ライフサイエンスコーパス: click

1 ve readout of the qubit produces a discrete 'click'.

2 community of biomedical researchers by mouse click.

3 nary proficiency in echolocation using mouth-clicks.

4 me, leading to the scaling between users and clicks.

5 xplicitly measure using trains of narrowband clicks.

6 muli delivered in a train was limited to two clicks.

7 e can echolocate for example by making mouth clicks.

8 fluoromethyl)-3H-diazirin-3-yl)phenol, AziPm-click (1)), for affinity-based protein profiling (ABPP)

9 eps stimulus 10 ms before click (Bi-10ms-C); click 25 ms before biceps (C-25ms-Bi); click alone (C on

10 igher prevalence of auscultatory midsystolic click (26 [72%] versus 6 [38%]; P=0.018) was also noted.

11 on someone else's content), "links clicked" (clicking a link to another site or article), or "status

12 d readers indicated that they saw a polyp by clicking a mouse.

13 nds additional associated diseases by double-clicking a node in the existing network.

14 s-C); click 25 ms before biceps (C-25ms-Bi); click alone (C only); and biceps alone (Bi only).

15 pentafluoro azobenzene-based photoswitchable click amino acid (F-PSCaa) was designed to isomerize in

16 showed elevated auditory brainstem response click and frequency-dependent hearing thresholds.

17 Photo-click and photo-caging methods are particularly useful b

18 yl-functionalized polymers via the thiol-ene click and photocuring reactions readily produced the cor

19 Hearing thresholds in response to clicks and frequencies higher than 8 kHz remain increase

20 cantly altered their behavior as measured by clicks and purchases.

21 -experience level resulted in up to 40% more clicks and up to 50% more purchases than their mismatchi

22 many complex analyses with only a few mouse clicks and, within the context of the same environment,

23 of human biosonar is the transmission (mouth click) and subsequent reception of the resultant sound t

24 ods, one based on the number of echolocation clicks, and another based on the detection of animal gro

25 were prepared through a two-step sequential click approach with a combination of oxime ligation and

26 ed by closed-loop auditory stimulation, when clicks are presented in synchrony with upcoming SO up st

27 abeled probes to Ebola virus RNA followed by click assembly and analysis of the read sequence by vari

28 cidal control options dwindling, research on click beetle biology and ecology is of increasing import

29 Wireworms, the larvae of click beetles (Coleoptera: Elateridae), have had a centu

30 stories and edges represent the consecutive clicks between two stories.

31 four paradigms: biceps stimulus 10 ms before click (Bi-10ms-C); click 25 ms before biceps (C-25ms-Bi)

32 itudinal data from animals, and we present a click-by-click guide for performing suitable analyses us

33 We further demonstrated that CB6 click can be used in conjunction with strain-promoted az

34 ks were identified by incorporating multiple click characteristics (spectral shape and inter-click in

35 eling of target proteins and biologics using click chemistries, (ii) for glycoengineering of antibodi

36 e being discussed, involving orthogonal and 'click' chemistries.

37 abolic labelling combined with bioorthogonal click chemistry (that is, reactions performed in living

38 he Fe(III)-HOPO ICP particles by copper-free click chemistry afforded colloidally stable nucleic-acid

39 Using click chemistry and a modified antibody array to detect

40 proteins, allowing for their detection using click chemistry and antibody arrays.

41 lly conserved compounds that are amenable to click chemistry and can be used as molecular probes in v

42 minescent quantum dot (QD) surfaces that use click chemistry and hydrazone ligation under catalyst-fr

43 We adapted newly developed procedures for click chemistry and iPOND (Isolation of proteins on nasc

44 ace N-glycoproteins by combining copper-free click chemistry and MS-based proteomics.

45 Whole cells are labelled via click chemistry and visualized using super-resolution mi

46 ole-based IL moieties were synthesized using click chemistry and were further copolymerized with laur

47 inal alkyne group, we were able to visualize click chemistry at the single-molecule level, which reve

48 fluoride exchange (SuFEx) is a new family of click chemistry based transformations that enable the sy

49 ith the ART probe can then be isolated using click chemistry before identification by liquid chromato

50 Click chemistry describes a family of modular, efficient

51 gamma-azido vinyl sulfones, and azide-alkyne click chemistry enabled the synthesis of vinyl sulfone-b

52 We report a new type of azide-alkyne click chemistry for the synthesis of protein conjugates

53 mizing reaction conditions, we converted CB6 click chemistry from a rotaxane synthesis tool into a us

54 Several forms of click chemistry have previously been used to modify poly

55 tocol and the labeling of DNA-Pt by means of click chemistry in cells.

56 he successful advancement of Cu(I)-catalyzed click chemistry in glycoscience and its applications as

57 and evaluated a pretargeting strategy using click chemistry in vivo to reduce kidney uptake and avoi

58 labeling followed by the use of reagent-free click chemistry is an established technique for in vitro

59 Target-guided synthesis by in situ click chemistry is combined with synthetic epitope targe

60 ds and their subsequent macrocyclization via Click chemistry is described.

61 osphors and polymer matrices via Diels-Alder click chemistry is devised as a method.

62 We present the use of a new form of click chemistry known as SuFEx (sulfur(VI) fluoride exch

63 Modifying Janus particles through thiol-yne click chemistry provides a fast-reacting, scalable synth

64 tion sequencing) library synthesis that uses click chemistry rather than enzymatic reactions for the

65 4-5-step process, involving as a key step a click chemistry reaction between ynamides and azides.

66 By taking advantage of a facile, one-pot click chemistry reaction, we report herein the preparati

67 Two click chemistry reactions were now combined to form nucl

68 We confirmed using 5-ethynyl-2'-deoxyuridine click chemistry that the Oc-Cre lineage includes very fe

69 Here, we successfully use click chemistry to construct DNA templates for sgRNA exp

70 zed peptides were synthesized by solid phase click chemistry to develop novel, potent, selective MC4R

71 ic modification of PG can be extended to use click chemistry to fluorescently label the mature PG in

72 polymer backbone by exploiting azide-alkyne click chemistry to functionalize the hydrogels with a pe

73 e cell labelling with azidomyristic acid and click chemistry to identify N-myristoylated proteins in

74 ligosaccharide engineering and bioorthogonal click chemistry to label various commensal anaerobes, in

75 olyprotein construct and DNA via copper-free click chemistry to PEG-coated substrates and a strong bu

76 Click chemistry was employed to cross-link peptides to D

77 can be employed for toxin derivatization by click chemistry with an azide-containing reporter molecu

78 t of the ligand to a surface by conventional click chemistry without disturbing selective interaction

79 Herein, we describe a "click chemistry" approach for the synthesis of PROTACs.

80 tion, controlled radical polymerization and "Click Chemistry" methods have significantly evolved over

81 t supramolecular catalysts for alkyne-azide "click chemistry" reactions, yielding the desired 1,4-add

82 of biomolecules via Huisgen cycloaddition ("click chemistry") for positron emission tomography (PET)

83 atalyzed Huisgen 1,3-dipolar cycloaddition ("click chemistry").

84 to activate cellulosic materials for CuAAC "click chemistry", to develop new fluorogenic esterase se

85 in one case and through a triazole linkage ('click chemistry') in the other.

86 METHODS AND Using crosslinking analogs, click chemistry, binding assays, and functional assays,

87 orthogonal amino acid using copper-catalyzed click chemistry, either before or after the silk fibers

88 We specifically focus on click chemistry, enzymatic ligation, and affinity bindin

89 various thiols by radical mediated thiol-ene click chemistry, followed by self-assembly in deionized

90 les for sulfur(VI) fluoride exchange (SuFEx) click chemistry, in which either the alkenyl moiety or t

91 vantages of highly chemo- and regioselective click chemistry, such as mild reaction conditions, effic

92 r cells and perform efficient, biocompatible click chemistry, thus acting as intracellular nanoscale

93 discovered by combinatorial copper-catalyzed click chemistry, was synthesized in situ by incubating e

94 can be covalently attached to surfaces using click chemistry, where they retain their abilities to in

95 eloped a robust, high-throughput compatible, click chemistry-based approach to identify small molecul

96 Here we describe a click chemistry-based approach, using an azido derivativ

97 transformation into acyl-CoAs and subsequent click chemistry-based detection, to demonstrate that zDH

98 uses a novel synthetic photoactivatable and click chemistry-taggable phospholipid probe, which, when

99 proteins with a non-canonical amino-acid and click chemistry.

100 dibenzocyclooctyne (DBCO)-Cy5 by subsequent click chemistry.

101 cently emerging applications in the field of click chemistry.

102 -selective peptide cyclo(FRGDLAFp(NMe)K) via click chemistry.

103 und to SH functionalities applying thiol-ene click chemistry.

104 ygen-sensing dendrimers through azide-alkyne click chemistry.

105 king such functionality available for use in click chemistry.

106 onversion to the corresponding triazoles via click chemistry.

107 nm in length were grown layer-by-layer using click chemistry.

108 hen assembled in a combinatorial fashion via click chemistry.

109 ementary oligonucleotides, and bioorthogonal click chemistry.

110 ovalent cross-linking using copper catalyzed click chemistry.

111 re conjugated to IRDye 800 using copper-free click chemistry.

112 oinitiators, which makes it truly two-photon click chemistry.

113 -selective peptide cyclo(FRGDLAFp(NMe)K) via click chemistry.

114 rged precursors, causing them to combine by "click" chemistry 1,000,000 times faster than without acc

115 Herein, we report for the first time a "click" chemistry approach to oligonucleotide probe elong

116 te a carbohydrate array via efficient local "click" chemistry strategy.

117 red to the surface utilizing bio-orthogonal "click" chemistry.

118 yzed azide-alkyne cycloaddition reaction in "click" chemistry.

119 sized using stepwise imine condensation, or "click" chemistry.

120 rivatized conducting PEDOT electrodes using "click" chemistry.

121 (68)Ga-aquibeprin was obtained by click-chemistry (CuAAC) trimerization of a alpha5beta1 i

122 We recently reported a click-chemistry based method for generating RNAseq libra

123 Assisted with click-chemistry coupling, we sandwiched one G-quadruplex

124 ogs followed by a fluorescent azide-coupling click-chemistry reaction.

125 unched AChE as a reaction vessel for in situ click-chemistry synthesis of high-affinity TZ2PA6 and TZ

126 ere surface functionalized with folate using click-chemistry to improve targeted uptake by the malign

127 active scaffolds was synthesized by means of click-chemistry under non-conventional microwave heating

128 sulfonates can be further functionalized via click-chemistry-based post-polymerization modification.

129 e analogue UV cross-linked and visualized by click-chemistry-mediated fluorescent labeling.

130 and have evolved four distinct sound types- clicks, chirps, whistles and vocalizations.

131 It is observed that Li is related with the clicks (Ci) to news stories and the age (Ti) of stories.

132 effective for rapid, unsupervised delphinid click classification across large datasets in which the

133 A challenge in echolocation click classification is to overcome the many sources of

134 e, a 1-standard-deviation increase in "likes clicked" (clicking "like" on someone else's content), "l

135 ng "like" on someone else's content), "links clicked" (clicking a link to another site or article), o

136 uals communicating using similar patterns of clicks (codas).

137 l-terminated transporters which can be thiol-click conjugated to a variety of probes, drugs and other

138 prosthetic group, followed by a copper-free click conjugation to a modified adnectin to generate (18

139 uorobenzyl azide followed by copper-mediated click conjugation with Sgc8-alkyne.

140 ooper-mediated 'click' coupling, copper-free click coupling and thiol-maleimide coupling were quantit

141 giving a yield of approximately 83% for the click coupling reaction.

142 f the detection of NS1 comparing copper free click coupling to carbodiimide coupling, one of the most

143 the ethynyl-functionalized peptide probe by click coupling, and the hydroxynaphthoquinone derivative

144 Carbodiimide coupling, cooper-mediated 'click' coupling, copper-free click coupling and thiol-ma

145 Azide-presenting peptides that clicked covalently onto this alkyne-presenting epitope w

146 molarity and thus evaluate the fulfilment of click criteria, we report a simple one-pot methodology i

147 uch as a dependency-free, browser-based, one click, cross-platform install and better navigation inte

148 ctivity in the copper-catalyzed azide-alkyne click (CuAAC) reaction.

149 high yields in copper-catalyzed 1,3-dipolar "click" cycloaddition using bis(TMS)butadiyne and other b

150 e widely used copper-catalyzed azide-alkyne "click" cycloaddition.

151 tional groups, including those from Huisgen 'click' cycloadditions and the Staudinger ligation.

152 ethod was applied to a dataset of 52 million clicks detected across five monitoring sites over two ye

153 le species identification were compared with clicks detected on sea-surface towed hydrophone arrays i

154 In the click-detection task, the pitch deviants evoked an early

155 assembly of oligonucleotides into a gene by click-DNA ligation.

156 cone was synthesized using a straightforward click/electrophilic addition or click/oxidative coupling

157 ent report, we collected a large database of click emissions with three blind people expertly trained

158 data from animals, and we present a click-by-click guide for performing suitable analyses using the s

159 We introduced an alkyne "click" handle into norketamine (alkyne-norketamine, A-NK

160 linking in a sequential manner, as well as a click-handle for subsequent functionalization.

161 Posted December 8, 2017.Click HERE to access Teaching Tool Components.

162 Posted September 20, 2017.Click HERE to access Teaching Tool Components.

163 A sensory stimulus, such as a click, immediately and consistently stopped the occurren

164 tect an individually adjusted near-threshold click in a melody.

165 The ASSR paradigm (1 ms, 85 dB clicks in 250-0.5 s trains at a frequency of 40 Hz; 0.5

166 or clathrin and AP2, employing a Monte Carlo click interaction, to simulate their collective aggregat

167 rge MinION datasets via a friendly point-and-click interface using commodity hardware.

168 ck characteristics (spectral shape and inter-click interval distributions) to distinguish within-type

169 a size of 18 A x 18 A, has been successfully clicked into the framework.

170 CB6 click is a promising new reaction for the development of

171 However, the term "click" is often applied inaccurately to polymer ligation

172 cripts using a nascent RNA capture approach (Click-iT chemistry), which identified transcription of a

173 Using a Click-iT flow cytometric assay to directly measure mitot

174 opargyl-puromycin and L-homopropargylglycine Click-iT technologies, and determined that these cells s

175 Click-knitted threads of two exclusively different molec

176 Purified fragments are "click ligated" via copper-catalyzed alkyne-azide cycload

177 ab and an anti-CD105 Fab, via bioorthogonal "click" ligation of trans-cyclooctene and tetrazine.

178 tion that is chemically orthogonal to CuAAC "click" ligation.

179 ndard-deviation increase in "likes clicked" (clicking "like" on someone else's content), "links click

180 iting and further developing the exceptional click-like reactivity of triazolinediones in various app

181 The resulting click-linked iLOV gene contains eight triazoles at the s

182 We report a double-click macrocyclization approach for the design of constr

183 demonstrating the application of the double-click macrocyclization approach to non-helical, extended

184 ties, together with auscultatory midsystolic click, may identify MVP patients who would need arrhythm

185 ling experiments demonstrated that metabolic click-mediated labelling with Kdo-N3 provides an efficie

186 The ribosome-templated in situ click method was expanded from a binary reaction (i.e.,

187 of tracks can also be customized, along with clicks, mouseovers, menus, and popup boxes.

188 o distinct approaches are used to form these click nucleic acid (CNA) polymers.

189 rough the use of a new synthetic DNA analog, click nucleic acids (CNAs).

190 By clicking on a search result, the user can visually compa

191 sy to use and intuitive interface with a few clicks on any desktop computer.

192 lizing three optimization strategies: 1. one-click optimization, 2. bulk optimization (by codon-type)

193 er before nor after noise exposure, nor were click- or noise-burst-evoked auditory brainstem response

194 aightforward click/electrophilic addition or click/oxidative coupling tandem procedures.

195 ty probes were installed in combination with click partners within Lipid II, thereby allowing, for th

196 (MIC) quantified the potency of the in situ click products and demonstrated the efficacy of this met

197 lyl deprotection in situ to give the ynamine click products.

198 We used click proteomics and click sequencing to explore the gen

199 dy II compared Driving stimulation with a "2-Click" protocol where the maximum of stimuli delivered i

200 practical applications of a new copper-free click reaction - namely, cooperative capture synthesis,

201 ring functionalisation was achieved using a click reaction after precise nanolitre spotting of speci

202 izing poly(ethylene glycol) chains through a click reaction after spacer assembly.

203 This protocol describes the double-click reaction between a 1,3-dialkynylbenzene linker and

204 f boronic ester formation as a bioorthogonal click reaction between abiotic boronic acids and diols.

205 Here, we use the click reaction between alkynes and azides as an example

206 to evaluate an overlooked candidate for the click reaction family: the addition of primary amines to

207 ration community, namely the thiol-ene photo-click reaction for bioconjugation and photocleavage reac

208 the amine-(t)NCO ligation is a powerful new click reaction for efficient macromolecular coupling.

209 RF) dye-labeled molecules by a bioorthogonal click reaction in cell cultures and in tumor-bearing mic

210 ide cycloaddition is the most widely adopted click reaction in the family, the fact that it is cytoto

211 A post-polymerization click reaction is reported that provides facile access t

212 This robust, efficient, and orthogonal click reaction of an ionic liquid, which we term Clickab

213 igation; and 3) attachment of a polymer by a click reaction with near-quantitative conversion.

214 cloaddition (CuAAC), popularly known as the "click reaction", serves as the most potent and highly de

215 copper-catalyzed azide-alkyne cycloaddition (Click reaction) was installed by nucleophilic substituti

216 copper-catalyzed azide-alkyne cycloaddition (click reaction).

217 fulfills the criteria for a polymer-polymer click reaction, achieving rapid, chemoselective, and qua

218 Using an orthogonal Click reaction, Green Fluorescent Protein (GFP) was engi

219 dative cyclizations, allenone synthesis, and click reaction, respectively.

220 n tagged with biotin on live cells through a click reaction, which allows further elaboration with st

221 at different emission wavelengths using the click reaction.

222 troduced by Suzuki-Miyaura cross-coupling or click reaction.

223 attached to AFM tips through a catalyst-free click reaction.

224 sfer radical polymerization reactions with a click reaction.

225 mplex and a subsequent in situ cycloaddition click reaction.

226 formed to the functionalized framework via a click reaction.

227 to functional molecules via an azide-alkyne click reaction.

228 p on every repeating unit via the thiol-ene "click" reaction achieves a full conversion of all the pe

229 ploying the combination of copper-catalyzed "click" reaction and P(n-Bu)3-catalyzed esterification re

230 ttached to the gold electrode surface via a "click" reaction between the amine and an epoxide group.

231 ore stable than unsupported cluster 1 under "Click" reaction conditions.

232 functionalized NPs were radiolabeled via a "click" reaction with copper-64 ((64)Cu)-1,4,7-triazacycl

233 n, this cycloaddition is considered to be a "click" reaction with many applications in chemical biolo

234 Cu-catalyzed alkyne-azide cycloaddition (or "click" reaction).

235 to respect the criteria that typify a true "click" reaction.

236 olabeling precursors via a copper-catalyzed 'click' reaction; and (ii) a one-step (18)F-labeling meth

237 tion through the azide-alkyne cycloaddition (click) reaction.

238 etabolic glycoengineering with bioorthogonal click reactions has focused on improving the tumor targe

239 ophilic substitution, olefin metathesis, and click reactions have been the methods of choice to fold

240 Click reactions have provided access to an array of rema

241 s are cross-linked by multiple bioorthogonal click reactions in situ on the surface of the target cel

242 ty and undermining the success of subsequent click reactions in which they are used.

243 An early example of copper-free click reactions that is rarely mentioned in the literatu

244 Although a number of click reactions were developed for this purpose, many ar

245 te moiety of which undergoes rapid thiol-ene click reactions with certain reactive C=C bonds to form

246 icles that can be modified through thiol-yne click reactions with commercially available thiols.

247 een exploring the development of copper-free click reactions, the most popular example so far being s

248 composite Janus particles through sequential click reactions.

249 alysed azide-alkyne cycloaddition (SP-CuAAC) click reactions.

250 Thiol-Michael "click" reactions are essential synthetic tools in the pr

251 high-yielding, and selective bioorthogonal "click" reactions employing nontoxic reagents are in high

252 onvenient, green catalysts for alkyne-azide "click" reactions in water.

253 reactions between alkynes and azides (i.e., "Click" reactions) at room temperature.

254 alized ceramides allowing for bio-orthogonal click-reactions to fluorescently label incorporated cera

255 restingly, complex 1 shows in vitro enhanced click reactivity in comparison to a previously reported

256 tro studies indicate similar DNA binding and click reactivity of both congeners observed by fluoresce

257 Subsequent click reactivity with nonfluorescent dansyl azide result

258 biaryl sulfonyl fluorides as bioorthogonal "click" reagents.

259 be accessed directly via a URL, allowing one-click reproduction of published results.

260 Unexpectedly, the bulky phenyltriazolyl "click" residue is well-accommodated at the 7-position of

261 fter for frequency-specific stimuli, whereas click responses became abnormal from postnatal month 13

262 A second in situ click screen identifies a molecular bridge between the t

263 An epitope-targeting in situ click screen is utilized to identify a second peptide ma

264 resent a novel biochemical approach, in vivo click selective 2'-hydroxyl acylation and profiling expe

265 icSHAPE (in vivo click selective 2-hydroxyl acylation and profiling exper

266 We used click proteomics and click sequencing to explore the gene regulatory function

267 hanism for voltage activation based on a one-click sliding helix conformational rearrangement.

268 sign, optimization, and validation of double-click stapled peptides encoding the Ctf4-interacting pep

269 Double-click stapling can enhance the binding affinity, proteol

270 A distinguishing feature of double-click stapling is the efficiency with which peptides bea

271 The entire double-click stapling protocol can be completed in approximatel

272 iazole linkage, it is referred to as 'double-click' stapling.

273 riving stimulation did not exceed those of 2-Click stimulation (p > 0.180), indicating the presence o

274 Indeed, a simple steady-state auditory click stimulation paradigm at gamma frequency (~40 Hz) h

275 se-locked spindle activity during repetitive click stimulation, suggesting that spindle refractorines

276 ) and testing their EEG entrainment to 40 Hz click stimuli at various time points (~7-62 min after tr

277 th a portable device that delivered auditory click stimuli through an earpiece, and electrical stimul

278 A paint-on liquid bandage containing a new, click-synthesized porphyrin dendrimer has been used to m

279 By developing new substrates for CB6 click that do not contain any cross-reactive functional

280 By clicking the SCP button, a patient-tailored SCP was gene

281 ousettus aegyptiacus, which produce sound by clicking their tongue, can dramatically change beam dire

282 s Feed and further studied users' choices to click through to ideologically discordant content.

283 omprehensive expression analyses with simple clicking through GEPIA greatly facilitate data mining in

284 silyl ether to be rapidly and quantitatively clicked to a polymer brush grown by free-radical polymer

285 recorded while subjects listened to auditory click trains presented at 20, 30, and 40 Hz.

286 The azide-containing polymers underwent click-type coupling reactions with dialkynes, while the

287 Automatically-identified click types from autonomous seafloor recorders without v

288 ification across large datasets in which the click types may not be known a priori.

289 Once click types were established, an algorithm for classifyi

290 Seven distinct click types were identified, one of which is known to be

291 variation, and identify distinct, persistent click types.

292 for the animals producing some echolocation click types.

293 roach a human analyst uses when categorizing click types: Clusters of similar clicks were identified

294 utenolide building block by regiocontrolled "click-unclick" oxazole-ynone Diels-Alder cycloaddition/c

295 With just one click, users can obtain a comprehensive analysis report

296 ion numbers and metadata, and then, with one click, users can submit this information to a web-server

297 Moreover, the timing of metronome clicks was represented in periodic modulation of induced

298 ategorizing click types: Clusters of similar clicks were identified by incorporating multiple click c

299 ion" protocol (vs "Sham") in which trains of clicks were presented in synchrony with SO up states bas

300 rs of short duration, broadband echolocation clicks which may be useful for species classification in