ライフサイエンスコーパス: client

1 with TIR1, confirming that TIR1 is an HSP90 client.

2 cosylated transthyretin (TTR) D18G misfolded client.

3 ers using web-based query tools or a desktop client.

4 uplicated to create a single record for each client.

5 ggesting that it is a direct, physical Hsp70 client.

6 s recruit an E3 ligase to ubiquitinate bound clients.

7 urrent data and ensure accurate messaging to clients.

8 t mediate interaction with a subset of Erv14 clients.

9 nd non-redundant roles in maintaining kinase clients.

10 distinct from sites utilized by other hsp90 clients.

11 increases in consistent condom use with all clients.

12 sary for efficient trafficking of all of its clients.

13 ting that these proteins maybe novel DNAJB6b clients.

14 drophobic lysine residues on Bag6-associated clients.

15 be readily remodeled to accommodate specific clients.

16 ing, dissociation, or remodeling of cellular clients.

17 ed more than one self-test to commercial sex clients.

18 numerous signalling proteins, also known as clients.

19 Viral suppression was higher among retained clients (77.7%) vs clients who were not retained (58.3%)

20 Among newly diagnosed clients, 90.5% (95% confidence interval [CI], 87.9%-93.2

21 ols, and dietary approaches to help patients/clients adapt these guidelines according to their socioc

22 n whose female partners had regular sex-work clients (adjusted OR = 0.38, 95% CI: 0.14, 1.03).

23 Finally, genetic knockdown of HSP90 and its client AKT, but not BTK, reduced CLL viability.

24 h DNAJB6 dysfunction, keratin 8/18, a DNAJB6 client also accumulated in DNAJB6b-F93L expressing mouse

25 However, we also determine that some Erv14 clients also directly engage an adjacent cargo-binding d

26 ed in a variety of environments and devices, client and server side alike.

27 xt] 4.6 s and [Formula: see text] 10.8 s for client and server side, respectively, on laptop computer

28 New technical enhancements at both, client and server sides, makes the user experience faste

29 y depends on their level of influence on the client and their merit relative to one another.

30 ally binds to the folded conformation of its clients and accompanies them from the ER to the Golgi co

31 inent group of heat shock protein 90 (Hsp90) clients and are recruited to the molecular chaperone by

32 vation of both the HSP90/R2TP system and its clients and further shows that Spag, unlike Saccharomyce

33 The affinity of mtHsp70 for its protein clients and its chaperone function are regulated by bind

34 th high levels of consistent condom use with clients and low use with steady partners in both study g

35 izes kinase specificity determinants in both clients and nonclients and acts as a general kinase scan

36 fficulty in transferring large-scale data to clients and the lack of native support for hardware-acce

37 educed ability of HSJ1 to bind ubiquitylated clients and to exert its chaperone activity.

38 ormations that are influenced by nucleotide, client, and co-chaperone binding.

39 adviser's current level of influence on the client, and relative merit prediction error affects acti

40 l and sexual violence, from law enforcement, clients, and intimate partners; unlawful arrest and dete

41 Attaining the UNAIDS targets in FSW, their clients, and MSM (but not in the rest of the population)

42 We present JS-MS, a 3-D, modular JavaScript client application for viewing MS data.

43 and a substrate-binding domain (SBD), where clients are bound.

44 e of NatA, and showed that a number of Hsp90 clients are previously unknown substrates of the Arg/N-e

45 kinase/phosphatase classification and Kinase Client Assay (KiC Assay) data--all of which provides con

46 n this observational study, we used data for clients attending the Silom Community Clinic for volunta

47 f a central imaging core incorporates a thin client-based integrative and modular data handling platf

48 Developing protein client-based probes to quantify the cellular proteostasi

49 rasses (Labroides dimidiatus) and their fish clients before, during and after repeated, standardised

50 isturbance appeared to have little effect on client behaviour, as evidenced by consistency of visit r

51 Interference with client binding impairs parasite infectivity, providing c

52 ome can be increased by tuning the chaperone-client binding strength.

53 folding of Hsp33's linker region facilitates client binding to an amphipathic docking surface on Hsp3

54 witch from self-recognition to high-affinity client binding.

55 is most pronounced at the broadly conserved client-binding region.

56 lysis and conformational flipping rearranges client-binding sites, providing a paradigm of how energy

57 s that reorganize into structurally distinct client-bound complexes.

58 UBQLN2 recognizes client-bound HSP70 and links it to the proteasome to all

59 ls indicated that a slow-diffusing, possibly client-bound Ydj1 fraction was asymmetrically enriched i

60 g game, two advisers competed to influence a client by modulating their own confidence in their advic

61 demonstrate that CDC37 can stabilise kinase clients by a mechanism that is not dependent on a substa

62 to challenge the conformational stability of clients by locally unfolding them.

63 duced HIV incidence in sex workers and their clients by more than 70%.

64 s and adoption of BitTorious Volunteer-based clients by the general public, the BitTorious portal may

65 dence in South African sex workers and their clients by up to 40% over a 10-year period.

66 the mutants was sufficient to protect kinase clients CDK4, CDK6, CRAF and ERBB2 from depletion induce

67 y to monitor the functional states of their 'client cells': namely, the parenchymal cells in the vari

68 communication between macrophages and their client cells, including tumour cells.

69 re described taking intervention-centric and client-centric perspectives to look at supply, demand, a

70 hese BCR constituents are present in a multi-client chaperone complex with HSP90.

71 and Bag3 control the stability of the Hsc70-client complex using at least two distinct protein-prote

72 lar UBL domain, and stabilizes the Ubiquilin-client complex.

73 pA, facilitates assembly of the Hsp90Ec-DnaK-client complex.

74 The visualization of Hsp90-client complexes at high resolution together with tools

75 ifically, we chemically precipitated teHSP90-client complexes from DLBCL cell lines with the small mo

76 ochaperone dissociation from inhibited HSP90-client complexes.

77 ative articles indicated that therapists and clients considered art therapy to be a beneficial, meani

78 n rapidly provide prognostic information for clients considering A&A treatment in cats with cytauxzoo

79 Mutants lacking calcineurin, or its client CrzA, displayed normal alkaline tolerance and nuc

80 ion, and use of cleaning incitation signals, clients did not retaliate as expected (i.e., by chasing)

81 gulated co-secretion of ERdj3 with misfolded clients directly links ER and extracellular proteostasis

82 s dictated primarily by comparatively slower client dissociation from SGTA and nonprivate capture by

83 Among previously diagnosed clients, EiC increased from 73.7% to 91.3% (RR = 1.24; 9

84 distinct manner of higher-order assembly and client engagement by a AAA+ ATPase and suggest a mechani

85 we examined pre-post outcomes among 3641 CCP clients enrolled before April 2011.

86 HSP90 binding capacity did not affect kinase client expression or activity; moreover, as with wild-ty

87 ishes an essential role of Hsp70 in deciding client fate during stress.

88 anslates into functional decisions regarding client fate is still unclear.

89 or disrupted, allowing the consequences for client fates to be determined.

90 ot essential for, the correct functioning of client Fe-S proteins in unchallenged conditions.

91 and explain how they use ubiquitin to triage clients for degradation via coordinated intra- and inter

92 y dependent on this chaperone, no equivalent clients for Hsp70 have been reported.

93 Cleaners inspected clients for longer and were significantly less cooperati

94 known to accelerate release of both ADP and client from Hsc70.

95 n bestow specificity and temporal control to client gene expression; however, characteristics of bind

96 to instil the values needed to care for this client group in an effective and personcentred way.

97 However, identifying where Hsp33 binds its clients has remained a major gap in our understanding of

98 TRC40 pathway clients have been identified using in vitro assays, howe

99 menters to provide counseling and support to clients identified as being at increased risk for type 2

100 ce, and clinical data using encrypted unique client identifiers, and data are processed and de-duplic

101 lly non-overlapping sets of obligate protein clients in cancer cells.

102 Clients in comprehensive HIV care coordination for perso

103 fect on non-condom use) among FSWs and their clients in the next decade.

104 f the Carolina Oral Health Literacy Project, clients in the Women, Infants, and Children's Special Su

105 romoted rapid release of nucleotide, but not client, in vitro Rather, we found that a non-canonical i

106 These "clients" include proteins with key roles in cancer, neur

107 The client includes a modular Java backend with a novel stre

108 iated degradation of AR as well as other p23 clients including AKT and Cdk4, and downregulates AR and

109 It can be used by a diverse range of clients including web browsers, command terminals, progr

110 maturation, stability and activation of its clients, including many oncogenic proteins.

111 90-mediated folding of kinase and non-kinase clients-including Tsc2-thereby preventing their ubiquiti

112 e 627 has previously been reported to reduce client interaction and Aha1 binding.

113 y tight ( approximately 260 nm) for an Hsp70-client interaction and involved non-canonical regions of

114 dings indicate that the lectin-based mode of client interaction is the predominant contributor to the

115 h conventional heat shock protein 70 (HSP70)-client interaction mechanisms.

116 that dictate the four key steps of chaperone-client interaction: initial binding, complex stabilizati

117 ficiency depends on oligomerization and that client interactions can occur both with and without olig

118 of thermodynamics and kinetics of chaperone-client interactions.

119 e code for the interface and an example REST client is available at ftp://ftp.thegpm.org/repos/gpmdb_

120 How the misfolded client is subsequently released from BiP so that it unde

121 The most stringent kinase client is the oncogenic kinase v-Src.

122 cipates in the selective recruitment of only client kinases.

123 ding to HSP90, but retained association with client kinases.

124 nism by which these chaperones assist their "client" kinases and the reason why some kinases are addi

125 data mining, a comprehensive RESTful API and client libraries in Python, Java and JavaScript for fast

126 A client library provides high-level distribution template

127 factor to maintain the function of a strong client like CRAF kinase.

128 This mechanism would parallel that in other clients like the aryl hydrocarbon receptor and HIF1alpha

129 ity mediated by retinoic acid, an endogenous client lipid of CRABP2.

130 the endoplasmic reticulum (ER) to manage ER client loads; however, key regulators within the UPR rem

131 e asymmetric function of each subunit during client maturation.

132 mations and complexes that are important for client maturation.

133 the BitTorious portal, upon which compatible clients may be built.

134 ations included female sex workers and their clients, men who have sex with men, serodiscordant coupl

135 le during ERAD of the misfolded glycosylated client null Hong Kong (NHK).

136 together, our studies identified AtWRI1 as a client of 14-3-3 proteins and provide insights into a ro

137 Chk1, a mitotic checkpoint kinase and a client of Hsp90, was degraded relatively slowly in wild-

138 years, had non-affective psychosis, had been clients of early intervention services for 12-30 months,

139 Reaching clients of FSW, as well as key populations, can efficien

140 ocial desirability bias, and (3) patients or clients of STI services were not interviewed, and theref

141 Data were collected on clients' OHL, sociodemographics, dental utilization, sel

142 cancer cell proliferation through depleting client oncoproteins and shutting down multiple oncogenic

143 antly predicted protected sex (P < .01), but clients paid on average 42.9% more for unprotected sex.

144 Clients partition differently depending on the ratio of

145 Within a work environment where clients' preferences determine condom use, FSWs effectiv

146 d related traumas, with flexibility based on client presentation.

147 due to the need for most chaperones to bind clients promiscuously.

148 CUL5) also delayed the earlier loss of HSP90 client protein activity at the same time as delaying coc

149 that the tumour suppressor FLCN is an Hsp90 client protein and its binding partners FNIP1/FNIP2 func

150 The interactions of Hsp70 with a client protein at different sites results in a fuzzy cha

151 proteostasis machine recognizes and sorts a client protein based on two biophysical properties of th

152 n cells, DeltaC-CDC37 also showed diminished client protein binding and was relatively unstable.

153 perones form a complex that is stabilized by client protein binding.

154 resolution structural characterization of a client protein bound to each of the three nucleotide sta

155 ions of intact unfractionated heparin with a client protein carried out directly by native ESI MS wit

156 Some client protein chaperone functions and interactions with

157 liferative and cytotoxic activity along with client protein degradation without induction of the heat

158 interactions to rapidly bind to its unfolded client protein Im7.

159 ormations of the SRC homology 3 domain (SH3) client protein interact with the ADP-bound form of the D

160 This study extends the SGT1b-HSP90 client protein list and broadens the functional scope of

161 c kidney disease (ADPKD) but also as a novel client protein of Hsp90.

162 in the outer mitochondrial membrane and is a client protein of HSP90beta, where it may play a role in

163 in the outer mitochondrial membrane and is a client protein of HSP90beta, where it may play a role in

164 We further show that COI1 is a client protein of SGT1b-HSP70-HSP90 chaperone complexes

165 lope membrane of chloroplasts (TOC) mediates client protein recognition and early stages of import.

166 is the first example of a topology-specific client protein redox catalyst in living cells.

167 The bound client protein shares a highly flexible N terminus and m

168 Hydrophobic collapse of the client protein then drives its folding.

169 as four distinct sites on a small 53-residue client protein, hTRF1.

170 nd dynamical heterogeneity in the DnaK-bound client protein, revealing that proteins may undergo some

171 e activity of Hsp90 and reduce levels of its client protein, SF3B2 may be developed as an adjuvant th

172 The Cct2 knockdown decreased its major client protein, transducing beta1 (Gbeta1).

173 inase (SYK), which we identified as an HSP90 client protein.

174 elieved by bacterial Hsp70 and an activating client protein.

175 inally, ethoxyquin reduced the levels of two client proteins (SF3B2 and ataxin-2) of a chaperone prot

176 s induced dramatic depletion of the examined client proteins and a very strong increase in the expres

177 "Super Spy" variants show tighter binding to client proteins and are generally more unstable than is

178 Client proteins are maintained in a folding-competent co

179 target unique substrates, some of which are client proteins associated with epigenetic control.

180 el substrates and causes the accumulation of client proteins at Hrd3.

181 ed iron-dependent depletion of HSP90 and its client proteins at pharmacologically achievable concentr

182 lerate the conformational cycle during which client proteins attain their final shape.

183 Understanding how the non-native client proteins bound to HtpG refold is of central impor

184 We also found that several putative Fe-S client proteins directly bind to GRXS17, such as XANTHIN

185 ly to pH and temperature stresses to protect client proteins from aggregation.

186 endent segregase that extracts ubiquitylated client proteins from membranes, protein complexes, or ch

187 Hsps) prevent aggregation of thermosensitive client proteins in a first line of defense against cellu

188 ein folding homeostasis by engaging unfolded client proteins in a process that is tightly coupled to

189 As p62 oligomerizes and sequesters client proteins in inclusions, the TRIM21-mediated p62 u

190 sting that the accumulation of mitochondrial client proteins in the absence of UBQLN1 is cytostatic.

191 ced decamers, promoting binding of unfolding client proteins in the center of Prx's ringlike structur

192 ation and processing of Hsp90-Aha1-dependent client proteins in vivo We conclude that it is possible

193 of ethoxyquin is mediated through these two client proteins of Hsp90.

194 trast to eukaryotic Hsp90, the functions and client proteins of Hsp90Ec are poorly known.

195 4 cell death, and CRK4 is likely to be among client proteins of protein glycosylation involved in BAK

196 pendent on Hsp42, which collected non-random client proteins of the Hsp104/Hsp70-refolding machinery,

197 n cellular by lower levels of Hsc70-specific client proteins on Western blot analyses.

198 een Hsp33's own metastable linker region and client proteins present a possible model for how Hsp33 u

199 nsfer from the biosynthetic apparatus to the client proteins preventing oxidative damage to [4Fe-4S]

200 mmon D-Q-Phi-X0,1-G-K-N-zeta-E motif in CsgC client proteins that is not found in Abeta42.

201 nts of the ISA [4Fe-4S] assembly complex and client proteins that need [4Fe-4S] clusters to function.

202 structural changes undergone by full-length client proteins upon interaction with DnaK (i.e., Escher

203 arin (or related GAGs) interactions with its client proteins use synthetically produced heparin mimet

204 such as acceleration or delay of folding, on client proteins via mechanisms that are poorly understoo

205 spectroscopy (TROSY) NMR, the interaction of client proteins with both the NTD and the pore-loop tyro

206 e dodecamer, accessible for interaction with client proteins, and distinct from previous undefined or

207 stromal cells, increased levels of the Hsp90 client proteins, HIF-1alpha, and PKM2 were found in LFS

208 Through these client proteins, Hsp90 is a key mediator of many physiol

209 n of HSP90 results in the degradation of its client proteins, in turn providing a means to concomitan

210 uses degradation of HSP chaperones and their client proteins, including epidermal growth factor recep

211 erone involved in the activation of numerous client proteins, including many kinases.

212 olecular chaperone that remodels hundreds of client proteins, many involved in the progression of can

213 Once activated, HdeB binds various unfolding client proteins, prevents their aggregation, and support

214 The NTD interaction destabilizes client proteins, priming them for subsequent unfolding a

215 gp93 was found capable of rescuing gp96 client proteins, such as Toll-like receptors (TLRs) and

216 Given fixed concentrations of chaperones and client proteins, the solubility of the proteome can be i

217 kedly alters the binding energetics for some client proteins, while another, p21(CIP1), is only mildl

218 Protein kinases phosphorylate client proteins, while protein phosphatases catalyze the

219 es on nucleotide-dependent interactions with client proteins, yet the structural features of folding-

220 al for maintaining the stability of numerous client proteins.

221 parated liquids that concentrate low valency client proteins.

222 f the previously known binding sites for its client proteins.

223 d that phospho-FAK (PTK2) and BRAF are HSP70 client proteins.

224 cally transforms the binding pocket for PCNA client proteins.

225 rophobic stretches in unfolded or aggregated client proteins.

226 lar functions via folding chaperone-specific client proteins.

227 g the degradation of Hsp90alpha -: dependent client proteins.

228 10, catalyzes folding of a subset of mtHsp70 client proteins.

229 bic sequence, favors more unfolded states of client proteins.

230 quired for the activity and stability of its client proteins.

231 uires UBQLN1 for survival to identify UBQLN1 client proteins.

232 ure of 14-3-3 affects the structures of many client proteins.

233 in tumor growth by stabilizing pro-survival client proteins.

234 es the conformation of hundreds of cytosolic client proteins.

235 ocal regulatory mechanism for chaperoning of client proteins.

236 h enable it to engage the degradation of its client proteins.

237 sis through its reversible interactions with client proteins.

238 d its ability to bind other partially folded client proteins.

239 cular chaperone that remodels its substrate 'client' proteins, facilitating their folding and activat

240 livery factors associated with Virginia ADAP clients' QHP enrollment and to assess the relationship b

241 In 2011, an estimated 512 911 HIV-infected clients received at least 1 RWHAP-funded non-AIDS Drug A

242 nteractions, highlighting a new principle of client recognition during protein quality control.

243 Moreover, client release did not seem to require the BAG domain or

244 cation site may afford a mechanism to couple client release from BiP and retrotranslocation.

245 less is known about the regions required for client release, and it is often assumed that this activi

246 nt's affinity to Spy decreases, which causes client release.

247 uring ERAD and suggest that positioning this client-release factor at the retrotranslocation site may

248 and this step because it determines how long clients remain in the inactive, bound state.

249 ey recognize and determine the fate of their clients remains unclear.

250 w energy from ATP hydrolysis can be used for client remodeling.

251 ADP-BiP is often recruited to the misfolded client, rendering it soluble and translocation competent

252 Client requests for condom use significantly predicted p

253 es are a substantial and important subset of clients requiring the key cochaperone CDC37.

254 urying hydrophobic residues in its core, the client's affinity to Spy decreases, which causes client

255 always considering it in the context of the client's folding pathway and biological function.

256 n based on two biophysical properties of the client's misfolded state (M state): its stability and it

257 er therapeutic alliance may underlie greater client satisfaction in crisis houses.

258 The web server follows a client-server architecture built on PHP and HTML and uti

259 The intervention consisted of a client service charter and a facility-based, quality-imp

260 triage system is divided into an uncommitted client-SGTA complex, a self-sufficient targeting module,

261 Client-SGTA engagement of the targeting module induces r

262 ence in their advice about which lottery the client should choose.

263 ns and to combine them with custom data for 'client-side' orthology prediction.

264 equire significant maintenance effort, or as client software that presumes technical expertise for in

265 This work identifies NACHO as an essential, client-specific chaperone for nAChRs and has implication

266 to fold itself, Spy circumvents the need for client-specific folding instructions.

267 ng endogenous CDC37, indicating that CDC37's client stabilising function cannot be inactivated by sub

268 rst catalyze UB transfer from an E2 to their client substrates and subsequent polyubiquitylation from

269 es that drive the engagement and movement of client substrates is a fundamental question.

270 an significantly bias the folding pathway of client substrates such that secondary structure forms fi

271 ividual monoubiquitin modifications onto CRL client substrates.

272 ors has benefited from the identification of clients, such as Raf-1 proto-oncogene, Ser/Thr kinase (R

273 sign while three used some type of simulated client survey referring to a fictitious case of a child

274 assessed the effects of this DN-Hsc70 on its client Tau.

275 apoptosis protein (XIAP), are obligate Hsp70 clients that are rapidly (within approximately 3-12 h) l

276 ereby facilitating processing of Hsp70-bound clients through protein folding and translocation pathwa

277 By allowing the client to fold itself, Spy circumvents the need for clie

278 nd degradation; and highlight the ability of clients to co-evolve with chaperones, ensuring quality c

279 rane proteins despite the potential for such clients to directly interact with Sec24.

280 ic sequence selects conformational states of clients to favor their productive participation in a sub

281 EEVD(Hsp70) minimizes transfer of Sis1-bound clients to Hsp70s that are primed for client transfer to

282 antiretroviral therapy among FSWs and their clients to meet WHO eligibility of a CD4 cell count of l

283 s by which cells triage Ydj1- and Sis1-bound clients to productive and quality control pathways, resp

284 ners might be taking advantage of distracted clients to reduce their service quality.

285 o-chaperones to facilitate the maturation of clients to their active states.

286 Kinase sorting within the client-to-nonclient continuum relies on the ability of C

287 -bound clients to Hsp70s that are primed for client transfer to folding and translocation pathways by

288 module induces rapid, private, and committed client transfer to TRC40 for successful biosynthesis.

289 Healthcare provider messaging should build client understandings of the meaning of partially effica

290 bors a mutation converting it into an SEC24D client, was rerouted from the axonal to the somatodendri

291 Using standardized patients ("mystery clients"), we assessed clinical practice for three diffe

292 6 to 2013, 8176 MSM came for VCT; 1999 (24%) clients were initially seronegative and returned for ano

293 3 were frequent and dispersed throughout the clients, whereas Grp170, ERdj4, and ERdj5 specifically r

294 tional chances at membrane targeting for the client, while simultaneously freeing Ubiquilin's UBL dom

295 lculated retention and viral suppression for clients who received RWHAP-funded HIV medical care in 20

296 was higher among retained clients (77.7%) vs clients who were not retained (58.3%).

297 ask or potentiate the impact of mutations in clients with remarkable influence on evolutionary adapta

298 needed to bind to a wide range of chaperone clients without compromising precise control of thermody

299 Clients without evidence of HIV care during the 6 months

300 mats such as JSON and FASTA while minimizing client work.