ライフサイエンスコーパス: clinical effect

1 l cytokines was not associated with a marked clinical effect.

2 despite limited and conflicting data on its clinical effect.

3 ), and CY pretreatment had no immunologic or clinical effect.

4 ce that would account for the specificity of clinical effect.

5 unction through which sibutramine exerts its clinical effect.

6 mology to endogenous TPOs, studies confirmed clinical effect.

7 th placebo-treated forearms did not show any clinical effect.

8 ention or delay of diabetes would have major clinical effect.

9 iting the target has little correlation with clinical effect.

10 and the other failed to show any beneficial clinical effect.

11 anisms have been postulated for the observed clinical effect.

12 ull spectrum of neurovascular injury and its clinical effect.

13 with RSHZ19 may, in part, explain its better clinical effect.

14 t to detect biases that can have significant clinical effect.

15 ssel concentration will result in a relevant clinical effect.

16 NMDAR) channel-blocking drugs with divergent clinical effects.

17 ct biological effects that may have variable clinical effects.

18 istence are crucial to achieving the desired clinical effects.

19 g replication early is sufficient to achieve clinical effects.

20 chanism of action that may contribute to its clinical effects.

21 aled that the K422T mutation per se had mild clinical effects.

22 opontine nucleus regions may differ in their clinical effects.

23 ust be administered at high doses to observe clinical effects.

24 ify the relation between amyloid removal and clinical effects.

25 he results demonstrate target engagement and clinical effects.

26 nants of methotrexate's pharmacokinetics and clinical effects.

27 exate plasma concentration is related to its clinical effects.

28 romodulatory effect thus resulting in larger clinical effects.

29 ems may contribute to isoflurane's important clinical effects.

30 gs are known to have opposing behavioral and clinical effects.

31 ief Psychiatric Rating Scale (BPRS) assessed clinical effects.

32 treatment was not evaluable due to negative clinical effects.

33 triction causes malnutrition and has adverse clinical effects.

34 evels on basophils contrast with more modest clinical effects.

35 mogenic Scn5a+/- hearts in parallel with its clinical effects.

36 Scn5a+/- murine hearts that recapitulate its clinical effects.

37 assessed for their physical, biological, and clinical effects.

38 ent pharmacopoeia tests, but provoke adverse clinical effects.

39 tor antagonists can strongly impact on their clinical effects.

40 ate markers of performance to correlate with clinical effects.

41 ization activity in direct relation to their clinical effects.

42 thus influencing their biological action and clinical effects.

43 and promoting their survival and consequent clinical effects.

44 evodopa, particularly doses at threshold for clinical effects.

45 e coding region of the HFE gene that produce clinical effects.

46 amine and help to explain their differential clinical effects.

47 l antiretroviral therapy have similar 4-year clinical effects.

48 , which may contribute to its behavioral and clinical effects.

49 to be administered at high doses to observe clinical effects.

50 concentrations may translate into beneficial clinical effects.

51 ntrations of anesthetics required to achieve clinical effects.

52 ed significant study heterogeneity and small clinical effects.

53 des of signal interference did not result in clinical effects.

54 ns may contribute to the drugs' differential clinical effects.

55 jury, and this acidosis may have detrimental clinical effects.

56 ell time on threat, which partially mediated clinical effects.

57 ognitive effects may underlie their positive clinical effects.

58 tes that are traceable to pharmacological or clinical effects.

59 ri primary outcome measures of cognitive and clinical effects.

60 nd-name and generic medications have similar clinical effects?

61 PRGF platelet concentrate failed to augment clinical effects achieved with the xenograft alone in tr

62 trate and MS produce similar hemodynamic and clinical effects acutely and chronically despite the fou

63 or (G-CSF) results in important biologic and clinical effects, although the mechanism by which this o

64 Among patients with asthma, the clinical effect and relative contribution of maternal sm

65 Based on the positive clinical effect and the ELA profile of GCF, it can be su

66 States, but little is known regarding their clinical effects and biokinetic distribution with long-t

67 This study evaluates the clinical effects and pathophysiologic basis of hypotherm

68 get of rapamycin (mTOR), has produced robust clinical effects and revolutionised the treatment of met

69 activity to better understand its potential clinical effects and role in disease prevention.

70 To assess the clinical effects and safety of the recombinant human LAL

71 ous studies evaluating the pharmacologic and clinical effects and safety profiles of these drugs in p

72 mones, because they have shown only a modest clinical effect, and are often used in combination with

73 ne effects will persist and reliably predict clinical effects, and by the challenge in interpreting t

74 e deficiency was not associated with adverse clinical effects, and the trauma-induced changes in leuk

75 genetic variation with the highest potential clinical effects, and uncertainty about clinically repor

76 to the cardiovascular system, data on their clinical effects are lacking.

77 ences of treatment and their relationship to clinical effects are not well understood.

78 widely prevalent in all communities yet its clinical effects are poorly understood and often overloo

79 its metabolite 1-hydroxymidazolam, the major clinical effects are thus likely caused by midazolam its

80 The reasons for this, including clinical effect, are unclear.

81 ge base supporting the safety and beneficial clinical effects associated with EECP, this therapy can

82 loited therapeutically to circumvent adverse clinical effects associated with IFN therapy.

83 to treat depression and to examine specific clinical effects associated with serious outcomes.

84 nological mechanisms underlie the beneficial clinical effects associated with the induction of HMW-MA

85 odegenerative environment and exert powerful clinical effects; at least a portion of these effects ma

86 ilot studies have shown significant positive clinical effects, but, thus far, no large randomized tri

87 enzodiazepine (BZ) anxiolytics mediate their clinical effects by enhancing the effect of gamma-aminob

88 b monotherapy is not having any demonstrable clinical effects by reducing the EGFR-positive pool of C

89 C5a activation fragment (C5aR1), a striking clinical effect can be realized.

90 in young individuals, at times with flagrant clinical effects caused by cerebral hemorrhages or seizu

91 ay between-group analyses of covariance) and clinical effects (clinically significant improvement) we

92 equivalence with no detectable difference in clinical effects, confirming that US Food and Drug Admin

93 d APOBEC3 may have beneficial or detrimental clinical effects depending on how they affect the bindin

94 e in human beings or animals to show adverse clinical effects due to the gadolinium deposition in the

95 ement of FEV(1) may not exert any meaningful clinical effect during tidal breathing.

96 release formulation produced no cognitive or clinical effect either in non-smokers or smokers.

97 Owing to the rapid and robust clinical effects, electroconvulsive therapy (ECT) repres

98 The study provides evidence of enhanced clinical effects for patients receiving active ABMT.

99 gen receptor modulators that elicit distinct clinical effects from estrogens used for hormone replace

100 Beneficial clinical effects have been demonstrated with the additio

101 mechanisms by which these agents exert their clinical effects have, until recently, remained unclear.

102 oxyglucose PET tracers that have a potential clinical effect in oncology.

103 d blood kinetics, biochemical responses, and clinical effects in 5 adult men and 5 adult women who vo

104 significant, anti-eosinophil and beneficial clinical effects in adult patients with active, corticos

105 gainst one melanoma subtype may have adverse clinical effects in another.

106 to mite allergens associated with favorable clinical effects in atopic dermatitis patients.

107 dynamically superior to IPC of the foot, its clinical effects in claudicants remain undetermined.

108 Data on the epidemiology and clinical effects in community-dwelling elderly persons a

109 th associated with significant antiviral and clinical effects in experimental human influenza.

110 the anti-CD40L Ab 5c8, demonstrated positive clinical effects in patients with autoimmune diseases; h

111 ion frequency in a manner reminiscent of its clinical effects in persons with PD.

112 n awake and anesthetized individuals and its clinical effects in the ischemia/reperfusion setting.

113 nts directed at amyloid-beta will have major clinical effects in the later stages of the disease.

114 ate that T-cell mosaicism may have different clinical effects in WAS.

115 prevent relapse and mediate other beneficial clinical effects including control of infections without

116 ons of these nutrients required to achieve a clinical effect make traditional delivery by capsules an

117 This limited added clinical effect may justify the use of a protocol combin

118 of the explanation for its observed positive clinical effects may be the stimulation of angiogenesis.

119 s each decrease susceptibility to CAIA, with clinical effects most pronounced in C5aR-deficient mice.

120 Although some have shown modest clinical effects, most have not been effective.

121 In control subjects, neither positive clinical effects nor cerebral blood flow decreases were

122 To examine the clinical effect of 14-3-3zeta overexpression in advanced

123 bdominal fluid protein loss and evaluate the clinical effect of accounting for abdominal fluid nitrog

124 his phase 3 trial, we aimed to determine the clinical effect of adding IMA901 to sunitinib, the stand

125 Data on the results and clinical effect of an invasive risk stratification strat

126 We report the clinical effect of B7-H1 in RCC patients with a median o

127 PubMed was searched for publications on the clinical effect of brain stimulation in dystonia up thro

128 Q3) What is the clinical effect of DAPT in stable patients who are >1 ye

129 ormed donor KIR genotyping and evaluated the clinical effect of donor KIR genotype and donor and reci

130 tion have a high degree of predictability of clinical effect of dopaminergic drugs on motor symptoms

131 erotonin in behavioral regulation and on the clinical effect of drugs for depression.

132 e to hyperuricemia and hypertension, but the clinical effect of fructose reduction on blood pressure

133 Epidemiology, risk factors, and clinical effect of infections by multiresistant bacteria

134 The epidemiology and clinical effect of inherited chromosomally integrated HH

135 anted and were unable to maintain satisfying clinical effect of inrathecally infused baclofen.

136 is study aimed to evaluate the incidence and clinical effect of jaundice in critically ill patients w

137 the mechanism responsible for the beneficial clinical effect of lipid-lowering therapies.

138 ding the molecular mechanisms underlying the clinical effect of lithium and myo-inositol-mediated ske

139 rant microRNA (miRNA) profiles; however, the clinical effect of miRNA expression has not previously b

140 The clinical effect of MiStent sirolimus-eluting stent compa

141 rovides preliminary evidence of the positive clinical effect of multiparametric MR imaging-directed I

142 The clinical effect of MYD88 mutation activating the nuclear

143 The clinical effect of newer-generation drug-eluting stents

144 The beneficial clinical effect of NK-cell alloreactivity has not been u

145 er 18 months of randomised follow-up and the clinical effect of open access to pressure information f

146 rstanding is limited regarding the long-term clinical effect of persistent CMV infection in immunocom

147 s and/or IL-6R antibodies might increase the clinical effect of platinum-based chemotherapy in otherw

148 med to assess the feasibility, accuracy, and clinical effect of point-of-care Xpert MTB/RIF testing a

149 trial is not sufficient to advocate the true clinical effect of PRF on recession treatment with CAF +

150 To evaluate the clinical effect of procedure duration on AST when either

151 sis that ADCC plays an important role in the clinical effect of rituximab at the level of the effecto

152 The clinical effect of routine intracoronary thrombus aspira

153 The clinical effect of routine oxygen therapy in patients wi

154 a mechanistic explanation for the remarkable clinical effect of the anti-CD20 mAbs in a representativ

155 The clinical effect of the observed lumen and vessel remodel

156 and treatment devices will have the profound clinical effect of their cardiological predecessors will

157 ive cytogenetic audit to assess the probable clinical effect of these proposed policy changes.

158 The national burden and clinical effect of this novel presentation of MRSA disea

159 However, the clinical effect of this SNP in LAP is ethnicity dependen

160 The clinical effect of this would ultimately result in a red

161 RIs, and may be a potential substrate of the clinical effect of treatment.

162 The goal of this study was to evaluate the clinical effect of using (90)Y-edotreotide to treat symp

163 daily living; however, information about the clinical effect of various strategies of cognitive rehab

164 f for abnormal is placed should indicate the clinical effect of wrong results.

165 randomized clinical trial is to evaluate the clinical effects of a Lactobacillus rhamnosus SP1-contai

166 he purpose of this study was to evaluate the clinical effects of a long-term calorie-restriction (CR)

167 mined the electrocardiographic, vascular and clinical effects of a medical food bar enriched with L-a

168 ly standardized instruments to determine the clinical effects of a preseasonal, ultra-short-course bo

169 microscope may have utility in assessing the clinical effects of a small interfering RNA (siRNA)-base

170 understanding the underlying biology of the clinical effects of AC medications.

171 nists at the NMDA receptor glycine site, the clinical effects of adding D-serine to clozapine were as

172 dies are recommended to better determine the clinical effects of adjunctive AZM in patients who smoke

173 ations are ideally suited for studies on the clinical effects of alleles that are rare in general pop

174 med a phase I study assessing the safety and clinical effects of AMD3100 in patients with multiple my

175 The clinical effects of amphetamine are quite variable, from

176 es related to AMR, focusing on epidemiology, clinical effects of AMR, discovery of novel agents to tr

177 e actions could contribute to some important clinical effects of anaesthetics.

178 designed to investigate the immunologic and clinical effects of antigen-loaded dendritic cells admin

179 open trials have demonstrated the beneficial clinical effects of aspirin desensitization (AD) in pati

180 ective study to determine the biological and clinical effects of bariatric surgery in patients with N

181 rosteroids, the role of neurosteroids in the clinical effects of BDZs is unknown.

182 pathways that likely underpin the beneficial clinical effects of calcitriol in patients with SR asthm

183 This study determined the clinical effects of chlorhexidine treatment on peri-impl

184 DA-DKP, which could account for some of the clinical effects of cHSA.

185 ing these elements, may underlie some of the clinical effects of clozapine.

186 ilable data concerning the immunological and clinical effects of CMVIG after heart or lung transplant

187 ng the utility of this strategy to index the clinical effects of CNVs.

188 s suggest the need to carefully evaluate the clinical effects of combination chemotherapies that inco

189 This may account for the superior clinical effects of combination LABA/corticosteroid trea

190 ing on cancer cell biology and emphasise the clinical effects of continued smoking in patients with c

191 Recent research suggests that some clinical effects of coxibs, selective inhibitors of cycl

192 se findings help clarify the immunologic and clinical effects of CTLA-4 antibody blockade in previous

193 animal models are clearly needed to explain clinical effects of DBS in TRD.

194 Curiously enough, clinical effects of DD did not strictly correlate with C

195 inical trials that compared the metabolic or clinical effects of different protein intakes in adult c

196 ed trials are needed to fully assess the net clinical effects of drug-eluting stents compared with ba

197 The beneficial clinical effects of eplerenone (as observed in the main

198 of the relation between pharmacodynamic and clinical effects of eptifibatide in such patients and ma

199 R-type Ca(2+) channels may contribute to the clinical effects of general anesthesia.

200 The clinical effects of gluten-sensitive enteropathy with vi

201 s study was the systematic evaluation of the clinical effects of glycine as an adjunct to the atypica

202 part of a previously published study of the clinical effects of GTR therapy without the use of bone

203 t this late time point rescued mice from the clinical effects of GVHD caused by T cells expressing ei

204 her organisms and may relate to the observed clinical effects of human mutations in that region.

205 cat)/K(0.5)(h)) and exhibits the most severe clinical effects of hypoglycemia.

206 The trial defined immune, hematologic, and clinical effects of IL-2 in this setting.

207 how a recipient's repertoire influences the clinical effects of induction therapy.

208 To explore the clinical effects of inflammation associated with vascula

209 r the accumulation of evidence regarding the clinical effects of inhibition of cyclooxygenase (COX)-1

210 ntrol and muscle metabolism, biochemical and clinical effects of insulin treatment in the severely bu

211 sible explanation of how the well-recognized clinical effects of ketogenic diets can alter human beha

212 We examined physiological and clinical effects of l-methylfolate, the fully reduced an

213 We determined the short-term hemodynamic and clinical effects of levosimendan, a novel calcium-sensit

214 performed this pilot project to examine the clinical effects of long-term low-dose androgens in men

215 t to compare the neurohormonal responses and clinical effects of long-term, high-dose versus low-dose

216 ome of the salutary electrophysiological and clinical effects of mineralocorticoid antagonists in myo

217 er, uptake 2, in the brain will speed up the clinical effects of norepinephrine reuptake inhibitor an

218 ationship between asthma and obesity and the clinical effects of obesity in children with asthma.

219 dy sought to assess the pharmacokinetics and clinical effects of oral BG9928 in heart failure (HF) pa

220 Despite the common occurrence and frequent clinical effects of peritumoral cysts in the central ner

221 es all the benefits of fish consumption, and clinical effects of plant-derived n-3 PUFA.

222 al is to clinically evaluate and compare the clinical effects of potassium-titanyl-phosphate (KTP) la

223 nd studied the impact of aspirin dose on the clinical effects of prasugrel.

224 We here describe clinical effects of recombinant TCR ligands (RTLs) compr

225 ps in knowledge regarding the biological and clinical effects of recurrent genomic aberrations or gen

226 ting clinical trials that aim to measure the clinical effects of restorative therapies after stroke.

227 examined the psychological, behavioral, and clinical effects of risk scanning with the Navigenics He

228 We examined the antimicrobial and clinical effects of scaling and root planing (SRP) with

229 non-small-cell lung cancer (NSCLC), but the clinical effects of SFK inhibition in NSCLC are unknown.

230 mechanisms of atherogenesis and thrombosis, clinical effects of smoking and benefits of cessation, a

231 The long-term clinical effects of soy protein containing various conce

232 The known and potential clinical effects of such antibodies are discussed.

233 rther studies are under way to determine the clinical effects of tezosentan in the setting of acute h

234 r the development of new drugs to hamper the clinical effects of the disease.

235 cle reviews the available data regarding the clinical effects of the new COX-2-specific inhibitors, a

236 p between the serotonin transporter gene and clinical effects of the selective serotonin reuptake inh

237 clinical trial is to evaluate the adjunctive clinical effects of the systemic administration of ornid

238 tionship of this boost to age paralleled the clinical effects of the vaccine observed during the effi

239 However, the clinical effects of these abnormalities cannot be determ

240 The clinical effects of these mutations are short stature, a

241 The clinical effects of these therapies are variable and oft

242 ance of this potentiation for the beneficial clinical effects of this combination of agents and the d

243 immense diversity coupled with differential clinical effects of this diversity suggest that an effec

244 ost-gut microbial relationship, what are the clinical effects of this shift in relationship?

245 dditional studies to further investigate the clinical effects of this treatment.

246 The clinical effects of TIPS have been confirmed, however, n

247 The beneficial clinical effects of tirofiban in high-risk patients can

248 , Placebo Controlled Study of the Short Term Clinical Effects of Tolvaptan in Patients Hospitalized f

249 tentially unique molecular, physiologic, and clinical effects of too much sitting (inactivity physiol

250 Clinical effects of transcranial electrical stimulation

251 The clinical effects of treatment with beta-adrenoceptor (be

252 ptable toxicity; the rapid onset and adverse clinical effects of tumor flare represent a significant

253 rmed a double-blind, cross-over trial of the clinical effects of ustekinumab in 104 patients with mod

254 The long-term clinical effects of wartime traumatic brain injuries (TB

255 hormone replacement seems to have a minimal clinical effect on bone.

256 types of protein (animal and soy) has little clinical effect on cardiovascular disease risk factors,

257 ected against IL-23p19 or IL-12/23p40 had no clinical effect on established inflammatory skin disease

258 savings could potentially have a substantial clinical effect on resource use and patient throughput.

259 ma medication, and had a positive, long-term clinical effect on rhinoconjunctivitis symptoms and medi

260 alamic nucleus target that provides the best clinical effect on stimulation.

261 reatment decisions at the point of care, and clinical effect on tuberculosis-related morbidity.

262 eatment (1970-1996) as well as analyzing its clinical effects on 360 patients with DSM-IV bipolar dis

263 The purpose of this study was to measure its clinical effects on healthy people.

264 a-2a interferon (IFN-alpha2a) has beneficial clinical effects on human T-cell leukemia virus type 1 (

265 ained-release green tea gel and to study its clinical effects on patients with chronic periodontitis

266 ACTH may account for some of its established clinical effects on the CNS.

267 have immunomodulatory and thereby beneficial clinical effects on the overall skin condition, as well

268 nt in EMD may be responsible for some of its clinical effects, or that amelogenin alone may not trigg

269 outcomes were identified (disease activity, clinical effects, pain, early morning stiffness duration

270 INTERPRETATION: Clinical effects ranged from seemingly not clinically im

271 Statistical (analysis of covariance) and clinical effects (reliable change index) were tested in

272 These data are consistent with the useful clinical effects reported with compounds that can augmen

273 ts and RPC cases, marijuana source and type, clinical effects, scenarios, disposition, and length of

274 These clinical effects seem to be intrinsically related to the

275 Body scheme alteration was the only clinical effect showing a lateralization, as they were e

276 Clinical effect size was moderate to large with high pro

277 of statins may account for their beneficial clinical effect: Statins decreased the migration of leuk

278 erspective on study results that ignores the clinical effects the study was conducted to measure.

279 Despite its high prevalence and clinical effect, the neurobiological substrates underlyi

280 lude a definitive statement about safety and clinical effect, these results provide the basis for lar

281 but also important differences in regards to clinical effects, toxicity and patient populations in wh

282 ations vs non-R882 mutations showed opposite clinical effects-unfavorable for R882 on RFS (all: hazar

283 These data reveal that PUFA may exert their clinical effects via their capacity to regulate the expr

284 However, proof of a clinical effect was lacking until the publication of thr

285 The clinical effect was larger in children with more severe

286 This clinical effect was lost in Treg-depleted mice, demonstr

287 This clinical effect was most prominent in low-distress BCSs.

288 This clinical effect was not restricted to a few of the teste

289 Clinical effect was noted as early as 1 week after initi

290 es, and the method he used to discover their clinical effects was open-minded, exploratory, comprehen

291 o 7.00 mg/L, which corresponds to an optimal clinical effect, was identified.

292 Trophic mechanisms of observed clinical effects were explored with molecular and cellul

293 Ex vivo splenic T cell responses and in vivo clinical effects were measured.

294 The greatest clinical effects were observed with the 22.5 mg and 75 m

295 precise dose-responses of physiological and clinical effects, whether fish oil provides all the bene

296 in cachexia could have positive or negative clinical effects, which must be distinguished through ap

297 TMS-treated patients showed positive clinical effects, which were indicated by a reduction in

298 The correlation of clinical effects with brain drug levels in the paroxetin

299 escription medications may result in serious clinical effects with potential life-threatening complic

300 A trial of a treatment that had a similar clinical effect would have a large increase in power, al