ライフサイエンスコーパス: client

1 per folding of its substrate proteins (i.e., clients).

2 more it slows the folding rate of the bound client.

3 is subunit imparts AIPL1 selectivity for its client.

4 sp70 binding to Hsp40 displaces the unfolded client.

5 an form a direct complex in the absence of a client.

6 sm that alters the folding properties of the client.

7 e fold that is recognized by HSP90 as a host client.

8 ggesting that it is a direct, physical Hsp70 client.

9 s competed with a rival for influence over a client.

10 ng with an increased export of LyzC, a Cab45 client.

11 s suggested that PEG10 and TRIM32 are direct clients.

12 nditions but also in their interactions with clients.

13 js also binding directly to unfolded protein clients.

14 s assumed to constrain the mobility of bound clients.

15 multiprotein complexes with cochaperones and clients.

16 like motifs over other representative 14-3-3 clients.

17 ase Doa10 controls cytoplasmic level of Msp1 clients.

18 icity by recognizing unfolded regions in its clients.

19 aperones-affects the activation of different clients.

20 be readily remodeled to accommodate specific clients.

21 ay, yet little is known about their cellular clients.

22 a dedicated Python package, or custom remote clients.

23 V) testing despite high prevalence among OTP clients.

24 s has great value in validating possible new clients.

25 and their contributions to the maturation of client [4Fe-4S] cluster-containing proteins.

26 31 683) had HIV attributed to IDU; among IDU clients, 6.3% (1988) accessed substance use services.

27 ntres provided HIV testing for 14 698 unique clients (7630 PWID and 7068 MSM.

28 Here, I propose a model of client activation by Hsp90 that predicts that this cycle

29 erone proteins regulate the ATP-driven Hsp90 client activation cycle.

30 under nonstress conditions, WT HSPB5 delays client aggregation solely through transient interactions

31 Finally, genetic knockdown of HSP90 and its client AKT, but not BTK, reduced CLL viability.

32 hydrolysis coincides with release of mature client and resetting the reaction cycle.

33 We demonstrate four independent client and server implementations, and the results of a

34 ed in a variety of environments and devices, client and server side alike.

35 y depends on their level of influence on the client and their merit relative to one another.

36 ere 15% relative increase in condom use with clients and 10% relative increase with stable partners;

37 (N), a middle domain (M) that interacts with clients and a C-terminal dimerization domain (C).

38 r chaperone activity against amyloid-forming clients and how cells defend against pathological tau ag

39 The affinity of mtHsp70 for its protein clients and its chaperone function are regulated by bind

40 th high levels of consistent condom use with clients and low use with steady partners in both study g

41 ng strategies that are attractive to healthy clients and might promote an inclusive and holistic visi

42 interventions of increasing condom use with clients and stable partners, extending ART to people wit

43 unbiased beliefs while advocating for their clients and that they must do so to secure just outcomes

44 fficulty in transferring large-scale data to clients and the lack of native support for hardware-acce

45 educed ability of HSJ1 to bind ubiquitylated clients and to exert its chaperone activity.

46 C samples, are heat shock protein 90 (HSP90) clients and undergo rapid degradation upon HSP90 pharmac

47 ctivated receptor alpha (PPARalpha), an IMP2 client, and PPARalpha protein.

48 adviser's current level of influence on the client, and relative merit prediction error affects acti

49 depression and inconsistent condom use with clients, and depression and HIV infection.

50 Attaining the UNAIDS targets in FSW, their clients, and MSM (but not in the rest of the population)

51 ange 27-51) of new infections in TWSW, their clients, and their stable partners over 10 years, with a

52 We present JS-MS, a 3-D, modular JavaScript client application for viewing MS data.

53 e of NatA, and showed that a number of Hsp90 clients are previously unknown substrates of the Arg/N-e

54 ns from the OMM, but it is unclear, how Msp1 clients are targeted for degradation.

55 g of its evolutionarily conserved downstream client as well as transcript accumulation of ER-resident

56 t protein induces changes in HSP70 and HSC70 client association and aggregation toward polypeptides w

57 could have a preference for interacting with clients at their later stages of folding.

58 with the question of how best to teach their clients be they humans, non-human animals or machines.

59 rasses (Labroides dimidiatus) and their fish clients before, during and after repeated, standardised

60 Eight of our 12 predictors of cleaner and client behaviour played a dynamic role in predicting bot

61 isturbance appeared to have little effect on client behaviour, as evidenced by consistency of visit r

62 options), whilst partner identity regulated client behaviours.

63 e domains (P1 and P2), but its mechanisms of client binding and chaperone function have remained uncl

64 n its complex with Hsp70, further regulating client binding and release.

65 d insights into the allosteric regulation of client binding by BiP and have enhanced our understandin

66 nd molecular dynamics simulations to map the client binding site(s) on SurA and interrogate the role

67 hanges appear crucial for exposing chaperone-client binding sites that are buried in the peroxidase-a

68 +)-bridged homodimers, which dissociate upon client binding.

69 g several conserved residues in the putative client-binding groove did not alter the UCS domain secon

70 ging highly conserved residues in a putative client-binding groove.

71 Removing the putative client-binding loop altered the secondary structure of t

72 p90(Ec) interaction involves residues in the client-binding region of Hsp90(Ec) and in the C-terminal

73 R805W, a mutation distant from the putative client-binding region, which in humans, has been known t

74 is most pronounced at the broadly conserved client-binding region.

75 p40 family members have different numbers of client-binding sites with distinct sequence selectivity,

76 lysis and conformational flipping rearranges client-binding sites, providing a paradigm of how energy

77 DP conformation of BiP, which represents the client-bound state of BiP.

78 ls indicated that a slow-diffusing, possibly client-bound Ydj1 fraction was asymmetrically enriched i

79 g game, two advisers competed to influence a client by modulating their own confidence in their advic

80 haperone Cdc37 aids Hsp90 to activate kinase clients by differentiating between these two intermediat

81 m20C plays a key role in the export of Cab45 clients by fine-tuning Cab45 oligomerization and thus im

82 A client can then call upon a remote server to implement p

83 My model assumes that an Hsp90-bound client can transition between a deactivating conformatio

84 Clients can perform queries on the API using different m

85 ate-binding surface and RDEL motif, ensuring client capture and retrieval.

86 ed in 3 US cities; all participants received client-centered care coordination (C4) and were offered

87 hese BCR constituents are present in a multi-client chaperone complex with HSP90.

88 en ATP-dependent conformational dynamics and clients/cochaperones recruitment remain elusive.

89 ructures of the various binding sites in the client complexed to the binding domains of the Hsp40 rev

90 E-mediated cross-linking of alpha-crystallin-client complexes could contribute to lens aging and pres

91 gnificantly higher in the glycated chaperone-client complexes than in glycated but uncomplexed protei

92 nder physiological conditions, the chaperone-client complexes underwent greater extents of cross-link

93 change inhibitor that stabilizes certain BiP-client complexes.

94 the ordered interactions of Hsp70/Hsp90 with clients could be a consequence of regulated changes in t

95 Mutants lacking calcineurin, or its client CrzA, displayed normal alkaline tolerance and nuc

96 We enable web client deployment of SciBet for rapid local computation

97 ion, and use of cleaning incitation signals, clients did not retaliate as expected (i.e., by chasing)

98 s dictated primarily by comparatively slower client dissociation from SGTA and nonprivate capture by

99 A multistate cohort of ADAP clients eligible for ADAP-funded QHPs were studied (2014

100 the RWHAP for the approximately 60% of RWHAP clients engaged in RWHAP-supported outpatient medical ca

101 midlevel providers and staff), and enhancing client engagement in primary HIV care to reduce emergenc

102 o maximize the HIV care workforce or improve client engagement.

103 ecific cleaning behavior in association with client fish and an exclusively monogamous life-style.

104 antennae, which are used both for attracting client fish and for intraspecific communication.

105 severe power asymmetries (e.g., the cleaner-client fish mutualism [9]) or snapshots of a single beha

106 It is generally assumed that protein clients fold following their release from chaperones ins

107 e sequential involvement of BiP and Grp94 in client folding where the conformation of BiP provides th

108 y dependent on this chaperone, no equivalent clients for Hsp70 have been reported.

109 Cleaners inspected clients for longer and were significantly less cooperati

110 ter structure (ERMES) complex Gem1 as native clients for Msp1 and Doa10.

111 C enables insertion and integrity of diverse clients, from tail-anchored to polytopic transmembrane p

112 a highly abundant protein, although very few clients have been identified and it is not essential for

113 Many potential HSP101 clients, identified by mass spectrometry of insoluble pr

114 Hsp40 engages the client in a highly dynamic fashion using a multivalent b

115 bstance use services utilization among RWHAP clients in 2017, nationally and in the 7 EHE-identified

116 s a protein holdase, binding and stabilizing clients in an ATP-independent process.

117 lly non-overlapping sets of obligate protein clients in cancer cells.

118 The client includes a modular Java backend with a novel stre

119 diverse types of protein substrates (called clients), including many kinases.

120 90-mediated folding of kinase and non-kinase clients-including Tsc2-thereby preventing their ubiquiti

121 ing and altering the structure of a putative client-interacting loop and 2) disrupt chaperone-client

122 e 627 has previously been reported to reduce client interaction and Aha1 binding.

123 y tight ( approximately 260 nm) for an Hsp70-client interaction and involved non-canonical regions of

124 h conventional heat shock protein 70 (HSP70)-client interaction mechanisms.

125 ll indirectly regulate their role in cleaner-client interaction patterns: context-dependency can henc

126 of a service-resource mutualism (the cleaner-client interaction), we identified consistent and dynami

127 To further define sHSP/client interactions and their relevance to sHSP chaperon

128 nt-interacting loop and 2) disrupt chaperone-client interactions by changing highly conserved residue

129 d mutations designed to 1) disrupt chaperone-client interactions by removing and altering the structu

130 ficiency depends on oligomerization and that client interactions can occur both with and without olig

131 n of clients (species recruited via scaffold-client interactions) fine-tunes it by transforming the s

132 fferent assays for both aggregation and sHSP/client interactions, and variable experimental condition

133 es, indicating a crucial role of R805 in UCS-client interactions.

134 "Closing" of dimers around clients is regulated by ATP binding, co-chaperones, and

135 lational database (Isabl DB), a command line client (Isabl CLI), a RESTful API (Isabl API) and a fron

136 in care and (2) viral suppression using 2016 client-level RWHAP Services Report data.

137 data mining, a comprehensive RESTful API and client libraries in Python, Java and JavaScript for fast

138 ing its localization and ability to retrieve clients like Ero1alpha and ERAP1 to the endoplasmic reti

139 e conformational switch, engaged early after client loading, that affects both local and long-range c

140 conformational changes that are required for client maturation.

141 ations included female sex workers and their clients, men who have sex with men, serodiscordant coupl

142 A simulated client method was used to measure non-prescription antib

143 pure LLPS is unfeasible, as binary scaffold-client mixtures.

144 Spy apparently permits sufficient client mobility to allow folding to occur while chaperon

145 bstantially decreased the levels of the IMP2 client mRNAs encoding carnitine palmitoyltransferase 1A

146 on through increased degradation of the IMP2 client mRNAs PPARalpha and CPT1A This finding indicates

147 re due to altered output from different IMP2 client mRNAs.

148 study highlights that consistency in cleaner-client mutualisms relies strongly on the local, rather t

149 ation and identified a potentially important client of E. coli Hsp90 (Hsp90(Ec)), FtsZ.

150 Chk1, a mitotic checkpoint kinase and a client of Hsp90, was degraded relatively slowly in wild-

151 summary, our data show HSP90 as a downstream client of phosphorylation-mediated signalling in an orga

152 on neuronal nitric oxide synthase (nNOS), a client of the Hsp90 and Hsp70 chaperone system, we have

153 years, had non-affective psychosis, had been clients of early intervention services for 12-30 months,

154 Reaching clients of FSW, as well as key populations, can efficien

155 ocial desirability bias, and (3) patients or clients of STI services were not interviewed, and theref

156 ained unclear why some proteins are obligate clients of the GroE system, whereas other closely relate

157 cking HSP27-regulated survival signaling and client-oncoprotein interactions.

158 ther preparing multiple quantum resources by clients or two-way quantum communication.

159 e enables Hsp90 to use ATP energy to drive a client out of thermodynamic equilibrium toward its activ

160 Twenty-four client-owned dogs (OA, n = 11; controls, n = 13) were re

161 We analyzed sera from 35 client-owned, 20 feral, and 30 specific pathogen-free (S

162 The Hsp90 clients participate in the full breadth of cellular proc

163 when the presence of third-party species and client partner abundance locally increased (creating cho

164 They reported data on more than 13,500 clients per year (mean = 969/site, SD = 1,351).

165 bility of Emc4 and the hydrophilicity of the client pocket are required for EMC function.

166 benefits of psychological interventions from client, practitioner, and societal perspectives is only

167 due to the need for most chaperones to bind clients promiscuously.

168 of the aggregation pathway to further delay client protein aggregation.

169 The interactions of Hsp70 with a client protein at different sites results in a fuzzy cha

170 proteostasis machine recognizes and sorts a client protein based on two biophysical properties of th

171 tially regulating the biogenesis of distinct client protein classes.

172 the ATP-independent chaperone Spy allows its client protein Im7 to fold into the native state while c

173 t contacts and encapsulates the unstructured client protein in the center of the decamer ring.

174 Understanding the mechanisms of client protein interaction with Hsp70 chaperones is esse

175 laucoma by reducing protein synthesis and ER client protein load in TM cells.

176 M promotes aberrant protein synthesis and ER client protein load, leading to TM dysfunction and cell

177 ng in nascent protein folding and regulating client protein location and translocation within the cel

178 ore clearly defines the role of NFU1 in Fe-S client protein maturation in Arabidopsis chloroplasts am

179 se and that delineates a largely hydrophilic client protein pocket.

180 olecular chaperone involved in ATP-dependent client protein remodeling and activation.

181 complex to degrade DLK-1, which is an Hsp90 client protein stabilized by the chaperones.

182 mTXNPx in complex with a thermally unfolded client protein, and revealed that the flexible N-termini

183 complexes formed between alphaBc and a model client protein, chloride intracellular channel 1.

184 as four distinct sites on a small 53-residue client protein, hTRF1.

185 m to propagate structural changes to a bound client protein.

186 ciating with Hsp70 after Hsp70 is bound to a client protein.

187 ures of an Hsp40 in complex with an unfolded client protein.

188 inase (SYK), which we identified as an HSP90 client protein.

189 elieved by bacterial Hsp70 and an activating client protein.

190 cturally diverse chains to interact with the client protein.

191 cytosol, but also need to accurately select client proteins and actively guide their clients to the

192 Hsp90 remodels over 300 client proteins and is essential for cell survival in eu

193 However, the client proteins and the metabolic processes served by th

194 he endoplasmic reticulum (ERQC) ensures that client proteins are properly folded.

195 target unique substrates, some of which are client proteins associated with epigenetic control.

196 chaperones govern the function of essential client proteins critical for normal cell function as wel

197 nabled identification of novel mitochondrial client proteins for HSP70.

198 , are among the best characterized groups of client proteins for the 90-kDa heat shock protein (HSP90

199 endent segregase that extracts ubiquitylated client proteins from membranes, protein complexes, or ch

200 ion and activity of HSP90 and the downstream client proteins implicated in various cancer cell capabi

201 Hsps) prevent aggregation of thermosensitive client proteins in a first line of defense against cellu

202 ein folding homeostasis by engaging unfolded client proteins in a process that is tightly coupled to

203 sting that the accumulation of mitochondrial client proteins in the absence of UBQLN1 is cytostatic.

204 ation and processing of Hsp90-Aha1-dependent client proteins in vivo We conclude that it is possible

205 mic acid (E) abolishes interactions with its client proteins p53 and UPF1.

206 he interaction of 14-3-3 proteins with their client proteins severely impairs high temperature-induce

207 ediated autophagy, leading to degradation of client proteins such as the transcription factors myocyt

208 ated Ubqln2 mutants and identifies candidate client proteins that are altered in vivo in disease mode

209 n ATP-independent manner by interacting with client proteins that are in states susceptible to aggreg

210 pede RNA entanglement and recruit additional client proteins that promote SG maturation or induce a l

211 sm by which alphaBc interacts with misfolded client proteins to prevent their aggregation.

212 This mechanism allows client proteins to remain mainly in the reduced state an

213 raction network of co-chaperone partners and client proteins while preserving essential chaperone fun

214 nd subsequent degradation of several hundred-client proteins, and activation of Hsp70 has been sugges

215 e dodecamer, accessible for interaction with client proteins, and distinct from previous undefined or

216 are confounded by the use of different model client proteins, different assays for both aggregation a

217 Among the client proteins, Hsps regulate numerous signal-transduct

218 one HSP90 facilitates the folding of several client proteins, including innate immune receptors and p

219 olding and functional activation of numerous client proteins, many of which are oncoproteins.

220 gp93 was found capable of rescuing gp96 client proteins, such as Toll-like receptors (TLRs) and

221 These interactions include client proteins, which physically interact with Hsp90 an

222 chaperone important for the activity of many client proteins.

223 olding and organize conformationally dynamic client proteins.

224 ugh protein-protein interactions (PPIs) with client proteins.

225 erves in the maturation of specific [4Fe-4S] client proteins.

226 their interactions with each other and with client proteins.

227 or the folding and activation of hundreds of client proteins.

228 rativity in their interactions with numerous client proteins.

229 otifs known to direct recruitment of PLKs to client proteins.

230 ng and activation of a disparate ensemble of client proteins.

231 rent evidence for droplet-driver and droplet-client proteins.

232 ure of 14-3-3 affects the structures of many client proteins.

233 al for maintaining the stability of numerous client proteins.

234 uires UBQLN1 for survival to identify UBQLN1 client proteins.

235 in tumor growth by stabilizing pro-survival client proteins.

236 es the conformation of hundreds of cytosolic client proteins.

237 s, transfer proteins load Fe-S clusters onto client proteins.

238 nfold, translocate, and subsequently degrade client proteins.

239 tions (PPIs) with each other and with their "client" proteins.

240 cular chaperone that remodels its substrate 'client' proteins, facilitating their folding and activat

241 the stabilisation and activity of oncogenic 'client' proteins.

242 gulation of its chaperone/co-chaperone based client relationships can be used to adjust the SCV toler

243 from BiP and ATP binding to BiP, and thereby client release.

244 ey recognize and determine the fate of their clients remains unclear.

245 w energy from ATP hydrolysis can be used for client remodeling.

246 d testing, described below, to tattoo studio clients reporting rashes.

247 The RSR include data on client retention in HIV care, prescription of antiretrov

248 always considering it in the context of the client's folding pathway and biological function.

249 al to inform the duration and intensity of a client's mental health treatment.

250 n based on two biophysical properties of the client's misfolded state (M state): its stability and it

251 -scaffold valencies form additional scaffold-client-scaffold bridges increasing stability.

252 More specifically, we show that in a client-server scenario, it is possible for the clients t

253 The intervention consisted of a client service charter and a facility-based, quality-imp

254 triage system is divided into an uncommitted client-SGTA complex, a self-sufficient targeting module,

255 Client-SGTA engagement of the targeting module induces r

256 action between Spy and a recently discovered client SH3 strongly inhibits the ability of the client t

257 ence in their advice about which lottery the client should choose.

258 Clients should consider a number of criteria when decidi

259 minates the phase landscape, introduction of clients (species recruited via scaffold-client interacti

260 My model may inform client-specific and cell-type-specific therapeutic inter

261 id-accessible membrane cavities which confer client-specific regulation, and a non-insertase EMC func

262 Once enrolled in ADAP-funded QHPs, ADAP clients stay enrolled.

263 ecular mechanism of Hsp90, cochaperones, and clients' structure and function.

264 ated mechanism that affects CRL activity and client-substrate ubiquitylation at multiple levels.

265 that cohesin complex members were endogenous client substrates of DCAF15.

266 ors has benefited from the identification of clients, such as Raf-1 proto-oncogene, Ser/Thr kinase (R

267 sign while three used some type of simulated client survey referring to a fictitious case of a child

268 ible toolkit which is driven through a local client that runs alongside vendor software and connects

269 apoptosis protein (XIAP), are obligate Hsp70 clients that are rapidly (within approximately 3-12 h) l

270 cally increase service quality for predatory clients that can "punish" more severely.

271 Whereas low-valency clients that compete for scaffold-scaffold binding sites

272 y components show reduced levels of one such client, the glutamate transporter EAAT1.

273 The more tightly Spy binds to its client, the more it slows the folding rate of the bound

274 re we implement a quantum API that enables a client to estimate the absolute value of the trace of a

275 ent SH3 strongly inhibits the ability of the client to fold while chaperone bound.

276 The server prepares quantum states for clients to encode messages to avoid the participants' co

277 among TWSW, their stable partners, and their clients to estimate the impact and cost-effectiveness of

278 g the stability, folding, and degradation of clients to maintain cellular protein homeostasis.

279 ners might be taking advantage of distracted clients to reduce their service quality.

280 ient-server scenario, it is possible for the clients to share a key and reveal nothing about what key

281 ect client proteins and actively guide their clients to the appropriate target membrane.

282 suite of co-chaperone molecules that bring "clients" to the primary chaperone for efficient folding.

283 module induces rapid, private, and committed client transfer to TRC40 for successful biosynthesis.

284 d do not vary their service quality based on client trophic position or cleaner shrimp group size.

285 tion of at least 300 proteins, also known as clients, under normal cellular conditions.

286 occasionally "cheat" and remove live tissue, clients use partner control mechanisms to maintain clean

287 ven good advice that had been ignored by the client using a situation where monetary incentives fail

288 HSP70 and 71 kDa heat shock cognate (HSC70) clients using a ubiquitin-mediated proximity tagging str

289 Order entry via mobile client was associated with decreased after-hours EHR use

290 Thirty-eight of 226 interviewed clients were identified as outbreak-associated cases.

291 In 2014, a majority of clients were male (71% versus 28% female and 0.2% transg

292 n directly interact even in the absence of a client, which opens up an alternative possibility that t

293 a highly diverse and numerous set of protein clients, which when combined with the high expression le

294 e this hope true more often, for more of the clients who need our services, despite severe resource c

295 A multistate cohort of ADAP clients who were eligible for ADAP-funded QHPs were stud

296 interactions with alpha-lactalbumin, a model client whose aggregation pathway is well defined.

297 Such businesses target prospective clients with misleading claims, expose patients to poten

298 In 2017, among RWHAP clients with reported age and transmission category, 6.7

299 tted from Mayo Clinic Laboratories reference clients, with positive results reported for three (11%):

300 single misfolded protein that extend to many clients within chaperone networks.