elevated glycosaminoglycans in blood and multip

111 Here we report an easy to use method, clearing-enhanced 3D (Ce3D), which generates excellent t

112 -/-) T cells to be intrinsically superior at clearing established tumors that secrete TGFbeta.

113 We established a method for clearing ETBF in mice, using the antibiotic cefoxitin.

114 Ss) regulate neuronal signal transmission by clearing excess neurotransmitters from the synapse, assi

115 ers play a key role in neuronal signaling by clearing excess transmitter from the synapse.

116 terval [CI], 1.2-3.0) but at similar risk of clearing existing alpha-9 HPV infections (HR, 0.9; 95% C

117 onal types (HRs, > 1.0) and at equal risk of clearing existing infections.

118 09 and 2013, both the efficacy of IPTp-SP at clearing existing peripheral malaria infections and the

119 CD4 T cells are critical for clearing experimental Chlamydia muridarum genital tract

120 ter shapes dopaminergic neurotransmission by clearing extracellular dopamine and by replenishing vesi

121 In addition to their primary role of clearing extracellular glutamate, the EAATs also possess

122 proinflammatory cells that are critical for clearing extracellular pathogens and for inducing multip

123 ivities like conventional gas drilling, land clearing, exurban and agricultural development and surfa

124 ersatile Free-of-Acrylamide SDS-based Tissue Clearing (FASTClear) protocol specifically designed for

125 duced habitat alteration (urbanization, land clearing for agriculture) or a suite of ecological facto

126 of arable land and fresh water would require clearing forests and exacerbating regional water scarcit

127 gram at 4 h after injection, respectively), clearing from background predominantly via the kidneys.

128 on, is required for timely nurse cell nuclei clearing from mature egg chambers.

129 o clearance mechanisms singly sufficient for clearing genital tract infections within six weeks; one

130 have shown that CD4 T cells are critical for clearing genital tract infections.

131 s significantly more effective than rhGAA in clearing glycogen from numerous skeletal muscle tissues

132 ary end point was the proportion of children clearing >/= 99% of their admission parasitemia at 24 ho

133 Tissue clearing has become an important tool for the investigat

134 Optical tissue clearing has revolutionized researchers' ability to perf

135 y supporting the role of innate immunity for clearing HCV definitively.

136 ients with chronic hepatitis C, successfully clearing hepatitis C virus (HCV) infection in some patie

137 We screened an online humanitarian clearing house (ReliefWeb), a large public NGO database

138 groups identified via the National Guideline Clearing House and author knowledge, and systematically

139 ogate of immunity and correlates of parasite-clearing immunity have not been identified.

140 hreatening parasite densities until parasite clearing immunity is achieved.

141 ed during the first 3 years following forest clearing in a temperate forest environment of the northe

142 ty-acquired SSTIs are uncomplicated and self-clearing in nature, some percentage of these cases progr

143 Herein, we present techniques for tissue clearing in which whole organs and bodies are rendered m

144 Current literature emphasizes how land clearing increases malaria incidence, leading to the con

145 t defense, monocytes play important roles in clearing infected microbes.

146 e-edged swords by playing essential roles in clearing infection but also causing tissue damage, yet b

147 The probability of clearing infection from baseline to 9 weeks was higher a

148 successful immune response and spontaneously clearing infection.

149 Slowly clearing infections (parasite clearance half-life >5 hou

150 which the efficacy of the immune response in clearing infections is directly proportional to the dens

151 Neutrophils are indispensable for clearing infections with the prominent human pathogen St

152 on of antibiotics and the immune response to clearing infections.

153 intains the majority of its effectiveness in clearing infections.

154 Airway mucus plays a critical role in clearing inhaled toxins, particles, and pathogens.

155 tial metabolic program that is also used for clearing intracellular pathogens.

156 are specialized phagocytic cells involved in clearing invading pathogens.

157 Here, we provide evidence that vein clearing is caused by pathogen-induced transdifferentiat

158 ogress has been made with intact methods for clearing, labeling, and imaging whole organs such as the

159 ly stages of infection, they were capable of clearing LCMV infection.

160 model, they developed small, purulent, self-clearing lesions with predictable areas of inflammation

161 Sorafenib is effective in clearing leukemic blasts in chemorefractory FLT3-ITD(+)

162 ever no treatments exist that are capable of clearing Lewy bodies.

163 to propose a new paradigm of LSEC and HDL in clearing LPS with a potential to avoid inflammation duri

164 RSV neutralizing antibodies responsible for clearing lung viral loads, we show that modulation of sp

165 d superior activity in immunogenicity and in clearing M. catarrhalis from mouse lungs.

166 licits a Th17 response that is necessary for clearing many fungal pathogens.

167 of immune capacity and cell dynamics in the clearing mechanism.

168 cts and evade unwanted removal by endogenous clearing mechanisms.

169 us to argue that the innate immune response clearing merozoites is the most likely, but not necessar

170 We describe a clearing method for enhanced visualization of cell morph

171 The clearing method is compatible with immunocytochemistry t

172 Optical clearing methods can facilitate deep optical imaging in

173 Next-generation clearing methods have been (re)designed with a better un

174 Recently, tissue clearing methods have enabled the investigation of a ful

175 Tissue clearing methods promise to provide exquisite three-dime

176 the Wolbachia in O. volvulus is effective in clearing microfilariae in the skin of onchocerciasis pat

177 viding a separate hydrolytic active site for clearing mischarged tRNA.

178 Protein quality control is essential for clearing misfolded and aggregated proteins from the cell

179 Thus, UBQLN1 plays an important role in clearing mislocalized mitochondrial proteins upon cell s

180 ypic signature: individual parasite variants clearing more slowly following drug treatment.

181 Without tissue staining or clearing, mPAM generates micrometer-resolution 3D images

182 new observations were made possible by using clearing MPM, demonstrating the utility of this techniqu

183 tophagy, which is an important mechanism for clearing mutant Htt.

184 from rhodopsin misfolding by preferentially clearing mutant rhodopsin and abnormal rhodopsin aggrega

185 cells are the primary cells responsible for clearing neuronal debris, but the cellular and molecular

186 c LeuRS domain called CP1 is responsible for clearing noncognate amino acids that are misactivated du

187 lerated mRNA degradation underlies the rapid clearing of a subset of transcripts, which is most prono

188 onitoring tool for predicting the recurrence/clearing of bladder cancer, and for screening undiagnose

189 observed light-dependent redistribution and clearing of CRY2-tethered proteins within the nucleus.

190 This suggests that the clearing of FMDV infection is associated with an enhance

191 In the early 21st century the extensive clearing of forestland, fresh water scarcity, and sharp

192 ine from midgut to hemolymph, but not in the clearing of hemolymph nicotine or in the exhalation of n

193 ial sojourn in resident macrophages promoted clearing of infection.

194 RIT) only if a repeat BM biopsy demonstrated clearing of lymphoma to less than 20% involvement.

195 associated with P23H rhodopsin and promoted clearing of mutant rhodopsin from photoreceptors.

196 ck-out (ApoE(-/-)) mice, which show impaired clearing of plasma lipoproteins and spontaneously develo

197 consequence of the patients' more efficient clearing of previously relevant WM traces and the accord

198 egions of the prion protein (PrP) led to the clearing of PrP(Sc) in cultured cells.

199 icularly cytotoxic cells, may be critical to clearing of reactivated HIV-1-infected cells.

200 score of 0 to 1 (indicating clearing or near-clearing of skin lesions) on the investigator's global a

201 to 70% of the mice survived, with efficient clearing of the invading pathogen, as visualized in real

202 Efficient methods to obtain optical clearing of the tissue for 3D visualisation are therefor

203 eatures within large tissue sections.Optical clearing of tissue has enabled optical imaging deeper in

204 tween viral genomes proceeds apace, randomly clearing one or the other genome from cells in the span

205 y found for women: "slow-clearing" and "fast-clearing." Only 68% (57%-78%) (posterior median and 95%

206 ebo group, had a score of 0 to 1 (indicating clearing or near-clearing of skin lesions) on the invest

207 Using wholemount tissue staining and clearing, or retrograde tracing in a MET(EGFP) transgeni

208 erosclerosis by potentially neutralizing and clearing OSE and preventing foam cell formation, suggest

209 one using different filtering parameters for clearing out contamination and noise of the RNAseq datas

210 herapy, which requires the host to assist in clearing parasites, offers an opportunity to measure pro

211 , biological mechanisms for sequestering and clearing pathogen lipids from the circulation have evolv

212 Thus, the cilia critical to clearing pathogenic infections from the middle ear are d

213 ting the role of IFNs and innate immunity in clearing persistent viral infection, and discussing the

214 The nuclear clearing phenotype was dependent on the presence of a di

215 After clearing, plant organs and thick tissue sections are ame

216 They are likely involved in clearing potentially harmful endobiotic and xenobiotic O

217 demonstrates short-term bexarotene treatment clearing preexisting beta-amyloid deposits from the brai

218 eveloped a highly reproducible and versatile clearing procedure called 3D imaging of solvent-cleared

219 10-15 times shorter and less intensive lens clearing procedures compared with an untreated endoscope

220 Our enhanced clearing process allowed us to fluorescently image and m

221 as fluorescence that is preserved during the clearing process.

222 to cigarette smoke (CS)-induced emphysema by clearing proline-glycine-proline (PGP), a triamino acid

223 analogues and presented with excellent iron-clearing properties.

224 ostasis by monitoring neuronal function, and clearing protein aggregates across the lifespan.

225 is a new sodium dodecyl sulfate (SDS)-based clearing protocol for the chemical clearing and imaging

226 We systematically compared seven clearing protocols with the FACT protocol, using transge

227 The small fast-clearing radiolabelled effector molecules with a complem

228 ethyl cinnamate) as a nontoxic solvent-based clearing reagent that can be handled without specific sa

229 of TLRs, the role of endosomal maturation in clearing receptors and terminating inflammatory response

230 ptic plasticity, maintaining exocytosis, and clearing release sites for vesicle replenishment.

231 Additionally, neutrophils, essential for clearing S. aureus, demonstrated sex-specific S. aureus

232 us tumor types, despite being ineffective at clearing SB-induced tumors.

233 Clearing senescent cells from 18-month-old naturally-age

234 ITY technique) tissue hydrogel embedding and clearing, smHCR can detect single mRNAs deep within thic

235 wo-segment platform begins with whole tissue clearing, staining, and imaging to globally delineate me

236 psis (Arabidopsis thaliana) using a combined clearing-staining technique on whole-mount tissue.

237 transporters terminate neurotransmission by clearing synaptically released glutamate from the extrac

238 We report on a nondestructive clearing technique that enhances transmission of light t

239 abeling of endothelial cells, a novel tissue-clearing technique, lightsheet microscopy, and automated

240 led advances in fluorescence-friendly tissue clearing technique, our cardiac LSFM enables dual-sided

241 Optical clearing techniques can alleviate these mismatches, but

242 describes the mechanisms underlying various clearing techniques, and discusses several of the major

243 Unlike other available clearing techniques, these methods do not use detergents

244 By combining our approach with tissue clearing techniques, we reveal the entire cardiac struct

245 ield unless the material is heated above the clearing temperature.

246 rtoli cells and to test novel antivirals for clearing testicular ZIKV infection.

247 e simplified CLARITY method (SCM) for tissue clearing that preserves epitopes of interest.

248 on, and reset proteostasis by enveloping and clearing the aggregates.

249 After clearing the allergic bronchial inflammation, post-AAI m

250 Cs but they contributed only a minor role to clearing the axon debris, even after widespread degenera

251 mune response against C rodentium infection, clearing the bacteria more slowly.

252 s, as a reflection of their dominant role in clearing the bulk of apoptotic cells.

253 at P. carabi mites assist burying beetles in clearing the carcass of bacteria as a side-effect of gra

254 d/or nascent polypeptide components, thereby clearing the cell of improper translation products and d

255 Clearing the commensal flora by antibiotics prevents the

256 ions in reward learning and decision-making, clearing the course for future empirical work.

257 ance is excessive, Mfd dissociates the RNAP, clearing the DNA for other processes.

258 nly ubiquitous cellular checkpoint known for clearing the error.

259 ell function, thus eradicating the virus and clearing the infection.

260 Neutrophils are not capable of clearing the infection.

261 tly in parasite killing by encapsulating and clearing the infection.

262 followed by a proliferative T-cell response, clearing the LMP-expressing B cells.

263 ife for liver retention is 4 h, with sensors clearing the lungs within 2 h after injection, thus avoi

264 revent P. acnes-induced inflammation by both clearing the organism and inhibiting microbial stimulati

265 respiratory-virus infection is essential for clearing the pathogen but, if excessive, can lead to tis

266 on in vivo, supporting its essential role in clearing the peptidoglycan for T3SS assembly.

267 immune responses capable of recognizing and clearing the rare cells in which HIV latency has been re

268 m reduction," leading to the 2001 IOM report Clearing the Smoke.

269 pite all the advantages of multidetector CT, clearing the spine in which injury is suspected continue

270 gy into the interstellar medium, potentially clearing the surrounding gas.

271 ich is sequentially regulated by temporarily clearing the transcription inhibitor Nrg1 upon activatio

272 owth factor beta (TGFbeta)/Smad signaling by clearing the type II TGFbeta receptor from the cell surf

273 hough NLRC5-deficient mice were defective at clearing the virus, they did not show an increase in mor

274 lthough efforts to eliminate the scatter by "clearing" the tissue have been ongoing for over a centur

275 forest loss with their carbon stocks before clearing, these results serve as a more accurate benchma

276 optimal gene expression depends on enhancers clearing this repressive mark.

277 luorescent signal was achieved by decreasing clearing time, adjusting the pH of the SDS solution, and

278 imensions of the workflow, including reduced clearing time, improved efficiency of fluorescent signal

279 Fast Free-of-Acrylamide Clearing Tissue (FACT) is a new sodium dodecyl sulfate (

280 chnique of multiphoton microscopy (MPM) with clearing to a new mouse model of cisplatin-induced CKD,

281 ers lifelong protection from AD pathology by clearing toxic Abeta.

282 istal tumor sites but were more effective at clearing tumors actively introduced into the peripheral

283 ry behavior, adhesion, and basement membrane clearing underlie target recognition and dynamic interac

284 Clearing up these conceptual confusions is a necessary f

285 vement of VE-cadherin and may play a role in clearing VE-cadherin from the site of TEM.

286 Recruitment of the LBRC may play a role in clearing VE-cadherin from the site of TEM.

287 ation (aOR 1.89, 95% CI 1.07-3.35, p=0.028), clearing vegetation (1.89, 1.11-3.22, p=0.020), and havi

288 CD8(+) T cells are critical for clearing viral infection, yet recent evidence shows that

289 ly infects Arabidopsis thaliana, Turnip vein clearing virus (TVCV) is the tobamovirus of choice for s

290 early during WNV infection are essential for clearing virus from the periphery, it is important to de

291 Arabidopsis thaliana with TVCV (Turnip vein-clearing virus)), but not in resistant host systems (Nic

292 the reduction of virus titers, presumably by clearing virus-infected cells from airway mucosa.

293 pathy (PDR), vitrectomy was resorted for non clearing vitreous hemorrhage.

294 rI]) of incident infections in men were slow-clearing, vs 77% (69%-84%) in women.

295 Accelerated clearing was achieved because the microfluidic system en

296 ubstrates for oestrogen synthesis as well as clearing waste products and xenobiotics from the fetal c

297 or >/=6,000 y and that only small, temporary clearings were made to build the geoglyphs; however, con

298 Clearing wild forests to grow food, fibre, and fuel prod

299 tic activity associated with prolonged wake, clearing worn components of heavily used synapses.

300 strated by the reduction, or abolition, of a clearing zone on plate-based bioassays.