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1 from 1-bromoethylbenzene undergoes NO-C bond cleavage at 120 degrees C with an activation energy of E
3 of transcription suggested that endonuclease cleavage at 3'-proximal sites was an early step in turno
4 s sequence-specific and frame-dependent mRNA cleavage at (5')AAA-G/A(3') sequences leading to rapid d
7 binding repeat region, which can result from cleavage at a furin cleavage site present in some apoER2
9 ssed in cilia that undergoes autoproteolytic cleavage at a G protein-coupled receptor proteolytic sit
10 sing peptidase and Oct1 and an autocatalytic cleavage at a highly conserved LGST motif yielding the a
12 tory region (NRR) that enables ADAM protease cleavage at a juxtamembrane site that otherwise lies bur
16 (C)) is subjected to the physiological alpha-cleavage at a region critical for both PrP toxicity and
18 ing experiments, (2) selective monitoring of cleavage at a single site in a peptide with multiple pro
20 der RNA has been shown to depend on RNase J1 cleavage at a single-stranded, AU-rich region just upstr
21 spase-3, an enzyme that is required for SipA cleavage at a specific recognition motif that divided th
27 ction in class switch recombination in which cleavage at activation-induced deaminase (AID)-initiated
28 tly, it has been postulated that proteolytic cleavage at Ala(1800) and protein kinase A phosphorylati
29 Notably, we found that this non-canonical cleavage at Ala-470-Asn-471 is instrumental for the onse
30 namics of dCas9-based binding and Cas9-based cleavage at all DNA sites with both canonical and non-ca
32 n of proteins leads to reproducible backbone cleavage at almost every inter-residue position, and in
35 he presence of Htt fragments consistent with cleavage at amino acid Asp-586 of Htt in the BACHD Casp6
36 17 amyloid, depends on a novel juxtamembrane cleavage at amino acid position 583 between the furin-li
37 yclic amine at C2 on the nucleobase promotes cleavage at an alternative site and it has a negative im
41 tives generated by spermine-catalyzed strand cleavage at Ap sites in duplex DNA can react with adenin
42 owed in vivo that the amount of endonuclease cleavage at approximately nucleotide 100 is decreased un
43 activation where Lnk2 presents the sites of cleavage at Arg(271) and Arg(320) to factor Xa in differ
44 without preference along the prethrombin-2 (cleavage at Arg(271) first) or meizothrombin (cleavage a
50 substrate leads to a decrease in the rate of cleavage at Arg(320) and a surprising increase in the ra
52 mbinase converts prothrombin to thrombin via cleavage at Arg(320) followed by cleavage at Arg(271).
53 binase activates prothrombin through initial cleavage at Arg(320) followed by cleavage at Arg(271).
54 or cleavage is implied by essentially normal cleavage at Arg(320) in recombinant prothrombin variants
55 ity for FXa to activate FVIII variants where cleavage at Arg(336) was accelerated due to flanking seq
58 r two sites is relatively fast compared with cleavage at Arg(372), which appears to be rate-limiting.
60 cleavage at Arg-740, we investigated whether cleavage at Arg-1689 influences catalysis at this step.
61 ve intermediate prethrombin-2 via an initial cleavage at Arg-271 followed by cleavage at Arg-320.
62 thrombin activation proceeds with an initial cleavage at Arg-320 yielding the catalytically active, y
65 c change in electrostatic surface induced on cleavage at Arg-51 allows us to propose a model for loca
67 ars rate-limiting and dependent upon initial cleavage at Arg-740, we investigated whether cleavage at
68 s citrullinated host peptides by proteolytic cleavage at Arg-X peptide bonds by arginine gingipains,
73 inactive intermediate prethrombin-2, initial cleavage at Arg320 generates the enzymatically active in
79 at residue Asn47, which is generated by APC cleavage at Arg46, mediates APC's cytoprotective signali
80 ither site, cleavage must occur at Arg12, as cleavage at Arg5 alone is insufficient for successful in
86 le N-TBDPS aziridine but caused nucleophilic cleavage at C(1) as well as C(10) without cleavage of th
88 rgonaute 2-loaded miRNAs via endonucleolytic cleavage at CA and UA dinucleotides, preferentially at s
89 containing MmeI sites at its ends, allowing cleavage at chromosomal sites 16-17 bp from the inserted
91 oteolysis, with complete blockade of peptide cleavage at constrained sites in the immediate vicinity
92 at is believed to be mediated by recombinase cleavage at cryptic recombination signal sequences (cRSS
99 ctivation by cleaving at the furin site, and cleavage at downstream sites is accomplished by membrane
102 ity deriving from tighter binding and faster cleavage at EcoRI* sites (one incorrect base pair).
103 process that is primed by an initial epsilon-cleavage at either T48 or L49, resulting in subsequent p
106 be directed by short RNAs to induce precise cleavage at endogenous genomic loci in human and mouse c
108 e R(max) change, combined with the increased cleavage at endosomal pH, indicates greater accessibilit
109 Both hairpin DNAs underwent double-strand cleavage at five sites within or near the original rando
114 ee DNA binding suppresses Top1-catalyzed DNA cleavage at high drug concentrations, whereas DNA cleava
115 ctivity was detected and increased total RNA cleavage at high Mg(2+) concentrations sufficient to fol
116 esidues on this receptor allow productive S2 cleavage at high temperatures and thereby serve as a buf
117 histidine and tryptophan also induced A-site cleavage at histidine and tryptophan codons, respectivel
118 3S), and its activation requires proteolytic cleavages at its C terminus, involving proteases involve
119 consensus motifs and the second showing slow cleavage at largely unique sites with low-scoring motifs
121 siloxycarbyne/CO species undergoes C-O bond cleavage at lower temperatures, indicating that monosily
122 Processing at Arg(162) was not required for cleavage at Lys(158) or regulation of chemerin bioactivi
125 nd ADAM17 have also been implicated in alpha-cleavage at Lys-109 downward arrowHis-110; however, we o
126 reover, we present a model where proteolytic cleavage at maturation results in migration of CA C-term
127 rotease cleavage site revealed that specific cleavage at Met(369) inhibited NCX1 activity (both forwa
128 Each of the DNAs underwent double-strand cleavage at more than one site, and all of the cleavage
129 ed Nup98 with 2A(pro) results in proteolytic cleavage at multiple sites in vitro, indicating that 2A(
132 at altered the 5' proximal AUG abolished Vhs cleavage at nearby sites, while mutations that changed s
136 To investigate how nucleosomes affect Cas9 cleavage at off-target sites in vitro, we used a single
137 site, specificity of cleavage (i.e. rate of cleavage at 'off-target' sites), and efficient/facile me
138 phorylation at several sites and proteolytic cleavage at one of these sites, resulting in nuclear tra
139 ites, held together by a resolvase tetramer; cleavage at one site stimulates cleavage at the partner
140 tRNA(Ala2), tRNA(Ser26) and tRNA(Ser24)) for cleavage at, or adjacent to, their anticodons, resulting
141 ed but not cleaved efficiently in vitro, and cleavage at other adventitious sites in plasmid substrat
143 YpeB cleavage sites reduced proteolysis, but cleavage at other sites still resulted in loss of full-l
144 prisingly differed in its ability to inhibit cleavage at other sites, a phenomenon attributed to long
146 two leader peptides that undergo sequential cleavage at positions G17/G18 and G35/A36 during export
147 strong DNA sequence specificity that favors cleavage at promoters and terminators and accounts for s
152 n that both FHC mutants increase the rate of cleavage at R133, ~45 residues N-terminal to the mutatio
154 rombin, which is generated by two sequential cleavages at R271 and R320 by the prothrombinase complex
157 ant, suggesting little dependence upon prior cleavage at residue 1689 as compared with thrombin.
158 , G409R and E410V, render LPL susceptible to cleavage at residue 297 (a known furin cleavage site).
159 ro-PanD, which undergoes an auto-proteolytic cleavage at residue Ser25 to yield the catalytic pyruvoy
160 at H2 activation at 2 proceeds via oxidative cleavage at Ru with concomitant hydride transfer to Zn.
167 omain (CTD) of Rrp5 is required for pre-rRNA cleavage at sites A0-A2 on the pathway of 18S rRNA synth
168 asses of sites for TFs, one displaying rapid cleavage at sites with robust consensus motifs and the s
169 5' end appears to increase the likelihood of cleavage at sites within the 5' untranslated region.
170 ain in human UTP24 was required for accurate cleavages at sites 1 and 2a in vivo, whereas mutation of
171 are essential for early pre-ribosomal (r)RNA cleavages at sites A0, A1/1 and A2/2a in yeast and human
172 ed rapid degradation of mRNAs beginning with cleavages at sites in the first 250 nucleotides, includi
178 ass spectrometry (LC-MS/MS) method to detect cleavage at the (374)ARGS site and the (1820)AGEG site.
179 positions the nuclease Nob1 for cytoplasmic cleavage at the 3'-end of 18S rRNA and is required for t
181 at these enzymes introduce a double-stranded cleavage at the 3'-side away from the recognized modifie
183 involve prenylation of the cysteine residue, cleavage at the AAX tripeptide and methylation of the ca
184 ha-ketoacyl derivatives generated by radical cleavage at the alpha-carbon position through the diamid
185 5)H(10)), slowly undergoes a second N-H bond cleavage at the alpha-N-H bond and elimination of hydrog
186 uctural microheterogeneity of signal peptide cleavage at the amino terminus of FGF2, whereas IGF1 dis
187 )J recombination entails double-stranded DNA cleavage at the antigen receptor loci by the RAG1/2 prot
189 mutation, we demonstrate efficient targeted cleavage at the beta-globin locus with minimal off-targe
190 CE1-GPI is mainly attributed to preferential cleavage at the beta-site and failure to detect +11 Abet
191 activated in a two-step process; proteolytic cleavage at the C terminus is followed by an intramolecu
197 arboxypeptidases is initiated by proteolytic cleavage at the C-terminal end of the propeptide by tryp
199 ed LysC proteolysis leads to high efficiency cleavage at the C-terminal side of the hinge lysine 222
200 SP1 lattice, whereas mutational abolition of cleavage at the CA-SP1 site results in virions in which
205 these factors may lead to either ineffective cleavage at the cognate restriction site or relaxed spec
207 hown to direct the Cas9 nuclease for precise cleavage at the desired sites and introduce mutation (in
208 y for therapeutic application: efficiency of cleavage at the desired target site, specificity of clea
209 nts obtained from Chloe mice that resist MMP cleavage at the DIPEN downward arrowFFGVG site in the in
210 previously shown to efficiently direct Cas9 cleavage at the edge of the strongly positioned 601 nucl
216 ey phenotype in mice by markedly suppressing cleavage at the G protein-coupled receptor proteolysis s
217 or DNA, enzyme and drug contributions to DNA cleavage at the gate, suggest a mechanism for DNA discri
218 dification of versican is a prerequisite for cleavage at the Glu(441)-Ala(442) site, as demonstrated
219 n occurs in vivo, in manners consistent with cleavage at the GPS site in polycystin-1 and the proprot
220 and PC2 first interact in the ER before PC1 cleavage at the GPS/GAIN site and determined that PC2 ac
221 emperatures were partially resistant to LysC cleavage at the hinge and resulted in a species where on
223 plication by blocking protease (PR)-mediated cleavage at the junction between capsid (CA) and spacer
227 ribute significantly to the mechanism of DNA cleavage at the lower pH, which is indicative of tighter
229 ficient cleavage at the Shadow site requires cleavage at the Main site, and remarkably, none of the s
231 cally disordered coil to a beta-hairpin upon cleavage at the matrix|capsid junction occurs five times
232 igand binding, the Notch4 receptor undergoes cleavage at the membrane and the Notch4-intracellular do
233 that IDE is highly processive in its initial cleavage at the middle of both the insulin A and B chain
234 oxidation of the oligomer results in strand cleavage at the mispair and at TT steps preceding it wit
235 sociation with 266 nm light yields homolytic cleavage at the modification site, generating a beta rad
236 argeted to mitochondria by sequence-specific cleavage at the N terminus by a cytosolic Ser protease (
239 ly studied atypical KlbA Ala(1) inteins: (a) cleavage at the N-terminal splice junction in the absenc
241 tered the stability of the NS4B protein, and cleavage at the NS4B/5A junction was significantly delay
242 in occurs in a highly regulated manner, with cleavage at the P2/3 junction influencing RNA template u
245 sts that the prodomain undergoes intradomain cleavage at the PGD downward arrow L(50) site followed b
246 ergoes nonamyloidogenic processing via alpha-cleavage at the plasma membrane, amyloidogenic beta- and
247 ne the basal mechanism of PADT and show that cleavage at the poly(A) site is not required for PADT.
249 nd that loss of EF-RNA interactions upon RNA cleavage at the polyadenylation site triggers disassembl
250 d the neoepitope generated after proteolytic cleavage at the prostasin/kallikrein cleavage site (K181
252 cleavage, and proteinuria is associated with cleavage at the putative prostasin/kallikrein site and r
254 ctivity of FGF23 is abrogated by proteolytic cleavage at the RXXR motif that lies at the boundary bet
256 of the wing and leg imaginal discs, whereas cleavage at the S1 site is sufficient to rescue Dpp func
257 s we demonstrate, by dpp mutant rescue, that cleavage at the S2 site of proDpp is required for develo
259 joining (NHEJ) DNA repair following repeated cleavage at the same critical site may permanently disru
261 e ends to form a circular mRNA inhibited Vhs cleavage at the same sites at which it cuts capped linea
262 ajor HBeAg form of genotype A corresponds to cleavage at the second ((156)RSPR(159)) motif, and the o
264 tes in Scw can be cleaved independently, but cleavage at the Shadow site is dependent on cleavage at
265 be cleaved independently, although efficient cleavage at the Shadow site requires cleavage at the Mai
266 ormational flexibility required for specific cleavage at the single-strand/double-strand DNA junction
268 n spectra of [PC - CH3](-) suggest favorable cleavage at the sn-2 position over the sn-1 due to disti
270 HIV-1 isolate Envs is not caused by aberrant cleavage at the tandem gp120/gp41 cleavage sites, which
271 he approach relies on dual-RNA:Cas9-directed cleavage at the targeted genomic site to kill unmutated
272 e to different degrees of phosphorus-LG bond cleavage at the TS for different substrates, the LG is s
273 exchange DNA strands after double-strand DNA cleavage at the two recombining att sites, and that many
277 ngdoms of life, responsible for the specific cleavages at the second phosphodiester bond 3' to inosin
279 n-coupled receptors activated by proteolytic cleavage at their amino termini by serine proteases.
284 Further repositioning leads to a loss in cleavage at this region with an abrupt shift toward slow
285 psbN gene is not transcribed suggesting that cleavage at this site is dependent on the formation of s
286 lphaC region blocked plasmin-mediated fibrin cleavage at this site, resulting in the generation of in
290 activated by thrombin or factor Xa-catalyzed cleavage at three P1 residues: Arg-372, Arg-740, and Arg
291 domain protein Utp24 is essential for early cleavages at three pre-rRNA sites in yeast (A0, A1 and A
292 dium channel (ENaC) involves furin-dependent cleavage at two extracellular sites within the alpha sub
293 pecific RAG endonuclease, which mediates DNA cleavage at two recombining gene segments and their flan
294 reaction involves DNA binding, synapsis, and cleavage at two RSSs located on the same DNA molecule an
298 find substantial differences in UDG-directed cleavage at uracils rotationally positioned toward (U-In
300 iently to the hypocotyls, where they undergo cleavage at varying rates, releasing functional auxins.
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