ライフサイエンスコーパス: clinical implication

1 or further mechanistic studies and potential clinical implication.

2 (-)ALCL, and in 29% of all ALCL cases with a clinical implication.

3 obesity have potential short- and long-term clinical implications.

4 ecture is a central biological question with clinical implications.

5 i for acute coronary syndrome with effective clinical implications.

6 cation, is of public health significance and clinical implications.

7 hat modulation of miRNA export has potential clinical implications.

8 brain activity would have enormous basic and clinical implications.

9 important role of central plasticity and its clinical implications.

10 ticular focus on the functional and possible clinical implications.

11 umour metabolism and epigenetics and outline clinical implications.

12 y genomic alterations in ILBC with potential clinical implications.

13 control may have significant theoretical and clinical implications.

14 d antitumour immunity and may have important clinical implications.

15 ovel therapeutic intervention with important clinical implications.

16 reast fibroepithelial tumors, with potential clinical implications.

17 nhibition of UGGT1 or p97 may have important clinical implications.

18 al burden of skin disease and have important clinical implications.

19 titute a fundamental question with important clinical implications.

20 ting and fundamental question with important clinical implications.

21 tify novel methylation-driven subgroups with clinical implications.

22 solves this important problem with potential clinical implications.

23 molecular mechanisms, and the biological and clinical implications.

24 f PEDF as a key regulator of GSC and suggest clinical implications.

25 phoid cell death could thus have significant clinical implications.

26 amics and the origins of ITH, with important clinical implications.

27 of pro-apoptotic ligands and have important clinical implications.

28 the development of OA and may have potential clinical implications.

29 pplications, these findings have substantial clinical implications.

30 basic biological principles and has profound clinical implications.

31 standing their interaction is likely to have clinical implications.

32 AF, and discusses device-detected AF and its clinical implications.

33 remains a clinical dilemma with significant clinical implications.

34 our understanding of its pathophysiology and clinical implications.

35 dopamine-serotonin opponency with potential clinical implications.

36 ction, and neoplasia' (XMEN) disease and its clinical implications.

37 ns vary across the life course has important clinical implications.

38 nd treatment response, all of which may have clinical implications.

39 high risk for late recurrence and assess its clinical implications.

40 /colistin and polymyxin B, and highlight the clinical implications.

41 sis for this aberrant elevation has profound clinical implications.

42 ut COPD, and its radiological correlates and clinical implications.

43 isease progression could lead to significant clinical implications.

44 aim is to create an LRG for every locus with clinical implications.

45 diated pulmonary inflammation with important clinical implications.

46 ab treatment, which has both mechanistic and clinical implications.

47 ypass (CPB) surgery with potential important clinical implications.

48 ommon somatic lesions in bladder cancer with clinical implications.

49 ks in different cancer types, with potential clinical implications.

50 results, sometimes with strikingly different clinical implications.

51 c disorders and may consequently have direct clinical implications.

52 ress susceptibility, these insights may have clinical implications.

53 romote IL-17A production with as yet unknown clinical implications.

54 the inhibition of glutaminolysis could have clinical implications.

55 g loss of function (LoF) of human genes have clinical implications.

56 nate the hematopoietic system have important clinical implications.

57 t knowledge of CTC biology and the potential clinical implications.

58 sted acceleration of healing has significant clinical implications.

59 sease perception or diagnosis with potential clinical implications.

60 cific conditions, which likely has important clinical implications.

61 e DEGs and the pathways may potentially have clinical implications.

62 o our understanding of tumor biology and its clinical implications.

63 can help to inform their interpretations and clinical implications.

64 bclinical, THV thrombosis may have important clinical implications.

65 el of liver regeneration and reflects on the clinical implications and areas for further study sugges

66 logical, and diagnostic issues, and identify clinical implications and areas for future research.

67 These findings have immediate clinical implications and expand the therapeutic options

68 This study has important clinical implications and highlights the role of individ

69 These data have important clinical implications and provide a basis for hemostasis

70 The present data have far-reaching clinical implications and raise the hypothesis that path

71 We also discuss the clinical implications and review concepts of targeted tr

72 This has both mechanistic and clinical implications and should be evaluated further.

73 These findings have important clinical implications and suggest novel research approac

74 his article reviews these discoveries, their clinical implications and the recent associated literatu

75 Clinical implications and the significance to human lupu

76 ular hypertension at 10 years have important clinical implications, and as such this information shou

77 y advances, their scientific and significant clinical implications, and future directions.

78 er age, with special emphasis on etiologies, clinical implications, and innovative concepts in the ma

79 The authors discuss the pathophysiology, clinical implications, and pertinent preclinical data an

80 We discuss pathophysiological mechanisms, clinical implications, and pharmacological and non-pharm

81 There are limited data on the incidence, clinical implications, and predisposing factors of trans

82 , risk factors, prevalence, natural history, clinical implications, and treatment options.

83 Educational and clinical implications are considered.

84 ation was the result of routine RBC storage; clinical implications are discussed.

85 to the sex disparity in ASD incidence, whose clinical implications are significant.

86 of PI-resistant HCV variants, the long-term clinical implications are unknown.

87 ow these genes function in vivo and what the clinical implications are.

88 of in vivo lipid peroxidation with important clinical implications as a breath biomarker of bacterial

89 This information has potentially important clinical implications as well as relevance for public he

90 The latter have major clinical implications, as latent infection allows the vi

91 This finding has important clinical implications, as stochastic expression of resis

92 These findings have important clinical implications because IDO inhibitors are used to

93 This finding may have clinical implications because microvascular dysfunction

94 force of microbial community structure, have clinical implications because of the frequent occurrence

95 This finding has important clinical implications because of the risk of additional

96 This may have clinical implications because SF3B1, a splicing factor t

97 These findings have important clinical implications because they directly highlight an

98 These results have important clinical implications, because topical therapies that ta

99 Clinical implications derived from these findings and po

100 t tumors within the same organism have major clinical implications, especially in the context of surg

101 east cancer (TNBC) phenotype, which may have clinical implication for providing novel biomarker(s) of

102 tand the biological mechanism, pathways, and clinical implication for risk management.

103 catenin and PKM2 inhibition which would have clinical implication for the cancer development and new

104 d survival of CD8(+) T cells, with potential clinical implications for adoptive cell transfer and vac

105 These findings have important clinical implications for assessing small-fiber function

106 of Parkinson's disease, these findings have clinical implications for behavioural symptoms and cogni

107 mechanisms imposed by PLN and SLN could have clinical implications for both heart and skeletal muscle

108 The clinical implications for CAD and a better understanding

109 w it functions in DSB repair, with potential clinical implications for cancer therapy.

110 hts into TOPBP1's role in HR, with potential clinical implications for cancer treatment.

111 complete immune suppression provides strong clinical implications for cell therapy-assisted minimiza

112 Our findings have important clinical implications for daily practice, including enha

113 Defining the latter may have important clinical implications for de-repressing fetal hemoglobin

114 This may have clinical implications for designing treatment strategies

115 Our results have clinical implications for diagnosis and cerebellar neuro

116 to Li-Fraumeni Syndrome (LFS) has important clinical implications for diagnosis, surveillance, and t

117 isuse-driven neuronal atrophy which may have clinical implications for disease management, including

118 s necessary to understand whether these have clinical implications for early detection of pancreatic

119 opsychological phenotype in ALS-FTD may have clinical implications for early diagnosis, disease manag

120 ully protect against GvHD and have important clinical implications for future clinical trials testing

121 in future in vivo experiments to clarify the clinical implications for hemostat use in post-surgical

122 tic) effects of scopolamine could have great clinical implications for humans; however, rats and mice

123 These results may have clinical implications for immunosuppressive therapy usin

124 These preliminary findings may have clinical implications for individuals consuming high-dos

125 between host and pathogen and has important clinical implications for infection outcome.

126 take and its distribution and excretion have clinical implications for its bioavailability and uptake

127 HPS and POPH have major clinical implications for liver transplantation.

128 lveolar macrophages and might have important clinical implications for local immunity and immunopatho

129 These finding have clinical implications for mechanisms of seizure-induced

130 ions to enable immune attack on tumors, with clinical implications for molecular markers to modify em

131 This may have clinical implications for pathologies associated with ce

132 These observations have immediate clinical implications for patients with ERBB2/HER2-negat

133 in CKD stage reclassification that has major clinical implications for predicting adverse outcomes af

134 of our four-pronged approach therefore have clinical implications for predicting which patients are

135 onal restart, a process that has significant clinical implications for relapsed staphylococcal infect

136 mTORC1-dependent granulomatous disease with clinical implications for sarcoidosis.

137 mechanisms underlying these concepts; their clinical implications for stratification of T2D manageme

138 nto how tactile end-organs function and have clinical implications for tactile dysfunctions.

139 These results could have important clinical implications for the design of post-PVI follow-

140 a signature of consciousness, with potential clinical implications for the detection of awareness in

141 Our observations have clinical implications for the development of successful

142 These findings have clinical implications for the diagnosis and monitoring o

143 These findings have clinical implications for the improvement of CD8(+) T-ce

144 1 are strong predictors of ESRD, indicating clinical implications for the management of chronic HCV.

145 insulin signaling in liver and has potential clinical implications for the management of various hepa

146 aling in adult cardiomyocytes with potential clinical implications for the prevention of cardiotoxici

147 processes, findings that may have important clinical implications for the treatment of disorders suc

148 These findings have clinical implications for the use of BMPs as regenerativ

149 l helminths to reduce DTH responses may have clinical implications for the use of skin test-based dia

150 ering and robust suppressor function and has clinical implications for the use of Tregs as cellular t

151 in a new era of understanding with potential clinical implications for those who suffer with IBM.

152 isms underlying walking adaptation, and have clinical implications for treating walking impairments a

153 pendent of the hematopoietic lineage and has clinical implications for treatment of osteopetrosis.

154 These data could have significant clinical implications for Treg-based therapy in immune-m

155 Our results have clinical implications for understanding and preventing c

156 scles synergies, and may also have important clinical implications for understanding movement dysfunc

157 on of functional brain networks and may have clinical implications for understanding the actions of a

158 scular function in humans may have important clinical implications for understanding the mechanisms u

159 This finding has important clinical implications given that boosted protease inhibi

160 rcuitry in vivo in humans may have important clinical implications given the comorbidity between majo

161 Our findings have immediate clinical implications given the potential of the identif

162 king viral antigens (P < .001) has important clinical implications, implicitly linked to the immunosu

163 teps following HMPV entry and have important clinical implications.IMPORTANCE Human metapneumovirus (

164 These results have broad clinical implication in cancer, chronic inflammation and

165 However, OmpA clinical implication in hospital-acquired infections rem

166 the perioperative period will have important clinical implications in attenuating metastatic disease

167 bring new focus to SMOC2 by highlighting its clinical implications in both human and veterinary medic

168 and MAGEA1-FBXW7 interactions have potential clinical implications in breast and ovarian cancer treat

169 anism of action of B7-H1 in T cells and have clinical implications in cancer immunotherapy when anti-

170 an provide both biological insights and have clinical implications in cancer.

171 1A expression with potential mechanistic and clinical implications in GC.

172 L-6- and IL-10-producing monocytes, may have clinical implications in HIV-infected patients that are

173 sively detected myocardial fibrosis (MF) has clinical implications in hypertrophic cardiomyopathy, th

174 rmal serotonergic synapse may have important clinical implications in sensory dysfunctions, such as t

175 These results have potential clinical implications in the active field of anthracycli

176 ns for cancer initiation and progression and clinical implications in the context of prolonged immuno

177 ion of liver fibrosis, this finding has many clinical implications in the etiology, prognosis and tre

178 borate these findings, they may have further clinical implications in the laboratory workup of uveiti

179 er, the results of this study have potential clinical implications in the prevention of AKI in at-ris

180 Furthermore, our findings suggest potential clinical implications in the use of steroid drugs.

181 us spatiotemporal MDSC infiltration may have clinical implications in tumour progression.

182 esearch suggests that this heterogeneity has clinical implications, in silico determination of the cl

183 breast cancer subtypes is proposed, and the clinical implications include a need for combinatorial t

184 Possible clinical implications include improving the accuracy of

185 Clinical implications include targeted monitoring for SC

186 tanding of human CSF flux and open important clinical implications, including concepts for drug deliv

187 The clinical implication is that Pten/ING4 negative and ING4

188 Despite its important clinical implications, little is known about ECM changes

189 rding food IgE sensitization is novel, and a clinical implication might be that even food sensitizati

190 lial barrier, a role that may have important clinical implications not only for digestive diseases, s

191 iated with activation of HSP72 has potential clinical implications not only for type 2 diabetes but a

192 s the EMT and metastasis of NPC cells, and a clinical implication of EBV-miR-BART7-3p as a potential

193 n healthy elderly, a population in which the clinical implication of microbleeds is unknown.

194 ements, our study has expanded the potential clinical implication of SD-OCT in evaluation of a variet

195 We explored the clinical implication of serum adiponectin in hepatogenic

196 Clinical implication of the NAC1-HDAC4-HIF-1alpha pathwa

197 purpose of this study is to investigate the clinical implication of these markers in clinical-radiol

198 R, and ascertain factors associated with and clinical implications of a lack of improvement in exerci

199 iation on the intestinal microbiota, and the clinical implications of a modified microbial balance af

200 We retrospectively assessed the clinical implications of CLL B-cell receptor immunoglobu

201 Clinical implications of complete left-sided reverse rem

202 gencies to tumor evolution and highlight the clinical implications of diversity within tumors.

203 cell transplantation (HCT) to determine the clinical implications of donor-recipient HLA matching.

204 ders to reference in order to understand the clinical implications of each patient's genetic makeup.

205 monitoring and its level of evidence or the clinical implications of early detection of serious diso

206 ls in an attempt to define the incidence and clinical implications of EMD.

207 spective presents these current concepts and clinical implications of epigenetic ITH, and the experim

208 uncertainty in key parameters (including the clinical implications of false-negative results), the ex

209 The studies concerning clinical implications of galectin-3 expression in patien

210 To illustrate the clinical implications of genetic variants with large eff

211 In this study, to evaluate the clinical implications of genomic alterations in this tum

212 uld stimulate a careful re-evaluation of the clinical implications of HPV mutation rates, transmissio

213 To determine the proportion and potential clinical implications of inherited variants detected usi

214 as our perspective on future directions and clinical implications of iPSC technology.

215 We now have a better understanding of the clinical implications of limb muscle dysfunction.

216 is study provides insight into the potential clinical implications of lncRNAs in breast cancer.

217 ticle by Tayari et al that suggests studying clinical implications of long noncoding RNAs as possible

218 In this review, we will discuss the clinical implications of MFCT in pregnancy, fetal surger

219 sms of mTOR in autophagy regulation, and the clinical implications of mTOR inhibitors in disease trea

220 pe study may be justified to investigate the clinical implications of multiple crypts, especially if

221 Follow-up for potential clinical implications of mutation detection was through

222 ore investigation is needed, and discuss the clinical implications of new basic research.

223 Given the significant clinical implications of optical imaging, there is an ur

224 The clinical implications of Optos FA findings have yet to b

225 rm risk and severity of TA, highlighting the clinical implications of our findings.

226 Further studies are needed to evaluate the clinical implications of our findings.

227 Clinical implications of our results are discussed.

228 Potential clinical implications of our study are illustrated by an

229 Clinical implications of persistent alanine aminotransfe

230 To examine the clinical implications of positive or negative direct imm

231 HBsAg and HBsAb positivity, and analyse the clinical implications of possible mutations in rt and HB

232 address the experimental, translational, and clinical implications of proteomics as applied to cardio

233 Biologic and clinical implications of putative subtypes of DM require

234 ore investigation is necessary, examines the clinical implications of randomized and observational cl

235 c processes, key findings in this specialty, clinical implications of research, and methodological is

236 We also outline the molecular and clinical implications of such findings and discuss futur

237 g different MDRO species, with the potential clinical implications of such interactions remaining lar

238 The clinical implications of switching from the existing Xpe

239 tudies will be needed to assess the ultimate clinical implications of targeted biopsy.

240 onal, and clinical scientists to address the clinical implications of the AGI, with a particular emph

241 eries examines the biological mechanisms and clinical implications of the cascade of events caused by

242 Future perspectives, including clinical implications of the findings from metagenomic i

243 This review also addresses the clinical implications of the newly proposed cell of orig

244 The clinical implications of the proposed flowchart includin

245 le addressing pertinent technical issues and clinical implications of the results.

246 There are significant differences in use and clinical implications of the test on the basis of race,

247 The potential clinical implications of these findings are also discuss

248 Clinical implications of these findings are discussed.

249 In this review the potential clinical implications of these findings are discussed.

250 Due to the important clinical implications of these fungi and based on the re

251 We also highlight the clinical implications of these recent findings in regard

252 Additionally, we demonstrate the clinical implications of these results by delineating a

253 The clinical implications of these results need further foll

254 The clinical implications of these variable protein levels r

255 The clinical implications of this association warrant furthe

256 Furthermore, the clinical implications of this concept will be discussed

257 However, the clinical implications of this decoupling remain unclear.

258 raining immunity and highlight the potential clinical implications of this discovery.

259 contributing to the formation of MAC and the clinical implications of this disease entity.

260 Larger studies are needed to understand the clinical implications of this finding.

261 iated with normal healing and we discuss the clinical implications of this hypothesised treatment.

262 c definition of chronic pain and discuss the clinical implications of this new definition as well as

263 rimentally confirmed at 7 Tesla (T), and the clinical implications of this new paradigm are illustrat

264 e prevalence, natural history, and potential clinical implications of this nonfamilial subgroup of HC

265 Clinical implications of this observation remain unclear

266 Future studies are required to determine the clinical implications of this observation.

267 l underlying pathophysiologic mechanisms and clinical implications of this observation.

268 the underlying molecular mechanisms and the clinical implications of this pharmacogenetic associatio

269 ng anti-TNF-driven IL-17A expression and the clinical implications of this phenomenon.

270 damental principles, recent discoveries, and clinical implications of this promising field of researc

271 risk of skeletal muscle dysfunction, but the clinical implications of this remain uncertain.

272 Clinical implications of this research include discussio

273 ological testing and evaluated the potential clinical implications of this technique.

274 nce, and offering a fresh perspective on the clinical implications of this work.

275 sed the incidence, potential predictors, and clinical implications of THV thrombosis as determined by

276 Here, we discuss the mechanisms and clinical implications of thymic recovery and new approac

277 tiple tumor types, and discuss the potential clinical implications of tumor clonal heterogeneity.

278 healthy controls and investigated long-term clinical implications of vitamin B-6 deficiency in stabl

279 d encourage shared decision making about the clinical implications of whether to pursue transplantati

280 by homologous recombination and the possible clinical implication on malignant melanoma therapy with

281 ebral amyloid angiopathy (CAA) has important clinical implications, our understanding of it and abili

282 In addition to its clinical implications, our work may shed light on a long

283 s-initiated herpesvirus replication may have clinical implications, particularly for herpesviruses th

284 in vitro and in vivo, thus raising profound clinical implications, particularly with respect to canc

285 We also discuss clinical implications, policy issues, and research gaps

286 These findings have important clinical implications regarding blood flow in the tumour

287 n of the inflammatory response has important clinical implications regarding fluid resuscitation and

288 ation and functions of hDBR1, with immediate clinical implications regarding the regulation of hDBR1

289 standing of their regulation has progressed; clinical implications remain at a preliminary stage.

290 The clinical implications remain unknown.

291 ough tumor-associated B cells with important clinical implications.Resistance to BRAFV600E inhibitors

292 Our findings have potential clinical implications since they demonstrate that inheri

293 ulmonary disease (COPD) and it has important clinical implications, such as reduced exercise toleranc

294 ntributes to the pathogenesis of ACS and the clinical implications that arise from these new pathogen

295 persistent pain, the present findings offer clinical implications that may serve to guide future stu

296 These mechanisms have clinical implications that relate to the increasing use

297 The clinical implication was studied in blood samples of pat

298 In light of these clinical implications, we also consider the therapeutic

299 CLINICAL IMPLICATIONS: We here evaluate allergen immunot

300 This has an important clinical implication when planning for anterior lamellar