ライフサイエンスコーパス: clinical evaluation

1 celles, providing a strong justification for clinical evaluation.

2 s for the development of small molecules for clinical evaluation.

3 lature of dacomitinib and is currently under clinical evaluation.

4 precision of 0.85 for a recall of 0.6 in the clinical evaluation.

5 nonsimulated "in vivo" specimens before full clinical evaluation.

6 nt blockade, with immediate implications for clinical evaluation.

7 s for the development of small molecules for clinical evaluation.

8 rational therapies, some of which are under clinical evaluation.

9 a) and approximately 40 currently undergoing clinical evaluation.

10 e functional effects using MRI combined with clinical evaluation.

11 in late-stage preclinical tests, poised for clinical evaluation.

12 component, paving the way for a larger-scale clinical evaluation.

13 tional therapeutics are in various stages of clinical evaluation.

14 s provides an improved candidate for further clinical evaluation.

15 were unrecognized by electrocardiography or clinical evaluation.

16 URKA inhibitors offers a sound rationale for clinical evaluation.

17 re approved for type 2 diabetes or are under clinical evaluation.

18 tolerogenic dendritic cells (ATDCs) is under clinical evaluation.

19 ents, and warrants consideration for further clinical evaluation.

20 that has now successfully completed phase I clinical evaluation.

21 his vector was not adequately attenuated for clinical evaluation.

22 roperties that resulted in its selection for clinical evaluation.

23 going NIH-supported IND-enabling studies for clinical evaluation.

24 o that of bleomycin which is currently under clinical evaluation.

25 l affinity for D3R versus D2R are undergoing clinical evaluation.

26 ic drug, offering immediate applications for clinical evaluation.

27 n previously established through traditional clinical evaluation.

28 bioresorbable scaffolds are currently under clinical evaluation.

29 ram-negative endotoxemia and warrant further clinical evaluation.

30 ed patients were investigated, with thorough clinical evaluation.

31 inical benefit; NaF imaging was not used for clinical evaluation.

32 ide (27, VU0424238), a compound selected for clinical evaluation.

33 ate model, was rapidly advanced into phase 1 clinical evaluation.

34 MP production and has entered a path towards clinical evaluation.

35 e outset to inform both candidate design and clinical evaluation.

36 be carefully assessed as part of a thorough clinical evaluation.

37 ed with MIP-1095, a PSMA ligand currently in clinical evaluation.

38 therefore, in developing USP7 inhibitors for clinical evaluation.

39 tiated a median of 6 hours after the initial clinical evaluation.

40 warranted using neuroimaging or conventional clinical evaluation.

41 rapies directed at mesothelin are undergoing clinical evaluation.

42 loss causes were determined from our ongoing clinical evaluations.

43 Each visit includes (1) Clinical evaluation: a slit lamp examination, fundoscopy

44 sh LCI from noninfluenza viral infections on clinical evaluations alone in this population of Banglad

45 Detailed clinical evaluation and a genome-wide linkage scan was c

46 -b-PEG-b-PLGA sol-gels may safely enable pre-clinical evaluation and clinical translation of poorly w

47 Rush Memory and Aging Project were based on clinical evaluation and cognitive performance tests.

48 A comprehensive algorithm, based on clinical evaluation and complementary tests, is presente

49 synthetic allergy vaccines that have reached clinical evaluation and discuss how molecular vaccine ap

50 aried cognitive and motor symptoms underwent clinical evaluation and DTI imaging.

51 Clinical evaluation and follow-up for 6 months were perf

52 nd second phase which consists of definitive clinical evaluation and follow-up interventions for chil

53 lopmental delays and subsequently undergoing clinical evaluation and follow-up interventions.

54 s were recruited for the study and underwent clinical evaluation and genetic analyses.

55 ementary information to patients' ophthalmic clinical evaluation and has usefulness as an outcome mea

56 PINK5 mutations were sequenced, and thorough clinical evaluation and histopathologic and immunohistoc

57 tion of sudden cardiac arrest after baseline clinical evaluation and imaging at enrollment (positron

58 s requires a methodical approach with expert clinical evaluation and investigations.

59 I-MIBG theranostics have been applied in the clinical evaluation and management of neuroendocrine tum

60 SS and 45 control subjects were enrolled for clinical evaluation and mass cytometry quantification of

61 Despite these gains, incomplete clinical evaluation and misdiagnosis by referring clinic

62 ohort of patients with detailed longitudinal clinical evaluation and neuropathology.

63 They underwent a standardized clinical evaluation and provided nasopharyngeal and orop

64 Finally, clinical evaluation and tests used in the assessment of

65 preciation of these factors will improve the clinical evaluation and treatment of chronic pruritus.

66 This article touches on core concepts in the clinical evaluation and treatment of CMN and infantile h

67 he context of epidemiology, pathophysiology, clinical evaluation and treatment, emphasizing the impor

68 nged periods have the potential to transform clinical evaluation and treatment.

69 Extensive clinical evaluation and WES of 32 Turkish patients clini

70 In summary, detailed clinical evaluation and WES with functional studies in D

71 Clinical evaluations and magnetic resonance imaging (MRI

72 nostic systems highlights the limitations of clinical evaluations and research studies that restrict

73 All participants agreed to undergo annual clinical evaluations and to donate their brains after de

74 Data from 7 subjects were used in the clinical evaluation, and a phantom study using an anatom

75 with an emphasis on the functional anatomy, clinical evaluation, and basic principles of specialized

76 This was a retrospective clinical evaluation, and performance is likely to be enh

77 New tuberculosis drugs are undergoing clinical evaluation, and renewed hope comes from fresh a

78 Follow-up data, including clinical evaluation, and results of esophagogastroduoden

79 n attractive chemical entity for further pre-clinical evaluation, and small-molecule inhibitors of MT

80 Several devices are under preclinical and clinical evaluation, and the early experience with more

81 Subjects underwent (i) clinical evaluations; and (ii) brain MRI scans analysed

82 from mechanistic studies and preclinical and clinical evaluation are discussed.

83 esting that (64)Cu-GTSM PET imaging warrants clinical evaluation as a diagnostic tool for AD and poss

84 enoinic acid (UAB30) is currently undergoing clinical evaluation as a novel cancer prevention agent.

85 or of cell division, is currently undergoing clinical evaluation as a target for cancer therapy.

86 with a preclinical safety profile to support clinical evaluation as antiobesity agents has been a cha

87 bloodstream infections and deserves further clinical evaluation as initial therapy in these infectio

88 Based on genetic and clinical evaluation as well as functional and structural

89 earliness of AD diagnostic, mainly based on clinical evaluation at present time.

90 Enrolled students underwent baseline clinical evaluations before the school year started and

91 were assessed through literature review and clinical evaluation by a multidisciplinary consortium of

92 All patients underwent a clinical evaluation by a pediatric endocrinologist and a

93 aged 55-90 years, underwent a comprehensive clinical evaluation by a trained occupational therapist

94 ber of potential causal variants that needed clinical evaluation compared to sequencing only the chil

95 nding specific biomarkers of liver damage in clinical evaluations could increase the pool of availabl

96 clinically affected trio with HCM underwent clinical evaluation, electrocardiography, echocardiograp

97 All groups were subjected to full clinical evaluation, ELISA anti-HCV antibodies screening

98 A clinical evaluation enrolled adults with suspected pulmo

99 se The Letrozole (Femara) Versus Anastrozole Clinical Evaluation (FACE) study compared the efficacy a

100 nd who had been followed up with imaging and clinical evaluation for at least 6 months.

101 Syk inhibitor which is currently undergoing clinical evaluation for autoimmune and oncology indicati

102 n (PCI) is a novel technology now undergoing clinical evaluation for its ability to improve the relea

103 02341066), an ALK/ROS inhibitor currently in clinical evaluation for lung cancer patients harboring R

104 ic autophagy induction with Sativex warrants clinical evaluation for metastatic disease.

105 ombinant expression and characterization for clinical evaluation for nearly a quarter of a century.

106 synergistic combination of drugs warranting clinical evaluation for PDAC treatment.

107 l-based therapies are under pre-clinical and clinical evaluation for the treatment of ischemic diseas

108 ACE1) inhibitor currently undergoing Phase 3 clinical evaluation for the treatment of mild to moderat

109 arge fever (RR, 1.00 [CI, 0.76 to 1.31]), or clinical evaluations for infection (RR, 1.06 [CI, 0.99 t

110 In a radiographic and clinical evaluation, four relevant distances were evalua

111 Results: NHANES included completed clinical evaluations from mobile examination centers on

112 For subjects with uninformative clinical evaluations, germline DNA samples were (re)sequ

113 omising therapeutic options is available for clinical evaluation; however, the numbers of patients wi

114 omal recessive inheritance, was subjected to clinical evaluation, immunologic assays, homozygosity ge

115 ell tolerated in humans and is available for clinical evaluation.IMPORTANCE EBOV hemorrhagic fever is

116 RSV vaccine candidate suitable for pediatric clinical evaluation.IMPORTANCE RSV and HPIV3 are the fir

117 e compared before surgery and at most recent clinical evaluation in 39 consecutive patients with obst

118 The yield of combined molecular autopsy and clinical evaluation in 82 surviving families was evaluat

119 s establish Torin2 as a strong candidate for clinical evaluation in a broad number of oncologic setti

120 or that has successfully undergone its first clinical evaluation in humans.

121 in animal models and is currently undergoing clinical evaluation in humans.

122 erate (surrogate) mouse or rat bsAbs for pre-clinical evaluation in immuno-competent rodents.

123 statin with this profile, has not undergone clinical evaluation in oncology.

124 -dependent ABC DLBCL lines, supporting their clinical evaluation in patients with ABC DLBCL.

125 eclinical proof of concept that rationalizes clinical evaluation in patients with advanced prostate c

126 n a novel pharmacologic avenue that requires clinical evaluation in patients with AWS.

127 ranostic targets should be taken for further clinical evaluation in PDA.

128 oherence tomography improves the accuracy of clinical evaluation in retinoblastoma management.

129 Combining molecular autopsy with clinical evaluation in surviving families increased diag

130 o reposition the approved drug auranofin for clinical evaluation in the therapy of CLL.

131 growth of BPDCN xenografts, supporting their clinical evaluation in this recalcitrant malignancy.

132 of faulty genes; several RNAi are undergoing clinical evaluation in various diseases.

133 nhibitors of the MET kinase are currently in clinical evaluation, in particular for NSCLC, liver, and

134 Clinical evaluation included motor and cognitive testing

135 Clinical evaluations included eye examination, color fun

136 In-person clinical evaluations included standardized evaluations f

137 In a clinical evaluation including 210 previously tested samp

138 Each patient underwent a complete clinical evaluation including a comprehensive battery of

139 oms possibly related to CMA were invited for clinical evaluation including cows' milk-specific IgE an

140 pectrometry; patients with amyloid underwent clinical evaluation including genotyping and (99m)TC-3,3

141 mple of 10- to 14-year-old adolescents using clinical evaluation including OFC to confirm the diagnos

142 ntly included in several vaccines undergoing clinical evaluation including those for tuberculosis, le

143 Patients underwent clinical evaluations including neurological rating scale

144 Patients underwent a multidisciplinary clinical evaluation, including clinical demographics, ge

145 All patients received a standard clinical evaluation, including collection of history, an

146 Longitudinal clinical evaluation, including full ophthalmic examinati

147 Thorough clinical evaluations, including brain magnetic resonance

148 s the differential diagnosis and outline the clinical evaluation indicated for a patient presenting w

149 Previous clinical evaluation indicated the need to increase the i

150 ing navigated with compounds currently under clinical evaluation is followed by a discussion of the n

151 Long term clinical evaluation is necessary to estimate functional

152 Further clinical evaluation is required to determine whether nut

153 disease is primarily cutaneous, and further clinical evaluation is therefore rarely pursued.

154 concordance between confocal microscopy and clinical evaluation (kappa = 0.768) and between confocal

155 , or low pretest probability of CDI based on clinical evaluation, laboratory, and imaging results.

156 ational cohort study, DCM patients underwent clinical evaluation, late gadolinium enhancement cardiov

157 Initial clinical evaluation led to a phase III trial in advanced

158 1999 and July 2012 were followed until last clinical evaluation, liver transplantation, or death.

159 nce, and the diagnostic gold standard is the clinical evaluation made by a movement disorders expert.

160 e properties of the cancer secretome, as its clinical evaluation may change the therapeutic landscape

161 e children were followed longitudinally with clinical evaluation, milk-specific IgE levels, and milk

162 In the immunocompromised host, the initial clinical evaluation must focus on both life-threatening

163 Among 117 patients with uninformative clinical evaluations, next-generation sequence analysis

164 Finally, an unblinded clinical evaluation of 1269 euploid and aneuploid sample

165 This is the first clinical evaluation of a large panel of TCGA-reported ge

166 These changes cannot be assessed during the clinical evaluation of a living patient.

167 We performed a clinical evaluation of a multiplex PCR panel, the enteri

168 The clinical evaluation of a novel, recently published metho

169 y, informing the decision to proceed or stop clinical evaluation of a targeted treatment within a mol

170 should be considered in the development and clinical evaluation of anti-amyloid beta immunotherapies

171 ur results offer a mechanistic rationale for clinical evaluation of ATM inhibitors in PTEN-deficient

172 uximab resistance, providing a rationale for clinical evaluation of AXL-targeting drugs to treat cetu

173 n together, our results strongly support the clinical evaluation of BAY 1187982 in cancer patients an

174 e results provide a biological rationale for clinical evaluation of BTK inhibition in AML patients.

175 Clinical evaluation of BTK inhibitors in AML seems warra

176 nventional chemotherapies and prompt further clinical evaluation of CDK inhibitors in AML patients ha

177 Our findings provide a rationale for the clinical evaluation of CFI-402257 in patients with solid

178 imaging assessment could change the current clinical evaluation of choroidal nevi.

179 The clinical evaluation of convalescent plasma (CP) for the

180 ts the impact of (1)H MR spectroscopy in the clinical evaluation of disorders of the central nervous

181 our data provide a preclinical basis for the clinical evaluation of E6201 in AML patients harboring F

182 These results will set the stage for future clinical evaluation of ELQ and atovaquone combination th

183 The MSA is appropriate for the clinical evaluation of EVD treatments.

184 ients of the randomized EXAMINATION study (A Clinical Evaluation of Everolimus Eluting Coronary Stent

185 pathways, and provide the rationale for the clinical evaluation of FTY720 in chronic pain patients.

186 ional examples provided here demonstrate how clinical evaluation of genomic alterations have refined

187 ith high accuracy and could be useful in the clinical evaluation of glaucoma.

188 ed on April 27, 2007, to enable longitudinal clinical evaluation of health outcomes of survivors of c

189 Although EVD may currently drive clinical evaluation of ill travelers arriving from Sierr

190 Retrospective clinical evaluation of individuals referred to our insti

191 these studies provide rationale for ongoing clinical evaluation of IPI-145 as a targeted therapy for

192 lmonary vascular homeostasis and support the clinical evaluation of iron replacement in patients with

193 administered at ages 1, 2, and 3 years, the Clinical Evaluation of Language Fundamentals-Preschool,

194 in EOC, and they offer a solid rationale for clinical evaluation of macitentan in combination with ch

195 Design: Annual follow-up of the CE-MARC (Clinical Evaluation of MAgnetic Resonance imaging in Cor

196 isease was retrospectively selected from the Clinical Evaluation of Magnetic Resonance Imaging in Cor

197 SPECT, and x-ray angiography as part of the Clinical Evaluation of Magnetic Resonance Imaging in Cor

198 tion, 100 negative adenosine images from the Clinical Evaluation of MR Imaging in Coronary Heart Dise

199 Our findings support further clinical evaluation of MV-NIS as an effective immunoviro

200 Here, we report results from a clinical evaluation of MV-NIS in patients with taxol- an

201 te our basic approach to the preclinical and clinical evaluation of new sepsis therapies.

202 s general application to the development and clinical evaluation of other mononegavirus vectors and v

203 in myeloma and provide the rationale for the clinical evaluation of PAK4 modulator in myeloma.

204 The clinical evaluation of patients included the Unified Myo

205 A checklist is provided for the clinical evaluation of patients with suspected usual int

206 The Clinical Evaluation of Pertuzumab and Trastuzumab (CLEOP

207 These findings provide the rationale for the clinical evaluation of pharmaceutical approaches that in

208 Our findings warrant clinical evaluation of PIM kinase inhibitors in patients

209 's regulatory framework for the prelicensure clinical evaluation of preventive vaccines and the clini

210 We then performed a long-term clinical evaluation of ranolazine in LQT3 patients carry

211 in breast cancer cell lines, suggesting that clinical evaluation of rational combination therapy with

212 y in NPM1 mutant AMLs, and warrant a broader clinical evaluation of regimen comprising a RA/arsenic c

213 graphy (OCTA) has provided novel insights in clinical evaluation of retinal diseases.

214 clinical rationale to explore broadening the clinical evaluation of ribavirin, currently being tested

215 Given these data, clinical evaluation of selumetinib may be warranted for

216 utput and could prove to be a useful tool in clinical evaluation of septic patients.

217 A practical and objective method for the clinical evaluation of SFN is needed to improve the mana

218 This is the first, to our knowledge, clinical evaluation of skull bone identification based o

219 Our results provide a rationale for clinical evaluation of Src-targeting regimens to treat p

220 tomographic (CT) angiography as part of the clinical evaluation of stable chest pain.

221 y in the development of new drugs and in the clinical evaluation of standard treatment approaches.

222 autopsy) in cases of SADS and comprehensive clinical evaluation of surviving relatives.

223 These findings are a step toward clinical evaluation of the anti-IL-11 therapy for tuberc

224 Careful clinical evaluation of the condyle coupled with appropri

225 Objective clinical evaluation of the correction equations for Gold

226 Clinical evaluation of the grafts showed significant imp

227 Clinical evaluation of the GRM1 signaling inhibitor rilu

228 l values and their correlations could affect clinical evaluation of the macula in healthy patients an

229 Clinical evaluation of the participants was conducted in

230 We conducted clinical evaluation of the rates of food allergies and a

231 We performed a clinical evaluation of the recently FDA-cleared illumige

232 ings generated, have the potential to affect clinical evaluation of the retina in healthy patients an

233 To the best of the authors' knowledge, a clinical evaluation of the safety of these toothbrushes

234 of nine subjects participated in this pilot clinical evaluation of the technology.

235 We completed the first clinical evaluation of the Triplex vaccine in 24 healthy

236 We report a clinical evaluation of the Xpert GBS LB assay, a molecul

237 isease models have been established, and pre-clinical evaluation of therapeutics and vaccines has beg

238 The mutations commonly used in clinical evaluation of these tumors are regionally distr

239 l form the basis for further preclinical and clinical evaluation of these vaccine candidates.

240 ctal cancer treatment, in support of ongoing clinical evaluation of this agent (LCC1315 NCT02010567).

241 ctal cancer treatment, in support of ongoing clinical evaluation of this agent.

242 ffects in multiple species precluded further clinical evaluation of this compound.

243 Previous clinical evaluation of this vaccine candidate suggested

244 The CLEOPATRA (Clinical Evaluation of Trastuzumab and Pertuzumab) study

245 cancer target but also a novel biomarker for clinical evaluation of treatment efficacy.

246 These observations inform and support clinical evaluation of TTM in melanoma.

247 or resistance and provides the framework for clinical evaluation of USP14/UCHL5 inhibitors to improve

248 naturally occurring alternative splicing for clinical evaluation of variants in disease-causing genes

249 trategies and we highlight challenges facing clinical evaluation of ZIKV vaccine candidates.

250 time point, patients underwent standardized clinical evaluations of extremity, hand grip, and respir

251 In contrast to informal clinical evaluations of oculomotor dysfunction frequency

252 Analytical and clinical evaluations of the assay were undertaken using

253 those recently reported during the long-term clinical evaluations of the same patients.

254 Clinical evaluations of therapeutic outcome from SCC DBS

255 eviously identified molecular diagnosis from clinical evaluation or a research-based epilepsy gene pa

256 ied anti-HCV+ persons cannot receive further clinical evaluation or antiviral treatment, and are unli

257 ble, some other technologies are still under clinical evaluation or in the early development phase.

258 st-tier test and compared it with a standard clinical evaluation performed in parallel.

259 , rationale for changes from prior criteria, clinical evaluation, physiologic features, psychosocial

260 GFR inhibitors that should be anticipated as clinical evaluation proceeds.

261 In the context of a comprehensive clinical evaluation process, this tool can support clini

262 Clinical evaluation revealed blended PTLS and CMT1A phen

263 Clinical evaluation revealed significant, gradually prog

264 Clinical evaluation revealed that the SmartCycler II, co

265 Clinical evaluations revealed that the majority of AIS c

266 racatinib, an inhibitor currently undergoing clinical evaluation, sensitized chemoresistant cells to

267 The primary clinical evaluation should include a CT of the abdomen a

268 Clinical evaluation showed lacrimal functional unit impa

269 A clinical evaluation showed that assay positivity signifi

270 The comparator tests were visual acuity, clinical evaluation (slit lamp), Amsler chart, color fun

271 MATERIAL/METHODS: This observational clinical evaluation study included 224 patients who were

272 Standard clinical evaluation suggested a diagnosis in 16% of case

273 These clinical evaluations support specific implantation targe

274 l as the most advanced drug candidates under clinical evaluation, tasimelteon and TIK-301, are high-a

275 AML LSC targeting and to consider methods of clinical evaluation that will be most effective for iden

276 atients (58 males, 61 +/- 9 years) underwent clinical evaluation, the Psychometric Hepatic Encephalop

277 blockade may offer an immediate strategy for clinical evaluation to improve treatment outcomes.

278 as been selected for vaccine manufacture and clinical evaluation to protect humans from wt H7N9 virus

279 the peripheral nervous system may help guide clinical evaluations to improve personalized care in lim

280 arrest, which was followed by comprehensive clinical evaluation, transthoracic echocardiography, and

281 In previous clinical evaluations, tRES and HESP individually were in

282 interpretation of Femara versus Anastrozole Clinical Evaluation Trial, and bring attention to posaco

283 We performed an initial clinical evaluation using serum from 10 people diagnosed

284 Clinical evaluation was performed by using the Constant

285 A full clinical evaluation was performed on all mutation carrie

286 Clinical evaluation was performed, and gingival crevicul

287 some miRNA therapies are already undergoing clinical evaluation, we stress the importance of integra

288 One- and 5-year clinical evaluations were completed in the United States

289 Clinical evaluations were performed at baseline and at 1

290 nal study at a genetics department, in which clinical evaluations were performed for 433 patients (29

291 asal cell carcinomas (BCCs) are diagnosed by clinical evaluation, which can include dermoscopic evalu

292 yearly evaluation, including a standardized clinical evaluation, whole blood flow cytometry to asses

293 Moebius syndrome remain elusive, accuracy in clinical evaluation will properly subdivide patients to

294 underwent a standardised video protocol and clinical evaluation with a validated questionnaire desig

295 We performed clinical evaluation with GERD-HRQoL questionnaire, upper

296 bitors, a concept currently undergoing human clinical evaluation with PLX8394.

297 ptomatic UTI in older women requires careful clinical evaluation with possible laboratory assessment

298 ); 52 consecutive patients with BP underwent clinical evaluation with the Bullous Pemphigoid Disease

299 ine strategies have advanced to the stage of clinical evaluation with unprecedented speed.

300 In the first clinical evaluation, Xpert was compared to two validated