ライフサイエンスコーパス: cleaved

1 4 of 51 of these proteins were substantially cleaved.

2 minal extension of SPI-1 was proteolytically cleaved.

3 the silica while the cytoplasmic region was cleaved.

4 ically similar peptides that do not bind are cleaved.

5 cific locus engineered into chromosome-1 and cleaved.

6 unintended off-targets might additionally be cleaved.

7 elles in which acid hydrolase substrates are cleaved.

8 stalled replication forks must therefore be cleaved.

9 ence that this domain is posttranslationally cleaved.

10 rt a pronounced ordering of hydroxyls on the cleaved (001) surface of Ca3Ru2O7 perovskite induced by

11 rt a pronounced ordering of hydroxyls on the cleaved (001) surface of the Ruddlesden-Popper perovskit

12 re-mRNA is recognized by the PB2 subunit and cleaved 10-13 nucleotides downstream of the cap by the e

13 We also find that the cleaved 3'-fragment retains its compacted pseudoknot fol

14 tures of the spliceosomal C complex with the cleaved 5' exon and lariat-3'-exon bound to the catalyti

15 hCG cleaved a few additional proteins, although this occurre

16 was associated with decreased expression of cleaved (activated) caspases 9 and 3, suggesting that Uc

17 /R1018Q/R1545Q, FV(DeltaIIa)) that cannot be cleaved/activated by thrombin or FXa also enhanced TFPI-

18 Interestingly, cleaved AIM retained a comparable potency with full-leng

19 Pre2, a nicked Pre2 derivative with a single cleaved Ala-470-Asn-471 bond.

20 Quantification of mature cleaved alphaENaC in membrane fractions showed that the

21 We have developed a cleaved amplified polymorphic sequence (CAPS) marker tig

22 vels of beta-secretase 1 (BACE-1) and BACE-1-cleaved amyloid precursor protein (APP) metabolites (sec

23 e similar in that trimethyllead (TML) is not cleaved and binds only to D99, whereas diethyllead (DEL)

24 he elementary reactions steps by which CO is cleaved and coupled at a single metal site.

25 ADAMTS-4 directly cleaved and degraded poly ADP ribose polymerase-1 (a key

26 We further show that it is cleaved and interacts with the JUN proto-oncogene, which

27 induced expression of pre-mRNAs prematurely cleaved and polyadenylated from cryptic polyadenylation

28 These previously undescribed prematurely cleaved and polyadenylated pre-mRNAs, some of which cont

29 qualitative changes (chlorogenic acids were cleaved and significant amounts of caffeic acid and feru

30 yet the cellular compartment where E3/49K is cleaved and the protease involved remained elusive.

31 be used to robustly rank and classify known cleaved and uncleaved peptides and that these structural

32 material was homogeneous (>95% pure), fully cleaved, and of the appropriate molecular weight and siz

33 G1/2 causes aberrant insertions by releasing cleaved antibody gene fragments that subsequently reinte

34 nal extension, or lacking the extension (pre-cleaved), are unable to complement an L27 deletion in St

35 The model amide is cleaved at an enzyme-like rate that renders the amide no

36 PAR2, which like PAR1 is also cleaved at an N-terminal arginine to unmask its tethered

37 Our data also show that ES7c is cleaved at early stages of the gene expression program t

38 s intact and in complex with Drs2p, which is cleaved at two positions, namely after Arg(104) and afte

39 The cleaved ATF6 fragment migrates to the nucleus to transcr

40 n reaction suggests that the N-H bond is not cleaved but serves to stabilize the turnover-determining

41 ) was discovered in which sugar substrate is cleaved but the products are not metabolised.

42 When the PYBs bind, the thiazolium ring is cleaved, but when the SCTs bind, ThDP is modified to thi

43 However, the propeptide is also cleaved by a furin-like proprotein convertase(s) (PCs) a

44 mines the propensity of a genomic site to be cleaved by a given sgRNA.

45 Therefore, Nrf1 must be cleaved by a non-proteasomal endoprotease that we show r

46 Once the peptide is recognized and cleaved by a protease, the ACC is released and produces

47 to be inactive against the insect but can be cleaved by a spruce beta-glucosidase, PgbetaGLU-1, which

48 Seizure protein 6 (SEZ6) is predominantly cleaved by BACE1, and Sez6 knockout mice share some phen

49 (AD), the amyloid precursor protein (APP) is cleaved by beta-secretase to generate a 99-aa C-terminal

50 Once internalized, heme is cleaved by both oxidative and nonoxidative mechanisms to

51 cleaved by the cocoa enzyme, (II) sequences cleaved by both pepsin and the cocoa enzyme, and (III) t

52 Here we provide evidence that VE-cadherin is cleaved by calpain upon entry into clathrin-enriched dom

53 PTPN13 is cleaved by calpain-2, which inactivates its phosphatase

54 IP3R1 can be cleaved by caspase or calpain into at least two receptor

55 Since PKCdelta can be proteolytically cleaved by caspase-3 during apoptosis, the prevailing as

56 e demonstrate that these fusion proteins are cleaved by caspases-1 and -11 at Asp-276.

57 The VC(S) linker was designed to be cleaved by cathepsin B, a lysosomal cysteine protease.

58 essing enzymes add to the number of epitopes cleaved by cathepsins, altogether generating a wider pep

59 by glycosidases, whereas O-glycans are often cleaved by chemical reaction.

60 The peptide substrate was cleaved by collagenase class I, II, Liberase MTF C/T, co

61 t interfering Ribonucleic Neutrals (siRNNs), cleaved by cytoplasmic enzymes into short interfering Ri

62 Interestingly, the peptide substrate was not cleaved by endogenous pancreatic protease such as trypsi

63 es such as benenodin-1 can be recognized and cleaved by enzymes called lasso peptide isopeptidases.

64 ap by strand displacement synthesis that was cleaved by Fen1, and DNA ligase sealed the nick for comp

65 Secreted osteopontin is cleaved by few known proteases, modulating its pro-infla

66 n addition, the adam13 cytoplasmic domain is cleaved by gamma secretase, translocates into the nucleu

67 The type 1-oriented stub is further cleaved by gamma-secretase at an -like site five amino a

68 99-aa C-terminal fragment (C99) that is then cleaved by gamma-secretase to generate the beta-amyloid

69 forward transport to the Golgi, where it is cleaved by Golgi-resident proteases, releasing the N-ter

70 ough peptide linkers that are designed to be cleaved by intracellular macrophage proteases.

71 only the native conformer of benenodin-1 is cleaved by its cognate isopeptidase.

72 Primary microRNA transcripts (pri-miRs) are cleaved by Microprocessor, a complex containing the RNas

73 the matrix compartment, Prx1 is sequentially cleaved by mitochondrial processing peptidase and then b

74 report, we identified the repertoire of RNAs cleaved by Mycobacterium tuberculosis toxin MazF-mt9 usi

75 Importantly, VISA was cleaved by nsp4 and released from mitochondrial membrane

76 They are made as proprotein dimers and then cleaved by proprotein convertases to release the C-termi

77 ying peptide substrates that are efficiently cleaved by proteases gives insights into substrate recog

78 ge of novel substrates that are specifically cleaved by RHBDL2, including the interleukin-6 receptor

79 Host-derived fibrin, the main substrate cleaved by Sak-activated plasminogen, was a major compon

80 S phase and are removed when cohesin Scc1 is cleaved by separase at anaphase onset.

81 transmembrane peptide substrates, which are cleaved by several unrelated rhomboid proteases, can be

82 The signal sequence is then cleaved by signal peptidase II (LspA) to give an N-termi

83 Brother (BB) and DA2, which are subsequently cleaved by the activated peptidase and destabilized.

84 and characterized: (I) sequences exclusively cleaved by the cocoa enzyme, (II) sequences cleaved by b

85 of COS-1 cells, mouse proprotein C is first cleaved by the convertases furin, PC5/6A, and PACE4.

86 xposed on the surface of the protein are not cleaved by the enzyme.

87 VWF is cleaved by the protease ADAMTS13 as a down-regulatory me

88 processing.Upon autophagy induction, LC3 is cleaved by the protease ATG4 and conjugated to the autop

89 w report that cytoplasmic DPPA3 is partially cleaved by the ubiquitin-proteasome system and an N-term

90 the thrombin-resistant R221A mutant is still cleaved by these PCs, revealing that convertase cleavage

91 Although avathrin is cleaved by thrombin, the C-terminal cleavage product con

92 ates are loaded into PIWI-clade proteins and cleaved by Zucchini/MitoPLD, yielding precursor piRNAs (

93 , PCY1 uses an unusual strategy in which the cleaved C-terminal follower peptide from the substrate s

94 We show that mature, cleaved, C-terminal AgRP, not the N-terminal domain, bin

95 Furthermore, reactive-center-cleaved C1INH attenuated pulmonary damage evoked by intr

96 s demonstrated by the use of reactive-center-cleaved C1INH, but dependent on its glycosylation status

97 wed widespread immunoreactivity for ZIKV and cleaved caspase 3 (CC3, a marker of apoptosis) throughou

98 ell death assessed via clonogenic assays and cleaved caspase 3 expression.

99 T-mediated dUTP biotin nick-end labeling and cleaved caspase 3 immunofluorescence.

100 (E12.5) according to both TUNEL staining and cleaved caspase 3 immunofluorescence.

101 cted and analyzed for apoptosis induction by cleaved caspase 3 immunohistochemistry.

102 n 1 (MCP-1), TNF-alpha, and IL-6 and hepatic cleaved caspase 3 in mice fed either a normal chow diet

103 4, cleaved Poly ADP-Ribosyl Polymerase 1 and cleaved Caspase 3 levels with a parallel decrease in ant

104 The effects of mTOR activation on hepatic cleaved caspase 3 were reversed by rapamycin, an inhibit

105 -) macrophages exhibit reduced expression of cleaved caspase-1 and NLRP3.

106 tress markers (BiP, pIRE1alpha, sXBP1, CHOP, cleaved caspase-12) were increased in septic WT mice, bu

107 unting and autoradiography and compared with cleaved caspase-3 (CC3) activation and DNA fragmentation

108 Immunohistochemistry for cleaved caspase-3 (CC3) revealed significantly increased

109 Increased apoptosis by cleaved caspase-3 (P = 0.03) and decreased proliferation

110 ity in the tumors positively correlated with cleaved caspase-3 (r = 0.85, P < 0.001) and TUNEL (r = 0

111 ERK, together with a decreased expression of cleaved caspase-3 in mice treated with 6-OHDA or rotenon

112 r than pyroptosis, as indicated by increased cleaved caspase-3 levels and the absence of caspase-1.

113 hosphohistone H3 staining, cell counting and cleaved caspase-3 levels.

114 , quantified by TUNEL positive myonuclei and cleaved caspase-3 positive myonuclei, was also elevated

115 disturbed distribution of cytochrome c, and cleaved caspase-3 positive staining indicated that incre

116 staining; p < 0.03) and apoptosis induction (cleaved Caspase-3 staining; p < 0.001) when compared to

117 Medial apoptosis (cleaved caspase-3) was significantly reduced by NOD.

118 nuating abnormal levels of Abeta1-42, p-Tau, cleaved caspase-3, and cleaved PARP proteins.

119 /-) mice had the lowest renal levels of Bax, cleaved caspase-3, and NADPH oxidase-4 expression and re

120 xpressions of Fas, Fas-L, Bax/Bcl-2, cyto-c, cleaved caspase-3, and PARP in a dose-dependent manner,

121 was validated ex vivo using gamma-counting, cleaved caspase-3, and terminal deoxynucleotidyl transfe

122 miR-K9 also decreased the protein levels of cleaved caspase-3, cleaved caspase-7, and cleaved poly(A

123 rated on mice, which correlated with reduced cleaved caspase-3, p85alpha, and Trp53.

124 tern blot were used to validate apoptosis by cleaved caspase-3, proliferation by Ki67, and pathway in

125 histologic markers of cell death, including cleaved caspase-3, whereas there was no such correlation

126 sed the protein levels of cleaved caspase-3, cleaved caspase-7, and cleaved poly(ADP-ribose) polymera

127 NA damage (H2AX) and apoptotic markers (p53, cleaved caspase-7, and TUNEL-positive cells).

128 a acetylated MnSOD(K68) Murine AEC SIRT3 and cleaved caspase-9 (CC-9) expression were assayed by immu

129 f the growth plate, accompanied by decreased cleaved caspase-9.

130 mmation (CD68) decreased and apoptosis (anti-cleaved-caspase 3 antibody) increased in aortic sinus sl

131 tasis was associated with activation of Bax, cleaved caspases-3 and -9, and down-regulation of Bcl-2,

132 experiments indicated that the C-terminally cleaved CaValpha2delta1 proteins up-regulate CaV1.2 chan

133 Metalloprotease-cleaved CD95L (cl-CD95L) is released into the bloodstrea

134 blocking fragment (extracellular portion of cleaved CDCP1) lead to increased LD abundance in primary

135 Factor XIa (FXIa) cleaved chem163S, generating a novel chemerin form, chem

136 Continuity of the highly extended, cleaved chromatin is also maintained, consistent with fo

137 stabilize a naturally occurring efficiently cleaved clade C Env, namely 4-2.J41, isolated from an In

138 ebrand factor type A (VWA) domain within the cleaved CLCA1 N-terminal fragment is necessary and suffi

139 Finally, we show that cleaved CLEC14A binds to sprouting endothelial tip cells

140 We assessed the in vivo role of cleaved CLEC14A in angiogenesis by using the rodent subc

141 Additionally, fluorescence signal from cleaved CNIR800 reaches maximal levels 4-6 hours after a

142 the synchrotron structure, the Fe-CO bond is cleaved; CO relocates to a new site near CuB, which, in

143 ex with calcium ions; and a DNA-bound, fully cleaved complex with magnesium ions.

144 nalysis of lactate dehydrogenase and caspase-cleaved cytokeratin 18 in the perfused medium.

145 ence of cholesterol, trypsin or proteinase K cleaved cytosolic loop 4, generating a protected fragmen

146 e cleavage, while 3' overhanging termini are cleaved distributively.

147 MMP9 highly efficiently cleaved DSP into distinct fragments in vitro, and the de

148 and a C-terminal fragment, which is further cleaved during apoptosis.

149 Both LTPs are initially cleaved during gastroduodenal proteolysis at three major

150 have shown that mature cytoplasmic tRNAs are cleaved during stress response to produce tRNA fragments

151 This bifunctional marker was efficiently cleaved during virus maturation, producing free mCherry

152 s epithelia to mucosal secretions, where the cleaved ectodomain (secretory component; SC) becomes a c

153 utants, indicating that concatemeric DNA was cleaved efficiently.

154 Oct1 cleaved eight amino acid residues from the N-terminal re

155 The cleaved ends are difficult to repair in vivo, which may

156 rolysed by CD38, whereas 8-Br-L-cIDPR is not cleaved, even at high enzyme concentrations.

157 pepsin and the cocoa enzyme, and (III) those cleaved exclusively by pepsin.

158 rexpressed in ovarian cancer tumors, and its cleaved extracellular domain can be detected in the seru

159 xhibited restricted specificity for protease-cleaved F(ab')2 fragments and did not bind the intact Ig

160 and testable on a wafer scale, requiring no cleaved facets or special mirror coating to function.

161 Rather, chymase cleaved fibronectin, inhibited ASM adhesion, and attenua

162 IPA14 is a hemolymph protein that is rapidly cleaved following a systemic infection.

163 , Singh et al. (1) showed that the truncated cleaved form of neurotransmitter neuropeptide Y (NPY) ac

164 e previously discovered that an N-terminally-cleaved form of RXRalpha (tRXRalpha), produced in tumour

165 n, intact Dkk4 inhibits MG extension but the cleaved form progressively increases during MG developme

166 +)/Cl(-) cotransporter (NCC), claudin-7, and cleaved forms of epithelial Na(+) channel (ENaC) alpha a

167 in D), the pore-forming effector protein, is cleaved, forms oligomers, and inserts into the membranes

168 been shown for whole 3'-UTRs as well as for cleaved fragments.

169 The short CLE peptide (12-13 amino acids) is cleaved from a larger pre-propeptide and functions as an

170 NLGN3 is cleaved from both neurons and oligodendrocyte precursor

171 Monomeric herpesvirus DNA is cleaved from concatemers and inserted into preformed cap

172 t markers of protein metabolism, as they are cleaved from larger polypeptides and proteins.

173 dation products, but are rather specifically cleaved from mature tRNA transcripts.

174 heir chromophore, phycocyanobilin (PCB), was cleaved from the apoprotein by solvolysis in alcohols an

175 hat the C-terminal kinase domain of TRPM6 is cleaved from the channel domain in a cell type-specific

176 gion and a DNA binding domain (DBD), is auto-cleaved from the ER membrane, and then enters the nucleu

177 ith a tight bicyclic core that appears to be cleaved from the middle of a larger 30-residue precursor

178 l region (RH5Nt) of unknown function that is cleaved from the native protein.

179 The asymmetric particles were easily cleaved from the resin without aggregation.

180 regions (ECRs) that are autoproteolytically cleaved from their membrane-embedded signaling domains.

181 ell-surface NHE3, NKCC2, NCC, alpha-ENaC and cleaved gamma-ENaC compared to NSD.

182 ve phosphorylation, was post-translationally cleaved generating differential amounts of long and shor

183 of a small group of genes and that most H3NT-cleaved genes displayed significant expression changes d

184 Indeed, the cleaved GIRK2 displays reduced binding to Gbetagamma and

185 assessed by measurement of plasma levels of cleaved high-molecular-weight kininogen, and efficacy wa

186 nd yeast surface display to produce properly cleaved HIV-1 Env variants that lack all 15 core gp120 g

187 ssed a single-surface endo-acting lyase that cleaved HS, reflecting its higher molecular weight compa

188 In contrast, AHA levels against pepsin-cleaved IgG2 were comparable.

189 tory AHA reactivity in RA was against pepsin-cleaved IgG4, with a 35% prevalence, >/=5.8-fold higher

190 Interestingly, both enzymes readily cleaved IL-18 and IL-33, two IL-1-related alarmins, as w

191 consequently, apoptosis whilst being itself cleaved in a caspase-8-dependent manner.

192 strate that exogenously administered CgA was cleaved in favor of the proangiogenic form and was assoc

193 anabolic pathway (re-)builds carbon bonds as cleaved in glycolysis in an aldol condensation of the un

194 receptor binding at synapses the receptor is cleaved in its transmembrane domain and releases a prote

195 RNAs from all three transcripts are cleaved in places not on path for circle formation, like

196 SREBPs are cleaved in the Golgi through the combined action of the

197 PawS1 was cleaved in vitro with recombinant sunflower HaAEP1 and i

198 CTGF is cleaved in vivo into distinct domains.

199 ocalize to the ER membrane and that they are cleaved into active N-terminal fragments, which then tra

200 In vivo, Slit is proteolytically cleaved into N- and C-terminal fragments, but the biolog

201 arasite, but unlike other LCAT enzymes it is cleaved into two proteolytic fragments that share the re

202 The cleaved kinase translocates to the nucleus, where it is

203 TRPM6-cleaved kinases (M6CKs) bind subunits of the protein arg

204 In contrast to other rhamnosidases, BT3686 cleaved l-Rha-alpha1,4-d-GlcA linkages through a retaini

205 that high expression of the autophagy marker cleaved LC3 expression correlates with poor clinical out

206 usly happens until all of the RNA probes are cleaved, leaving the nanoparticles unprotected and thus

207 e linked basic groups to insulin via a light cleaved linker.

208 insoluble but injectable polymer via a light cleaved linker.

209 d the association of total (M65) and caspase-cleaved (M30) serum keratin-18 fragments (n = 204) with

210 luble native trimeric form of an efficiently cleaved membrane-bound Env, 4-2.J41, may be beneficial f

211 rminal four-C2 domain module; and 4) calpain-cleaved mini-dysferlinC72, which is particularly resista

212 different mass concentrations of intact and cleaved molecular forms.

213 ee new components in the cavity of hexon-the cleaved N terminus of precursor protein VI (pVIn), the c

214 terminus of precursor protein VI (pVIn), the cleaved N terminus of precursor protein VII (pVIIn2), an

215 The cleaved N-terminal domain binds phosphoinositides and ca

216 from lipid rafts to nonlipid rafts where it cleaved Notch.

217 he Notch pathway by nuclear translocation of cleaved Notch1 intracellular domain (NICD) and upregulat

218 After C1 treatment, cleaved nucleolar proteins were identified by proteomic

219 The present study investigates whether the cleaved occludin is released into the blood stream and h

220 ing the plasma membrane, signal peptides are cleaved off and mature domains reach their destinations

221 is synthesized with a C-terminal extension, cleaved off by a specific endopeptidase during maturatio

222 ed that the RxLR sequence of native AVR3a is cleaved off prior to secretion by the pathogen and the N

223 Following the ligation reaction, SpyTag is cleaved off, rendering PBSL traceless, and only the labe

224 o acid ester moiety, which are enzymatically cleaved-off inside cells to release the free nucleoside

225 ived OPN for HSC aging and identify thrombin-cleaved OPN as a novel niche informed therapeutic approa

226 Exposure of aged HSCs to thrombin-cleaved OPN attenuates aging of old HSCs, resulting in i

227 D2768 which contains an SPQTG motif, are not cleaved or anchored to the cell wall by sortase.

228 ORF2 (ORF2i), glycosylated ORF2 (ORF2g), and cleaved ORF2 (ORF2c).

229 sion molecule-1 and endocan [full-length and cleaved p14 fragment]) were obtained before and after LT

230 However, the fate of the cleaved p75 TM domain is unknown.

231 of Abeta1-42, p-Tau, cleaved caspase-3, and cleaved PARP proteins.

232 Recombinant HaAEP1 cleaved PawS1 at multiple positions, and in situ, its fl

233 which one biotinylated electrochemistry (EC)-cleaved peptide was identified after affinity enrichment

234 Furthermore, 3C cleaved PinX1 at the site of Q50-G51 pair through its pr

235 in N-termini to comprehensively characterize cleaved podocyte proteins in the glomerulus in vivo We f

236 we found overexpression of caspase-3, higher cleaved poly (ADP-ribose) polymerase levels (p < 0.007),

237 shown by an increase in Bcl2-like protein 4, cleaved Poly ADP-Ribosyl Polymerase 1 and cleaved Caspas

238 of cleaved caspase-3, cleaved caspase-7, and cleaved poly(ADP-ribose) polymerase (PARP).

239 is, as reflected by caspase-3/7 activity and cleaved poly(ADP-ribose) polymerase, in different cell l

240 hased, trans-acting siRNAs (tasiRNAs), whose cleaved precursor fragments are converted to double-stra

241 Cleaved presequence peptides then need to be efficiently

242 ures of the unprocessed precursor and of the cleaved pro-mature complex.

243 pendent cleavage, resulting in releasing the cleaved product containing a fluorophore.

244 Competition assays showed that both cleaved products are required for the PDI phenotype alth

245 beta-Amyloid precursor protein (APP) and its cleaved products are strongly implicated in Alzheimer's

246 rates low coverage reads at both ends of the cleaved products, we corrected this loss of sequencing c

247 d, an unexpected in vivo abundance of stable cleaved proteins revealed pervasive, functionally releva

248 Following TBI, calpain-2 activation cleaved PTPN13, activated c-Abl and triggered tau tyrosi

249 e reaction is that the stronger Ph-O bond is cleaved rather than the weaker aliphatic O-R bond.

250 ase-like enzymes based on the amino acids in cleaved reactive sites.

251 Both enzymes cleaved recombinant HA from several strains of the H1 an

252 In vitro, kallikrein cleaved recombinant human CHGA to catestatin, verified b

253 lex 2 creates completed complex 2 which when cleaved releases additional Driver Fragment 1.

254 ontaining multiple cleavage sites that, when cleaved, releases multiple bioactive peptides.

255 e mechanism by which the transposon ends are cleaved remained unknown.

256 I transmembrane protein that is subsequently cleaved, resulting in secretion of its large ectodomain

257 rd of a slit allele (slit-UC) that cannot be cleaved revealed that midline repulsion is still present

258 The 5' cleaved RNA fragments are marked with uridylation for de

259 The 3'-end of cleaved RNA(3'-rA) consists of 2',3'-cyclic phosphate wh

260 Cmr-alpha cleaved RNAs complementary to crRNA present in the compl

261 Moreover, the 60S subunits containing ES7c-cleaved rRNA cofractionate with intact subunits in sucro

262 Soluble-cleaved (sc) uPAR levels were determined in serum throug

263 Fusion occurs only after S proteins are cleaved sequentially, first during their secretion throu

264 by fusogenic complexes incorporating BoNT/A-cleaved SNAP-25.

265 envelope structure has depended in part on a cleaved, soluble trimer, known as SOSIP.664, stabilized

266 13, cryo-EM and x-ray structures of soluble, cleaved SOSIP Env trimers from the clade A BG505 strain

267 hat specific enrichment of electrochemically cleaved spirolactone-containing peptides can be used for

268 so suggests a possible link between decay of cleaved target mRNAs and miRNA stability in RISC.

269 Furthermore, hepsin directly cleaved the aggrecan core protein at a novel cleavage si

270 It cleaved the C-As bond in aromatic arsenicals such as the

271 Raney Ni reduction of antatollamide A cleaved the dimer to the corresponding monomeric cyclic

272 particular glycan modifications, yet always cleaved the peptide bond immediately preceding the glyco

273 riptase to an active protease, which in turn cleaved the pericellular substrates protease-activated r

274 he drug from the nanoparticle, but that once cleaved, the drug escapes the acidic endo-lysosomal comp

275 ted platelets released soluble activity that cleaved this pro-EGF1020-1027 peptide.

276 tastatic IECs contained both full-length and cleaved TLR3, demonstrating surface expression of both f

277 e dynamic redistribution and accumulation of cleaved TLR9 to phagosomes.

278 that the sequence of APP and possibly other cleaved TM helices may be designed, in part, to make the

279 HIV-1 envelope spike [Env; trimeric (gp160)3 cleaved to (gp120/gp41)3] induces membrane fusion, leadi

280 IV-1 envelope spike [Env; trimeric (gp160)3, cleaved to (gp120/gp41)3] poses challenges for vaccine d

281 lpha-substituted homobenzylic aldehydes were cleaved to benzylic aldehydes and ketones, respectively,

282 entiated [4Fe-4S] cluster and is reductively cleaved to generate a 5'-deoxyadenosyl radical, which in

283 elenium, the B-B and C(1) -H bonds of 8 were cleaved to give the cyclic 1,9-diborylanthracene 9.

284 lpha-carotene, a provitamin A carotenoid, is cleaved to produce retinol (vitamin A) and alpha-retinol

285 Although the C4-H bond that must be cleaved to produce the chol 4-OOH and 6-OOH products is

286 ther reaction with NaTeC6H5 were reductively cleaved to provide 2 equiv of the corresponding aromatic

287 ssembled, transported into the periplasm and cleaved to release the mature product(7-10).

288 branched products could be straightforwardly cleaved to the corresponding esters or amides using a re

289 ident protein, to the Golgi where SREBP-2 is cleaved to translocate to the nucleus and activate gene

290 uinoline directing group that can be readily cleaved to unmask net beta,gamma-dicarbofunctionalized c

291 The outer layer proteins, VP4 (cleaved to VP8* and VP5*) and VP7, surround a transcript

292 The presence of cleaved transcripts of miRNA-targeted ARFs in C. roseus

293 solution from those adopted by a stabilized, cleaved trimer (SOSIP) or by a membrane-bound Env trimer

294 lope glycoprotein (Env), such as the soluble cleaved trimer BG505 SOSIP, have improved the elicitatio

295 ans we confirmed that this engineered Env is cleaved, trimeric, and it retains its native-like quater

296 inimal orthoester formation, while it can be cleaved under mild conditions.

297 tosol via N-terminal presequences, which are cleaved upon exposure to the mitochondrial processing pr

298 e stable, we show that it can be efficiently cleaved upon treatment with dithionite.

299 This cleaved villin fragment severs actin in an unregulated f

300 A metabolite in which one of the rings was cleaved was not a ligand.

301 a folded state, its thioester bond could be cleaved with the small-molecule nucleophiles methylamine

302 es coupled to the antibodies are efficiently cleaved without loss of protein target antigenicity.