ライフサイエンスコーパス: cleft palate

1 facial processes that leads to cleft lip and cleft palate.

2 tiology of common congenital defects such as cleft palate.

3 h SBBYSS also have thyroid abnormalities and cleft palate.

4 ary and mandibular skeletal deformation, and cleft palate.

5 l interaction and a novel genetic factor for cleft palate.

6 /-);bt/bt mice, which have a fully penetrant cleft palate.

7 ociation study of cleft lip with and without cleft palate.

8 shortly after birth, most likely because of cleft palate.

9 potential therapeutic approach for rescuing cleft palate.

10 in the palatal mesenchyme, exhibit isolated cleft palate.

11 n signaling pathway, leads to cleft lip with cleft palate.

12 e processes leads to the congenital anomaly, cleft palate.

13 pear to be associated with increased risk of cleft palate.

14 enesis, and they provide candidate genes for cleft palate.

15 causes craniofacial abnormalities, including cleft palate.

16 , in particular those with cleft lip but not cleft palate.

17 on of the palatal shelves and, subsequently, cleft palate.

18 A single patient had a cleft palate.

19 is associated with human defects, including cleft palate.

20 ds to abnormal oral epithelial adhesions and cleft palate.

21 caused severe craniofacial defects including cleft palate.

22 te fusion during embryogenesis is a cause of cleft palate.

23 o similar patterns were observed for risk of cleft palate.

24 ed or nonsyndromic cleft lip with or without cleft palate.

25 levation of the palatal shelves leading to a cleft palate.

26 lay in palatal shelf elevation, resulting in cleft palate.

27 ent, resulting in the common birth defect of cleft palate.

28 r contributors to cleft lip, with or without cleft palate.

29 of the GABA synthetic enzyme (Gad1) leads to cleft palate.

30 ecause of aortic arch defects and a severely cleft palate.

31 d disruption of their activity may result in cleft palate.

32 dontia, ankyloblepharon and cleft lip and/or cleft palate.

33 d granular keratinocyte differentiation, and cleft palate.

34 ial malformations such as dental defects and cleft palate.

35 ain patterning, hydrocephalus incidence, and cleft palate.

36 respiratory failure, neonatal lethality and cleft palate.

37 d abnormal oral periderm and 17% developed a cleft palate.

38 craniosynostosis, mandibular hypoplasia and cleft palate.

39 ar to that of Tgfbr2 mutant mice, as well as cleft palate.

40 mus hypoplasia, cardiovascular anomalies and cleft palates.

41 eborn infants with cleft lip with or without cleft palate, 123 with cleft palate, 163 with conotrunca

42 t lip with or without cleft palate, 123 with cleft palate, 163 with conotruncal heart defects, and 36

43 e 377 infants with cleft lip with or without cleft palate, 196 with cleft palate only, and 763 contro

44 in midline facial development, ranging from cleft palate (52%) to complete cleft face (44%).

45 ds ratio = 3.2 for cleft lip with or without cleft palate (95% confidence interval: 1.0, 10.2) and od

46 bation of any of these processes could cause cleft palate, a common birth defect that significantly a

47 is a useful genetic model for non-syndromic cleft palate, a common congenital disorder.

48 ects in any of these processes can result in cleft palate, a common human birth defect.

49 ions in secondary palate fusion will lead to cleft palate, a common human birth defect.

50 tt homozygotes also show facial clefting and cleft palate abnormalities.

51 nt phenotypes: (1) cleft lip with or without cleft palate and (2) cleft palate only.

52 98, there were 1,572 cases of cleft lip with cleft palate and 1,122 cases with cleft lip only.

53 bryos having exencephaly, pericardial edema, cleft palate and abnormal limb development, phenotypes n

54 le homozygous mutant for either gene exhibit cleft palate and an early arrest of tooth formation.

55 X-linked cleft palate and ankyloglossia results from loss-of-func

56 ault, hypertelorism, open-bite malocclusion, cleft palate and arrested tooth development.

57 generally divided into two groups, isolated cleft palate and cleft lip with or without cleft palate,

58 autosomal-dominant disorder characterized by cleft palate and congenital contractures of the hands an

59 ew causes of developmental disorders such as cleft palate and congenital heart disease.

60 terns in most tissues and completely rescued cleft palate and cranial skeletal developmental defects

61 chromosome Xq22.1 associates with epilepsy, cleft palate and developmental defects in heterozygous f

62 Deletion of mouse Kir2.1 also causes cleft palate and digital defects.

63 However, despite of formation of cleft palate and ectopic cartilage, forced expression of

64 ester exposure to inhaled beta2-agonists for cleft palate and gastroschisis and found a potential new

65 lications, atresia, fistulas, hypertelorism, cleft palate and hamartoma.

66 are 5-fold more sensitive to dioxin-induced cleft palate and hydronephrosis as compared with embryos

67 he Ahr locus that influence the incidence of cleft palate and hydronephrosis in developing mice expos

68 2,3,7,8-tetrachlorodibenzo-p-dioxin) induces cleft palate and hydronephrosis in mice, when exposed in

69 The incidence of cleft palate and hydronephrosis was not significantly di

70 The incidences of cleft palate and hydronephrosis were assessed and genomi

71 tor or its ligand endothelin-1 (ET-1) causes cleft palate and hypoplasia of the mandible, otic cup, a

72 as performed on a subject with micrognathia, cleft palate and hypotonia that harbored a de novo, bala

73 tion of multiple genes genetically linked to cleft palate and identify AP-2alpha (TFAP2A) as a co-reg

74 aneurysms, hypertelorism, and bifid uvula or cleft palate and is caused by heterozygous mutations in

75 ciated with different malformations, such as cleft palate and limb deformation, resembling the human

76 l levels, had craniofacial defects including cleft palate and micrognathia, and limb patterning defec

77 lead to PNH associated with toe syndactyly, cleft palate and neurodevelopmental delay.

78 lopmental defects in Osr1(-/-) mice and with cleft palate and open eyelids at birth in Osr2(-/-) mice

79 neural crest cells leads to perinatal death, cleft palate and other cranial bone defects, which are a

80 the X-linked human EPHRIN-B1 gene result in cleft palate and other craniofacial anomalies as part of

81 in new approaches to defining the causes of cleft palate and other facial clefts that may result fro

82 f these cells leads to birth defects such as cleft palate and persistent truncus arteriosus (PTA).

83 iopathy phenotypes, including cystic kidney, cleft palate and polydactyly.

84 We apply our method to data on cleft lip/cleft palate and schizophrenia.

85 Cleft palate and skull malformations represent some of t

86 eobox gene are associated with non-syndromic cleft palate and tooth agenesis in humans.

87 vascular defects were also found, along with cleft palates and ectopically located thymi, in Wnt1-Cre

88 ithout cleft palate (CL/P), 99 with isolated cleft palate, and 588 controls from a California populat

89 ognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic "question-mark" ear m

90 dline defects, excencephaly, hyperterlorism, cleft palate, and a striking loss of many NC and paraxia

91 first trimester, mothers of limb deficiency, cleft palate, and cleft lip cases were, respectively, 1.

92 acterized by hypoplasia of the facial bones, cleft palate, and middle and external ear defects.

93 m, small mandible, syndactyly, clinodactyly, cleft palate, and scoliosis, which, together with cardio

94 sks were seen in children with microcephaly, cleft palate, and selected eye, cardiac, and renal defec

95 drome in humans, the most common syndrome of cleft palate, and the most common syndrome of conotrunca

96 ities, including anophthalmia, microcephaly, cleft palates, and mandibular malformations.

97 Fallot, coarctation of the aorta, cleft lip, cleft palate, anorectal atresia/stenosis, and limb reduc

98 identified associations with cleft lip with cleft palate (aOR = 1.23) and anorectal atresia/stenosis

99 prises long nose, small mouth, micrognathia, cleft palate, arachnodactyly and intellectual disability

100 r without cleft palate (CL+/-P) and isolated cleft palate are influenced by variation at several loci

101 vidence that the risks of CL+/-P or isolated cleft palate are related to the RARA variant analyzed.

102 uman phenotypes, including craniosynostosis, cleft palate, arterial aneurysms, congenital heart disea

103 f epithelial differentiation that results in cleft palate as a consequence of adhesion between the pa

104 7% of the mixed background mutants displayed cleft palate as well as retardation of skull development

105 in Nog mutants that may be relevant to human cleft palate as well.

106 ibular hypoplasia that leads to agnathia and cleft palate at birth.

107 xial polydactyly, heart defects, hypomastia, cleft palate/bifid uvula, progressive scoliosis, and str

108 ibution of cleft lip only and cleft lip with cleft palate by covariate.

109 to neurocristopathies such as cleft-lip and cleft-palate, cardiac septal defects, and eye defects.

110 of defects with reduced penetrance, such as cleft palate, choanal atresia, septal defects of the hea

111 ion would decrease cleft lip with or without cleft palate (CL +/- P) risk and that menstrual regulati

112 sk of nonsyndromic cleft lip with or without cleft palate (CL+/-P) and isolated cleft palate (CP) is

113 ks of nonsyndromic cleft lip with or without cleft palate (CL+/-P) and isolated cleft palate are infl

114 3 individuals with cleft lip with or without cleft palate (CL/P) and 19 individuals with both orofaci

115 a novel locus for cleft lip with or without cleft palate (CL/P) at 9q22-q33.

116 ed or nonsyndromic cleft lip with or without cleft palate (CL/P) is a common birth defect with a comp

117 Cleft lip with or without cleft palate (CL/P) is a common congenital anomaly.

118 Non-syndromic (NS) cleft lip with or without cleft palate (CL/P) is a common disorder with a strong g

119 ork suggested that cleft lip with or without cleft palate (CL/P) is genetically distinct from isolate

120 Cleft lip with or without cleft palate (CL/P) is one of the most common congenital

121 s with the risk of cleft lip with or without cleft palate (CL/P) or cleft palate (CP).

122 ants with isolated cleft lip with or without cleft palate (CL/P), 99 with isolated cleft palate, and

123 lude non-syndromic cleft lip with or without cleft palate (CL/P), are among the most common birth def

124 orofacial clefting, including cleft lip and cleft palate (CL/P).

125 ibrium test analysis, cleft lip with/without cleft palate, cleft lip with palate plus cleft palate on

126 exposure to inhaled steroids were confirmed (cleft palate, cleft lip, anal atresia, and hypospadias).

127 er craniofacial defects, middle-ear defects, cleft palate, cleft lip, limb defects, limb-reduction de

128 Cleft lip and cleft palate (CLP) are common disorders that occur eithe

129 cleft palate (CP), cleft lip with or without cleft palate (CLP), conotruncal defects, or limb deficie

130 hree common diseases, isolated cleft lip and cleft palate (CLP), hypothyroidism and thyroid cancer al

131 aly, spina bifida, cleft lip with or without cleft palate (CLP), or cleft palate only.

132 ave implications for the pathogenesis of the cleft palate component of Smith-Lemli-Opitz syndrome and

133 Micrognathia, glossoptosis, and cleft palate comprise one of the most common malformatio

134 and effective therapies for the treatment of cleft palate conditions and other single-gene disorders

135 fidget mutations die soon after birth due to cleft palate, consistent with the overlapping expression

136 t lip and palate (CLP) cases than seen among cleft palate (CP) and cleft lip (CL) cases.

137 The cleft palate (CP) appears to be the result of micrognath

138 ip with or without palate (CLP) and isolated cleft palate (CP) are common human developmental malform

139 Cleft palate (CP) is a common birth defect occurring in

140 r without cleft palate (CL+/-P) and isolated cleft palate (CP) is influenced by genetic variation at

141 Isolated cleft palate (CP) was also associated, indicating that F

142 IRF6 was also associated with cleft palate (CP) with impaction of permanent teeth (p<1

143 s increased risks of delivering infants with cleft palate (CP), cleft lip with or without cleft palat

144 t lip with or without cleft palate (CL/P) or cleft palate (CP).

145 which haploinsufficiency results in isolated cleft palate (CPO).

146 missense mutations in patients with X-linked cleft palate (CPX) and ankyloglossia.

147 syndrome (BOFS) is a rare autosomal-dominant cleft palate-craniofacial disorder with variable express

148 e method of Farrall and Holder for cleft lip/cleft palate data is not consistent with the prevalence

149 n in the palatal epithelium does not cause a cleft palate defect, we conclude from our results that N

150 the ectodysplasin (Eda) pathway, can resolve cleft palate defects in Pax9(-/-) embryos in utero.

151 e type of alcohol consumed, particularly for cleft palate (distilled spirits > wine > beer).

152 In zebrafish, untreated pdgfra mutants have cleft palate due to defective neural crest cell migratio

153 e, heterozygosity for the deletion manifests cleft palate, early postnatal lethality, postnatal growt

154 : a failure in midline fusion resulting in a cleft palate, ectopia cordis, and a large omphalocele.

155 to Jeff heterozygotes, Jeff homozygotes show cleft palate, facial clefting and perinatal lethality.

156 Recent data suggest that the risk of cleft palate formation after in-utero glucocorticoid exp

157 cer also leads to a hypoplastic mandible and cleft palate formation in mice.

158 medial edge seam (MES), ultimately causing a cleft palate formation, a phenotype resembling that in T

159 Loss of BMP signaling leads to cleft palate formation.

160 cluding hepatomegaly, thymic involution, and cleft palate formation.

161 the first trimester may increase the risk of cleft palate formation.

162 ngenital anomalies, including heart defects, cleft palate, fusion of the ribs, short limbs, distal co

163 x22, the mouse homolog of the human X-linked cleft palate gene, as a putative downstream target of Mn

164 However, individuals with isolated cleft palate had increased health risks and mortality.

165 it the cessation of DNA synthesis and induce cleft palate; however, the precise intracellular mechani

166 pproximately 6-fold increased sensitivity to cleft palate, hydronephrosis, and lethality.

167 Individuals with isolated cleft palate (ie, without cleft lip) had increased morta

168 n in the Golgb1 gene that co-segregated with cleft palate in a new mutant mouse line.

169 sforming growth factor alpha (TGFA) gene and cleft palate in an Irish study.

170 g protein, SATB2, result in micrognathia and cleft palate in both humans and mice.

171 loinsufficiency led to greater penetrance of cleft palate in bt mice, with a similar defect in palata

172 sis is reflected by the common occurrence of cleft palate in humans.

173 IRF6 disrupt orofacial development and cause cleft palate in humans.

174 ads to craniofacial malformations, including cleft palate in mice (Tgfbr2(fl/fl);Wnt1-Cre mice).

175 d Pitx2 loss of function mutations result in cleft palate in mice.

176 ASK or SAP97, another MAGUK protein, lead to cleft palate in mice.

177 mutations are associated with cleft lip and cleft palate in mice; however, the cause of these defect

178 suggest an indirect mechanism for secondary cleft palate in Nog mutants that may be relevant to huma

179 similar exposure of CBA/J (CBA) dams led to cleft palate in only 8% and hydronephrosis in 69% of emb

180 factor in the development of phocomelia and cleft palate in RBS.

181 Additionally, we found that the cleft palate in Rspo2(-/-) mice is not associated with d

182 Cleft palate in Snai1(+/-) Snai2(-/-) embryos is due to

183 Cleft palate in Tgfbr2 mutant mice results from a cell p

184 Cleft palate in these mice was associated with delay/fai

185 either unilateral or bilateral cleft lip and cleft palate in two male siblings.

186 therapies that can either prevent or correct cleft palates in humans.

187 bers cause craniofacial deformities, such as cleft palate, in mice.

188 lead to pharmacological approaches to reduce cleft palate incidence in genetically predisposed humans

189 Cleft palate, including submucous cleft palate, is among

190 Homozygous null mice display cleft palate, incomplete fusion of the ribs at the midli

191 mong individuals with isolated cleft lip and cleft palate, increased risks of intellectual disability

192 severe developmental disorder manifested by cleft palate, intellectual disability, and skeletal abno

193 Cleft lip with or without cleft palate is a common birth defect affecting 1 in eve

194 Cleft palate is a common birth defect caused by disrupti

195 Cleft palate is a common birth defect in humans and is a

196 Cleft palate is a common birth defect in humans.

197 Cleft palate is a common major birth defect for which cu

198 A possible cause of cleft palate is a delay of proper palatal shelf elevatio

199 Cleft palate is among the most common birth defects in h

200 of the developing palatal shelves, submucous cleft palate is characterized by defects in palatal bone

201 egions of the genome play in the etiology of cleft palate is not well studied.

202 Cleft palate is one of the most common birth defects in

203 Cleft palate is one of the most common birth defects in

204 Cleft palate is one of the most common human birth defec

205 Cleft lip with or without cleft palate is the most common congenital malformation

206 rning normal palatogenesis nor the causes of cleft palate is well understood.

207 Cleft palate, including submucous cleft palate, is among the most common birth defects in

208 have no cranial defects (Lhx6) or show only cleft palate (Lhx7).

209 been identified as genetic risk factors for cleft palate, little is known about the relationship bet

210 y associated with cleft lip with and without cleft palate (MAFB, most significant SNP rs13041247, wit

211 Wnt1-Cre;Erk2(fl/fl) mice exhibited cleft palate, malformed tongue, micrognathia and mandibu

212 ectrum of craniofacial defects that included cleft palate, mandibular hypoplasia and cartilage malfor

213 Although cleft lip with cleft palate may simply represent a more severe form of

214 These mutants also show complete secondary cleft palate, most likely due to inhibition of posterior

215 y with an X-linked lethal disorder involving cleft palate, neonatal seizures, contractures, central n

216 for non-syndromic cleft lip with or without cleft palate (NS CL/P).

217 Nonsyndromic cleft lip with/without cleft palate (nsCL/P) and nonsyndromic cleft palate only

218 gy of nonsyndromic cleft lip with or without cleft palate (NSCL/P) in populations of Asian and Europe

219 Nonsyndromic cleft lip with or without cleft palate (nsCL/P) is among the most common human bir

220 Nonsyndromic cleft lip with or without cleft palate (NSCL/P) is one of the most common congenit

221 that nonsyndromic cleft lip with or without cleft palate (NSCL/P) is strongly associated with SNPs i

222 s for nonsyndromic cleft lip with or without cleft palate (NSCL/P).

223 for non-syndromic cleft lip with or without cleft palate (NSCL/P).

224 Non-syndromic cleft lip with or without cleft palate (NSCLP) is a common birth defect.

225 Non-syndromic cleft lip with or without cleft palate (NSCLP) results from the complex interactio

226 osourea-induced mouse model of non-syndromic cleft palate (NSCP) that is caused by an intronic Prdm16

227 Cleft palate occurred in nearly all mice homozygous for

228 x3 in cranial neural crest cells resulted in cleft palate, ocular defects, malformation of the spheno

229 ave an infant with cleft lip with or without cleft palate (odds ratio = 2.2, 95% confidence interval:

230 he consequence of failure in this process is cleft palate, one of the most common birth defects in hu

231 ithelial fusion, failure of which results in cleft palate, one of the most common birth defects in hu

232 Unfortunately, for patients with cleft palate-one of the most common of congenital birth

233 nterval: 1.0, 10.2) and odds ratio = 3.0 for cleft palate only (95% confidence interval: 0.7, 13.0).

234 ttle is known about the genetic etiology for cleft palate only (CPO).

235 thout cleft palate (nsCL/P) and nonsyndromic cleft palate only (nsCPO) are the most frequent subpheno

236 on of some loci with NSCL/P and nonsyndromic cleft palate only (NSCPO) in cohorts from Africa (Ghana,

237 Nonsyndromic cleft palate only (nsCPO) is a facial malformation that

238 detectable that is shared with nonsyndromic cleft palate only (nsCPO).

239 2.2, 95% confidence interval: 1.1, 4.2) and cleft palate only (odds ratio = 2.6, 95% confidence inte

240 ith spina bifida, 277 with CLP, and 117 with cleft palate only in addition to 785 controls.

241 showed association with MSX1 (p = 0.04) and "cleft palate only" with TGFB3 (p = 0.02).

242 t lip with or without cleft palate, 196 with cleft palate only, and 763 controls.

243 out cleft palate, cleft lip with palate plus cleft palate only, and all datasets combined showed evid

244 ffect was observed for the fetal NOG1 SNP on cleft palate only, opposite in direction to the effect o

245 eft lip with or without cleft palate and (2) cleft palate only.

246 t lip with or without cleft palate (CLP), or cleft palate only.

247 Cleft palate (OR, 1.63; 95% CI, 1.05-2.52) and gastrosch

248 ded to be near to (cleft lip, cleft lip with cleft palate) or to exceed (cleft palate) unity.

249 Cases with a cleft lip, cleft palate, or both and unaffected controls delivered

250 uding hypospadias, cleft lip with or without cleft palate, or hydrocephalus.

251 We found that cleft palate pathogenesis in Pax9-deficient embryos is a

252 are also found in around 5% of non-syndromic cleft palate patients.

253 expectedly, the birth prevalence of isolated cleft palate per 1,000 livebirths increased linearly wit

254 the Msx1(-/-) palatal mesenchyme rescued the cleft palate phenotype and neonatal lethality.

255 In addition, we observe a unique cleft palate phenotype at the anterior end of the second

256 n multiple craniofacial defects, including a cleft palate phenotype distinct from that observed in Sn

257 In the present study, the cleft palate phenotype in Tgf-beta3-/- mice was rescued

258 ized Pax9(-/-) mouse model with a consistent cleft palate phenotype to test small-molecule Wnt agonis

259 expression of the beta3 subunit rescued the cleft palate phenotype, a nonneuronal GABAergic system i

260 ypomorphic alleles (Hand2(LoxP/-)) display a cleft palate phenotype.

261 thelial specific deletion of Hand2 creates a cleft palate phenotype.

262 scue the neurological phenotype, but not the cleft palate phenotype.

263 the level required to rescue the EGF-induced cleft palate phenotype.

264 /fl);Wnt1-Cre mice and previously identified cleft palate phenotypes in genetically engineered mouse

265 enetic etiology of cleft lip with or without cleft palate, relatively little is known about the genet

266 Humanitarian surgical organisations provide cleft palate repair for patients without access to surgi

267 d cleft palate and cleft lip with or without cleft palate, representing a heterogeneous group of diso

268 Cleft palate represents one of the most common congenita

269 Cleft palate represents one of the most common congenita

270 ty, with the assumption that an accompanying cleft palate represents the more severe form.

271 Cleft palate resulted from a temporally specific delay i

272 skull, hypoplastic maxilla and mandible, and cleft palate resulting from a failure of palatal shelves

273 While overt cleft palate results from defects in growth or fusion of

274 ivo and in vitro analyses indicated that the cleft palate seen in Msx1 mutants resulted from a defect

275 etions of 20p12 are variably associated with cleft palate, short stature, and developmental delay.

276 es accompanied by intellectual disability, a cleft palate, short stature, and dysmorphic features.

277 t a Tbx22(null) mouse, which has a submucous cleft palate (SMCP) and ankyloglossia, similar to the hu

278 ntify the gene as an important candidate for cleft palate studies in the human population.

279 d to the palatal mesenchyme, did not display cleft palate, suggesting that palatal clefting in Wnt1-C

280 normalities apart from a partially penetrant cleft palate syndrome.

281 malies were more prevalent in cleft lip with cleft palate than other cleft types.

282 pathogenesis of the bilateral cleft lip and cleft palate that results from mutation of Tp63, we anal

283 d for the development of therapies for human cleft palates that arise from single-gene disorders.

284 Cleft palate, the most frequent congenital craniofacial

285 tives of the pharyngeal apparatus, including cleft palate, thymus gland aplasia and cardiac outflow t

286 splays a consistent phenotype of a secondary cleft palate, to test a novel therapeutic.

287 , cleft lip with cleft palate) or to exceed (cleft palate) unity.

288 rmal development of the neural crest such as cleft palate, ventricular septal defect, abnormal develo

289 pregnancy BMI, the adjusted risk of isolated cleft palate was 2.3 times higher (95% confidence interv

290 Associated with the rescue of the cleft palate was a restoration of Shh and Bmp2 expressio

291 One locus segregating with dioxin-induced cleft palate was identified (p < 0.01) and designated as

292 Cleft palate was observed in both conditional knockout a

293 The presence of cleft palate was significantly associated with c.8057G>A

294 mutant known to display a 100% incidence of cleft palate, we examined the interaction between TGFbet

295 Problems in nasal development and cleft palate were also observed.

296 bral hemisphere to divide, hydrocephalus and cleft palate which have been observed in a human patient

297 Snai2(-/-) mice exhibit cleft palate, which is completely penetrant on a Snai1 h

298 Cleft palate with ankyloglossia (CPX; MIM 303400) is inh

299 rge syndrome/TBX1, ACTH deficiency/TBX19 and cleft palate with ankyloglossia/TBX22.

300 ) mice exhibit VSDs with ~50% penetrance and cleft palate with less than 10% penetrance; and Fz2(-/-)