ライフサイエンスコーパス: cleavage by

1 , provide insights into the mechanism of DNA cleavage by 1.

2 ~1-2 kcal mol(-1) and the following H-H bond cleavage by ~10 kcal mol(-1), respectively.

3 increase the RPR's apparent rate of correct cleavage by 11,140-fold, compared to only 480-fold for m

4 ealed that the TgAMA1(L/G) mutation enhanced cleavage by 13-fold compared with wild type.

5 es have been identified for catalysis of RNA cleavage by 2'-hydroxyl transesterification, forming 2',

6 Studies on the mechanism of cleavage by 3-finger ZFNs established that the preferred

7 contrast, the TgAMA1(AG/FF) mutation reduced cleavage by 30-fold, whereas the TgAMA1(GG/FF) mutation

8 ific PABP cleavage and demonstrate that PABP cleavage by 3C regulates EMCV replication.

9 This substitution inhibited the hinge cleavage by 98% and suggests that the redox active natur

10 o group I introns, the LC ribozyme catalyzes cleavage by a 2',5' branching reaction, leaving the 3' p

11 -terminal domain binds PARP and improves its cleavage by a chimeric caspase-3 by approximately 30-fol

12 eptide ending in a dibasic motif, suggesting cleavage by a furin-like proprotein convertase (PC).

13 Most of these coupled sites underwent cleavage by a mechanism described previously by the Povi

14 preparing the substrate for subsequent ring cleavage by a meta-cleaving enzyme.

15 g by Fe.BLM leads to increased double-strand cleavage by a novel mechanism and identify a specific DN

16 they bound to the poly(U) and catalyzed its cleavage by a process analogous to that used by the enzy

17 The enzymes were stabilized against self-cleavage by a single point mutation in each cleavage sit

18 or base and involves rate-limiting B-N bond cleavage by a small water cluster, (H2O)n.

19 Intron removal from tRNA precursors involves cleavage by a tRNA splicing endonuclease to yield tRNA 3

20 Ectodomain cleavage by A-disintegrin and -metalloproteases (ADAMs)

21 rly in drug treatment and then decrease upon cleavage by activated caspases.

22 endothelial cells can promote CgA C-terminal cleavage by activating the plasminogen activator/plasmin

23 d that interrogates 10(11) DNA sequences for cleavage by active, dimeric ZFNs.

24 Here we show that receptor cleavage by ADAM (A Disintegrin And Metalloprotease) met

25 restingly, the reaction rate of pro-TNFalpha cleavage by Adam 17 was also reduced by a small molecule

26 a-119 downward arrowVal-120, with additional cleavage by ADAM10 at Gly-227 downward arrowArg-228 near

27 Surprisingly, we not only found cleavage by ADAM10, ADAM17, and BACE1 C-terminal to the

28 Additional cleavage by ADAM8 was observed at the previously propose

29 emolytic-uremic syndrome) or with inadequate cleavage by ADAMTS-13 of ULVWF multimeric strings secret

30 6 scissile bond within the VWF A2 domain for cleavage by ADAMTS13.

31 a key protective determinant against FL-VWF cleavage by ADAMTS13.

32 Blockade of APP cleavage by AEP in mice alleviates pathological and beha

33 ll interfering RNAs that guide transgene RNA cleavage by AGO1.

34 Unlike AGO2, target cleavage by AGO3 requires both 5'- and 3'-flanking regio

35 ta-elimination mechanism for glycolytic bond cleavage by Alg17c are similar to those observed for fam

36 it is essential for irreversible ether lipid cleavage by alkylglycerol monooxygenase.

37 ions of the TL strongly impair intrinsic RNA cleavage by all three RNAPs and eliminate the interspeci

38 APP cleavage by alpha-secretase produces potentially neurotr

39 uire allosteric changes induced via receptor cleavage by alpha-thrombin to mediate heterodimer format

40 ion of CD23 synthesis or inhibition of mCD23 cleavage by an a disintegrin and metalloprotease 10 inhi

41 s ectodomain, which is shed from cells after cleavage by an ADAM family metalloprotease, ADAM17 (TNFa

42 ared reaction mechanism that catalyzes their cleavage by an elaborated variant of the two-metal, in-l

43 ively, and no consequences for stability and cleavage by an endonuclease (EcoRI).

44 leting surface ProN levels through prodomain cleavage by an exogenous protease.

45 ) that releases a downstream activator after cleavage by an upstream DNAzyme.

46 These data indicate that PAR3 cleavage by APC at Arg41 can initiate distinctive APC-li

47 We also mapped the cleavage by Arg-specific gingipains to the reactive site

48 Here, we report that RNA cleavage by Argonaute3 initiates production of most Piwi

49 s frequently provide protection against self-cleavage by associated homing endonucleases.

50 four new pbs1 alleles, two of which blocked cleavage by AvrPphB.

51 o dissociate protein cis-dimers required for cleavage by BACE1 at low pH values.

52 ies, we confirm that A673T APP shows reduced cleavage by BACE1 in transfected mouse primary neurons a

53 ion makes APP a less favorable substrate for cleavage by BACE1.

54 Symmetric cleavage by BCO1 yields retinoids (beta-15'-apocarotenoi

55 We also show that a stepwise cleavage by BCO2 and BCO1 with APO10ol as an intermediat

56 -15'-apocarotenoids, C20), whereas eccentric cleavage by BCO2 produces long-chain (>C20) apocarotenoi

57 y promotes APP distribution in endosomes and cleavage by beta secretase.

58 CsrA stabilizes CsrB against RNase E cleavage by binding to two canonical sites adjacent to t

59 cipal modifiers of substrate recognition and cleavage by both ADAMTS5 and ADAMTS13.

60 nges in collagen associated with proteolytic cleavage by both enzymes.

61 omain (Toc159G) of pea (Pisum sativum) using cleavage by bound preproteins conjugated with the artifi

62 nds complement component C5 and prevents its cleavage by C5 convertases, inhibiting release of both t

63 ave investigated the mechanism of C1-C2 bond cleavage by cAD using a fatty aldehyde that incorporates

64 Moreover, stimulation of NRG1 cleavage by calcyon was recapitulated in HEK 293 cells s

65 We show that proteolytic cleavage by CalpA generates Cactus fragments lacking an

66 Full IL-1alpha activity required cleavage by calpain after necrosis, which increased its

67 that are produced in these complexes through cleavages by calpains or other nonprocessive proteases.

68 ions was achieved by prodrugs susceptible to cleavage by carboxylesterase 1.

69 e S-peptide can protect its s10 part against cleavage by carboxypeptidase Y (CPY).

70 Double-stranded DNA (dsDNA) cleavage by Cas9 is a hallmark of type II CRISPR-Cas imm

71 and was associated with blockage of Beclin 1 cleavage by caspase 8 at two sites.

72 Additionally, TRIF cleavage by caspase-1 diminished NLRP3 inflammasome acti

73 Preventing TRIF cleavage by caspase-1 in an in vivo model of P. aerugino

74 a is a complex process involving proteolytic cleavage by caspase-1.

75 e, its linker molecule ASC, and pro-IL-1beta cleavage by caspase-1.

76 to form homo- and heterodimers, but feedback cleavage by caspase-3 at Asp-330 removed the linker enti

77 d mechanistic studies, we show that upon DDD cleavage by caspase-3 the resulting DEVD-T peptide acts

78 tophagy is unleashed due to lack of Beclin 1 cleavage by caspases and can contribute to cancer cell s

79 YY1 is a target for cleavage by caspases in vitro and in vivo as well, but v

80 log and study the myriad proteins subject to cleavage by caspases, we are beginning to appreciate the

81 pH approximately 12) and reductive C-Cl bond cleavage by cast zerovalent iron, Fe(0).

82 Intramembrane cleavage by catalytically active SPP provided the primar

83 Indeed, cleavage by cathepsins is required for native TLR3 to si

84 bon limitation via the disruption of sucrose cleavage by cell wall invertases in developing ovaries.

85 oselectivity of aliphatic carbon-carbon bond cleavage by changes involving an intermediate in the rea

86 ein phosphatase PP2A(Cdc55) inhibits cohesin cleavage by counteracting polo-kinase phosphorylation of

87 ide mechanistic insights into RNA-guided DNA cleavage by Cpf1 and establish a framework for rational

88 We found that cleavage by CRISPR-Cas was more efficient than cleavage

89 understanding of target DNA recognition and cleavage by CRISPR-Cas9 nucleases, methods to determine

90 ogen, is thermodynamically stable, such that cleavage by CTRC leads to an equilibrium mixture contain

91 observed a hierarchy of preferred amino acid cleavage by cytosolic aminopeptidases.

92 maximum rate (Vmax) of pre-microRNA (miRNA) cleavage by Dicer and facilitates loading of miRNA onto

93 es of double-stranded RNA precursors through cleavage by Dicer or a Dicer-like protein.

94 In vitro, Loqs-PD enhances the rate of dsRNA cleavage by Dicer-2 and also enables processing of subst

95 le than the corresponding oxopeptides toward cleavage by dipeptidyl peptidase 4, the principal regula

96 cretin hormones are terminated via enzymatic cleavage by dipeptidyl peptidase-4 (DPP-4) and through r

97 omic DNA, we show that the intrinsic rate of cleavage by DNase I closely tracks the width of the mino

98 ic DNA protects the underlying sequence from cleavage by DNase I, leaving nucleotide-resolution footp

99 quence in Uc.283+A, which prevents pri-miRNA cleavage by Drosha.

100 Unexpectedly, Mg(2+)-catalyzed DNA cleavage by EcoRI is profoundly inhibited by Cu(2+) bind

101 Inhibition of TLR3 cleavage by either treatment with cathepsin inhibitor or

102 ed viral protease or fusion to ubiquitin and cleavage by endogenous ubiquitin proteases.

103 addition, mutant TREM2 becomes sensitive to cleavage by endoglycosidase D under conditions that inhi

104 Our findings support a model in which GP cleavage by endosomal cysteine proteases unmasks the bin

105 ion strongly depended upon MMP-dependent ECM cleavage by enlarging matrix pore diameters, and integri

106 The structural basis for branch-specific cleavage by ERManI and GMIA was explored by replacing an

107 plex strongly promotes transcript hydrolytic cleavage by establishing a network of interactions that

108 vating proteases, nor were they sensitive to cleavage by exogenous trypsin.

109 hat the ATXalpha insertion is susceptible to cleavage by extracellular furin-like endoproteases, but

110 DNA cleavage by fCas9 requires association of two fCas9 mono

111 ynthesis acts in concert with alternate flap cleavage by flap endonuclease 1 (FEN1) to mediate CAG re

112 itors that can independently block both PA's cleavage by furin and its subsequent oligomerization.

113 We investigated whether cleavage by furin of prM on partially mature West Nile v

114 esult in any potentiation in the rate of FIX cleavage by FXIa-LC.

115 domain shedding and subsequent intramembrane cleavage by gamma-secretase leads to release of a solubl

116 Transmembrane cleavage by gamma-secretase occurs at three gamma-sites

117 The proteolytic cleavage by gamma-secretase of its C-terminal fragment p

118 of Notch signaling requires intramembranous cleavage by gamma-secretase to release the intracellular

119 into the observed dependence of C99 protein cleavage by gamma-secretase, critical to the formation o

120 tion that would have prevented C99 secondary cleavage by gamma-secretase.

121 helix, making it well suited for processive cleavage by gamma-secretase.

122 even when endogenous mCD23 is protected from cleavage by GI254023X, indicating that IgE synthesis is

123 The coronavirus (CoV) S protein requires cleavage by host cell proteases to mediate virus-cell an

124 IL-1beta cleavage by human and mouse neutrophils was blocked by s

125 of mouse 18S rRNA to monitor expression and cleavage by hybridization.

126 estigated the ability of DNA to catalyze RNA cleavage by hydrolysis rather than transesterification,

127 utilization of three DSBR pathways following cleavage by I-SceI or CRISPR/Cas9 nucleases.

128 IgG-selective cleavage by IdeS thus neutralizes NMO-IgG pathogenicity,

129 eactions; DNA 13 underwent double-strand DNA cleavage by independent single-strand cleavages at all f

130 We demonstrate that NusG slows RNA cleavage by inhibiting backtracking.

131 all-molecule inhibitors that attenuated PARP cleavage by inhibiting gamma-H2AX, which in turn inhibit

132 TA-1 being protected from caspase-3-mediated cleavage by interaction with the chaperone heat shock pr

133 e we report that ceramide stimulates CREB3L1 cleavage by inverting the orientation of TM4SF20 in memb

134 combination was also protective against MEK2 cleavage by lethal toxin or adenylyl cyclase activity by

135 n and exhibits a kinetic effect on substrate cleavage by LF.

136 Regulation of ADAM17-mediated Neogenin cleavage by Lrig2 is required for neurite growth inhibit

137 rocessing and turnover requires knowledge of cleavages by major endoribonucleases within a living cel

138 Identification of the sites of cleavage by mass spectrometry allowed us to test the fun

139 e requirements for substrate recognition and cleavage by matriptase than by furin.

140 ha was shed by keratinocytes via proteolytic cleavage by matrix metalloproteinases upon stimulation w

141 ptibility of the core protein to proteolytic cleavage by matrix metalloproteinases.

142 of the MazF dimer prevents mRNA binding and cleavage by MazF.

143 rategy in which antibody-targeted controlled cleavage by micrococcal nuclease releases specific prote

144 n factors, including SPL13, are targeted for cleavage by miR156.

145 otease and a second inefficient or regulated cleavage by mitochondrial intermediate protease.

146 trix of the mitochondria, where it underwent cleavage by mitochondrial processing peptidase to a matu

147 cleavage during import, involving efficient cleavage by mitochondrial processing protease and a seco

148 s of the chimeras indicated that the rate of cleavage by MMP-1 of the chimera containing six triplets

149 collagen type I and type IV are resistant to cleavage by MMP-1, MMP-2, MMP-9, and MMP-13, whereas non

150 phaIIbbeta3 is a necessary cofactor for PAR1 cleavage by MMP-2 by binding the MMP-2 hemopexin domain,

151 protect both SLRPs and collagen fibrils from cleavage by MMPs.

152 A is protected from restriction endonuclease cleavage by modifying the DNA using a DNA methyltransfer

153 ytic sites of PEDV nsp5 probably impact NEMO cleavage by modulating potential interactions of nsp5 wi

154 The complex facilitates HJV cleavage by MT2, and release of the cleaved HJV from the

155 he inhibitory effect of RAD51 on 3'-flap DNA cleavage by MUS81-EME1 through its RAD51 filament disrup

156 tion forks at CFSs and hence facilitates CFS cleavage by MUS81-EME1.

157 The cleavage by NE results in dissociation of the FRET fluor

158 Cleavage by NEIL3 is the primary unhooking mechanism for

159 Cleavage by NS3-4A occurs at Cys 11, removing the cytoso

160 We further showed that cleavage by nta-miR6019 triggers RNA-dependent RNA polym

161 an a tetrapeptide, as required for efficient cleavage by other caspases.

162 ally using kinetic isotope effects show that cleavage by oxidative addition of an O-H bond in H2O is

163 ent to target a protein for export, and that cleavage by plasmepsin V is not coupled directly to the

164 port is dependent on PI(3)P binding, without cleavage by plasmepsin V.

165 n the SK beta-domain were deleted to prevent cleavage by plasmin (Pm) and to disable Pg substrate bin

166 These FXII mutants rapidly activate after cleavage by plasmin, escape from inhibition through C1 e

167 ce new sites that are sensitive to enzymatic cleavage by plasmin.

168 Inositol cleavage by PLCgamma1 simultaneously triggers both endop

169 ed greater susceptibility to redox-dependent cleavage by proteases present in serum.

170 bitrary DNA sequences could be addressed for cleavage by protein engineering, ushering in the breakth

171 roT and ProT(S195A), the pathway of FPR-ProT cleavage by prothrombinase was redirected from meizothro

172 ases, and the dependence of S. aureus on L27 cleavage by Prp validates the enzyme as a target for pot

173 phosphorylation by c-Abl affects galectin-3 cleavage by PSA.

174 We show that ATP-dependent DNA cleavage by R-proteins occurs at fixed positions (6-7 nu

175 /monomer) are required for site-specific DNA cleavage by R-proteins.

176 s in vivo and in vitro, and enhances 3' tail cleavage by Rad1/Rad10 in a purified system in vitro.

177 The susceptibility of gene segments to cleavage by RAG is associated with histone modifications

178 ue (K233) results in a large increase of DNA cleavage by RAG1/2.

179 hat the Dsc E3 ligase acts on SREBP prior to cleavage by Rbd2.

180 ations in DSP-PP(240) had similar effects on cleavage by recombinant human BMP1, a candidate physiolo

181 ort a method to reduce nonspecific substrate cleavage by reducing stool protease coextraction in the

182 sylated proteins in the ER, controlled Msb2p cleavage by regulating transcriptional induction of Yps1

183 EME1 for replication fork and flap structure cleavage by relaxing substrate specificity.

184 strategies as (i) bisulfite treatment, (ii) cleavage by restriction endonucleases, and (iii) immuno/

185 to an unusual mechanism of PT-dependent DNA cleavage by restriction enzymes in the face of partial P

186 in IRTT, rendering the sequence resistant to cleavage by RgpB.

187 that the most important determinant for mRNA cleavage by ribosome-dependent toxins is interaction wit

188 cules: the light-regulation of catalytic RNA cleavage by RISC and the light-regulation of seed region

189 RNA cleavage by RNA polymerase (RNAP) is the central step in

190 iversal bacterial factor that stimulates RNA cleavage by RNA polymerase (RNAP), the functions of line

191 monophosphate triggers rapid endonucleolytic cleavage by RNase E.

192 domain protein, CsrD, which targets them for cleavage by RNase E.

193 re ASOs, 3'-SpSpRp, that promotes target RNA cleavage by RNase H1 in vitro and provides a more durabl

194 replication; however, the RNAs targeted for cleavage by RNase L under these conditions have not been

195 suggests that viral RNPs are susceptible to cleavage by RNase L.

196 ide modifications also make RNA resistant to cleavage by RNase L.

197 ion initiation factor eIF2 and stimulate RNA cleavage by RNase L.

198 ma transcript 1) and MEN beta, are formed by cleavage by RNase P and are capped but not polyadenylate

199 d signaling enzymes, and myofilament protein cleavage by ROS-activated proteases) that have been impl

200 the mechanisms underlying symmetrical strand cleavages by RuvC, we performed crystallographic and bio

201 seudomonas sp. strain DCA1) versus C-Cl bond cleavage by S(N)2 reaction (Xanthobacter autotrophicus G

202 y establishes atomic mechanisms of substrate cleavage by separase and suggests competitive inhibition

203 ing S and destroyed at anaphase through Scc1 cleavage by separase.

204 receptor that is activated after proteolytic cleavage by serine proteases, including mast cell trypta

205 -length 135-kDa precursor though proteolytic cleavage by serine proteases.

206 Rem cleavage by signal peptidase in the ER is necessary for

207 ellular fragment of ODZ1 through proteolytic cleavage by signal peptide peptidase-like 2a.

208 ns were also shown to be prone to hydrolytic cleavage by SIRT1-3 and SIRT6, supporting recent finding

209 endoplasmic reticulum (ER) to the Golgi for cleavage by site-1 and site-2 proteases.

210 RNA cleavage by some endoribonucleases and self-cleaving rib

211 (UTR) that renders it directly refractory to cleavage by SOX.

212 idate features of Pro-sigma(K) important for cleavage by SpoIVFB, coexpression of the two proteins in

213 new substrate for consecutive intramembrane cleavage by SPPL2a/b.

214 wise unreactive amide bond towards sigma N-C cleavage by switchable coordination.

215 ts suggest that activity-dependent substrate cleavage by synaptic metalloproteases and gamma-secretas

216 nstead serve as activators that stimulate PG cleavage by target enzymes called amidases to promote ce

217 this context, in further support of a direct cleavage by TF/FVIIa.

218 ay-selective PAR2 mutant resistant to direct cleavage by TF:FVIIa and FXa was activated by these prot

219 ibility to ubiquitin-independent ("default") cleavage by the 20S core proteasome was unchanged.

220 o show that eIF4E promotes the rate of eIF4G cleavage by the 2A protease.

221 u-fluvalinate to a form suitable for further cleavage by the carboxylesterases that also contribute t

222 ate guide RNAs that direct site-specific DNA cleavage by the Cas9 endonuclease in cultured cells.

223 e SMN pre-mRNA by specifically inhibiting 3' cleavage by the cleavage and polyadenylation specificity

224 found that the target RNA per se induces DNA cleavage by the Cmr complex in vitro.

225 OS-1 cells is exclusively dependent on prior cleavage by the convertases, because both R198A and R221

226 e first step of the reaction is the N-H bond cleavage by the coordinated acetate group (OAc).

227 nding of the PAM-dependent, crRNA-guided DNA cleavage by the Cpf1 family nucleases.

228 ey are generated following transcription and cleavage by the DROSHA/DGCR8 and DICER/TRBP/PACT complex

229 The major cleavage by the endonuclease activity occurs at a positi

230 be synthesized first to protect the DNA from cleavage by the endonuclease.

231 ted when the fluorescent domains separate on cleavage by the endopeptidase, and emission from the dir

232 In metazoans, cleavage by the endoribonuclease SMG6 is often the first

233 virus F must undergo endocytic recycling and cleavage by the endosomal/lysosomal protease cathepsin L

234 colloidal microparticles and the subsequent cleavage by the enzyme was observed in real time and lab

235 itiated events, mutations reflect sequential cleavage by the enzyme.

236 ion that the sequence context influences the cleavage by the enzymes can be interpreted as a hint for

237 ein products generated from intramembraneous cleavage by the gamma-secretase complex is not well defi

238 In stationary phase, surface M1 protein cleavage by the GAS cysteine protease SpeB eliminated Fg

239 n cells and are activated through sequential cleavage by the Golgi-localized Site-1 and Site-2 protea

240 xylation of the olefin with oxone, oxidative cleavage by the in situ-generated 3,4,5,6-tetramethyl-2-

241 Mature IL-1beta secretion requires cleavage by the inflammasome.

242 ansmembrane macrophage proteins subjected to cleavage by the inflammation-responsive protease ADAM17.

243 ediator of innate immune defense because its cleavage by the inflammatory caspases 1, 4, 5, and 11 yi

244 d bilayer of the inner membrane, followed by cleavage by the inner membrane peptidase.

245 ther intramembrane proteolysis, specifically cleavage by the intramembrane-cleaving aspartyl protease

246 rporated into the probe design, allowing for cleavage by the kidney brush border enzymes of the CPP b

247 on or that the glycans are desulfated before cleavage by the lyases.

248 cts the peptidoglycan of dividing cells from cleavage by the major autolysin LytA and occurs at the s

249 of A2E photodegradation resulted in reduced cleavage by the matrix metalloproteinases MMP2 and MMP9.

250 posite precursor protein Atp25 upon internal cleavage by the matrix processing peptidase MPP, and in

251 a predominantly unfolded structure following cleavage by the mature protease.

252 P binding by the CBS domain and Pro-sigma(K) cleavage by the membrane domain.

253 the result of an increased susceptibility to cleavage by the metalloprotease ADAM10.

254 eed expose the S2 site and, crucially, allow cleavage by the metalloprotease TACE (TNF-alpha-converti

255 tically, the Abs also bound and inhibited C3 cleavage by the nephritic factor-stabilized convertase.

256 unodominant peptide of MOG is susceptible to cleavage by the NOX2-controlled cysteine cathepsins L an

257 olve this conundrum by showing that aldehyde cleavage by the Np AD also requires dioxygen and results

258 ss sequence provides protection against self-cleavage by the nuclease, whereas the nuclease promotes

259 tructure of cellular pre-mRNA to promote its cleavage by the PA subunit.

260 a unique phenomenon of PEDV nucleocapsid (N) cleavage by the PEDV-encoded 3C-like protease (3Cpro) du

261 that the N terminus of LapA is required for cleavage by the periplasmic cysteine protease LapG and r

262 e p15NC must interact with RNA for efficient cleavage by the PR.

263 Initial cleavage by the protease dimer occurs from within these

264 e nuclear association of PRH and induces its cleavage by the proteasome.

265 precursor protein (APP) endoproteolysis and cleavage by the rate-limiting beta-site enzyme 1 (BACE1)

266 s, thus allowing activation upon proteolytic cleavage by the respective proteases.

267 fied that interact with APP and modulate its cleavage by the secretases.

268 In particular, we detected 5'splice site cleavage by the spliceosome, showing that cleaved upstre

269 tecture appropriate for interaction with and cleavage by the terminase large subunit prior to DNA tra

270 force synapsis of the transposon ends before cleavage by the transposase occurs.

271 structure in positioning each DNA strand for cleavage by the two Cas9 nuclease domains is unknown.

272 The minimum type III sequence necessary for cleavage by the two collagenases was 5 GXY triplets, inc

273 DNA cleavage by the Type III restriction enzymes requires lo

274 DNA cleavage by the Type III Restriction-Modification (RM) e

275 ositioned at the active site for optimal DNA cleavage by the tyrosine hydroxyl nucleophile to facilit

276 Following cleavage by the unknown protease, the N-terminal portion

277 Cleavage by the wild-type enzyme is not activated by unr

278 d some of the linkages that are resistant to cleavage by the wild-type enzyme.

279 This accelerated site-specific DNA cleavage by the zinc-finger nuclease, without enhancing

280 is the opposite of amyloid precursor protein cleavage by these two enzymes.

281 luence the rate of 5'-monophosphate-assisted cleavage by these two ribonucleases.

282 flammatory activity modulated by proteolytic cleavage by thrombin and plasma carboxypeptidase B2 (CPB

283 Upon cleavage by thrombin, the B-domain and the associated PE

284 d for optimal alignment of protein C for its cleavage by thrombin.

285 ered allele that is susceptible to inducible cleavage by tobacco etch virus protease.

286 MPs blocking interaction with receptors, and cleavage by tolloid proteinases is thought to relieve th

287 Our data suggest that increased cadherin cleavage by transgenic MMP20 in the WT background releas

288 pathway that controls proteolytic N-cadherin cleavage by transporting ADAM10 protease to the plasma m

289 mmature particles from cells, and subsequent cleavage by trypsin confers infectivity.

290 PAR-2 is activated via proteolytic cleavage by trypsin-like serine proteases, including kal

291 Cleavage by Tsp occurs in the periplasmic domain of TcpP

292 We detected cleavage by two out of three transcription activator-lik

293 endent enzymes enhance the rate of C-Co bond cleavage by up to approximately 10(12)-fold to generate

294 to monitor the kinetics and products of RNA cleavage, by use of a program designed to mass-match obs

295 ; (ii) the LnmJ-SH domain catalyzes C-S bond cleavage by using l-cysteine and l-cysteine S-modified a

296 h a thrombospondin type 1 motif, member 13), cleavage by which in the VWF A2 domain is dependent on e

297 In the absence of Ca(2+), S-2288 cleavage by wild-type HABP2 was Na(+)-dependent, with Km

298 GreA factors activate RNA cleavage by wild-type RNAPs to similar levels.

299 yme and the 5' end created from an endolytic cleavage by yeast at a site distinct from where potato e

300 Constitutive OPA1 cleavage by YME1L and OMA1 at two distinct sites leads t