ライフサイエンスコーパス: cleavage

1 est interactions with uncaging and molecular cleavage).

2 otenoids as substrate or perform double-bond cleavage.

3 ngaged in R-loops and the other by MutLgamma cleavage.

4 ce that exposes an otherwise buried site for cleavage.

5 reased IQGAP1 acetylation and reduced IQGAP1 cleavage.

6 ospholipids (PE, PS, and PC), via ester bond cleavage.

7 from modified SM lipid anions via amide bond cleavage.

8 but also activates it for efficient O-O bond cleavage.

9 via a single Cu atom to accomplish N-O bond cleavage.

10 alytic mechanisms exist for xylan and glucan cleavage.

11 ssembly and dictate the extent of maturation cleavage.

12 al kinase activation and initiator caspase 8 cleavage.

13 dogenous functions, such as stimulating Ctr1 cleavage.

14 precursor, which substantially enhances its cleavage.

15 poor protection capability against enzymatic cleavage.

16 ts own proteolytic activity mediates zymogen cleavage.

17 part, to make their backbones accessible for cleavage.

18 steine protease, Prp, which carries out this cleavage.

19 ns upon derivatization followed by reductive cleavage, a degradative method that cleaves beta-ether b

20 gh a mechanism that required an intact SREBP cleavage-activating protein (SCAP) pathway.

21 a1 induction of enzymes that cause autocrine cleavage/activation of PAR2, possibly through a biased s

22 tion drastically accelerates the proteolytic cleavage activity, even in the absence of forces or dena

23 inity binding to cell wall carbohydrates and cleavage activity.

24 mice with this inhibitor reduces tau and APP cleavage, ameliorates synapse loss and augments long-ter

25 equency of susceptibility to gamma-secretase cleavage among human RTKs.

26 Assembly of the inflammasome allows for the cleavage and activation of inflammatory caspases.

27 Pyroptosis requires cleavage and activation of the pore-forming effector pro

28 ssociated with significant decline in oocyte cleavage and blastocyst development after in-vitro ferti

29 ive of the isotope effects pertinent to bond-cleavage and bond-formation reactions during chloraminat

30 ep is not rate-determining, but the C-H bond cleavage and C-Si bond-forming steps together influence

31 Coupled C-S cleavage and CO2 release to yield [(bpy)3Pd3(micro3-S)2]

32 cal to epitope presentation, such as protein cleavage and gene expression.

33 )] ligand are involved in the key step of H2 cleavage and hydrogen transfer to the olefin.

34 ately characterize intestinal alpha-carotene cleavage and its relative contribution to postprandial v

35 ucP) or dried urine spot workup by conjugate cleavage and liquid extraction (DUSglucE).

36 Alternative cleavage and polyadenylation (APA) generates mRNA isofor

37 , including the newly discovered alternative cleavage and polyadenylation of NaV1.8 mRNA.

38 e we have systematically mapped and compared cleavage and polyadenylation sites (PASs) in two yeast s

39 n the pre-mRNA polyadenylation signal by the cleavage and polyadenylation specificity factor (CPSF) c

40 primarily interact with Fip1, a component of cleavage and polyadenylation specificity factor (CPSF).

41 utations decreased the binding of NS1 to the cleavage and polyadenylation specificity factor 30 (CPSF

42 Termination of mRNAs is coupled to cleavage and polyadenylation while noncoding transcripts

43 ction of CPSF in mediating PAS-dependent RNA cleavage and polyadenylation.

44 The proteolytic cleavage and posttranslational acetylation modification

45 lar potassium significantly reduced IL-1beta cleavage and release in response to T. gondii infection,

46 target sequence and chromatin state modulate cleavage and repair kinetics.

47 QCA was likely formed through oxidative ring cleavage and subsequent decarboxylation of acridine, a w

48 They can catalyze site-specific RNA cleavage, and as a result, they have relevance in gene r

49 beta maturation and secretion, pro-caspase-1 cleavage, and speck formation by apoptosis-associated sp

50 esion by protecting the cohesin complex from cleavage, and this has been shown in yeasts to be mediat

51 mechanisms underlying target recognition and cleavage are highly conserved.

52 The rates of GreA-dependent cleavage are lower for DeltaTL RNAP variants, suggesting

53 Our findings implicate TOP2A cleavage as a broad DNA damage mechanism in oncogenic tr

54 pport degradation pathways that include meta-cleavage as well as ortho-cleavage, which has not been p

55 trate preference using a fluorogenic peptide cleavage assay.

56 nd XBP1-depleted cells, validation using RNA cleavage assays, and 5' RACE identified the prooncogenic

57 mong the mildest conditions reported for C-H cleavage at a Ni center.

58 late sequential strand displacement and flap cleavage at other genomic sites.

59 uctural microheterogeneity of signal peptide cleavage at the amino terminus of FGF2, whereas IGF1 dis

60 of both molecular interactions (for example, cleavage, binding, folding and unfolding) and biological

61 h molecules is arbitrated by their regulated cleavage brought about by components of a multiprotein c

62 ed Cdc48 cofactor Ufd1 is required for SREBP cleavage but does not interact with the Cdc48-Rbd2 compl

63 omain (Toc159G) of pea (Pisum sativum) using cleavage by bound preproteins conjugated with the artifi

64 The coronavirus (CoV) S protein requires cleavage by host cell proteases to mediate virus-cell an

65 rategy in which antibody-targeted controlled cleavage by micrococcal nuclease releases specific prote

66 ally using kinetic isotope effects show that cleavage by oxidative addition of an O-H bond in H2O is

67 re ASOs, 3'-SpSpRp, that promotes target RNA cleavage by RNase H1 in vitro and provides a more durabl

68 ellular fragment of ODZ1 through proteolytic cleavage by signal peptide peptidase-like 2a.

69 itiated events, mutations reflect sequential cleavage by the enzyme.

70 d bilayer of the inner membrane, followed by cleavage by the inner membrane peptidase.

71 cts the peptidoglycan of dividing cells from cleavage by the major autolysin LytA and occurs at the s

72 In the absence of Ca(2+), S-2288 cleavage by wild-type HABP2 was Na(+)-dependent, with Km

73 GreA factors activate RNA cleavage by wild-type RNAPs to similar levels.

74 eptide removal from neurotoxin precursors by cleavage C-terminal of the PQM.

75 s evidence on compounded deprivation, racial cleavages, civic engagement, institutional cynicism, and

76 served local sequence preferences, occurs in cleavage cluster regions (CCRs), and is enriched in intr

77 leavage site becomes embraced to achieve its cleavage competent conformation.

78 Gyrase maintained lower levels of cleavage complexes with positively supercoiled (compared

79 ls that target DNA gyrase by stabilizing DNA-cleavage complexes, but their clinical utility has been

80 ntiproliferative effect of Cas9-mediated DNA cleavage confounds such measurement of genetic dependenc

81 In human carotid plaques, MerTK cleavage correlated with plaque necrosis and the presenc

82 This cleavage creates the structure that Exo1 requires for 5'

83 Here, we use natural cleavage defects on Muscovite mica to investigate the ac

84 c-resistant alpha1C Prevention of C-terminal cleavage did not alter beta-adrenergic stimulation of Ca

85 that miR-449b expression improves the first cleavage division, epigenetic reprogramming and apoptoti

86 ryonic development is characterized by rapid cleavage divisions, which impose significant constraints

87 ransposase binding to the inner 12DRs (where cleavage does not occur), followed by capture of the 12D

88 XRN2, a key coordinator of multiple pre-rRNA cleavages, driving mature rRNA formation and discarded r

89 We therefore conclude that inhibition of C5 cleavage during the bacteremic stage of sepsis could be

90 e identify a strong correlation between Cas9 cleavage efficiency and the stability of the DNA-RNA (R-

91 Because cleavage efficiency is pivotal in the generation of the

92 esins from chromosomes without changing Scc1 cleavage efficiency, promoting dissolution of cohesion.

93 lation between ribosome density per mRNA and cleavage efficiency.

94 r polycistronic nature, small size and high "cleavage" efficiency.

95 tional characteristic marker ions from alpha-cleavage, enables convenient structure assignment of ca.

96 is protected by Sgo2 from Separase-mediated cleavage ensuring that sister chromatids are kept togeth

97 -carotene oxygenase 2 (BCO2) is a carotenoid cleavage enzyme located in the inner mitochondrial membr

98 which is a product of both alpha- and gamma-cleavage events, could also induce TrkB phosphorylation.

99 late precise, regularly spaced upstream mRNA cleavage events.

100 s solfataricus TFS1 functions as a bona fide cleavage factor, while the paralogous TFS4 evolved into

101 g/accepting a proton (H(+)) via its N-H bond cleavage/formation.

102 by overproduction, thus separating filament cleavage from curing activities.

103 lowers the activation barrier for C-OH bond cleavage from the metallocarboxylic acid intermediate.

104 (ECM) remodeling is thought to stabilize the cleavage furrow and maintain cell shape during cytokines

105 cence polarization microscopy and found that cleavage furrow ingression initiates by contraction of a

106 unequal cortical expansion, ensuring correct cleavage furrow positioning and the establishment of phy

107 (CPC) and centralspindlin that instructs the cleavage furrow.

108 and use the technology to characterize TOP2A cleavage genome-wide in the human K562 leukemia cell lin

109 nyl sulfide also showed competitive C-S bond cleavage giving phenyl sulfinic acid and ionization to d

110 We find that TOP2A cleavage has functionally conserved local sequence prefe

111 visiae promote site-specific endonucleolytic cleavage in 25S ribosomal RNA (rRNA) adjacent to the c l

112 ein that promotes proofreading by transcript cleavage in elongation complexes backtracked by nucleoti

113 eavage in oxidation by persulfate, C-Cl bond cleavage in Fe(0)-mediated reductive dechlorination and

114 Furthermore, the first C-H bond cleavage in methane is favored as the local oxidation st

115 a "bottom-up" fundamental insight, C-H bond cleavage in methane over Ni-based catalysts was investig

116 agreement with expected mechanisms (C-H bond cleavage in oxidation by persulfate, C-Cl bond cleavage

117 Depletion of FXII in AD mice inhibited HK cleavage in plasma and reduced neuroinflammation, fibrin

118 ations as well as a functional role of TOP2A cleavage in regulating transcription elongation and gene

119 tiation and is activated through proteolytic cleavage in response to ligand engagement.

120 rocessing as well as downstream procaspase-3 cleavage in several cell types and under multiple condit

121 core is generated with a noteworthy C-C bond cleavage in the case of the substituted nitriles.

122 xosite differentially affects MKK and NLRP1B cleavage in vitro and in cultured cells.

123 n, and recombinant histones protect DNA from cleavage in vitro.

124 active isoforms of PKCs generated by calpain cleavage, in the sensory neuron and L7 are required to m

125 e to trapping and processing of the covalent cleavage intermediate.

126 Because endonuclease cleavage is a likely point of regulation for RNA editing

127 along the one-dimensional DNA contour before cleavage is activated.

128 Rapid disulfide bond formation and cleavage is an essential mechanism of life.

129 sign to improve the efficiency of target/DNA cleavage is critical to ensure the success of CRISPR scr

130 chanistic insight into the ribozyme-mediated cleavage is gained.

131 Maturation by proteolytic cleavage is known to activate the enzyme.

132 use the accumulation of S-OPA1 due to L-OPA1 cleavage is observed in mitochondrial fragmentation and

133 ism by which co-translational signal-peptide cleavage is prevented.

134 s increased in a mouse model of AD, and this cleavage is temporally correlated with the onset of brai

135 or the recognition by PCs), but the order of cleavage is unknown.

136 The cleavage kinetics of a number of disulfides were investi

137 at a lincRNA-specific co-transcriptional RNA cleavage mechanism acts to induce premature termination.

138 per understanding of Cas9 activation and its cleavage mechanism can enable further optimization of Ca

139 DNA cleavage mechanism of AgeI is novel among Type IIP restr

140 Three cleavage methods were compared in terms of yield and pur

141 hanism and an explanation for RAG off-target cleavage observed in humans.

142 Rate-limiting C-O bond cleavage occurs to generate a three-coordinate product o

143 ng this process in vitro, Hfq guides RNase E cleavage of a representative small-RNA precursor for int

144 aimed at inhibiting this protease-dependent cleavage of Akt may prove beneficial in preventing tau h

145 ons in APP that increase toxic amyloidogenic cleavage of APP and produce amyloid beta (Abeta) at the

146 ulating BACE1 distribution in axons and beta cleavage of APP at synapses remain largely unknown.

147 estriction, Gag promotes secretase-dependent cleavage of APP, resulting in the overproduction of toxi

148 This interaction promotes a proteolytic cleavage of arid3a and its translocation to the nucleus

149 tocatalytic method for the aerobic oxidative cleavage of C=C bonds has been developed.

150 ences in enzyme selectivity for peptide bond cleavage of camel and bovine milk proteins as well as di

151 n induced Beclin-1 cleavage with concomitant cleavage of caspase-3, indicating the onset of apoptosis

152 ohexanol occurs via an E1 mechanism with the cleavage of Cbeta-H bond being rate determining.

153 tion by polyphosphate in PRP resulted in 75% cleavage of chem163S.

154 process is an attractive drug target because cleavage of concatemeric DNA is not required in mammalia

155 Metal homoenolates, produced via C-C bond cleavage of cyclopropanols, have been extensively invest

156 MRN-mediated endonucleolytic cleavage of DNA at sites of protein adducts requires ATP

157 ng these factors revealed that Ire1-mediated cleavage of ER-associated mRNAs results in ribosome stal

158 nt and proinflammatory functions mediated by cleavage of fibrinogen and PAR1, the trypsin-like protea

159 onooxygenases (LPMOs) catalyze the oxidative cleavage of glycosidic bonds in recalcitrant polysacchar

160 show how the rate of reversible heterolytic cleavage of H2 can be controlled, spanning 4 orders of m

161 and P), have been developed for heterolytic cleavage of H2 into a proton and a hydride, akin to frus

162 The products of heterolytic cleavage of H2, Mo hydride complexes bearing protonated

163 Cleavage of high-molecular-weight kininogen (HK), a mark

164 excessive bradykinin release resulting from cleavage of high-molecular-weight kininogen.

165 poptosis through activation of caspase-3 and cleavage of HuR in paclitaxel-resistant oral cancer cell

166 ying biologic process driving production and cleavage of iFGF23, or alternatively the increased level

167 LDL secretion and free fatty acid uptake via cleavage of LFABP, which occurs in response to oleic aci

168 ducing basal caspase-2 levels and preventing cleavage of MDM2 and BID.

169 , which leads to activation of caspase-3 and cleavage of microtubules.

170 ypass activation of C3 is mediated by direct cleavage of native C3 by mannan-binding lectin-associate

171 olled vascular gateway specifically opens by cleavage of NPY by CD26 signaling via NPY2 and NPY5 rece

172 lete PACE4 knock-out mice suggested that the cleavage of overexpressed proprotein C is predominantly

173 led vessel method is a new approach for fast cleavage of PCB from phycocyanin and gave at 120 degrees

174 GF, that HMW-EGF is active, that proteolytic cleavage of pro-EGF first occurs at the C-terminal argin

175 We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its

176 A similar beta-cleavage of PrP(C) is observed in mouse retinal lysates.

177 NC formation requires the cleavage of S-C bonds.

178 th excitation of fully cyclized GNRs induces cleavage of sacrificial carbonyl groups, resulting in at

179 lst displaying distinct efficiencies for the cleavage of specific substrates.

180 didate endonucleases have been implicated in cleavage of stalled replication forks to permit end rese

181 sociated DNA damage arising from nucleolytic cleavage of stalled replication forks.

182 Cleavage of syntaxin 17 inhibits not only autophagy but

183 t down ER-mitochondria communication through cleavage of syntaxin 17.

184 Cleavage of TAS3 by ARGONAUTE7 results in the production

185 sidues in alpha1C and C-terminal proteolytic cleavage of the alpha1C subunit.

186 LTs catalyze the non-hydrolytic cleavage of the bacterial peptidoglycan cell-wall polyme

187 d TBHP as the green oxidant via the C-H bond cleavage of the benzylic carbon under mild reaction cond

188 ura and Buchwald-Hartwig reactions involving cleavage of the C(acyl)-O bond of aryl esters that proce

189 he metal center of Cp*RhCl to accelerate the cleavage of the C-H bond of N-pentafluorophenylbenzamide

190 nd NacNacAl (1) results in the unprecedented cleavage of the C-N multiple bond to give, after rearran

191 c residues facilitate the post-translational cleavage of the CaValpha2delta1 subunit at the predicted

192 omes and lysosomes does not provide complete cleavage of the drug from the nanoparticle, but that onc

193 dephosphorylation by ALP, but CES-catalyzed cleavage of the ester bond on the molecules results in d

194 nt types of indels obtained by Cas9-mediated cleavage of the GFP gene, guided by three independent sg

195 Furthermore, we observed that proteolytic cleavage of the host extracellular matrix protein fibron

196 Here, we provide evidence that proteolytic cleavage of the macrophage efferocytosis receptor c-Mer

197 on the back of the sensor to accelerate the cleavage of the magnetic nanobeads-peptide moieties away

198 he mutant APP, and inhibited gamma-secretase cleavage of the mutant C99 to generate Abeta, leading to

199 The controlled cleavage of the peptide linkers is not only a useful str

200 ding oxidation of the benzene ring after the cleavage of the piperazine ring (e.g., CIP product with

201 gands activate Notch by inducing proteolytic cleavage of the receptor ectodomain, an event that requi

202 This oxidation is followed by mesolytic cleavage of the resulting radical cation species, which

203 nerate an adenosyl radical via the homolytic cleavage of the S-C(5') bond of SAM.

204 Upon cleavage of the transit peptide and additional proteolyt

205 ns (HNH and RuvC), responsible for concerted cleavage of the two DNA strands.

206 Thioesterases catalyze the cleavage of thioester bonds within many activated fatty

207 einase) proteases are involved in ectodomain cleavage of transmembrane proteins, and ADAM17 is known

208 Methane undergoes highly facile C-H bond cleavage on the stoichiometric IrO2(110) surface.

209 n elongated O-O bond but did not lead to O-O cleavage or reactivity toward external substrates.

210 tabolizes lignin-derived biphenyl via a meta-cleavage pathway.

211 ell cycle asynchrony maintains the invariant cleavage pattern driving morphogenesis of the ascidian b

212 ienting mechanism underpinning the invariant cleavage pattern.

213 s method will aid in developing enzymes with cleavage patterns optimized for producing paCOS with def

214 rement of chromatin accessibility to DNase I cleavage, permitting identification of de novo active ci

215 lymerase II termination via depletion of the cleavage/polyadenylation machinery, circular RNA levels

216 ggested that KLK7 exerts a chymotryptic-like cleavage preference.

217 The cleavage preferences of Kallikrein-related peptidase 7 (

218 s, KLK7 was found to exert chymotryptic-like cleavage preferences.

219 tions in the VWF A2 domain, facilitating the cleavage process, cause a distinct form of von Willebran

220 neprilysins and Drosophila Abeta (dAbeta), a cleavage product of APPL.

221 eins of different sizes present, one being a cleavage product of the full-length form.

222 y and levels of the matrix metalloproteinase cleavage product soluble receptor for advanced glycation

223 ionizing radiation (IR), determined that HuR cleavage product-1 (HuR-CP1) bound and promoted the expr

224 n pathways of complement activation, and its cleavage products C3a and C3b mediate several functions

225 y, WRN also influences the formation of FEN1 cleavage products during strand displacement on a nontel

226 The cleavage products of HuR are known to promote cell death

227 Addition of purified C3 cleavage products to cultured neurons suggested that C3b

228 but oxidation of 2H-pyrans also gives alkyl cleavage products.

229 loaded transferrin blocked MT2-mediated Tfr2 cleavage, providing further insights into the mechanism

230 kinetics revealed a 20-fold increase in the cleavage rate for the Gly1629Glu mutant compared with th

231 We find that the cleavage rates for 5 flaps are significantly higher than

232 mic aspects of twister RNA folding along the cleavage reaction coordinate.

233 osidases that exhibit selective carbohydrate cleavage reactivity toward l-fucose over d-glucose.

234 how TerL binds DNA during translocation and cleavage remains mysterious.

235 ms facilitating caspase-3 activation and HuR cleavage remains unknown.

236 red long OPA1 (L-OPA1) undergoes proteolytic cleavage resulting in short OPA1 (S-OPA1).

237 both forward transport of the precursor and cleavage, resulting in nuclear import.

238 The change to early cleavage results in decreased viral fitness compared to

239 o We found evidence that defined proteolytic cleavage results in various proteoforms of important pod

240 Furthermore, based on frequency of cleavage sequences, putative target mRNAs for these VapC

241 hat the overall rate-limiting step for aldol cleavage shifted from C-C bond scission (or an earlier s

242 tracellular site different from the thrombin-cleavage site and thus initiates biased receptor signali

243 n, which inserts the segment upstream of the cleavage site as an extra beta-strand in a central beta-

244 rate prior to T1 closure such that the U5-A6 cleavage site becomes embraced to achieve its cleavage c

245 pr construct, in which 2xCL denotes a tandem cleavage site for the viral protease.

246 an "immature" Chikungunya virus in which the cleavage site has been mutated to inhibit proteolysis.

247 hat cells clear trailing chromatids from the cleavage site in a two-step cell elongation and demonstr

248 o 21-bp direct repeats and a major terminase cleavage site in the phage genome.

249 The cleavage site is 11/9 nucleotides downstream of the A re

250 the domain immediately downstream of the S2' cleavage site is the FP (amino acids 798-818 SFIEDLLFNKV

251 pro-TGF-beta1 with the proprotein convertase cleavage site mutated to mimic the structure of the TGF-

252 APP mutation, shifted the preferential beta-cleavage site of BACE1 in APP from the Glu(11) site to t

253 pared human FXII variants lacking the Arg353 cleavage site required for conversion to alphaFXIIa (FXI

254 P673 regulates APP processing, and the BACE1 cleavage site selection is critical for amyloidogenesis

255 PP673 regulates APP processing and the BACE1 cleavage site selection is critical for amyloidogenesis

256 by an increased availability of the ADAMTS13 cleavage site through A2-domain-fold thermodynamic desta

257 s residue is just before the gamma-secretase cleavage site, we then investigated whether the p75(alph

258 e site, thereby having minimal impact on the cleavage site.

259 catalysis and allow hydrolases to access the cleavage site.

260 e G40 and adenosine A32 close to the G53-U54 cleavage site.

261 t overlap or are immediately upstream of the cleavage site.

262 termed Proteomic Identification of protease Cleavage Sites (PICS).

263 haFXIIa (FXII-R353A), or lacking the 3 known cleavage sites at Arg334, Arg343, and Arg353 (FXII-T, fo

264 oughput sequencing technology to define TOP2 cleavage sites at single-base precision, and use the tec

265 We have identified caspase-3 cleavage sites in GIRK1 ((387)ECLD(390)) and GIRK2 ((349

266 Site-directed mutagenesis of the phytaspase cleavage sites in prosystemin abrogated not only the phy

267 n of MMP-2, -3, -7, -8, -9 and -12 substrate-cleavage sites on independent tests.

268 As by juxtaposing poly(A) signals (PASs) and cleavage sites that are otherwise too far apart.

269 distribute CTCF/cohesin occupancy rewire DNA cleavage sites to novel loop anchors.

270 Flap closure traps the Gag cleavage sites within the catalytic cleft of protease.

271 nds are at or near preferred gamma-secretase cleavage sites, suggesting that the sequence of APP and

272 h the protease, 32 of which were outside Gag cleavage sites.

273 ls release a protease with chymotrypsin-like cleavage specificity in response to GBS.

274 ples approach to determining the binding and cleavage specificity of novel LHEs that should also be g

275 pecific transcription, which highlighted the cleavage stage as being highly distinctive.

276 three individual H3.3 residues in oogenesis, cleavage-stage embryogenesis and early development.

277 mouse cells maintained modest activation of cleavage-stage genes driven by conventional promoters bu

278 isotope effects indicated that the C-H bond cleavage step is not rate-determining, but the C-H bond

279 es, includes the critical O-O bond reductive cleavage step.

280 eplication fork repair by mediating the fork cleavage that permits initiation of HR-mediated repair a

281 Aap requires proteolytic cleavage to act as an intercellular adhesin.

282 The diheptacenes undergo thermal cleavage to heptacene at high temperatures in the solid

283 res after urine precipitation with conjugate cleavage (UglucP) or dried urine spot workup by conjugat

284 We describe Cleavage Under Targets and Release Using Nuclease (CUT&R

285 ompanied by increased Caspase-1 and IL-1beta cleavage upon NLRP3, but not AIM2 or NLRC4 inflammasome

286 s9 in two allele-specific systems, comparing cleavage using a SNP-derived PAM to a guide specific app

287 Blocking p75 cleavage using inhibitor X (Inh X), a compound that inhi

288 a 2-kDa macrocyclic peptide inhibitor of C5 cleavage, using in vitro whole-blood assays and an in vi

289 positively charged N-terminal anchors, whose cleavage via the prepilin peptidase, essential for pilin

290 tion and mediates post-translational BMPR-II cleavage via the sheddases, ADAM10 and ADAM17 in pulmona

291 Gbb NS cleavage was also required for viability through its reg

292 d to forces of 50-350 piconewtons, thioester cleavage was no longer observed.

293 nd in CEs when the exergonicity of C-Cl bond cleavage was reduced in an organic solvent (reaction wit

294 14 RNAi phenotypes and its infection-induced cleavage were abolished in a TEP1 loss-of-function backg

295 culature revealed that aggrecan and aggrecan cleavage were more abundant in human arteries than in hu

296 that include meta-cleavage as well as ortho-cleavage, which has not been previously shown.

297 se 3C directly targets GSDMD and induces its cleavage, which is dependent on the protease activity.

298 as IGF1 displayed homogeneous amino-terminal cleavage with complete removal of the bombyxin signal pe

299 time, B. abortus infection induced Beclin-1 cleavage with concomitant cleavage of caspase-3, indicat

300 mmunoproteasome reduced internal destructive cleavages within the ALY epitope compared with the const