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1 ment; however, the study was not powered for clinical efficacy.
2 table T cell targets and may help to predict clinical efficacy.
3 eric antigen receptor (CAR) shows remarkable clinical efficacy.
4 received regulatory approval or demonstrated clinical efficacy.
5 ntended mechanism of action, and encouraging clinical efficacy.
6 eting IL-23 and IL-17 have shown significant clinical efficacy.
7 cificity, "off-target" toxicity, and limited clinical efficacy.
8 nicotine vaccine formulations to move toward clinical efficacy.
9 ce molecules have thus far failed to achieve clinical efficacy.
10 ng developed, the first of which are showing clinical efficacy.
11 for antibodies that have already shown some clinical efficacy.
12 ts where NK cells are partly responsible for clinical efficacy.
13 ve been developed and demonstrate remarkable clinical efficacy.
14 ansplant recipients, demonstrated safety and clinical efficacy.
15 escaping vectors are important for improving clinical efficacy.
16 therapeutic monoclonal antibodies has shown clinical efficacy.
17 R monoclonal antibody that has shown limited clinical efficacy.
18 sibility, safety, and strong indications for clinical efficacy.
19 candidates is often required for predicting clinical efficacy.
20 n amyotrophic lateral sclerosis did not show clinical efficacy.
21 directed toward this pathway show promising clinical efficacy.
22 oxidized by CYP3A4, thereby extending their clinical efficacy.
23 these circuits may underlie this plateau in clinical efficacy.
24 ent, suggesting that resistance limits their clinical efficacy.
25 ), and recent studies have suggested similar clinical efficacy.
26 ical trials, however, drug resistance limits clinical efficacy.
27 mmune responses and contribute to their full clinical efficacy.
28 25 mAbs on hDCs that may contribute to their clinical efficacy.
29 are needed to assess long-term toxicity and clinical efficacy.
30 ion has resulted in substantial increases in clinical efficacy.
31 e emergence of drug resistance hampers their clinical efficacy.
32 in vitro, there are few data supporting its clinical efficacy.
33 of prostate cancer is the marginal, if any, clinical efficacy.
34 ination during chemotherapy are required for clinical efficacy.
35 easibility, safety and strong indications of clinical efficacy.
36 therapeutics, substantially improving their clinical efficacy.
37 novel long-acting A2A agonists with improved clinical efficacy.
38 often translating into major improvements in clinical efficacy.
39 er long-term studies are warranted to assess clinical efficacy.
40 wed considerable variability that may impact clinical efficacy.
41 or T-cell receptors (TCRs) has demonstrated clinical efficacy.
42 ion and antinociceptive tolerance, limit its clinical efficacy.
43 ting, novel mechanisms of action, and higher clinical efficacies.
44 was suspended in 136 cases (mostly owing to clinical efficacy [38.2%], inefficacy [26.5%], and ADRs
47 r design that compared the pharmacokinetics, clinical efficacy, adverse events, or immunogenicity of
51 gative infections and the adequacy of GNC on clinical efficacy and all-cause mortality in the telavan
52 s we speculate that it may indicate a better clinical efficacy and be a better choice than current tr
57 vo cellular kinetic analyses to characterize clinical efficacy and CRS severity associated with CTL01
58 hese cells and develop strategies to enhance clinical efficacy and extend this therapy to other malig
59 rass pollen extracts resulted in significant clinical efficacy and has been shown to be a safe treatm
60 eclinical development hinders predictions of clinical efficacy and identifying factors that underlie
62 in the management of PAH patients; however, clinical efficacy and long-term tolerability of some pro
64 terol concentrations achieved at 4 weeks and clinical efficacy and safety in the FOURIER trial of evo
66 ional research is necessary to determine the clinical efficacy and safety of CMV suppression in this
67 ation may be a promising strategy to improve clinical efficacy and safety of current BMP therapeutics
69 The aim of this study was to evaluate the clinical efficacy and safety of Phleum pratense subcutan
71 at induce immunologic tolerance and enhanced clinical efficacy and safety over that noted for subcuta
72 imer's disease and examines the evidence for clinical efficacy and the major problems with safety-i.e
75 in lung transplant recipients, evaluates the clinical efficacy and toxicity of the various antifungal
77 rtain, and more definitive conclusions about clinical efficacy and utility will require comparison wi
78 -density lipoprotein cholesterol reductions, clinical efficacy, and adverse events and the relevance
80 eceptor (A2A) agonists is critical for their clinical efficacy, and we sought to better understand ho
84 d toxicity studies-which, in addition to pre-clinical efficacy, are critical for partnering with Big
85 these pharmaceuticals demonstrate a limited clinical efficacy as multiple Gq-coupled receptor subtyp
87 lving allergen immunotherapy (AIT) products, clinical efficacy assessment is currently based on doubl
90 To definitively explore the potential for clinical efficacy at well-tolerated dosing schedules req
91 However, crucial concerns regarding safety, clinical efficacy, best setting, and cost-effectiveness
93 roxyurea provides SCA-related laboratory and clinical efficacy, but optimal dosing and monitoring reg
95 tive value of cell chemosensitivity test for clinical efficacy, cancer cells were suggested to be enc
96 cleared drugs, but have not yet improved the clinical efficacy compared to the non-encapsulated drug.
97 y, the large cell number required to achieve clinical efficacy constitutes an important limitation.
98 eeded World Allergy Organization-established clinical efficacy criteria (>/=20% improvement vs placeb
100 inase inhibitors of EGFR, which display poor clinical efficacy despite overexpression and/or mutation
103 ited data from case-control studies indicate clinical efficacy equivalent to the proportion seroconve
104 of poliomyelitis in Nigeria and to calculate clinical efficacy estimates for the oral poliovirus vacc
105 tin sulfate preservative free showed similar clinical efficacy, evaluated with OSDI score, TBUT and S
106 Three BKIs were then selected for safety and clinical efficacy evaluation in the calf model for crypt
107 hlight AIT-related aspects of public health, clinical efficacy evaluation, mechanisms, development of
109 ivir, SCY-635, and NIM811) have demonstrated clinical efficacy for the treatment of hepatitis C infec
113 apy has been available for 20 years, yet its clinical efficacy has never been conclusively demonstrat
114 can unleash a T-cell response, and although clinical efficacy has proven elusive, therapeutic target
115 Findings suggest that: (1) drugs with known clinical efficacy have consistent effects on disease rel
116 cting at the GLP-1 receptor, although having clinical efficacy, have been associated with severe adve
118 ffects of QGE031 with those of omalizumab on clinical efficacy, IgE levels, and FcepsilonRI expressio
124 RAF inhibitors (BRAFi) have shown remarkable clinical efficacy in BRAF mutant melanoma patients.
125 cific BRAF(V600E) inhibitor, has significant clinical efficacy in BRAF(V600E)-positive melanomas, but
126 ional immune suppressive agents have limited clinical efficacy in chronic GVHD, and prolonged immune
128 of the CDK4/6 cell-cycle kinases have shown clinical efficacy in estrogen receptor (ER)-positive met
131 oncogenic BRAF V600E, have shown significant clinical efficacy in melanoma patients harboring this mu
132 n genetic abnormality in melanoma, has shown clinical efficacy in melanoma patients, response is, inv
133 ly human CTLA-4-specific mAb, showed durable clinical efficacy in metastatic melanoma; its mechanism
134 ide is an immunomodulatory drug (IMiDs) with clinical efficacy in multiple myeloma (MM) and other lat
137 Specific BRAF and MEK inhibitors have shown clinical efficacy in patients for the treatment of BRAF-
138 r the ligand or receptor, have shown notable clinical efficacy in patients with a variety of cancers,
139 4A1 may be a predictive marker of vitamin D3 clinical efficacy in patients with advanced prostate can
141 pha such as estradiol (E2) have demonstrated clinical efficacy in patients with heavily treated breas
143 sly reported that CTL019 achieved impressive clinical efficacy in patients with relapsed/refractory B
144 SLIT in the second treated year showed good clinical efficacy in reducing symptoms and SMS of JCP, a
145 SLIT in the third treated year showed good clinical efficacy in reducing symptoms and TNSMS of JCP,
146 oxviral-based cancer vaccine, have suggested clinical efficacy in some patients with breast, ovarian,
147 ssessed safety outcomes for all patients and clinical efficacy in the largest patient subgroup, those
148 rned from these models to accurately predict clinical efficacy in the later phase testing of new chem
149 Ueq/ml showed both immunological effects and clinical efficacy in the TNPT compared with placebo.
152 ibitory receptor blockade, have demonstrated clinical efficacy in treating tumors refractory to conve
153 chemotherapy did not translate into enhanced clinical efficacy including the role of the enhanced per
154 IASD at 6 months, together with measures of clinical efficacy, including functional capacity and cli
155 ome was discontinuation of all ISDs owing to clinical efficacy, inefficacy, adverse drug reaction (AD
156 onse inhibition (Stop Signal Task [SST]) and clinical efficacy (Investigator Rated Conners Adult ADHD
157 rily cytostatic, not cytotoxic, the observed clinical efficacy is a reflection of disease stabilizati
159 e for only a subset of beta-blockers showing clinical efficacy is in heart failure, where members of
161 rum, ribosome-targeting antibacterials whose clinical efficacy is seriously threatened by multiple re
163 reatment of influenza pathologies, for which clinical efficacy may have been limited owing to poor bi
164 T-cell immunotherapy can produce remarkable clinical efficacy, most patients do not achieve durable
165 ivo efficacy in experimental models (n = 4), clinical efficacy (n = 2), taste (n = 2), or compliance
166 h more research is needed to establish their clinical efficacy, novel delivery systems will allow for
168 y, 2001, and December, 2012, to estimate the clinical efficacies of all four OPVs in use and combined
173 aim of the present study was to evaluate the clinical efficacy of a fixed combination of xanthan gum
180 rticular malignancies, as highlighted by the clinical efficacy of agents that target nuclear hormone
181 globally harmonized method for analysing the clinical efficacy of AIT products in RCTs is required.
185 bility, resistance-associated mutations, and clinical efficacy of antibiotic therapy, identified via
186 clinical assessment of safety and potential clinical efficacy of autologous CMV-specific T-cell ther
187 y significant difference was detected in the clinical efficacy of Biodentine/Fuji IX when used as ind
188 rmine the extra costs associated with or the clinical efficacy of biological mesh materials for the r
194 alaria infection (CHMI) study to compare the clinical efficacy of ChAd63-MVA CS with ChAd63-MVA ME-TR
198 may be substantial gender differences in the clinical efficacy of commonly prescribed 5-HT-active dru
202 Genotypes of CYP2B6 had an interaction with clinical efficacy of docetaxel and thiotepa on metastati
203 t EMMA is a feasible platform for estimating clinical efficacy of drugs and inclusion criteria screen
204 bers play in human disease and we review the clinical efficacy of drugs that block CD28 ligands.
208 Accurate preclinical predictions of the clinical efficacy of experimental cancer drugs are highl
211 ate protocol development) will determine the clinical efficacy of fosfomycin as step-down oral therap
212 progress has been made in demonstrating the clinical efficacy of harnessing the immune system to tre
214 inical rationale to immediately evaluate the clinical efficacy of ibrutinib in patients with PDAC.
218 ger trials of longer duration to measure the clinical efficacy of itraconazole, especially relative t
219 apeutic intervention, as demonstrated by the clinical efficacy of kinase inhibitors in kinase-mutant
221 vide preliminary evidence for the safety and clinical efficacy of long-term, low-dose plerixafor in W
222 between baseline blood eosinophil count and clinical efficacy of mepolizumab in patients with severe
223 nward clinical investigations to examine the clinical efficacy of minocycline treatment regimens agai
224 fety and tolerability, pharmacokinetics, and clinical efficacy of multiple intrathecal doses of nusin
225 n approach to improve effector functions and clinical efficacy of next-generation IgG1-based therapeu
226 overing a potential explanation for the poor clinical efficacy of Notch inhibitors observed in this s
231 espite better pharmacodynamic properties and clinical efficacy of prasugrel compared with clopidogrel
233 The primary objective was to assess the clinical efficacy of Ragweed MATA MPL (short ragweed pol
235 The purpose of this study is to clear the clinical efficacy of SLIT by comparing with other therap
237 The purpose of this study is to clear the clinical efficacy of SLIT in the second treated year by
238 The purpose of this study is to clear the clinical efficacy of SLIT in the third treated year by c
243 rinciple study, we demonstrate the potential clinical efficacy of the immunosensor for monitoring of
246 n is necessary in order to prove the overall clinical efficacy of these devices in refractory cardiog
249 in diverse, potentially redundant ways, the clinical efficacy of these inhibitors as monotherapies h
251 qualified for a strong rating supporting the clinical efficacy of these materials for periodontics an
253 date the molecular mechanisms underlying the clinical efficacy of tofacitinib in patients with psoria
254 is study was to determine safety and midterm clinical efficacy of transcatheter PVL closure using an
256 In this randomized, split-mouth trial, the clinical efficacy of two different photoablative dental
259 mized trial is required to adequately define clinical efficacy, optimal post-procedure medical therap
264 TOR inhibitors have failed to produce useful clinical efficacy, potentially because mTOR is also crit
265 d adolescents 12 years of age and older, the clinical efficacy, safety, and tolerability of omalizuma
266 acceptable toxicity profile and significant clinical efficacy, single-agent brentuximab vedotin is a
267 m cells are emerging in the field, but their clinical efficacy still needs to be defined in future tr
270 d bivalent OPV (29.5%, 20.1-38.4) had higher clinical efficacy than trivalent OPV (19.4%, 16.1-22.8).
271 s, but also importantly define parameters of clinical efficacy that justify further investigation in
272 ass of therapeutic modalities with promising clinical efficacy that requires modification or formulat
275 d clinical use of AGs strongly reduced their clinical efficacy through the selection of resistant bac
276 arly-onset/comorbidity cluster had the least clinical efficacy to treatments (eg, -0.076% change in F
277 of of concept supporting the initiation of a clinical efficacy trial in patients with platinum-sensit
279 cal sleeve gastrectomy (VSG), a surgery with clinical efficacy very similar to that for RYGB, in whol
289 rms were not the same, neither mortality nor clinical efficacy was reported, only pharmacokinetic or
294 INTERPRETATION: On the basis of the improved clinical efficacy with a manageable safety profile, the
298 otency observed in vitro has translated into clinical efficacy, with HCV RNA declining by ~3-4 log10
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