ライフサイエンスコーパス: cleavage furrow

1 (CPC) and centralspindlin that instructs the cleavage furrow.

2 rminant cortical domains are bisected by the cleavage furrow.

3 zation at sites of mechanical stress and the cleavage furrow.

4 itotic entry, and formation of a cytokinesis cleavage furrow.

5 ins that participate in the formation of the cleavage furrow.

6 of key proteins, including GpIb alpha to the cleavage furrow.

7 lophase spindle midzone, which specifies the cleavage furrow.

8 on of AMR contraction with ingression of the cleavage furrow.

9 ng from defects in contractile forces at the cleavage furrow.

10 ted insertion of basolateral membrane in the cleavage furrow.

11 ytes and express both NMIIA and NMIIB at the cleavage furrow.

12 hich actin and membrane are delivered to the cleavage furrow.

13 tment of FIP3 and recycling endosomes to the cleavage furrow.

14 n is required for complete ingression of the cleavage furrow.

15 t how this actin and membrane traffic to the cleavage furrow.

16 cytosed membrane is focally delivered to the cleavage furrow.

17 he interphase cortex but not the cytokinetic cleavage furrow.

18 of Kif12, DdINCENP fails to localize on the cleavage furrow.

19 , the rafts were clearly associated with the cleavage furrow.

20 orial cell cortex at the site of the nascent cleavage furrow.

21 adhesions (FAs) controls the symmetry of the cleavage furrow.

22 bed to impaired accumulation of actin in the cleavage furrow.

23 tile ring and triggers the ingression of the cleavage furrow.

24 ed cytokinesis without any ingression of the cleavage furrow.

25 contractile ring, and the ingression of the cleavage furrow.

26 stitutively active RhoA induced NMIIA at the cleavage furrow.

27 ole for one or more phosphoinositides at the cleavage furrow.

28 c cells, the majority of which had a visible cleavage furrow.

29 reconstruction of the plasma membrane in the cleavage furrow.

30 king, potentially important processes at the cleavage furrow.

31 g that drives the rapid ingression of a deep cleavage furrow.

32 involved in the delivery of endosomes to the cleavage furrow.

33 and later concentrates in the region of the cleavage furrow.

34 equired for localization of myosin II to the cleavage furrow.

35 and localization of the cortexillins to the cleavage furrow.

36 sitioning defects of the mitotic spindle and cleavage furrow.

37 tes with astral microtubules to position the cleavage furrow.

38 A and phospholipids to anchor anillin at the cleavage furrow.

39 or the correct placement of the proteloblast cleavage furrow.

40 structions and the maintenance of the stable cleavage furrow.

41 ased to central spindle-based positioning of cleavage furrows.

42 ilizing and preventing retraction of nascent cleavage furrows.

43 bryo, the centrosome coordinates assembly of cleavage furrows.

44 ppeared to be caused by formation of ectopic cleavage furrows.

45 protein does not localize to the membrane or cleavage furrows.

46 rexpressed Buc-GFP, accumulates at embryonic cleavage furrows.

47 nd ARX-2/Arp2 facilitates ingression of weak cleavage furrows.

48 gether with other factors, organize into the cleavage furrow [1].

49 ted in fly spermatocytes that fail to form a cleavage furrow [3] and during monopolar cytokinesis whe

50 t cortical movements are concentrated in the cleavage furrow [8-13].

51 teins to their proper location, corrects the cleavage furrow abnormalities, and restores genomic stab

52 n showed that RMD1 is required for myosin II cleavage furrow accumulation, acting in parallel with me

53 in II to identify factors involved in myosin cleavage furrow accumulation.

54 sis-deficient mutant cell line devoid of the cleavage furrow actin bundling protein, cortexillin I.

55 s to keep sister genomes apart and guide the cleavage furrow after anaphase.

56 t can be activated if DNA is retained in the cleavage furrow after completion of anaphase.

57 ted cells caused by failed abscission of the cleavage furrow after telophase.

58 These vesicles are recruited to the cleavage furrow along the central spindle and a distinct

59 GpIb alpha and Aurora B redistribute to the cleavage furrow along with other cleavage furrow protein

60 aphase and telophase, myosin II moves to the cleavage furrow and appears to "push" rather than carry

61 ning recycling endosomes accumulate near the cleavage furrow and are required for successful completi

62 n the delivery of recycling endosomes to the cleavage furrow and are, together with Rab11, essential

63 fficking and membrane remodeling to form the cleavage furrow and complete daughter cell separation.

64 feres with the localization of MyoGEF to the cleavage furrow and decreases MyoGEF activity toward Rho

65 body, a structure that anchors the ingressed cleavage furrow and guides the assembly of abscission ma

66 tokinesis, by allowing mispositioning of the cleavage furrow and inappropriate cytokinesis.

67 onclude that PtdIns(4,5)P2 is present at the cleavage furrow and is required for normal cytokinesis a

68 but also endocytic vesicle transport to the cleavage furrow and it does so through sequential intera

69 (ECM) remodeling is thought to stabilize the cleavage furrow and maintain cell shape during cytokines

70 It concentrates at the cleavage furrow and midbody during anaphase, telophase,

71 e of the spindle during anaphase, and to the cleavage furrow and midbody during telophase.

72 a multi-domain protein that localizes to the cleavage furrow and midbody of mitotic cells, where it i

73 umulation of RAB-11-positive vesicles at the cleavage furrow and midbody that is not a consequence of

74 ive vesicles into the plasma membrane at the cleavage furrow and midbody.

75 elophase FP-PP1gamma also accumulates at the cleavage furrow and midbody.

76 n and dynactin co-localize to the developing cleavage furrow and mitotic spindle, a novel localizatio

77 nd Rac1-GTP in epithelial cells--RhoA at the cleavage furrow and RhoA and Rac1 at cell-cell junctions

78 anous organelle, the fusome, grows along the cleavage furrow and the remnants of the mitotic spindle

79 senger proteins are known to localize on the cleavage furrow and to play a role in cytokinesis.

80 reover, Mkif5Ba is required to enrich Buc at cleavage furrows and for the ability of Buc to promote e

81 ically, Mkif5Ba is required to recruit GP to cleavage furrows and thereby specifies PGCs.

82 Sti recruits Nebbish to the cleavage furrow, and both proteins are required for midb

83 MYH10 [NMIIB]), only NMIIB localizes at the cleavage furrow, and its subsequent absence contributes

84 to key cytokinetic structures including the cleavage furrow, and later, the abscission site.

85 RhoA and active myosin were absent from the cleavage furrow, and myosin was redistributed to cortica

86 dissolution of the midbody, reopening of the cleavage furrow, and realignment of chromosomes at the m

87 , becomes associated with the unipolar first cleavage furrow, and remains enriched in animal pole bla

88 is recruited to the adherens junction at the cleavage furrow, and that inhibiting recruitment of Vinc

89 d dynactin participate in stimulation of the cleavage furrow, and their interaction promotes elongati

90 are required to maintain the position of the cleavage furrow, and these signals control the localizat

91 f filamentous fungi and dendritic spines, in cleavage furrows, and in retracting membrane protrusions

92 umulation and phospholipid metabolism at the cleavage furrow are unchanged in cells expressing ARF6 m

93 nd separation, and it accumulated within the cleavage furrow around the spindle midzone.

94 a molecular link between the centrosome and cleavage furrow assembly.

95 ge furrows in early embryos, is required for cleavage furrow assembly.

96 CM2, blocks the binding of CEN and disrupts cleavage furrow assembly.

97 r within a domain highly homologous to yeast cleavage furrow-associated protein CDC15.

98 ance of maintaining a delicate balance among cleavage furrow-associated proteins during mitosis.

99 ts, suggesting that TOE-2 might position the cleavage furrow asymmetrically to generate daughter cell

100 sion, chromosomes must clear the path of the cleavage furrow before the onset of cytokinesis.

101 ential for Arf1 to function at the Golgi for cleavage furrow biosynthesis.

102 ndergo symmetric cell divisions in which the cleavage furrow bisects the apical domain.

103 filaments is necessary for targeting to the cleavage furrow but not to the interphase cortex.

104 rens junction proteins are stabilized at the cleavage furrow by increased tension.

105 mbrane accumulates at the apices of the late cleavage furrow by means of a BFA-sensitive mechanism.

106 ilament assembly, fails to accumulate at the cleavage furrow, cannot rescue myoII-null cytokinesis, a

107 ted in anaphase could be induced to initiate cleavage furrows, cells arrested in metaphase could not.

108 Because citron kinase is localized in cleavage furrows, citron kinase may be involved in regul

109 ion errors, defective assembly of actin into cleavage furrows, cleavage failure, a rise in cyclin E l

110 t of cell contacts is to position the D cell cleavage furrow closer to the animal pole, and the enhan

111 results indicate that anillin is a conserved cleavage furrow component important for cytokinesis.

112 an important role for Anillin in scaffolding cleavage furrow components, directly stabilizing intrace

113 ase, and was maximally activated just before cleavage furrow constriction.

114 n, and controls the symmetry and kinetics of cleavage furrow contractility during cytokinesis.

115 uding spindle assembly, spindle positioning, cleavage furrow contraction and abscission.

116 surface protrusions, it is excluded from the cleavage furrow cortex during cytokinesis.

117 tin crosslinkers have slower kinetics in the cleavage furrow cortex than in the pole, that their kine

118 ntractile ring and subsequent formation of a cleavage furrow, DdINCENP is important for the abscissio

119 ono- and di-phosphorylated MLC were found in cleavage furrows, di-phosphorylated MLC showed more cons

120 At cellularization, however, cleavage furrows do not invaginate between nuclei and co

121 l culture localized to the cell membrane and cleavage furrow during cell division as well as in the n

122 90 results in decreased RhoGTP levels at the cleavage furrow during cytokinesis, p190 and the RhoGEF

123 er a molecular mechanism for positioning the cleavage furrow during cytokinesis.

124 cells, but both accumulated together at the cleavage furrow during cytokinesis.

125 if12 is found on the central spindle and the cleavage furrow during cytokinesis.

126 le midzone, and poles during mitosis and the cleavage furrow during cytokinesis.

127 of interphase cells and translocates to the cleavage furrow during cytokinesis.

128 olarize; additionally, it accumulates in the cleavage furrow during cytokinesis.

129 reakdown at mitosis, and concentrates at the cleavage furrow during embryonic cell division.

130 The geometry of the cleavage furrow during mitosis is often asymmetric in vi

131 r chromosomal structure, centrosome, and the cleavage furrow during prophase through telophase.

132 tes during mitosis and concentrates near the cleavage furrow during telophase.

133 ne that normally develops at the apex of the cleavage furrow during the final phase of cytokinesis do

134 pseudocleavage furrows, and to somatic cell cleavage furrows during the postcellularization embryoni

135 hese mutant cells initiate the ingression of cleavage furrows earlier than normal, shortening the sta

136 with how the mitotic apparatus positions the cleavage furrow for standard cytokinesis, and relate our

137 In the absence of hemicentin, cleavage furrows form but retract prior to completion, r

138 r lobulation, suggesting a relationship with cleavage furrow formation and abortive cytokinesis.

139 ion to the equatorial cortex, and suppresses cleavage furrow formation and cell division.

140 The central spindle regulates cleavage furrow formation and cytokinesis and is compose

141 retardation protein (dFMRP) is required for cleavage furrow formation and functions within dynamic c

142 tor of the small GTPase RhoA, which controls cleavage furrow formation and ingression.

143 etaphase-anaphase transition, Plk1 initiates cleavage furrow formation and is then progressively degr

144 t modulate the actin cytoskeleton to promote cleavage furrow formation and progression during cytokin

145 t regulation of CCT subunits is required for cleavage furrow formation and that at least one of its s

146 copy reveals that this is due to a defect in cleavage furrow formation and thus cytokinesis.

147 RhoA controls cleavage furrow formation during cell division, but whet

148 nd this role is also likely to be crucial in cleavage furrow formation during cell division.

149 f Ect2 are essential for RhoA activation and cleavage furrow formation in human cells.

150 y identified protein Centrocortin to promote cleavage furrow formation in the early embryo.

151 Cleavage furrow formation marks the onset of cell divisi

152 y RNA interference, 58% displayed defects in cleavage furrow formation or completion, or germline cyt

153 pendent regulation of CCT contributes to the cleavage furrow formation phenotype.

154 show that the C terminus of CNN coordinates cleavage furrow formation through binding to CEN, thereb

155 on that occurs after chromosome segregation, cleavage furrow formation, and contraction have complete

156 RP-dependent regulation and new effectors of cleavage furrow formation, we used two-dimensional diffe

157 pindlin is essential for central spindle and cleavage furrow formation.

158 MRP (dFMRP) is required in early embryos for cleavage furrow formation.

159 genetically that tral itself is required for cleavage furrow formation.

160 ) leads to defects earlier in M phase before cleavage furrow formation.

161 We conclude that the two pathways of cleavage-furrow formation are mechanistically distinct.

162 lar, we conclude that the astral pathway for cleavage-furrow formation involves the negative regulati

163 inesis into two separate daughter cells by a cleavage furrow formed by the actomyosin-based contracti

164 le ring but during septation appeared in the cleavage furrow, forming a washer or disc structure.

165 d to maintain myosin II in the cortex of the cleavage furrow, generating unseparated daughter cells c

166 e present or of functional importance at the cleavage furrow has not been published.

167 ipolar mitosis followed by regression of the cleavage furrow hours later.

168 e, targeted membrane secretion occurs at the cleavage furrow in animal cells, and proteins that regul

169 g generates force to ingress the cytokinetic cleavage furrow in animal cells, yet its filament organi

170 Cytokinesis partitions the cell by a cleavage furrow in animals but by a new cross wall in pl

171 -cell contacts also direct ingression of the cleavage furrow in coordination with FAs in epithelial c

172 How myosin II localizes to the cleavage furrow in Dictyostelium and metazoan cells rema

173 oglycan chondroitin in the completion of the cleavage furrow in dividing Caenorhabditis elegans embry

174 ntrast, localization of the long MLCK to the cleavage furrow in dividing cells requires the five DXRX

175 mental biological problem-positioning of the cleavage furrow in dividing cells-to explain how and why

176 a protein that is highly concentrated in the cleavage furrow in numerous animal cells in a pattern th

177 in which LET-99 localizes to the presumptive cleavage furrow in response to the spindle and myosin.

178 checkpoint in mammalian cells stabilizes the cleavage furrow in the presence of a chromatin obstructi

179 do not polymerize in vitro do not go to the cleavage furrow in vivo.

180 The cleavage furrow in Xenopus zygotes is positioned by two

181 ch associates with centrosomes and also with cleavage furrows in early embryos, is required for cleav

182 otubules (MTs) are known to be important for cleavage furrow induction and spindle positioning, and l

183 tuent of the spindle apparatus essential for cleavage furrow induction.

184 ns embryos causes late cytokinesis failures: cleavage furrows ingress but subsequently regress and th

185 In anillin knockdown cells, the cleavage furrow ingressed but failed to complete the ing

186 ottom (i.e., substrate attached side) of the cleavage furrow ingressed less than the top (i.e., unatt

187 kinesis, there is a lengthy interval between cleavage furrow ingression and abscission, during which

188 ence supporting a novel role for ARF6 during cleavage furrow ingression and cytokinesis.

189 alizes to the plasma membrane at the site of cleavage furrow ingression and midbody formation, and do

190 the postmitotic cells, resulting in partial cleavage furrow ingression during cytokinesis.

191 -function mutations in fws caused failure of cleavage furrow ingression in dividing spermatocytes and

192 t the conserved Arf GAP Asap is required for cleavage furrow ingression in the early embryo.

193 cence polarization microscopy and found that cleavage furrow ingression initiates by contraction of a

194 Remodeling of the plasma membrane during cleavage furrow ingression involves the exocytic and end

195 the fission yeast Schizosaccharomyces pombe, cleavage furrow ingression is driven by polymerization o

196 ic event in Drosophila embryos, to show that cleavage furrow ingression is kinetically coupled to the

197 Furthermore, cleavage furrow ingression is sensitive to the balance o

198 tubules formed, which correlated with slower cleavage furrow ingression rates.

199 hiphysin-null embryos correlates with faster cleavage furrow ingression rates.

200 ive cell imaging, we have found that, during cleavage furrow ingression, vesicles are internalized fr

201 coordinate sister chromatid segregation with cleavage furrow ingression.

202 h the small molecule PPMP, causes failure of cleavage furrow ingression.

203 s, a reservoir of microvilli unfolds to fuel cleavage furrow ingression.

204 regulate actomyosin ring contraction during cleavage furrow ingression.

205 these pathways converge to ensure successful cleavage furrow ingression.

206 ctomyosin ring, but its role, if any, during cleavage-furrow ingression and abscission is poorly unde

207 hain fatty acids, block or dramatically slow cleavage-furrow ingression during early telophase in div

208 negative Rho1 inhibited SS formation but not cleavage-furrow ingression or the concomitant actomyosin

209 S formation), while simultaneously promoting cleavage-furrow ingression through primary septum format

210 over, Rho1 is temporarily inactivated during cleavage-furrow ingression; this inactivation requires t

211 med cell membranes from cytokinesis, whereas cleavage furrow initiation, mitotic spindle function, ka

212 or that localizes to the central spindle and cleavage furrow, interacts with centrosome/spindle pole-

213 By manipulating the cleavage furrow into different shapes, we show that the

214 f cellularization, leading to the failure of cleavage furrow invagination and the generation of multi

215 During cytokinesis, cleavage furrow invagination requires an actomyosin-base

216 ium INCENP (DdINCENP) with the cortex of the cleavage furrow involves interactions with the actin cyt

217 The inactivation of Rac1 at the cleavage furrow is controlled by MgcRacGAP.

218 Formation of the mitotic cleavage furrow is dependent upon both microtubules and

219 how that the localization of DdINCENP at the cleavage furrow is modulated by myosin II but it occurs

220 ortex after anaphase onset but that a normal cleavage furrow is not induced until contact with MTs ha

221 During animal cell division, the cleavage furrow is positioned by microtubules that signa

222 Anillin accumulation at the cleavage furrow is Rho guanine nucleotide exchange facto

223 Myosin II localization to the cleavage furrow is severely depressed in Kif12-null (Del

224 actile-ring constriction, but the rim of the cleavage furrow is the main site for endocytosis.

225 st that chromatin trapped in the cytokinetic cleavage furrow is the more likely reason for furrow reg

226 The cytokinetic cleavage furrow is typically positioned symmetrically re

227 n, an actin-binding protein localized at the cleavage furrow, is required for cytokinesis.

228 membrane addition occurs specifically in the cleavage furrow late in telophase independent of contrac

229 sma membrane, we observed the recruitment of cleavage furrow markers, including an active RhoA report

230 ular matrix may be a general requirement for cleavage furrow maturation and contractile ring function

231 This spindle-independent cleavage furrow mechanism may be relevant to other highl

232 s elegans, dynamin localized to newly formed cleavage furrow membranes and accumulated at the midbody

233 icle traffic from recycling endosomes to the cleavage furrow/midbody where they are tethered prior to

234 the adherens junctions by a parallel mitotic cleavage furrow, most re-establish contact with the apic

235 le into a discrete ring in the Dictyostelium cleavage furrow of adherent cells.

236 s of Acanthamoeba myosin II also goes to the cleavage furrow of Dictyostelium myosin II-null cells.

237 o colocalize with this myosin isoform in the cleavage furrow of dividing cells by indirect immunofluo

238 at extracellular hemicentins assemble at the cleavage furrow of dividing cells in the C. elegans germ

239 How myosin II localizes to the cleavage furrow of dividing cells is largely unknown.

240 ell cortex, lamellar actin networks, and the cleavage furrow of dividing cells--always together with

241 the endoplasmic reticulum, mitochondrion, or cleavage furrow of dividing cells.

242 in myosin II-null cells and localizes to the cleavage furrow of dividing cells.

243 calized to the newly forming and contracting cleavage furrow of dividing cells.

244 e, the leading edge of motile cells, and the cleavage furrow of dividing cells.

245 e polarity protein Pard3 is localized to the cleavage furrow of dividing progenitors, and then mirror

246 time scale, including rapid migration to the cleavage furrow of mitotic cells.

247 t the plasma membrane and accumulated in the cleavage furrow of the Q.a and Q.p neuroblasts, suggesti

248 her microcephalic mouse mutants, mitosis and cleavage furrows of cortical stem cells appear normal in

249 RhoA was localized at the cleavage furrow or at the necks of blebs.

250 hypothesis that the exquisite control of the cleavage furrow orientation in mammalian neural precurso

251 e asymmetry are key determinants for correct cleavage furrow placement and cortical expansion, thereb

252 and triplet microtubules and have defects in cleavage furrow placement and meiosis.

253 ucleus positioning, but resulted in aberrant cleavage furrow placement and the generation of non-equi

254 y of a robust central spindle to specify the cleavage furrow position, to prevent separated chromosom

255 unequal cortical expansion, ensuring correct cleavage furrow positioning and the establishment of phy

256 identify a spindle-independent mechanism for cleavage furrow positioning in Drosophila neuroblasts.

257 ar number, microtubule rootlet organization, cleavage furrow positioning, and basal body structural p

258 studies suggest that membrane domains at the cleavage furrow possess a signaling pathway that contrib

259 osophila cleavage, myosin recruitment to the cleavage furrows proceeds in temporally distinct phases

260 nd physically interacts with three conserved cleavage furrow proteins, F-actin, myosin II and septins

261 bute to the cleavage furrow along with other cleavage furrow proteins.

262 perpendicular to two basal domains and their cleavage furrow rarely bifurcates the luminal domains.

263 nisms as the assembly domain is required for cleavage furrow recruitment of a truncated coiled-coil t

264 g spindle morphology and kif12 and myosin II cleavage furrow recruitment.

265 2b-deficient cells attempt anaphase, but the cleavage furrow regresses and cytokinesis fails.

266 s time to resolve the obstruction before the cleavage furrow regresses or breaks the chromosomes, pre

267 r collapses to one side of the cell, and the cleavage furrow regresses.

268 lear size and morphology, chromatin bridges, cleavage furrow regression, and tetraploidy.

269 d with subtle Golgi reorganization preceding cleavage furrow regression.

270 ed in which an ectopic myosin cap shifts the cleavage furrow relative to the spindle center.

271 icles with new membrane are deposited to the cleavage furrow relatively evenly during contractile-rin

272 The mitotic spindle determines the cleavage furrow site during metazoan cell division, but

273 I generates regional mechanics by increasing cleavage furrow stiffness and slows furrow ingression du

274 furrows that are structurally related to the cleavage furrows that assemble during somatic cell divis

275 ccumulated locally at the apices of the late cleavage furrows that form the persisting intercellular

276 nents in diverse morphogenetic events in the cleavage furrow, the germline, and neurons.

277 control assembly of two alternative forms of cleavage furrows: the 'Rappaport' furrows, which govern

278 division, N-cadherin is enriched in the post-cleavage furrow; then one cell pivots around the other,

279 RhoA-regulated actomyosin contraction of the cleavage furrow; this process is aborted in megakaryocyt

280 ivity that impairs NMIIA localization at the cleavage furrow through increased actin turnover.

281 The cleavage-furrow tip adjacent to the actomyosin contracti

282 ys, including endocytic tubules that form at cleavage furrow tips (CFT-tubules).

283 This leads either to failure of the cleavage furrow to form or later defects in which daught

284 he neck of cellular appendages and/or at the cleavage furrow to help compartmentalize the plasma memb

285 reaction and has been proposed to attach the cleavage furrow to the intercellular bridge.

286 ll during anaphase, effectively shifting the cleavage furrow toward the smaller daughter cell.

287 We show that Myosin relocalizes to the cleavage furrow via two distinct cortical Myosin flows:

288 3xAsp myosin II's localization to the cleavage furrow was rescued by constructs encoding rcdBB

289 In anaphase, p120 is enriched at the cleavage furrow where it binds MKLP1 to spatially contro

290 lines revealed asymmetry in the shape of the cleavage furrow, where the bottom (i.e., substrate attac

291 the peripheral ends of the first and second cleavage furrows, where they form part of the zebrafish

292 to the interphase cortex or the cytokinetic cleavage furrow, whereas a 500-residue region (1350-1865

293 filament reorientation along the cytokinetic cleavage furrow, which might have implications for diver

294 tes the actomyosin-driven contraction of the cleavage furrow, which proceeds until the formation of a

295 g to failure to inhibit formation of ectopic cleavage furrows, which result in mitotic defects and DN

296 cles or tubulovesicular structures along the cleavage furrow while the exocyst tethers vesicles at th

297 the region of the plasma membrane where the cleavage furrow will assemble is a classic question in c

298 1 and Ect2 in regulating Rho activity in the cleavage furrow, with GEF-H1 catalyzing Rho activation i

299 bbistatin, that inhibited contraction of the cleavage furrow without disrupting mitosis or contractil

300 and F-actin are familiar cohabitants of the cleavage furrow yet how they might be functionally conne