ライフサイエンスコーパス: cleave

1 stalled replication forks must therefore be cleaved.

2 ence that this domain is posttranslationally cleaved.

3 tures of the spliceosomal C complex with the cleaved 5' exon and lariat-3'-exon bound to the catalyti

4 Furthermore, while Nei and NEIL1 also cleave a psoralen-induced four-stranded DNA substrate to

5 tease, which canonically cleaves ENLYFQS, to cleave a very different target sequence, HPLVGHM, that i

6 hCG cleaved a few additional proteins, although this occurre

7 h the alpha-sarcin/ricin loop (SRL) where it cleaves a conserved adenine.

8 se excision repair (UBER) enzymes target and cleave A3G-edited uridine-containing viral cDNA.

9 n of CsBGLU18 (an ABA beta-glycosidase) that cleaves ABAGE.

10 /R1018Q/R1545Q, FV(DeltaIIa)) that cannot be cleaved/activated by thrombin or FXa also enhanced TFPI-

11 Pre2, a nicked Pre2 derivative with a single cleaved Ala-470-Asn-471 bond.

12 pectic polysaccharide rhamnogalacturonan-II, cleaving all but 1 of its 21 distinct glycosidic linkage

13 Although this region appears important for cleaving all LF protein substrates, we found that mutati

14 ely broad specificity suggests that they may cleave almost any substrate if present in high enough co

15 We have developed a cleaved amplified polymorphic sequence (CAPS) marker tig

16 vels of beta-secretase 1 (BACE-1) and BACE-1-cleaved amyloid precursor protein (APP) metabolites (sec

17 Due to the fact that it also cleaves amyloid precursor protein, BACE1 is a therapeuti

18 erize the capability of commensal species to cleave and transport mucin-associated monosaccharides an

19 e similar in that trimethyllead (TML) is not cleaved and binds only to D99, whereas diethyllead (DEL)

20 We further show that it is cleaved and interacts with the JUN proto-oncogene, which

21 ing agent, while the aminopeptidase activity cleaves and inactivates the chemotactic tripeptide Pro-G

22 terized proinflammatory functions, including cleaving and activating chemokines and controlling cell

23 nths, and exerts its effects by specifically cleaving and inactivating SNAP25.

24 G1/2 causes aberrant insertions by releasing cleaved antibody gene fragments that subsequently reinte

25 ons, beta-site APP cleaving enzyme 1 (BACE1) cleaves APP at minor Asp(1) site to generate C99 for amy

26 The model amide is cleaved at an enzyme-like rate that renders the amide no

27 Our data also show that ES7c is cleaved at early stages of the gene expression program t

28 , we also show that archaeal RNaseH2 rapidly cleaves at embedded ribonucleotides (200-450 s(-1)), but

29 eductive cleavage, a degradative method that cleaves beta-ether bonds, indicating that at least a fra

30 ytic subunit of the gamma-secretase complex, cleaves betaCTF to produce Abeta.

31 N (APN), a multifunctional protease known to cleave biologically active peptides and aide in coronavi

32 ases capable of selectively and controllably cleaving biotechnologically or therapeutically relevant

33 umain, is a lysosomal cysteine protease that cleaves both amyloid precursor protein (APP) and tau, me

34 When the PYBs bind, the thiazolium ring is cleaved, but when the SCTs bind, ThDP is modified to thi

35 However, the propeptide is also cleaved by a furin-like proprotein convertase(s) (PCs) a

36 Here we provide evidence that VE-cadherin is cleaved by calpain upon entry into clathrin-enriched dom

37 PTPN13 is cleaved by calpain-2, which inactivates its phosphatase

38 IP3R1 can be cleaved by caspase or calpain into at least two receptor

39 by glycosidases, whereas O-glycans are often cleaved by chemical reaction.

40 The peptide substrate was cleaved by collagenase class I, II, Liberase MTF C/T, co

41 es such as benenodin-1 can be recognized and cleaved by enzymes called lasso peptide isopeptidases.

42 n addition, the adam13 cytoplasmic domain is cleaved by gamma secretase, translocates into the nucleu

43 ough peptide linkers that are designed to be cleaved by intracellular macrophage proteases.

44 only the native conformer of benenodin-1 is cleaved by its cognate isopeptidase.

45 Primary microRNA transcripts (pri-miRs) are cleaved by Microprocessor, a complex containing the RNas

46 the matrix compartment, Prx1 is sequentially cleaved by mitochondrial processing peptidase and then b

47 They are made as proprotein dimers and then cleaved by proprotein convertases to release the C-termi

48 ying peptide substrates that are efficiently cleaved by proteases gives insights into substrate recog

49 ge of novel substrates that are specifically cleaved by RHBDL2, including the interleukin-6 receptor

50 transmembrane peptide substrates, which are cleaved by several unrelated rhomboid proteases, can be

51 Brother (BB) and DA2, which are subsequently cleaved by the activated peptidase and destabilized.

52 of COS-1 cells, mouse proprotein C is first cleaved by the convertases furin, PC5/6A, and PACE4.

53 processing.Upon autophagy induction, LC3 is cleaved by the protease ATG4 and conjugated to the autop

54 w report that cytoplasmic DPPA3 is partially cleaved by the ubiquitin-proteasome system and an N-term

55 the thrombin-resistant R221A mutant is still cleaved by these PCs, revealing that convertase cleavage

56 ter differentiate oxyBAC from other ROs that cleave C-N(+), and presumably facilitate the cleavage of

57 The bimetallic species are capable of cleaving C-H bonds in the supporting ligands, and kineti

58 Furthermore, reactive-center-cleaved C1INH attenuated pulmonary damage evoked by intr

59 s demonstrated by the use of reactive-center-cleaved C1INH, but dependent on its glycosylation status

60 n 1 (MCP-1), TNF-alpha, and IL-6 and hepatic cleaved caspase 3 in mice fed either a normal chow diet

61 -) macrophages exhibit reduced expression of cleaved caspase-1 and NLRP3.

62 tress markers (BiP, pIRE1alpha, sXBP1, CHOP, cleaved caspase-12) were increased in septic WT mice, bu

63 unting and autoradiography and compared with cleaved caspase-3 (CC3) activation and DNA fragmentation

64 Increased apoptosis by cleaved caspase-3 (P = 0.03) and decreased proliferation

65 ERK, together with a decreased expression of cleaved caspase-3 in mice treated with 6-OHDA or rotenon

66 disturbed distribution of cytochrome c, and cleaved caspase-3 positive staining indicated that incre

67 /-) mice had the lowest renal levels of Bax, cleaved caspase-3, and NADPH oxidase-4 expression and re

68 miR-K9 also decreased the protein levels of cleaved caspase-3, cleaved caspase-7, and cleaved poly(A

69 sed the protein levels of cleaved caspase-3, cleaved caspase-7, and cleaved poly(ADP-ribose) polymera

70 a acetylated MnSOD(K68) Murine AEC SIRT3 and cleaved caspase-9 (CC-9) expression were assayed by immu

71 f the growth plate, accompanied by decreased cleaved caspase-9.

72 tasis was associated with activation of Bax, cleaved caspases-3 and -9, and down-regulation of Bcl-2,

73 experiments indicated that the C-terminally cleaved CaValpha2delta1 proteins up-regulate CaV1.2 chan

74 CtsB cleaves CD18 from the surface of immune cells, but its c

75 FXIa, generated on contact phase activation, cleaves chem163S to generate chem158K, which can be furt

76 ebrand factor type A (VWA) domain within the cleaved CLCA1 N-terminal fragment is necessary and suffi

77 Additionally, fluorescence signal from cleaved CNIR800 reaches maximal levels 4-6 hours after a

78 ests that coagulation proteases can directly cleave complement proteins.

79 rt that recombinant AGO3 loaded with miR-20a cleaves complementary target RNAs, whereas AGO3 loaded w

80 ex with calcium ions; and a DNA-bound, fully cleaved complex with magnesium ions.

81 nt maturation, but recombinant Csm5 fails to cleave crRNAs in vitro.

82 agents and assays, we show that the two MMPs cleave different substrates, suggesting that this is the

83 eld semi-immobilized FLPs, which are able to cleave dihydrogen heterolytically at ambient temperature

84 e cleavage, while 3' overhanging termini are cleaved distributively.

85 Thus we postulate that viral terminases cleave DNA by the canonical RuvC-like mechanism.

86 or the use of CRISPR/Cas9 is its tendency to cleave DNA non-specifically at "off-target" sites.

87 of packaging unlocks the nuclease domains to cleave DNA.

88 ated functionalization of a therapeutic mRNA-cleaving DNAzyme at the particle's surface.

89 RNA-cleaving DNAzymes are the catalytic DNAs discovered the

90 ts (CRISPR)-associated 9 (Cas9) endonuclease cleaves double-stranded DNA sequences specified by guide

91 The RNA-guided Cpf1 nuclease cleaves double-stranded DNA targets complementary to the

92 MMP9 highly efficiently cleaved DSP into distinct fragments in vitro, and the de

93 on state governs how chemical bonds form and cleave during a chemical reaction and its direct charact

94 have shown that mature cytoplasmic tRNAs are cleaved during stress response to produce tRNA fragments

95 This bifunctional marker was efficiently cleaved during virus maturation, producing free mCherry

96 utants, indicating that concatemeric DNA was cleaved efficiently.

97 asion, and recombinantly active PMIX and PMX cleave egress and invasion factors in a 49c-sensitive ma

98 Oct1 cleaved eight amino acid residues from the N-terminal re

99 fibrillin-2 but not fibrillin-1 and does not cleave either.

100 induced, we were able to avoid mosaicism in cleaving embryos and achieve a high yield of homozygous

101 AGO1 complex acts to specifically target and cleave endogenous transposable element (TE) mRNAs produc

102 t that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) pr

103 The cleaved ends are difficult to repair in vivo, which may

104 on (PACE) of TEV protease, which canonically cleaves ENLYFQS, to cleave a very different target seque

105 enerated by cleavage of APP by beta-site APP cleaving enzyme 1 (BACE-1), is the primary cause of the

106 Under normal conditions, beta-site APP cleaving enzyme 1 (BACE1) cleaves APP at minor Asp(1) si

107 lopment.SIGNIFICANCE STATEMENT beta-site APP cleaving enzyme 1 (BACE1) is essential for amyloid beta

108 beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the major neuronal beta-sec

109 NT beta-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) trafficking and synaptic local

110 , this study identifies matriptase as an APP-cleaving enzyme, an activity that could have important c

111 ha and enhanced translation of beta-site APP cleaving enzyme-1 (BACE1).

112 The pduCDE enzymes are responsible for cleaving ethoxylate chain units into aldehydes before th

113 rolysed by CD38, whereas 8-Br-L-cIDPR is not cleaved, even at high enzyme concentrations.

114 (MMPs) are extracellular proteases that can cleave extracellular matrix and alter signaling pathways

115 xhibited restricted specificity for protease-cleaved F(ab')2 fragments and did not bind the intact Ig

116 and testable on a wafer scale, requiring no cleaved facets or special mirror coating to function.

117 Rather, chymase cleaved fibronectin, inhibited ASM adhesion, and attenua

118 , termed spacers, that guide Cas proteins to cleave foreign DNA.

119 e previously discovered that an N-terminally-cleaved form of RXRalpha (tRXRalpha), produced in tumour

120 +)/Cl(-) cotransporter (NCC), claudin-7, and cleaved forms of epithelial Na(+) channel (ENaC) alpha a

121 NLGN3 is cleaved from both neurons and oligodendrocyte precursor

122 t markers of protein metabolism, as they are cleaved from larger polypeptides and proteins.

123 heir chromophore, phycocyanobilin (PCB), was cleaved from the apoprotein by solvolysis in alcohols an

124 hat the C-terminal kinase domain of TRPM6 is cleaved from the channel domain in a cell type-specific

125 gion and a DNA binding domain (DBD), is auto-cleaved from the ER membrane, and then enters the nucleu

126 regions (ECRs) that are autoproteolytically cleaved from their membrane-embedded signaling domains.

127 MMP-20 was added to the CS-AMEL hydrogel to cleave full-length amelogenin during the growth of ename

128 ell-surface NHE3, NKCC2, NCC, alpha-ENaC and cleaved gamma-ENaC compared to NSD.

129 Inflammatory caspases cleave gasdermin-D in the interdomain linker but not GSD

130 ooxygenases (LPMO10s) use redox chemistry to cleave glycosidic bonds in the two foremost recalcitrant

131 , and -7, but not the inflammatory caspases, cleave GSDMB at 88DNVD91 within the N-terminal domain.

132 EV71 3C cleaves GSDMD at the Q193-G194 pair, resulting in a trun

133 assessed by measurement of plasma levels of cleaved high-molecular-weight kininogen, and efficacy wa

134 uppressor of hepatic hepcidin expression and cleaves HJV.

135 It also cleaves Host cell factor 1 (HCF-1) by a mechanism in whi

136 ssed a single-surface endo-acting lyase that cleaved HS, reflecting its higher molecular weight compa

137 ns of PACE contains 20 non-silent mutations, cleaves human IL-23 at the target peptide bond, and when

138 tory AHA reactivity in RA was against pepsin-cleaved IgG4, with a 35% prevalence, >/=5.8-fold higher

139 Interestingly, both enzymes readily cleaved IL-18 and IL-33, two IL-1-related alarmins, as w

140 receptor binding at synapses the receptor is cleaved in its transmembrane domain and releases a prote

141 RNAs from all three transcripts are cleaved in places not on path for circle formation, like

142 crystals of tetragonal structure are easy to cleave into perfect square-shaped pieces due to the van

143 cathepsin S (Ctss), a cysteine protease that cleaves invariant chains and produces antigenic peptides

144 LsAA9A additionally cleaves isolated xylan substrates.

145 spacers to candidate vaccines, or recommend cleaving it off before using for vaccination.

146 host atypical miRNA processing machinery to cleave its small non-coding RNA into a 22-nt RNA fragme

147 leukocyte transmigration by proteolytically cleaving its endothelial substrates.

148 uitinase enriched in postsynaptic densities, cleaves K63-chains from PSD-95.

149 TRPM6-cleaved kinases (M6CKs) bind subunits of the protein arg

150 The MUS81-EME1 endonuclease cleaves late replication intermediates at common fragile

151 that high expression of the autophagy marker cleaved LC3 expression correlates with poor clinical out

152 insoluble but injectable polymer via a light cleaved linker.

153 e linked basic groups to insulin via a light cleaved linker.

154 d the association of total (M65) and caspase-cleaved (M30) serum keratin-18 fragments (n = 204) with

155 HMB-based single crystals prepared by simple cleaving method satisfy all required crystal characteris

156 rminal four-C2 domain module; and 4) calpain-cleaved mini-dysferlinC72, which is particularly resista

157 F is a highly specific protease, exclusively cleaving mitogen-activated protein kinase kinases (MKKs)

158 cteria, RelE shuts down protein synthesis by cleaving mRNA within the ribosomal A site.

159 It can cleave multiple substrates including itself, fibronectin

160 The cleaved N-terminal domain binds phosphoinositides and ca

161 , an enzyme enriched in oligodendroglia that cleaves N-acetyl-l-aspartate (NAA) to acetate and l-aspa

162 We report that ADAM17 and ADAM10 cleave Nectin-4 and release soluble Nectin-4 (sN4).

163 ansmembrane proteins, and ADAM17 is known to cleave Nectin-4 in breast cancer.

164 markably, BoNT/X is the only toxin that also cleaves non-canonical substrates VAMP4, VAMP5 and Ykt6.

165 from lipid rafts to nonlipid rafts where it cleaved Notch.

166 ing endonucleases (LHEs) are a class of rare-cleaving nucleases that possess several unique attribute

167 lease 1 (TREX1) is an anti-viral enzyme that cleaves nucleic acids in the cytosol, preventing accumul

168 Natural antibodies capable of cleaving nucleic acid, protein, and polysaccharide subst

169 After C1 treatment, cleaved nucleolar proteins were identified by proteomic

170 mplicated in regulating cytokine activity by cleaving numerous cytokines and chemokines.

171 ing the plasma membrane, signal peptides are cleaved off and mature domains reach their destinations

172 is synthesized with a C-terminal extension, cleaved off by a specific endopeptidase during maturatio

173 ed that the RxLR sequence of native AVR3a is cleaved off prior to secretion by the pathogen and the N

174 o acid ester moiety, which are enzymatically cleaved-off inside cells to release the free nucleoside

175 he development of materials that selectively cleave one of the four C-H bonds of methane and thus mak

176 ordinated micro-OCS2, which on deprotonation cleaves one C-S bond and simultaneously forms a C-O bond

177 ived OPN for HSC aging and identify thrombin-cleaved OPN as a novel niche informed therapeutic approa

178 Exposure of aged HSCs to thrombin-cleaved OPN attenuates aging of old HSCs, resulting in i

179 or isomerization of amino acids in nature by cleaving or shifting a C-N bond.

180 ORF2 (ORF2i), glycosylated ORF2 (ORF2g), and cleaved ORF2 (ORF2c).

181 enzyme candidates used by the heterotroph to cleave organic groups and hydrolase polymeric organic ma

182 However, the fate of the cleaved p75 TM domain is unknown.

183 atelet activation induced by weak stimuli by cleaving PAR1 at a noncanonical extracellular site diffe

184 Recombinant HaAEP1 cleaved PawS1 at multiple positions, and in situ, its fl

185 is transcriptional control of pcdh8l, adam13 cleaves pcdh8l generating an extracellular fragment that

186 Because proteases irreversibly cleave peptide bonds of protein substrates, their activi

187 e known thermal decomposition reactions that cleave peptides and proteins specifically at the C-termi

188 gies have been adopted, among which 2A "self-cleaving" peptides have garnered increased interest for

189 mor-associated macrophage differentiation by cleaving peroxisome proliferator-activated receptor gamm

190 triphosphate (dNTP) triphosphohydrolase that cleaves physiological dNTPs into deoxyribonucleosides an

191 Furthermore, 3C cleaved PinX1 at the site of Q50-G51 pair through its pr

192 we showed that 3C promoted apoptosis through cleaving PinX1, a telomere binding protein, and that thi

193 in N-termini to comprehensively characterize cleaved podocyte proteins in the glomerulus in vivo We f

194 of cleaved caspase-3, cleaved caspase-7, and cleaved poly(ADP-ribose) polymerase (PARP).

195 nt copper-dependent enzymes that oxidatively cleave polysaccharides.

196 CPF cleaves pre-mRNAs, adds a polyadenylate tail, and trigge

197 ess pro-caspase-1 to active caspase-1, which cleaves pro-inflammatory IL-1beta o mature IL-1beta caus

198 Competition assays showed that both cleaved products are required for the PDI phenotype alth

199 a deficiency in von Willebrand factor (VWF)-cleaving protease ADAMTS13.

200 ceptor and scaffold of coagulation proteases cleaving protease-activated receptor 2 (PAR2) that plays

201 e of electron capture dissociation (ECD) for cleaving protein backbone bonds while preserving noncova

202 omics workflow uses trypsin to enzymatically cleave proteins C-terminal to lysine and arginine residu

203 d, an unexpected in vivo abundance of stable cleaved proteins revealed pervasive, functionally releva

204 NEIL3 from Xenopus laevis has been shown to cleave psoralen- and abasic site-induced ICLs in Xenopus

205 the ability of published anti-HIV-1 gRNAs to cleave publicly available patient-derived HIV-1 sequence

206 e reaction is that the stronger Ph-O bond is cleaved rather than the weaker aliphatic O-R bond.

207 ase-like enzymes based on the amino acids in cleaved reactive sites.

208 Both enzymes cleaved recombinant HA from several strains of the H1 an

209 e mechanism by which the transposon ends are cleaved remained unknown.

210 substrates near the catalyst, and the other cleaves remote C-H bonds.

211 Finally, the gRNAs linked by the self-cleaving ribozymes and tRNA could be expressed from RNA

212 Small self-cleaving ribozymes have been discovered in all evolution

213 o the discovery of a new class of small self-cleaving ribozymes named Pistol.

214 tol RNA motif represents a new class of self-cleaving ribozymes of yet unknown biological function.

215 The 5' cleaved RNA fragments are marked with uridylation for de

216 The 3'-end of cleaved RNA(3'-rA) consists of 2',3'-cyclic phosphate wh

217 c DNAs discovered the earliest, and they can cleave RNAs in a sequence-specific manner.

218 e (RNase) H2 is the principal enzyme able to cleave rNMPs in DNA.

219 Soluble-cleaved (sc) uPAR levels were determined in serum throug

220 raminidase from Clostridium perfringens that cleaves sialic acid monomers with an alpha2-3,6,8,9 link

221 ometimes covalently linked to proteases that cleave signaling proteins.

222 ng amide bond hydrolysis, although they both cleave simple single-stranded DNA oligonucleotides.

223 FEN1 precisely cleaves single-stranded (ss) 5'-flaps one nucleotide int

224 DNA-catalyzed, radical reaction process that cleaves single-stranded DNA and requires only redox-inac

225 by fusogenic complexes incorporating BoNT/A-cleaved SNAP-25.

226 envelope structure has depended in part on a cleaved, soluble trimer, known as SOSIP.664, stabilized

227 hat specific enrichment of electrochemically cleaved spirolactone-containing peptides can be used for

228 Lpg1137 binds to and cleaves syntaxin 17, a soluble N-ethylmaleimide-sensitiv

229 e CV-A16, CV-A6, and EV-D68 3C(pro) proteins cleave TAK1 to inhibit the NF-kappaB response.

230 so suggests a possible link between decay of cleaved target mRNAs and miRNA stability in RISC.

231 oralis produces a neuraminidase, NanA, which cleaves terminal sialic acid.

232 t proteins demonstrated that SepA is able to cleave the A domain of Aap at residue 335 and between th

233 nonical alpha-, beta-, and gamma-secretases, cleave the amyloid precursor protein (APP) and modulate

234 belong to glycoside hydrolase family 16 and cleave the beta-1,4 linkage of kappa-carrageenan.

235 olites possess active sites that are able to cleave the C-H bond of methane at temperatures </=200 de

236 nusual enzyme reactions have also evolved to cleave the C-P bond.

237 a bacterial cell and requires hydrolases to cleave the cross-links for insertion of nascent PG mater

238 onsists of two components: Cas-proteins that cleave the foreign DNA and CRISPR array that suits as a

239 -Ribosylation is reversed by hydrolases that cleave the glycosidic bonds either between ADP-ribose un

240 y conserved process because yeast Oct1 could cleave the human mitochondrial peroxiredoxin Prx3 when e

241 akly acidic 4-NO2-phenol, and stronger acids cleave the metal-O bonds, releasing H2O2.

242 A (PNGase F and A) or anhydrous hydrazine to cleave the N-glycans from glycopeptides.

243 After processing in the Golgi to cleave the N-terminal prodomain from the C-terminal grow

244 osolic expression of the FMDV 3C protease to cleave the P1 polyprotein into mature capsid proteins, b

245 to measure carboxypeptidase activities that cleave the proline-phenylalanine dipeptide bond in Ang I

246 deficiency curing is a result of failure to cleave the Sup35p amyloid filaments to make new seeds, w

247 -R353A and FXII-T activate prekallikrein and cleave the tripeptide S-2302, demonstrating proteolytic

248 suggested that other cysteine cathepsins can cleave the VC(S) linker.

249 particular glycan modifications, yet always cleaved the peptide bond immediately preceding the glyco

250 nuclease activity of MRN apparently directly cleaves the 5' strand DNA at more distal sites.

251 l Co-atom form a metal-oxygen site-pair that cleaves the C-H bond via a sigma bond metathesis reactio

252 s DNA translocation and an endonuclease that cleaves the concatemeric genome at both initiation and c

253 DA1 peptidase activity also cleaves the deubiquitylase UBP15, which promotes cell pr

254 ecognizes an asymmetric 5'-GCCGC-3' site and cleaves the DNA 7 and 6/7 nucleotides downstream on the

255 te that, upon photoactivation, the conjugate cleaves the DNA backbone specifically near the mismatch

256 ase associates with a CRISPR RNA (crRNA) and cleaves the double-stranded DNA target complementary to

257 ctional thymine DNA glycosylase (Tdg), which cleaves the glycosidic bond of the bases to give potenti

258 Here we show that caspase-3 cleaves the GSDMD-related protein DFNA5 after Asp270 to

259 ur previous studies showed that HIV protease cleaves the host protein procaspase 8 to generate Casp8p

260 MRP ribonucleoprotein (RNP) from HeLa cells cleaves the human pre-rRNA in vitro at at least one site

261 h, upon further protonation, heterolytically cleaves the N-N bond to release [Fe(IV) identical withN]

262 as substrates for NADase, which selectively cleaves the nicotinamide's glycosidic bond yielding (tz)

263 Top1-dependent events arise when the enzyme cleaves the non-transcribed strand of DNA.

264 that over-expressed RNase H1, an enzyme that cleaves the RNA of RNA/DNA hybrids in B cells.

265 ls, expression of excessive TbRNaseH1, which cleaves the RNA strand of the RNA:DNA hybrid, brought te

266 n exerts a unique ribonuclease activity that cleaves the single-stranded 3'-end from tRNAs that conta

267 tly initiates the resection of clean DSBs by cleaving the 5' strand DNA approximately 10-20 nucleotid

268 initiate the repair of A:oxoG by selectively cleaving the A base from the A:oxoG base pair.

269 Siw14p is a pyrophosphatase specifically cleaving the beta phosphate from 5-diphosphoinositol pen

270 it prevents autolysins such as lysozyme from cleaving the PG.

271 he drug from the nanoparticle, but that once cleaved, the drug escapes the acidic endo-lysosomal comp

272 donuclease 1 (APE1) binds, but inefficiently cleaves, the AP for activation of vascular endothelial g

273 An endonuclease cleaves these into monomers, and a ligase seals these in

274 ted platelets released soluble activity that cleaved this pro-EGF1020-1027 peptide.

275 tastatic IECs contained both full-length and cleaved TLR3, demonstrating surface expression of both f

276 that the sequence of APP and possibly other cleaved TM helices may be designed, in part, to make the

277 IV-1 envelope spike [Env; trimeric (gp160)3, cleaved to (gp120/gp41)3] poses challenges for vaccine d

278 lpha-substituted homobenzylic aldehydes were cleaved to benzylic aldehydes and ketones, respectively,

279 entiated [4Fe-4S] cluster and is reductively cleaved to generate a 5'-deoxyadenosyl radical, which in

280 lpha-carotene, a provitamin A carotenoid, is cleaved to produce retinol (vitamin A) and alpha-retinol

281 ther reaction with NaTeC6H5 were reductively cleaved to provide 2 equiv of the corresponding aromatic

282 branched products could be straightforwardly cleaved to the corresponding esters or amides using a re

283 uinoline directing group that can be readily cleaved to unmask net beta,gamma-dicarbofunctionalized c

284 The outer layer proteins, VP4 (cleaved to VP8* and VP5*) and VP7, surround a transcript

285 The presence of cleaved transcripts of miRNA-targeted ARFs in C. roseus

286 lope glycoprotein (Env), such as the soluble cleaved trimer BG505 SOSIP, have improved the elicitatio

287 pendent, suggesting that CdiA-CT(EC869) only cleaves tRNA in the context of translationally active GT

288 Deubiquitinase enzymes cleave ubiquitin from substrates and are implicated in d

289 The CI-inducing DUB, CidB, cleaves ubiquitin from substrates and is encoded in a tw

290 that USP7 preferentially interacts with and cleaves ubiquitin moieties that have free Lys48 side cha

291 Assembled BoNT/X cleaves VAMP2 and VAMP4 in cultured neurons and causes f

292 Similar to BoNT/B/D/F/G, BoNT/X cleaves vesicle-associated membrane proteins (VAMP) 1, 2

293 sts of several components acting together to cleave viral DNA into unit length genomes and translocat

294 c thrombocytopenic purpura (cTTP) who cannot cleave VWF multimers because of genetic ADAMTS13 deficie

295 a folded state, its thioester bond could be cleaved with the small-molecule nucleophiles methylamine

296 e IIP restriction enzyme that recognizes and cleaves within the symmetric sequence 5'-TCGA-3'.

297 es coupled to the antibodies are efficiently cleaved without loss of protein target antigenicity.

298 nuclease (RNase), a key mediator of the UPR, cleaves Xbp1 mRNA to generate a potent transcription fac

299 nsitive to the reducing agent potential when cleaving xylan, suggesting that distinct catalytic mecha

300 ngly, the binding of YscP to the slowly self-cleaving YscU variant P264A conferred significant protec