ライフサイエンスコーパス: clinical endpoint

1 s awaiting all patients to reach the primary clinical endpoint.

2 are intended to predict the true, meaningful clinical endpoint.

3 nths, and disease recurrence was used as the clinical endpoint.

4 not the NPPB variant, was associated with a clinical endpoint.

5 ction between ischemia and treatment for any clinical endpoint.

6 (26%) had reached one of the pre-established clinical endpoints.

7 ment protocols; and measurement of different clinical endpoints.

8 early biomarkers for subsequent conventional clinical endpoints.

9 prior treatment, CD4(+) T cell response, and clinical endpoints.

10 by surgery as well as long-term trials with clinical endpoints.

11 s in SUVmax between 0, 5, and 10 wk for both clinical endpoints.

12 al wound infection but failed to reach their clinical endpoints.

13 data are available correlating viraemia with clinical endpoints.

14 nt immunodeficiency leading to AIDS-defining clinical endpoints.

15 but the other loci were not associated with clinical endpoints.

16 lowering by B-vitamins improves only certain clinical endpoints.

17 d+ lesions and showed a beneficial effect on clinical endpoints.

18 discordant results between neuroimaging and clinical endpoints.

19 pnea treatment on cardiovascular disease and clinical endpoints.

20 andomized PCV13 pediatric trial has included clinical endpoints.

21 roups of patients and varying definitions of clinical endpoints.

22 nimal studies and Phase IIB/III studies with clinical endpoints.

23 d of measuring adherence without reliance on clinical endpoints.

24 easily correlate with measureable objective clinical endpoints.

25 s limit the contemporary utility of standard clinical endpoints.

26 asure that fulfils the criteria for an ideal clinical endpoint and that is meaningful to patient and

27 at there is a rational linkage to the drug's clinical endpoint and/or site of action.

28 dies are needed to develop novel biomarkers, clinical endpoints and interventions for young children

29 o test for associations between metabolic or clinical endpoints and overall survival (OS), progressio

30 o test for associations between metabolic or clinical endpoints and progression-free survival (PFS) o

31 ed in a phase III trial it failed to achieve clinical endpoints and revealed neurotoxicity.

32 e survival (EFS, primary endpoint) and other clinical endpoints and toxicities were assessed.

33 eeks to provide core principles, appropriate clinical endpoints, and endpoint definitions to be used

34 d bioactive metabolites, effects on specific clinical endpoints, and existing dietary guidelines.

35 e, the doses of study drug used, insensitive clinical endpoints, and the patient population selected

36 ed biomarkers, inefficient physiological and clinical endpoints, and variable regulatory review world

37 onverting a genome discovery into a tangible clinical endpoint are numerous and formidable.

38 The underlying clinical endpoints are analysed in seasonal time periods

39 with GA lesions or progression, alternative clinical endpoints are being sought.

40 Molecular imaging and clinical endpoints are frequently discordant in Parkinso

41 with adequate control groups and predefined clinical endpoints are necessary to determine the true r

42 ized silymarin is dosed to identify specific clinical endpoints are urgently needed.

43 olymer stent for a device-oriented composite clinical endpoint at 12 months in an all-comer populatio

44 receiver operating characteristic curve) the clinical endpoint at 12 weeks.

45 aphy and intravascular ultrasound; composite clinical endpoints based on death, myocardial infarction

46 are being applied to predict preclinical and clinical endpoints, but the reliability of these predict

47 Clinical endpoints (cardiac death, myocardial infarction

48 uestions about rare diseases and "harmonize" clinical endpoints collected from administrative records

49 n the blinded adjudication of an independent clinical endpoint committee.

50 The combined clinical endpoint consisted of death, reinfarction, targ

51 e data, including phase 3 controlled trials, clinical endpoint data, virologic and immunologic endpoi

52 Clinical endpoints defined as hepatic decompensation (as

53 or study using strict inclusion criteria and clinical endpoint definition.

54 ctralis, and each OCT scan was linked to EMR clinical endpoints extracted from EPIC.

55 subsequent decompensation are accepted hard clinical endpoints, fibrosis and fibrosis progression al

56 the suitability of viral load as a surrogate clinical endpoint for clinical trials for cytomegaloviru

57 r devices, and defining single and composite clinical endpoints for clinical trials.

58 In addition, clinical endpoints for studies and care remain poorly de

59 imaging database was performed and linked to clinical endpoints from the EMR.

60 a causal relationship between NT-proBNP and clinical endpoints has not been established.

61 ultrasound, but no clinical trials assessing clinical endpoints have yet been completed.

62 ial design is hampered by lack of a feasible clinical endpoint in this population.

63 ification of biomarkers as a surrogate for a clinical endpoint in tuberculosis is very challenging, a

64 Standardization and harmonization of clinical endpoints in AIT trials as well as current know

65 nificant immunodeficiency, and AIDS-defining clinical endpoints in some animals.

66 We observed modest changes in clinical endpoints including circulating levels of F.IX

67 with real microarray datasets, one where the clinical endpoint is disease group and another where it

68 f donor, rather than recipient, genotypes on clinical endpoints is unknown.

69 te cancer patients for two post-radiotherapy clinical endpoints: late rectal bleeding and erectile dy

70 received IFNalpha-based therapies developed clinical endpoints less frequently than those treated wi

71 Clinical endpoints (liver-related death, liver transplan

72 Supplemental oxygen-free days as a clinical endpoint may allow smaller sample sizes for tri

73 Clinical endpoints measured in terms of duration, such a

74 groups were assigned to define the following clinical endpoints: mortality, stroke, myocardial infarc

75 n 2.0 assay reports fewer subjects below the clinical endpoint of HIV-1 RNA <50 copies/mL in HIV clin

76 The 30-day primary clinical endpoint of target lesion failure occurred in 0

77 The primary clinical endpoint of the study was the occurrence of maj

78 surfaces, but no significant improvements in clinical endpoints of defect resolution were observed.

79 tients (n = 9) in the UDCA group who reached clinical endpoints of disease progression (the developme

80 ed between the patient groups divided by the clinical endpoints of histological grade, histological t

81 ns and newer calcium antagonists have on the clinical endpoints of myocardial infarction and death is

82 logical studies been initiated, with defined clinical endpoints of periodontal disease, to address th

83 iction of risk, detection, and prediction of clinical endpoints of prostate cancer (PCa).

84 ets and develop 360 predictive models on six clinical endpoints of varying predictability.

85 measured by immunological, virological, and clinical endpoints over a 15-month period.

86 nths revealed no differences in the combined clinical endpoints (p = 0.22).

87 classifiers in this MAQC-III/SEQC study for clinical endpoint prediction using neuroblastoma as a mo

88 n cancer research to identify biomarkers for clinical endpoint prediction.

89 microarray-based models perform similarly in clinical endpoint prediction.

90 A-specific immunity, and impact on surrogate clinical endpoints provides a scientific rationale for f

91 The mean time in seconds to reach the clinical endpoint ranged from HAND 289 +/- 193, US 194 +

92 MeTIL signature scores were correlated with clinical endpoints reflecting overall or disease-free su

93 t set the standard for selecting appropriate clinical endpoints reflecting safety and effectiveness o

94 Large trials with clinical endpoints, some already in progress, are needed

95 Numerous large clinical endpoint studies are under way to investigate t

96 ation of the guidelines, data from two large clinical endpoint studies have been presented that show

97 Because PEPI was not designed to assess clinical endpoints, studies of the impact of hormone-med

98 epresent a more tractable genetic trait than clinical endpoints such as schizophrenia.

99 as shown that PROs can be prognostic of hard clinical endpoints such as survival time (time from stud

100 east cancer therapy is ultimately defined by clinical endpoints such as survival.

101 Furthermore, the impact of RFA on secondary clinical endpoints, such as renal function outcomes, has

102 sitizing versus insulin-providing therapy on clinical endpoints, symptom relief, and perceived health

103 nues to be debate about the most appropriate clinical endpoint that should be used in future randomiz

104 ns that are even more effective in achieving clinical endpoints, that are not hampered by resistance,

105 For some clinical endpoints, the combined use of molecular analys

106 e radiomics has been associated with several clinical endpoints, the complex relationships of radiomi

107 ed to develop evidence-based definitions and clinical endpoints through which the pathophysiology can

108 anscatheter aortic valve implantation (TAVI) clinical endpoints to make them more suitable to the pre

109 omozygous familial hypercholesterolaemia and clinical endpoint trials will be needed for PCSK9 and CE

110 Results of major clinical endpoint trials with fibrates, although not uni

111 have been increasingly highlighted in large clinical endpoint trials with lipid therapy.

112 The secondary clinical endpoint was a composite of cardiac death, myoc

113 The primary clinical endpoint was confirmed >/= 50% PSA decline vers

114 The secondary clinical endpoint was good functional outcome, defined a

115 Our primary clinical endpoint was progression-free survival, analyse

116 8.1% to 17.2% (p < 0.001), and the composite clinical endpoint was significantly reduced from 50.0% t

117 The primary clinical endpoint was the 30-day rate of target lesion f

118 The clinical endpoint was the occurrence of ischemic stroke.

119 The clinical endpoint was the occurrence of ischemic stroke.

120 ournal, the case for the use of a variety of clinical endpoints was analyzed, and the article conclud

121 sion following prostatectomy as the relevant clinical endpoint, we found that ensemble tree classifie

122 For clinical endpoints, we defined eligibility criteria as r

123 eq and microarray-based models in predicting clinical endpoints, we divide the cohort randomly into t

124 Clinical endpoints were all-cause mortality or hospitali

125 Clinical endpoints were assessed by intention to treat d

126 Several clinical endpoints were explored to assess whether intra

127 ing to patient and study characteristics and clinical endpoints were extracted.

128 Clinical endpoints were gingival bleeding (papillary ble

129 sing 6MWD in patients with PAH and reporting clinical endpoints were included in a meta-analysis.

130 Standard clinical endpoints were modeled to evaluate efficacy, in

131 Because clinical endpoints were not assessed for the new antigen

132 r this novel agent, although other objective clinical endpoints were not different from those of cont

133 The clinical endpoints were overall survival (OS) and cancer

134 ost strongly influenced by the nature of the clinical endpoint, whereas technological platforms (RNA-