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1 f a previously uncharacterized C-terminal C3 cleavage product.
2 compared with controls and the GrB-EH(ITSN) cleavage product.
3 ated serine (p.S216L) in the 32-kDa enamelin cleavage product.
4 ection, resulting in the previously observed cleavage product.
5 NA cleavage rather than simply stabilize the cleavage product.
6 RNA, full-length protein, and SREBP-2 active cleavage product.
7 caspase-6 also generates a 45-kDa PPARgamma cleavage product.
8 ion with no appreciable increase in p52, its cleavage product.
9 gamma-cleavage without affecting the epsilon-cleavage product.
10 n and solvent dependence) will favor the C-C cleavage product.
11 ible hepatic production of prolactin and its cleavage product.
12 e engulfment proteins or their peptidoglycan cleavage products.
13 s-match observed MS peaks with predicted RNA cleavage products.
14 s have been used for analysis of deaminative cleavage products.
15 proprotein convertase family that match the cleavage products.
16 was no accumulation of caspase-mediated HuR cleavage products.
17 ts are required to determine the fate of the cleavage products.
18 lution containing the apolactoferrin and its cleavage products.
19 ydroquinone yields a mixture of 1,2- and 1,6-cleavage products.
20 oteins and a decrease in the accumulation of cleavage products.
21 s that generate secretory-stage ameloblastin cleavage products.
22 critical step for determining splicing over cleavage products.
23 e structures of some of the aldehyde-bearing cleavage products.
24 ctivation by removing siRNA passenger strand cleavage products.
25 e full-length amelogenin and its proteolytic cleavage products.
26 rocessed miRNAs constitute a minority of the cleavage products.
27 lectrophoresis was used to measure the probe cleavage products.
28 nt decrease in AICD but not of any other APP cleavage products.
29 rix metalloproteinase (MMP)-derived collagen cleavage products.
30 arance of beta-amyloid (Abeta) affecting its cleavage products.
31 but oxidation of 2H-pyrans also gives alkyl cleavage products.
32 ing molecule or via its numerous proteolytic cleavage products.
33 eading to the generation of an unique set of cleavage products.
34 tions are well-known and so are the expected cleavage products.
35 le RNAs consisting of the 5' portions of the cleavage products.
36 tibodies against NfH, NfH aggregates and NfH cleavage products.
37 s converted to a normal T in the 3'-fragment cleavage products.
38 ncorporating oxygen from O2 and H2O into its cleavage products.
39 copy analysis of selected immunoprecipitated cleavage products.
40 cation, and a lack of detection of secondary cleavage products.
42 ionizing radiation (IR), determined that HuR cleavage product-1 (HuR-CP1) bound and promoted the expr
44 amounts of full-length TDP-43 as well as its cleavage products (35 kDa and 25 kDa) in the urea-solubl
46 at terminate between residues 90-115, termed cleavage product A or 1 (cp-A/1), form intracellular and
47 e studies attribute these changes to the APP cleavage product Abeta, in recent years it became appare
48 nous FPR ligand, annexin A1 (ANXA1), and its cleavage product Ac2-26, which mediate activation of ROS
49 c function and generates a carboxyl-terminal cleavage product, acCED-8, that promotes PS externalizat
55 used: an SDS-PAGE based assay to detect IgG cleavage products and a surface plasmon resonance spectr
56 d to monitor both time-resolved formation of cleavage products and disappearance of full-length RNA.
57 raphy were used to further purify huntingtin cleavage products and enrich for the cp-1/cp-2 fragments
58 ed these smaller fragments to be proteolytic cleavage products and identified a limited number of pro
59 cineurin and immunoblot analysis of spectrin cleavage products and showed that both substrates were c
61 eased accumulation of precursor proteins and cleavage products and this is attenuated by lysosomal, b
62 rminally truncated species were not the main cleavage products, and calpain I activity present in cel
64 , as varying degrees of heterogeneity of the cleavage products appear to accompany the emergence of t
66 ents from insoluble bacterial cell walls and cleavage products are able to trigger responses typicall
77 discussed to explain the variations in bond cleavage products as a function of the driving forces fo
78 otypes, but these fragments are not terminal cleavage products as they are subject to further proteol
80 omelanocortin peptide (POMC), and its opioid cleavage product, beta-endorphin, are expressed in the m
84 xon1 was devoid of polyQ peptides as partial cleavage products by incomplete proteolysis, indicating
88 n pathways of complement activation, and its cleavage products C3a and C3b mediate several functions
91 together, our findings suggest that peptide cleavage products can affect cellular function beyond th
93 thrin is cleaved by thrombin, the C-terminal cleavage product continues to exert prolonged inhibition
97 cleavage of histone pre-mRNA, the downstream cleavage product (DCP) is degraded by the 5'-3' exonucle
99 preciable change in FP, probably because the cleavage product did not have sufficiently increased mob
103 y, WRN also influences the formation of FEN1 cleavage products during strand displacement on a nontel
104 binds tighter to miRNA targets than its RNAi cleavage product, even though the cleaved product contai
105 single cellular substrate and sequesters the cleavage product, evolutionary pressure has likely selec
106 -LIF, the assay signal is the peak height of cleavage product formed after a fixed incubation time.
108 cells is negatively regulated by prohormone cleavage products formed from plasmin-mediated proteolys
113 udor domain protein Qin prevents Aubergine's cleavage products from becoming Piwi-bound piRNAs, ensur
116 demonstrate that the C-terminal JunB caspase cleavage product functions as a potent inhibitor of AP-1
117 nsible for the degradation of the downstream cleavage products generated by ASOs or siRNA targeting m
123 275, respectively, to generate an N-terminal cleavage product (GSDMD-NT) that triggers inflammatory d
124 evidence by modified 5'-RACE for a MYB mRNA cleavage product guided by miR828 in Pinus resinosa.
126 ff after assembly into microfibrils, and the cleavage product has been implicated in tumor angiogenes
128 t the matriptase-2 and proprotein convertase-cleavage products have different roles in the regulation
130 of full-length D187N gelsolin and its 68-kDa cleavage product in blood-demonstrating the importance o
131 We also identify an additional caspase-5 cleavage product in LPS-stimulated monocytes, which corr
133 HDV ribozyme transition state resembles the cleavage product in the degree of proton transfer to the
135 ugh cathepsin L generated the requisite TLR9 cleavage products in a cell-free in vitro system, severa
136 sis greatly reduces the level of undesirable cleavage products in O-glycan analysis and increases the
137 n vitro, and the accumulation of proteolytic cleavage products in SCA7 patients and mouse models has
142 ration of FVIII (1 nm), the formation of VWF cleavage product increases dramatically as a function of
143 type III machines also transported the YopE cleavage product into the cytosol of tissue culture cell
145 sor ion scan experiment, the resulting ozone cleavage product ions were used to determine the positio
146 inetic isotope effect on cleavage; the major cleavage product is an RNA strand terminated by a 5'-ald
149 hat this cholesterol-modified amino-terminal cleavage product is responsible for all HH-dependent sig
150 -terminal fragments, we show that this toxic cleavage product is specific for pathologic inclusions i
153 g requires endocytosis and that the level of cleavage products is regulated during neuronal different
154 SAH (a SAM analog) or 5'-dAdo and l-Met (SAM cleavage products) is consistent with the canonical mech
155 (MAPK) activity ratio caused by the GrB/ITSN cleavage products lead to EC proliferation and selection
158 biological effects of each of the resultant cleavage products make ascribing causality much more com
159 utoantibodies against NfH aggregates and NfH cleavage products may explain the variable expression of
160 posed to catalyze the hydrolysis of the meta-cleavage product (MCP) 4,11-dicarboxy-8-hydroxy-9-methox
164 ning these proteoforms are stable functional cleavage products, most with unknown functional implicat
165 vage site, but instead produced two unstable cleavage products, neither of which were stabilized by i
167 tely 90 kDa, similar in size to the putative cleavage product observed in poliovirus-infected cells.
168 Here, we report that all of the prominent cleavage products observed during primer extension on th
169 of its cosubstrate dioxygen into the rubber cleavage product ODTD, and we show that RoxA is isolated
170 ls of brain amyloid-beta, a secreted peptide cleavage product of amyloid precursor protein (APP), is
174 ed that beta-apo-13-carotenone, an eccentric cleavage product of beta-carotene, antagonizes the activ
175 At baseline, NH2-terminal (NT)-proBNP, a cleavage product of BNP, was inversely associated with a
182 entin phosphoprotein (DPP) is the C-terminal cleavage product of DSPP that binds collagen and induces
185 ta-defensin 2 (hBD2), and the carboxypeptide cleavage product of human cathelicidin (hCAP18), LL-37,
188 dies have implicated an N-terminal caspase-6 cleavage product of mutant huntingtin (htt) as an import
190 wever, that OBPC-1 is a cathepsin B-mediated cleavage product of OBP, suggesting that OBPC-2 is the p
191 The presence of increased levels of the cleavage product of PARP indicated apoptosis in response
194 on from the precursor peptide (a proteolytic cleavage product of prostatic acid phosphatase, PAP(248-
196 I) collagen alpha chain, suggesting that the cleavage product of the alpha3(VI) collagen does not eli
199 nent is the beta-amyloid peptide, which is a cleavage product of the amyloid precursor protein (APP).
200 is of this study is that a carboxyl-terminal cleavage product of the cardiac L-type calcium channel (
203 ract with the membrane bilayer, is a tryptic cleavage product of the outer capsid spike protein, VP4.
204 special emphasis on alphaA1-172 which is the cleavage product of the Ser172-Ser173 bond, unique to hu
207 ontaining AU elements are cleaved and the 5' cleavage product of these RNAs persists for many hours.
208 and CTFalpha APP metabolite production, both cleavage products of ADAM10, concordant with increased A
209 he proteolytic processing of mouse Nrf3 into cleavage products of approximately 80-kDa (glycated) and
214 are consistent with the hypothesis that the cleavage products of ICP0 function in topologically dist
217 fication of cDNA ends, deep sequencing of 3' cleavage products of mRNA and bioinformatic analysis.
218 We focused on NSP1alpha and NSP1beta (self-cleavage products of NSP1 during virus infection) and NS
223 d Delta-peptides, which are small C-terminal cleavage products of sGP secreted by ebolavirus-infected
224 0-kDa complex that also contained C-terminal cleavage products of TDP-43 linked to neuropathology.
225 ed in whole cells; the two smaller forms are cleavage products of the 210-kD protein and were the pre
226 ribonuclease followed by RNA-seq) to profile cleavage products of the essential endoribonuclease RNas
227 SPR(159)) motif, and the other two forms are cleavage products of the first ((151)RRDR(154)) and thir
228 und to a protein, followed by separating the cleavage products on a denaturing electrophoresis gel to
230 dence suggesting that the native proteolytic cleavage product P148 may have an important functional r
231 native 20-kDa porcine amelogenin proteolytic cleavage product P148 that is prominent in developing en
232 orcine amelogenin (P173) and its predominant cleavage product (P148) can inhibit spontaneous calcium
233 e nonstructural proteins (NSPs) P200 and its cleavage products, P150 and P90 (N and C terminal within
234 ) is an integral membrane glycoprotein whose cleavage products, particularly amyloid-beta, accumulate
235 3'UTR) are deadenylated and cleaved, but the cleavage products persist for hours, in contrast to the
237 O atom into either of its carbon-carbon bond cleavage products, pregnenolone and isocaproaldehyde .
243 A POLYMERASE 6 (RDR6) to ARGONAUTE 1-derived cleavage products, resulting in more efficient amplifica
245 ases by transcriptome-wide profiling of mRNA cleavage products retaining 5' phosphate groups in mouse
247 atly facilitates direct visualization of the cleavage product, revealing important characteristics of
248 gth Mst1, and N- and C-terminal caspase Mst1 cleavage products, reverted an early lethal phenotype in
249 t amelogenin (rP172), a homolog of its major cleavage product (rP148), and a native amelogenin lackin
250 e the enzymatically derived 38/40 amino acid cleavage product(s) of Tn-PSM containing approximately 1
253 higher macrophage MerTK, lower levels of the cleavage product soluble Mer, improved efferocytosis, sm
254 y and levels of the matrix metalloproteinase cleavage product soluble receptor for advanced glycation
257 cohol and o-dihydroxybenzene as well as ring-cleavage products such as glyoxal were also identified a
258 tion of tasiRNAs and over-accumulation of 3' cleavage products, suggesting positive effects of transl
259 nous caspase, calpain, and metalloproteinase cleavage products, terminating between residues 400-600,
261 reased the rate of appearance of a secondary cleavage product that decreased the T/P duplex length to
262 mes process amelogenin to generate the major cleavage products that accumulate during the secretory s
263 These cleavages generate all of the major cleavage products that accumulate in porcine secretory-s
264 ting protein fibrinogen, yielding fibrinogen cleavage products that acted as TLR4 ligands on airway e
266 -Arg(170)) and 15-kDa (Val(1)-Gln(130)) AMBN cleavage products that concentrate in the sheath space d
267 is impaired on such substrates, resulting in cleavage products that do not allow direct religation.
268 tously expressed transmembrane protein whose cleavage product, the amyloid-beta (Abeta) protein, is d
269 gth protein and its major Deltapsi-dependent cleavage product to the cytosolic face of the outer mito
272 nant VWF-A2 as determined by quantifying the cleavage products using Western-blotting, enhanced cleav
275 generation of the calpain-specific spectrin cleavage product was not observed in lens tissue from ca
276 -secretase within the endosome; however, the cleavage product was proteasome-sensitive and failed to
278 In hippocampal slices, this increase in cleavage products was accompanied by a significant reduc
280 alization of both MMTV-SP and the C-terminal cleavage product, we prepared plasmids expressing green
281 raphy and mass spectrometric analysis of the cleavage products, we report the ability to demonstrate
283 alyzed by SDS-PAGE and Western blotting, and cleavage products were characterized by N-terminal seque
284 ldolase, HpaI, in complex with substrate and cleavage products were determined to 1.8-2.0 A resolutio
287 cyclin D1, whereas caspase activity and PARP cleavage products were increased in tumors of drug-treat
288 rity and dynamic range for detection of BoNT cleavage products were initially examined, including the
291 tion limits obtained by monitoring the ether cleavage products were somewhat higher (between 100 and
293 osphorylated PRH produces a stable truncated cleavage product which we have termed PRHDeltaC (HhexDel
294 ull-length 315-kDa and a 190-kDa proteolytic cleavage product), which are type I single-pass membrane
295 ilbenes and flavonoids to muconoid-type ring-cleavage products, which are likely the first steps in t
296 ficking of the full-length UL37 glycoprotein cleavage products, which divergently traffic either thro
297 , mature Mst1 as well as both of its caspase cleavage products, which localize to distinct subcellula
298 or cytoplasmic Dis3L1 degraded mRNA upstream cleavage products, which were not bound by the 5'-cap bi
299 nvert to two forms of a ferryl heme O-O bond-cleavage product, whose nu(Fe horizontal lineO) frequenc
300 V ribozymes appear to be similar, generating cleavage products with 5'-hydroxyl and 2',3'-cyclic phos
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