ライフサイエンスコーパス: cleavable

1 ly dimeric and conclude that LexA dimers are cleavable.

2 >20 nucleolar proteins were identified as C1 cleavable.

3 and then linked to Ad via a single reduction-cleavable 5kDa PEG.

4 ional moieties to the polysaccharide through cleavable acetal linkages.

5 Probe variants incorporating enzyme-cleavable acetomethoxy ester groups are processed by int

6 inhibitor as a single, macrocyclic esterase-cleavable (acyloxy)alkoxy prodrug.

7 re we demonstrate that photo-activation of a cleavable air-stable dimeric dopant can result in kineti

8 s spectrometry due to the presence of easily cleavable alkoxyamine bonds formed in step (ii).

9 Compared with the non-cleavable alpha7 chain, the cleaved form enhances cell a

10 The readily cleavable amide group has been utilized as a directing g

11 yrins and prodrug models, attached via (1)O2-cleavable amino-acrylate linker, to the SCPNs, we show t

12 njugating photosensitizer via singlet oxygen-cleavable aminoacrylate linker.

13 ize reactive macromers that contain protease-cleavable and fluorescent peptides and are able to form

14 tility of this connection with both protease-cleavable and reductively cleavable antibody-drug conjug

15 with both protease-cleavable and reductively cleavable antibody-drug conjugates that were effective a

16 prenylated peptides using mass spectrometry-cleavable approaches was developed.

17 c peptide fragment through the attachment of cleavable arginine tags.

18 on of the purines (A and G) via a chemically cleavable azido-based linker, with different length link

19 To realize this transformation, a cleavable bidentate directing group is used to control t

20 ivated alkenes has been developed, wherein a cleavable bidentate directing group is used to control t

21 oped, wherein selectivity is controlled by a cleavable bidentate directing group.

22 dition to the previously described aspartase-cleavable biosensors, we report development of granzyme

23 Five cleavable biotin probes are described for use in labelin

24 A. phagocytophilum, a membrane-impermeable, cleavable biotin reagent, sulfosuccinimidyl-2-[biotinami

25 and evaluation of a novel set of chemically cleavable biotinylated dideoxynucleotides, ddNTPs-N(3)-b

26 an acid-sensitive bond (1) or a cathepsin B cleavable bond (3) for ensuring an effective release of

27 to anticancer drug doxorubicin (Dox) by a pH-cleavable bond that is physically loaded onto the exosom

28 hese reagents incorporate a single gas-phase cleavable bond within their linker region that can be se

29 genomic viral RNA with VPg linked via a 'non-cleavable' bond.

30 ge, redox-cleavable bonds, and enzymatically-cleavable bonds are also thoroughly described.

31 The cross-linker was designed to contain cleavable bonds such as geminal diol, disulfide, and ace

32 nd pH-degradable bonds, amide linkage, redox-cleavable bonds, and enzymatically-cleavable bonds are a

33 otocleavable group, and new low-energy MS/MS cleavable bonds.

34 the end-groups of the dendron through enzyme-cleavable bonds.

35 /CYT-2, the ErbB4 isoform that is proteinase cleavable but does not contain a PI3K-binding domain in

36 at render the mutational target sequence non-cleavable by a restriction enzyme are quantified by dilu

37 eviously identified as the minimal substrate cleavable by ADAMTS-13.

38 rove the selection of residues that are less cleavable by aminopeptidases predominantly at N-flanking

39 regulin-1 family member neuregulin-3 is also cleavable by BACE1.

40 7 cleavage site (30)DETD(33) in ORF57 is not cleavable by caspase-3, although both enzymes use DEXD a

41 asis for developing antibody-drug conjugates cleavable by intracellular proteases for the targeted de

42 To sense protease release, peptides cleavable by MMP9 were designed to contain a donor/accep

43 yproline (Dyp) is a typical protecting group cleavable by traces of TFA.

44 o a VPg-triazole-RNA construct that was 'non-cleavable' by TDP2.

45 by a near-infrared imaging approach using a cleavable cathepsin-selective probe.

46 Two cleavable cationic lipids were designed to trigger the f

47 tudy, we report the generation of a protease-cleavable CD1d variant with a similar trafficking patter

48 technology that couples a mass spectrometric-cleavable chemical cross-linker with high-resolution mas

49 N-succinyl-Ala-Ala-Pro-Phe p-nitroanilide, a cleavable chromogen, were conjugated to primary amines o

50 not affect etoposide-stabilized topo II-DNA cleavable complex formation.

51 merase II and prevent the resolution of the "cleavable complex," in which one DNA duplex is passed th

52 d measuring the formation of the topo II-DNA cleavable complex.

53 y disabling the formation of the topo II-DNA cleavable complex.

54 ormation of etoposide-stabilized topo II-DNA cleavable complex.

55 ormation of etoposide stabilized topo II-DNA cleavable complex.

56 omerase II and prevents the formation of the cleavable complex.

57 izing the Top1-DNA intermediate or cleavage (cleavable) complex.

58 IIalpha inhibitors are unable to induce DNA-cleavable complexes and cell death.

59 Pathways influencing the repair of cleavable complexes are expected to be major determinant

60 Rb facilitates processing and repair of TOP2-cleavable complexes by recruiting proteins like BRCA1 to

61 s to the formation of an increased number of cleavable complexes ultimately resulting in rise in DNA

62 the hairpin cleavage rate and to form active cleavable complexes with Rnt1p.

63 ross-links (including topoisomerase I and II cleavable complexes) produce stalling and collapse of re

64 We observe that degradation of trapped TOP2-cleavable complexes, liberation of DNA strand breaks, an

65 ks, which include stable DNA-topoisomerase I cleavable complexes.

66 ide kill cells by trapping covalent TOP2-DNA cleavable complexes.

67 concentrations ranging from non-cleavable to cleavable concentrations obtained from in vitro cleavage

68 nsition of LexA from its noncleavable to its cleavable conformation and therefore operates, at least

69 ti-HisRS antibody recognizing its granzyme B-cleavable conformation by immunoblotting and immunohisto

70 Thus, the structure represents a non-cleavable conformation of the repressor, but one that is

71 this significant problem to be addressed, a cleavable conjugate of the antibiotic kanamycin and a no

72 amide directing group plays a dual role as a cleavable coordinating moiety as well as an essential co

73 on as amine-reactive sulfoxide-containing MS-cleavable cross-linked peptides, thus permitting their s

74 he use of a tandem mass spectrometry (MS/MS) cleavable cross-linker (containing a 1,3-bis-(4-oxo-buty

75 Second, the homobifunctional thiol-cleavable cross-linker 3,3'-dithiobis(sulfosuccinimidylp

76 The strength of our cleavable cross-linker is that characteristic patterns o

77 The introduction of a cleavable cross-linker makes this process reversible and

78 e present the use of novel mass spectrometry cleavable cross-linkers and tags to stabilize intact pro

79 er demonstrates that sulfoxide-containing MS-cleavable cross-linkers offer robust and predictable MS2

80 cross (X)-linked peptides) by integrating MS-cleavable cross-linkers with isobaric labeling reagents.

81 es of amine-reactive sulfoxide-containing MS-cleavable cross-linkers.

82 oc159 in reverse orientation functioned as a cleavable cTP that guided the fluorescent protein to the

83 ngth-dependent manner, expression of the non-cleavable D266N/D344N form of polyQ-expanded ataxin-7 at

84 eports the synthesis of the first functional cleavable detergent designed specifically for applicatio

85 Applications of the functional cleavable detergents to the profiling of whole cell lysa

86 al interference originating from traditional cleavable detergents.

87 the discovery of new transformations and new cleavable DGs.

88 NA'), and have modified them using the photo-cleavable di-methoxy nitro phenyl ethyl group (DMNPE) gr

89 ipening, and the encoded enzyme converts the cleavable diglycosides of the smoky-related phenylpropan

90 f cardiolipin (CL) via a linker containing a cleavable disulfide; (2) 2',2''-bis-(AzC12)-CL with two

91 material with an optimal ratio of an enzyme-cleavable drug or immunotherapy (effector elements) and

92 each DsbD domain, we constructed a thrombin-cleavable DsbD (DsbDTH) from which we could generate all

93 hylene oxide block copolymer, which was made cleavable due to the intervening disulfide bond.

94 n 3 (nsP3) or insertion of the reporter as a cleavable element between the capsid and PE2 structural

95 Also, ADCs with a nonprotease-cleavable enantiomer, the VC(R) isomer, mediated effecti

96 ores (fluorescein and Cy3) through an Fe(II)-cleavable endoperoxide bridge, where Fe(II)-triggered pe

97 The polymerization of vinyl monomers with cleavable enzymatic substrates has been shown to lead to

98 ng with their use as electrospray ionisation-cleavable (ESI-Cleavable) hybridization probes for the d

99 ry prodrug pyrene-aspirin (P-aspirin) with a cleavable ester bond and also facilitate loading the pro

100 ed polyethylene glycol chains on SWNTs via a cleavable ester bond to obtain a water-soluble SWNT-PTX

101 o ensure attachment to the Au surface) and a cleavable ester bridge connecting the two spin-labeled b

102 an alcohol derivative of thapsigargin via a cleavable ester linkage.

103 a recombinant NDV (rNDV) whose F protein is cleavable exclusively by prostate-specific antigen (PSA)

104 ncodes isoforms containing a metalloprotease cleavable extracellular domain (JM-a), exon 15 for a cle

105 nalysis approach that is based on chemically cleavable fluorescent antibodies.

106 rnal reflection fluorescence microscopy of a cleavable fluorescent calpain substrate.

107 merase as substrates, are combined with four cleavable fluorescent dideoxynucleotides to perform SBS.

108 lyl-modified nucleotides, forming chemically cleavable fluorescent nucleotide reversible terminators,

109 ied as reversible terminators by attaching a cleavable fluorophore to the base and capping the 3'-OH

110 sis, we have determined the structure of the cleavable form of Escherichia coli maltose-binding prote

111 Expression of a non-cleavable form of golgin-160 impairs apoptosis induced b

112 n vivo in comparison with cells expressing a cleavable form of HuR.

113 fferent tissue, expression of its granzyme B-cleavable form was enriched in the lung and localized to

114 wever, determination of the structure of the cleavable form, which is populated only transiently, rem

115 erminal helices in MBP are unfolded in their cleavable form.

116 ematic approach to determining structures of cleavable forms by protein engineering and native-state

117 accessibilities of partially unfolded forms (cleavable forms) under native conditions.

118 Here we have designed a hyper-cleavable fragment of lambda repressor containing the hi

119 ed which enables the facile incorporation of cleavable functional groups, i.e., esters, thioesters, a

120 of crambin containing Pro22 and Leu25) as a cleavable fusion with staphylococcal nuclease and refold

121 ne-disruptive chains that are masked by acid-cleavable galactose residues.

122 to HPMA copolymer side chains via an enzyme-cleavable GFLG linker.

123 f cytotoxic gemcitabine by introducing Pd(0)-cleavable groups in positions that are mechanistically r

124 The auto-cleavable hairpin structure can be activated on site at

125 mammalian species an avian H5N1 virus with a cleavable hemagglutinin requires adaptive changes in pol

126 Thus, the ATXalpha insertion constitutes a cleavable heparin-binding domain that mediates interacti

127 ogeneity on a 10-100 mg scale using protease-cleavable His(10)-tagged constructs.

128 ted using a trimerization domain linked to a cleavable histidine tag.

129 ic residue-targeting sulfoxide-containing MS-cleavable homobifunctional cross-linker, dihydrazide sul

130 here the development of new isotope-coded MS-cleavable homobifunctional cross-linkers: d0- and d10-la

131 Our results indicated that, cellular non-cleavable HuR controls COX-2 mRNA expression and enzymat

132 se as electrospray ionisation-cleavable (ESI-Cleavable) hybridization probes for the detection and qu

133 orifices surrounding the nanopores contained cleavable imine double bonds.

134 essing wild-type or mutant SOD1 containing a cleavable IMS targeting signal to directly investigate t

135 Because galectin-3 is cleavable in vitro by MMPs, we have developed differenti

136 immunoassay platform that adopts stable and cleavable ionic probes as mass reporter; these probes ma

137 Overexpression of a non-cleavable isoform, HuR-D226A, revealed a potent dominant

138 Cleavable isoforms of ErbB4 release a soluble intracellu

139 First, the cysteine specificity of cleavable isotope-coded affinity tags (cICAT) was employ

140 e-3 or ectopic expression of a caspase-3 non-cleavable lamin B mutant blocks nuclear opening formatio

141 et of fifteen ORs to examine the effect of a cleavable leucine-rich signal peptide sequence (Lucy tag

142 ield binding specificity motifs and identify cleavable LHE targets using a combination of bioinformat

143 y, Tf-containing nanoparticles with the acid-cleavable linkage avoid major endothelium retention by s

144 ining, 80-nm gold nanoparticles with an acid-cleavable linkage between the Tf and the nanoparticle co

145 gen, a molecular complex is formed where the cleavable linkage is held in proximity to the photoactiv

146 With the Abs, the addition of the acid-cleavable linkage provided no improvement to in vivo bra

147 s conjugated to a fluorescent eTag through a cleavable linkage.

148 h small gold nanoparticles (Au NPs) via acid-cleavable linkages in order to explore the possibility o

149 ll as their development for incorporation of cleavable linkages into the network of micro- and nanoge

150 This can be achieved by introducing stimuli-cleavable linkages into the scaffold structures.

151 We also describe the synthesis of chemically cleavable linked conjugates designed to enable mild elut

152 in prodrug whereby the PEG is attached via a cleavable linker (col-aaPEG) introducing an acetic acid

153 to fluorophores through a novel azide-based cleavable linker are utilized to detect their protein ta

154 h incorporation of a boronic acid-containing cleavable linker between polycationic cell-penetrating p

155 ptamer sensors through the installation of a cleavable linker between the two DNA fragments that comp

156 e group that is appended to a drug through a cleavable linker is achieved by organocatalyzed ring-ope

157 ogenicity associated with Javelin J1 and the cleavable linker is consistently observed with multiple

158 tion of the hybrid epitope and introducing a cleavable linker sequence between the Javelin and the ep

159 ing from which to develop this near-IR light cleavable linker strategy.

160 (CuAAC), is applied to generate a gas-phase cleavable linker suitable for the formation of reporter

161 al antibody (cAC10) conjugated by a protease-cleavable linker to a microtubule-disrupting agent, mono

162 l-penetrating peptide (CPP) is coupled via a cleavable linker to a neutralizing peptide.

163 the 3'-O-modified dNTPs, and an azido-based cleavable linker to attach the fluorophores to the ddNTP

164 -gpNMB monoclonal antibody, conjugated via a cleavable linker to monomethyl auristatin E.

165 a functionalized biotin reagent containing a cleavable linker via Cu(I)-catalyzed azide-alkyne cycloa

166 nucleobase protecting groups and a UV-light cleavable linker were used.

167 odules of an anticancer agent (taxoid with a cleavable linker) that is activated to its cytotoxic for

168 olobenzodiazepine (PBD) dimer via a protease-cleavable linker, against acute myeloid leukemia (AML) c

169 anised antibody against HER2, a novel enzyme-cleavable linker, and a topoisomerase I inhibitor payloa

170 -terminal fibrinogen-like domain (FLD) via a cleavable linker, and both full-length Angptl4 and its i

171 (L-glutamic acid) by means of a pH-sensitive cleavable linker, and load the polymeric drug (pDox) int

172 mer, protein scaffold, or antibody), spacer, cleavable linker, and therapeutic warhead, criteria for

173 was conjugated to trastuzumab by a protease-cleavable linker, maleimido-caproyl-valine-citruline-p-a

174 30-specific monoclonal antibody by an enzyme-cleavable linker, producing the antibody-drug conjugate

175 g pyrrolobenzodiazepine dimer via a protease-cleavable linker.

176 s covalently linked to the carrier through a cleavable linker.

177 ngineered cysteines (THIOMABs) by a protease cleavable linker.

178 ed to hyperbranched polyglycerol (PG-M) by a cleavable linker.

179 lene glycol (PEG)ylated lipids with esterase-cleavable linkers (e.g., ME42) to promote intracellular

180 These results suggest that protease-cleavable linkers are unlikely to increase the therapeut

181 NDCs generated with protease-cleavable linkers demonstrated that the site of conjugat

182 Here, we describe cleavable linkers designed for the traceless release of

183 ADCs with cleavable linkers mediated in vivo efficacy via all thes

184 elivery system that utilizes enzyme assisted cleavable linkers to release conjugated cargo within the

185 Thus, our data suggest that ADCs with cleavable linkers work on a broad range of targets, and

186 uch less important for R-sshRNAs that have a cleavable loop.

187 We recently demonstrated that protease-cleavable luciferase biosensors detect granzyme B and pr

188 e aryl phthalate esters were conjugated with cleavable masking groups sensitive to light and hydrogen

189 protein, the N terminus of Bbeta2 acts as a cleavable mitochondrial import signal.

190 CYP27, which contains a canonical cleavable mitochondrial signal, required all of the peri

191 CYP27, which contains a canonical cleavable mitochondrial signal, required all of the peri

192 These isoforms differ by their cleavable mitochondrial targeting peptides, whereas the

193 However, deactivation of photo-cleavable MO activity has remained elusive.

194 Here, we describe photo-cleavable MOs with which it is possible to activate or d

195 As a broader approach for the use of photo-cleavable MOs, we show temporal control over gal4 functi

196 at flanking mutations producing more or less cleavable motifs can increase or decrease epitope produc

197 However, a non-cleavable mutant, N570T, undergoes the transition revers

198 n in the gut, blood, and tissues by removing cleavable N- and C-termini and by shielding components f

199 The sole exception is cytochrome f, whose cleavable N-terminal cpSecA-dependent signal sequence en

200 we demonstrate that L27 variants with an un-cleavable N-terminal extension, or lacking the extension

201 Different human BCO2 isoforms possess cleavable N-terminal leader sequences critical for mitoc

202 n cytosolic ribosomes as a preprotein with a cleavable N-terminal presequence that is the mitochondri

203 Est55, which lacks a classical, cleavable N-terminal signal sequence, was found to be se

204 The activity of CADA maps to the cleavable N-terminal SP of hCD4.

205 ly expressed Tm as alpha.beta dimers using a cleavable N-terminal tag on one of the two chains.

206 These LAADs employ a non-cleavable N-terminal twin-arginine translocation (Tat) p

207 Also, PSA-cleavable NDV failed to replicate in chicken embryos, in

208 new dimethide precursor expressing a readily cleavable O-benzyl residue, sulfone 34 should prove usef

209 of-of-concept of PODs, by fusion of protease cleavable oligomers of glucagon-like peptide-1, a type-2

210 nditions, the Id-carrier protein linkage was cleavable only after maleimide conjugation.

211 monomethyl auristatin D with either protease-cleavable or noncleavable linkers.

212 A brief stimulation of myocytes expressing cleavable or uncleavable pro-BDNF elicits synaptic poten

213 gated to an auristatin through a stable, non-cleavable oxime linkage to afford a chemically homogeneo

214 Beads displaying photochemically cleavable pepstatin A were distributed into droplets and

215 ith human serum albumin (HSA) via a thrombin-cleavable peptide (GFPRGFPAGGCtPA).

216 The presence of a cleavable peptide bond near the CH2 end of the hinge app

217 Moreover, a cleavable peptide linker successfully reduced kidney upt

218 ed to a fluorescence quencher by a caspase-3 cleavable peptide linker.

219 tested with endosomal furin- and cathepsin B-cleavable peptide linkers located between the integrin-b

220 als containing an alternate and non-protease-cleavable peptide sequence are stable in both in vitro a

221 ESI-cleavable peptide TNT isotopomers were introduced into P

222 alpha-chymotrypsin (Cht) (a protease) and a cleavable peptide-chromogen (pro-drug) covalently incorp

223 roof-of-concept for the use of a cathepsin K cleavable peptide-linked conjugate for targeting of bisp

224 made of a PEG core conjugated with protease-cleavable peptides, we explore a vast design space and i

225 oop motif (118)HCTHGXNRT(126) in binding the cleavable phosphate and stabilizing the transition state

226 ting conformational transitions shifting the cleavable phosphate by one step.

227 Using HJs containing non-cleavable phosphorothioate-containing linkages in one st

228 ture-sensitive properties, as well as enzyme-cleavable polysaccharides for targeted bioactive deliver

229 article (TBN) comprising of an enzymatically cleavable porous gelatin nanocore encapsulated with gefi

230 M23 complex) sorts precursor proteins with a cleavable presequence either into the matrix or into the

231 d mass spectrometry, it is convenient to use cleavable probes that allow release of labeled biomolecu

232 ion that was restored by the addition of non-cleavable proNGF.

233 ndent upon the presence of a proteolytically cleavable propeptide and sensitive to warfarin, a vitami

234 zes simple chemistry on the prenyl group and cleavable properties of a sulfoxide group in the gas pha

235 interlayer coupling gives rise to the highly cleavable property of the single crystal specimens.

236 The acid-cleavable protecting groups for secondary alcohol and ur

237 CRAC performed using cleavable proteins (split-CRAC) revealed that Rrp44 endo

238 ation was enhanced by inclusion of the photo-cleavable radical initiator di-tert-butyl peroxide (DTBP

239 ur previously developed sulfhydryl-reactive, cleavable, radioiodinated photocross-linking reagent: me

240 These MS-cleavable reagents have allowed us to establish a common

241 To date, studies have utilized non-cleavable rhodopsin (Rho) tags and/or chaperones (i.e. R

242 The RNAi-microsponges consist entirely of cleavable RNA strands, and are processed by the cell's R

243 Further, PSA-cleavable rNDV caused specific lysis of androgen-indepen

244 Functional analysis of the cleavable RTKs indicated that proliferation promoted by

245 PEGylated, cleavable RTN formulations offer prospects for tumor-spe

246 Transfection efficiency by PEG-modified, cleavable RTNs improved approximately 2-fold in 4 differ

247 etion of SCC1 by RNAi or expression of a non-cleavable SCC1 resulted in karyokinesis failure.

248 Using the dominant negative phenotype of non-cleavable SCC1 we investigated checkpoint regulation of

249 Assembling a peptide-based Cathepsin B cleavable sensor over a large array of nano-needles allo

250 -drug conjugates which contain enzymatically cleavable sequences (GFLG) in both polymeric backbone an

251 An amphiphilic polymer with cleavable side chain and main chain functional groups ha

252 at encodes a predicted 68 kDa protein with a cleavable signal peptide and a patatin-like phospholipas

253 The cleavable signal peptide at the N terminus of NS4B, a pe

254 otein by 69 amino acids, reveals a predicted cleavable signal peptide, and suggests structural homolo

255 ueried for the presence of an amino-terminal cleavable signal peptide, the absence of transmembrane d

256 achment inhibits processing of a potentially cleavable signal peptide.

257 It is synthesized with an amino-terminal cleavable signal peptide.

258 spans the membrane twice and is made with a cleavable signal peptide.

259 Tat precursors are targeted by hydrophobic cleavable signal peptides with twin arginine (RR) motifs

260 roteins and the presence or the absence of a cleavable signal sequence at their N termini.

261 to the ER by the first 31 aa which act as a cleavable signal sequence.

262 orismate mutase (*MtCM) with a 33-amino-acid cleavable signal sequence; hence, it belongs to the *Aro

263 inguish SRP-dependent from non-SRP-dependent cleavable signal sequences.

264 an in-house created (18)O-labeled peptide, a cleavable SIL peptide, and an internal standard created

265 ate the lack of commutability of tryptic and cleavable SIL peptides as internal calibrators across va

266 isotopically labeled (SIL) tryptic peptides, cleavable SIL peptides, and a full-length SIL protein we

267 an a peptide that models a potential but non-cleavable site just 2-triplets away and NMR studies show

268 Use of the acid-cleavable solubility tag strategy should facilitate synt

269 Here we adopted an acid-cleavable solubility tag strategy that facilitated synth

270 ree HNs exhibited similar affinities for all cleavable soluble substrates, their activities were 5- t

271 sox10 function after deactivation of a photo-cleavable sox10-MO at different time points.

272 avirus mouse hepatitis virus (MHV) express a cleavable spike glycoprotein that mediates viral entry a

273 g a disulfide bifunctional initiator lead to cleavable structures, underlining the role of initiator

274 A cathepsin B-specific cleavable substrate (KGRR) conjugated with triacetylated

275 rally designed by placing fluorochromes on a cleavable substrate in close proximity to one another, s

276 BoNT-cleavable substrates contain a C-terminal Nle, while BoN

277 from a precursor in which the S1 site is non-cleavable, such that the linker domain remains covalentl

278 ins of E. chaffeensis, membrane-impermeable, cleavable Sulfo-NHS-SS-Biotin was used to label intact b

279 re chemically conjugated with T3 using a non-cleavable sulfo-SMCC linker.

280 surfactants including stimuli-responsive and cleavable surfactants.

281 This chemistry, the cleavable tag immunoassay (CTI), is a low- to medium-den

282 ity, stability, and simplicity of the enzyme-cleavable taurine motif promise new ways to promote the

283 ed on our previous work with photochemically cleavable terminators.

284 d in the design: a lysosomally (cathepsin B) cleavable tetrapeptide GFLG spacer conjugated doxorubici

285 d down using magnetic beads decorated with a cleavable tetrazine-modified linker.

286 ly attaching lactic acid to 8-arm PEG-SH via cleavable thioester bonds.

287 at different concentrations ranging from non-cleavable to cleavable concentrations obtained from in v

288 The released pro-IL-1beta was cleavable to mature bioactive IL-1beta in the extracellu

289 sistance and that the attachment of multiple cleavable toxophores enhances the efficiency of this sma

290 eveal that distinct type-III effectors use a cleavable transit peptide to localize to chloroplasts, a

291 de while AtCML30 utilizes an N-terminal, non-cleavable transit peptide.

292 other, hydrophobic membrane proteins lacking cleavable transit sequences into the inner mitochondrial

293 They lack a cleavable trigger in the linker and consist of a maleimi

294 Cells with a non-cleavable UmuD exhibit essentially no UV-induced mutagen

295 hat installs a S-Se bond in peptides that is cleavable upon 266 nm ultraviolet photodissociation (UVP

296 Here, we examine the effect of the protease-cleavable valine-citrulline [VC(S)] linker on ADC effica

297 ll, phosphatidyl choline, while the protease cleavable version of CD1d contains bound sphingomyelin a

298 the fact that this novel UmuD variant is non-cleavable, we find that cells harboring it display pheno

299 ors transfected with wild-type FasL (wtFasL; cleavable), which could produce both sFasL and mFasL, el

300 However, the cleavable wtFasL eye tumors failed to trigger protective