ライフサイエンスコーパス: clinical importance

1 unistic mycobacterial pathogen of increasing clinical importance.

2 increasingly understood to have significant clinical importance.

3 tion consequent to neuronal injury may be of clinical importance.

4 ute risk increase was small and of uncertain clinical importance.

5 inodal targets is likely to be of increasing clinical importance.

6 toward HCV GT-1a, a strain with significant clinical importance.

7 cingulate cortex function is likely to be of clinical importance.

8 d be a useful biomarker for determination of clinical importance.

9 dered a fundamental cerebellar impairment of clinical importance.

10 ith prognosis, suggesting its biological and clinical importance.

11 ifference between treatments is of uncertain clinical importance.

12 l validation, as well as assessment of their clinical importance.

13 r insufficient for many outcomes of greatest clinical importance.

14 of secondary metabolites, some of which have clinical importance.

15 ible S. aureus (MSSA), despite its continued clinical importance.

16 nderstanding their mechanism of action is of clinical importance.

17 s been revealed in adult humans and has high clinical importance.

18 en questions were rated as being of greatest clinical importance.

19 es as well as further investigation of their clinical importance.

20 can reveal tumor subgroups of biological and clinical importance.

21 symptoms at 4-month follow-up, of uncertain clinical importance.

22 e, but this improvement is unlikely to be of clinical importance.

23 vulnerability to ischemia are of increasing clinical importance.

24 variants), leaving 334 variants of potential clinical importance.

25 f undesirable postoperative outcomes, are of clinical importance.

26 c targets for preventing podocyte injury has clinical importance.

27 ion of probable autoimmune hepatitis and its clinical importance.

28 specific off-target promiscuity of potential clinical importance.

29 event or delay such occurrences are of great clinical importance.

30 ratumor heterogeneity is therefore of direct clinical importance.

31 anner, MDT revealed information of potential clinical importance.

32 tic glucose metabolism is therefore of great clinical importance.

33 rial infections after injury are of enormous clinical importance.

34 emerging epidemiologic trends that may have clinical importance.

35 egulate this process has both biological and clinical importance.

36 y sleep deprivation is clearly of social and clinical importance.

37 olism, these genetic findings have potential clinical importance.

38 trition existing in the elderly, which is of clinical importance.

39 ic cell infiltration of the CNS, despite its clinical importance.

40 ly versatile and evolving bacterium of great clinical importance.

41 he molecular and cellular levels despite its clinical importance.

42 channel drug binding are therefore of vital clinical importance.

43 N. meningitidis strains or other microbes of clinical importance.

44 lls are poorly understood and yet of extreme clinical importance.

45 expression is modulated may have significant clinical importance.

46 creasingly incorporated components of lesser clinical importance.

47 molecular phenotype of grade is of potential clinical importance.

48 emain uncharacterized despite their enormous clinical importance.

49 ition of these enzymes is therefore of great clinical importance.

50 its inactivation is therefore of particular clinical importance.

51 or withdrawal, and whether withdrawal is of clinical importance.

52 tor network regulation also has considerable clinical importance.

53 , understanding how mast cells develop is of clinical importance.

54 lth has emerged as an area of scientific and clinical importance.

55 us disease personnel remain unaware of their clinical importance.

56 tic effects and directly model covariates of clinical importance.

57 these findings suggest that the syndrome has clinical importance.

58 e to Staphylococcus aureus are of increasing clinical importance.

59 e fifth globally common type of rotavirus of clinical importance.

60 din in epidermal regeneration with potential clinical importance.

61 he lower risk did not exceed a criterion for clinical importance.

62 sions and Relevance: Measles remains of high clinical importance.

63 a a simple noninvasive procedure is of great clinical importance.

64 for developing Alzheimer disease (AD) is of clinical importance.

65 unique properties of these cells that are of clinical importance.

66 the race-centric networks and of particular clinical importance.

67 p for incidental imaging findings of limited clinical importance.

68 gh statistically significant is of uncertain clinical importance.

69 bolic-related disease, including BrCA, is of clinical importance.

70 red to postpartum is not considered to be of clinical importance.

71 hibition is not fully understood despite its clinical importance.

72 nt stem cells during lung regeneration is of clinical importance.

73 ne on inhibitory control may thus be of high clinical importance.

74 delineates our current understanding of the clinical importance, aetiology and pathophysiology of ac

75 tion in HIV-infected populations are of high clinical importance, although evidence supporting lung c

76 Furthermore, we highlight their clinical importance and analyze the development of drugs

77 Despite its clinical importance and health-related costs, it often r

78 Further studies are needed to determine the clinical importance and long-term consequences of these

79 Despite the clinical importance and significant cost of short-term m

80 lar bone as our tissue model, because of its clinical importance and the challenges associated with i

81 The rationale for this has stemmed from the clinical importance and therapeutic potential of modulat

82 The experts developed four questions of clinical importance and used an evidence-based strategy

83 burden for data collection, has substantial clinical importance, and has acceptable reliability.

84 cholesterol concentration as a phenotype of clinical importance, and identified the cis-regulated va

85 ong pathogenic bacteria is an issue of great clinical importance, and new approaches to therapy are u

86 Many of these findings are of clinical importance, and ongoing studies implementing cl

87 PHER patient report, and genes of recognized clinical importance are highlighted and prioritized.

88 Glucocorticoids have great clinical importance as antiinflammatory drugs and can ac

89 rebral embolic events have become a focus of clinical importance as complications of vascular procedu

90 I interferonopathies becoming of increasing clinical importance as treatment options are developed b

91 ERalpha status is of clinical importance, as ERalpha-positive breast cancers

92 dynamics in vivo in patients has significant clinical importance, as the structure and function is al

93 These bacterial aggregates are of clinical importance, as they are a major source of recur

94 Of clinical importance, AT pO2 negatively correlated with C

95 This integrated concept is of potential clinical importance because it offers numerous innovativ

96 Recognizing patients with CID/HIES is of clinical importance because of the difference in prognos

97 rogression to WHO grade III or IV is of high clinical importance because the initiation of a specific

98 conscious emotions in FTLD patients may have clinical importance because these deficits may underlie

99 Our data are of clinical importance, because they indicate that both CD1

100 lpha1 poorly induces IP-10 is potentially of clinical importance, because this subtype may be more be

101 elin biology is therefore of fundamental and clinical importance, but no tools currently exist to des

102 l can show lesions which are of questionable clinical importance, but which frequently preclude trial

103 Despite the clinical importance, cell-intrinsic molecular mechanisms

104 In addition to its clinical importance, DBS presents a powerful approach to

105 the host for months or years and might be of clinical importance during NK cell adoptive immunotherap

106 ossreactive memory T cells are of particular clinical importance, especially given the emergence of c

107 dii is an obligate intracellular parasite of clinical importance, especially in immunocompromised pat

108 tyrosinase (TY), was selected based on their clinical importance for a range of pathologies.

109 n human breast cancer, which is of potential clinical importance for determining disease risk and for

110 nonaggressive prostate cancer is of critical clinical importance for disease prevention and treatment

111 therapy patients, -17(p13) and t(4;14) have clinical importance for estimating time to progression a

112 s (k = 59) show a small benefit of uncertain clinical importance for patients and their caregivers.

113 stem/progenitor cells (HSPCs) ex vivo is of clinical importance for stem cell expansion and gene the

114 residual endogenous glucose production is of clinical importance given the risk of sudden death in th

115 Despite their potential clinical importance, how CSCs are regulated at the molec

116 Despite their potential clinical importance, how CXCR4 expression in breast canc

117 Despite its functional and clinical importance, how vascular cells integrate phosph

118 estimating thresholds could be of particular clinical importance in combination with focused stimulat

119 (KPC) is an emerging problem of significant clinical importance in Gram-negative bacteria.

120 antiviral response activity that could have clinical importance in HIV infection.

121 sms of TACC3-mediated EMT and its functional/clinical importance in human cervical cancer remain elus

122 lanoma and discover new genes with potential clinical importance in human melanoma.

123 Despite its clinical importance in infection and autoimmunity, the a

124 f scientific inquiry to address questions of clinical importance in periodontology for which there is

125 Despite their clinical importance in sexually transmitted infection an

126 pertoire of pollen allergens of a grass with clinical importance in subtropical regions, where an inc

127 and that such disturbance is of significant clinical importance in terms of behavioral symptoms.

128 These activities may have clinical importance in terms of new treatments, targeted

129 neation of complotype could be of increasing clinical importance in the future.

130 arly diagnosis and risk stratification is of clinical importance in the long QT syndrome (LQTS), howe

131 Liver regeneration is of major clinical importance in the setting of liver injury, rese

132 Detecting these variants has clinical importance in the treatment of diseases.

133 mutations and oncogenic driver alleles with clinical importance in the treatment of human cancer.

134 minoglycoside antibiotics, although of major clinical importance in the treatment of serious Gram- ne

135 ing TNBC and discovered genes with potential clinical importance in TNBC.

136 ucible expression of VEGF in EC, which is of clinical importance in tumor growth and the progression

137 tated or amplified cancer genes of potential clinical importance included PI3K (PIK3CA, AKT1, PIK3CG)

138 ciations were statistically significant, the clinical importance is relatively modest.

139 Of particular clinical importance is whether scaling and root planing

140 e these variants, and to identify those with clinical importance, is often difficult to assess throug

141 Despite its clinical importance, it is largely unknown how cytokine

142 Of particular clinical importance, lenalidomide also allowed NK cells

143 Despite its clinical importance, little is known about innate immuni

144 Despite their clinical importance, little is known about the binding t

145 Despite the clinical importance, little is known about the gene regu

146 Despite their clinical importance, little is known about the host fact

147 Despite its clinical importance, little is known about the human imm

148 However, despite its clinical importance, little is known about the principle

149 is, PET using labeled amino acids has gained clinical importance, mainly regarding the differentiatio

150 Because of its clinical importance, many studies have sought to determi

151 dipivoxil (ADV); however, its incidence and clinical importance may be underappreciated given the la

152 Apart from its clinical importance, mirror visual feedback paves the wa

153 Despite the clinical importance, no DENV vaccine or anti-DENV drug i

154 Despite its clinical importance, no vaccine prophylaxis against RSV

155 Such a capability could be of great clinical importance, not only in patients with hypoxic o

156 This study demonstrates the clinical importance of a discharge diagnosis of critical

157 These data highlight the clinical importance of a thorough understanding of Notch

158 n an increased awareness of the presence and clinical importance of abdominal compartment syndrome.

159 Despite the functional and clinical importance of arteriogenesis, the biology of th

160 To investigate the clinical importance of changes in diabetic retinopathy s

161 ic value in heart failure (HF), although the clinical importance of changes in NP from baseline is un

162 However, the clinical importance of chromosome 17 anomalies, in parti

163 This report emphasizes the clinical importance of considering CA-MRSA as a causativ

164 Although the clinical importance of CSCs remains unproven, new eviden

165 here has been great progress in defining the clinical importance of CTCs, and it now seems likely tha

166 Given the clinical importance of D2 antagonists, the goal of this

167 These effect sizes emphasise the clinical importance of direct interventions.

168 Given the clinical importance of dyskalemias in patients, these no

169 These data highlight the clinical importance of evaluating adults with histiocyto

170 All previous studies assessing the clinical importance of extent of resection have not acco

171 The clinical importance of fibrosis in hypertensive heart di

172 Considering the potential clinical importance of focal lamina cribrosa (LC) defect

173 The clinical importance of GISA, and particularly hGISA, wil

174 Despite the clinical importance of herpes simplex virus (HSV)-induce

175 Despite the clinical importance of HSV-2, relatively little is known

176 Recently the clinical importance of human organic cation transporters

177 Despite the clinical importance of hypoxia, modulation of hypoxic in

178 subset of prostate tumors and highlight the clinical importance of identifying molecularly defined t

179 Despite the clinical importance of identifying the HLA types, very f

180 The physiological and clinical importance of IGF-1 prompted challenging chemic

181 over time and examine temporal trends in the clinical importance of individual components of these co

182 s Review, we discuss the epidemiological and clinical importance of influenza and respiratory bacteri

183 Despite the clinical importance of influenza virus in pediatric resp

184 ver, after several decades of discovery, the clinical importance of inverse agonist ligands is still

185 These results illustrate the clinical importance of ligand-induced resistance to kina

186 The possible clinical importance of many of the various IGH transloca

187 To investigate the clinical importance of MCT4 in GBM, we examined clinical

188 In view of the clinical importance of mechanical hyperalgesia in inflam

189 Despite the clinical importance of metastasis, there remain fundamen

190 The clinical importance of microbial causes of dacryocystiti

191 Because of the clinical importance of MTA1 established in PD, we looked

192 These findings suggest clinical importance of nonobstructive CAD and warrant fu

193 The clinical importance of pAKT localization and the mechani

194 However, the clinical importance of Paneth cells' associations with s

195 The clinical importance of peanut (Arachis hypogaea) allergi

196 The clinical importance of podocyte binding to the GBM via a

197 These findings demonstrate the clinical importance of primary infection with this rapid

198 Low treatment rates highlight the clinical importance of questioning patients about eating

199 trating adamantane resistance highlights the clinical importance of rapid surveillance for antiviral

200 The clinical importance of reducing 2-hour glucose level in

201 Given the clinical importance of rhinovirus, we sought to determin

202 Despite the clinical importance of S. saprophyticus, little is known

203 Considering the biological and clinical importance of S6K1, a complete understanding of

204 cent literature describing the detection and clinical importance of serum antibodies in patients with

205 mphocytic leukemia (CLL) and demonstrate the clinical importance of small TP53-deleted subclones dete

206 The clinical importance of SREBP-2 is revealed in patients w

207 and regulatory agencies in interpreting the clinical importance of statistically significant finding

208 These findings indicate the clinical importance of studies into the molecular hetero

209 results of other imaging modalities, and the clinical importance of such findings is uncertain.

210 Purpose To evaluate the effect and clinical importance of sunitinib on pancreatic volume in

211 sly controlled active infections support the clinical importance of T-cell immunity in mediating prot

212 Given the biological and clinical importance of the ALK1 signaling pathway, we so

213 These findings corroborate the clinical importance of the C9ORF72 mutation in frontotem

214 issue of Blood, Steinberg et al describe the clinical importance of the distribution or "packaging" o

215 Further research is needed to assess the clinical importance of the effect size and to determine

216 The heterogeneity and the increasing clinical importance of the Enterobacter cloacae complex

217 Despite the clinical importance of the itch sensation, its mechanism

218 To evaluate the clinical importance of the observed experimental results

219 Despite the clinical importance of the ocular motor system, little i

220 The clinical importance of the RBCs storage lesion (ie, the

221 Depending on the clinical importance of the respective errors, careful co

222 New knowledge of the biological and clinical importance of the steroid hormone 1alpha,25-dih

223 MT pharmacogenetics highlights the potential clinical importance of the translation of pharmacogeneti

224 Although the clinical importance of these "rising" clones remains to

225 The clinical importance of these chemokines was validated by

226 However in this preliminary work the clinical importance of these degrees of misalignment was

227 Further research is needed to assess the clinical importance of these differences and measure lon

228 The potential clinical importance of these endothelial lncRNAs to vasc

229 urther research is required to determine the clinical importance of these findings and the effect on

230 However, despite the clinical importance of these findings and the potential

231 However, the clinical importance of these findings has not been deter

232 The clinical importance of these findings in asthmatic patie

233 not given; the challenges of researching the clinical importance of these findings or seeking special

234 The clinical importance of these findings remains to be dete

235 The clinical importance of these findings remains unknown.

236 The clinical importance of these findings will require furth

237 To investigate the clinical importance of these findings, in the present st

238 ma lung epithelium, underlying the potential clinical importance of these findings.

239 rosclerotic lesions underlying the potential clinical importance of these findings.

240 ma lung epithelium, underlying the potential clinical importance of these findings.-Shi, N., Zhang, J

241 ets compared to narrow sockets; however, the clinical importance of these relative dimensional change

242 g epidemics of obesity and AF underscore the clinical importance of these results.

243 This demonstrates the clinical importance of these sensors for cancer marker d

244 ISA/hGISA strains so that the prevalence and clinical importance of these strains can be assessed pro

245 However, the clinical importance of this association is uncertain.

246 Further research is needed to understand the clinical importance of this finding in patients with hyp

247 The clinical importance of this finding is not clear.

248 The duration and clinical importance of this finding is uncertain but mer

249 The clinical importance of this improvement remains to be de

250 d poor prognosis, highlighting the potential clinical importance of this molecule.

251 and pharmacology of visceral pain proves the clinical importance of this pain entity.

252 With regard to the potential clinical importance of this pathway, NRG4 expression was

253 Despite the clinical importance of this relationship, we do not unde

254 The clinical importance of this stress response remains to b

255 erative disorders in humans, emphasizing the clinical importance of this system.

256 Therefore, we sought to study the clinical importance of TLRs in HCV genotype 1 patients w

257 Despite the clinical importance of venous thrombus resolution, the c

258 are prevalent in asthmatic patients, but the clinical importance of ventilation defects is poorly und

259 The clinical importance of vitamin A as an essential nutrien

260 nerate human neurons of specific subtypes of clinical importance offers experimental platforms that m

261 oject were to identify MATE1 inhibitors with clinical importance or in vitro utility and to elucidate

262 Although clinical importance remains to be substantiated, results

263 mportant new treatment concept, although its clinical importance remains unproven.

264 n of disease progression, which, despite its clinical importance, remains poorly understood with resp

265 Of clinical importance, Sema3E and Plexin D1 were found to

266 These alterations could have significant clinical importance, such as the case of Pseudomonas aer

267 Many bacteria of clinical importance survive and may grow in different en

268 Despite potential clinical importance, target cells for mother-to-child tr

269 e of strong or weak is considered of greater clinical importance than a difference in letter level of

270 lection pressure with both environmental and clinical importance that potentially contributes to the

271 Despite its clinical importance the global effects of vancomycin exp

272 In addition, and of clinical importance, the cohort of p53-null clones showe

273 Despite its clinical importance, the exact mechanism by which daptom

274 Despite its clinical importance, the mechanisms that mediate or gene

275 Despite its physiological role and clinical importance, the molecular basis of its action i

276 Despite this clinical importance, the molecular basis of the brain me

277 Despite its clinical importance, the molecular biology of HIV-1 late

278 Despite their clinical importance, the molecular mechanisms by which v

279 Despite their fundamental biological and clinical importance, the molecular mechanisms that regul

280 Despite its clinical importance, the molecular mechanisms underlying

281 Despite its clinical importance, the molecular regulation of neutrop

282 Despite its clinical importance, the normal role of UBE3A in neurons

283 Despite its clinical importance, the underlying neural mechanisms of

284 Due to their clinical importance, there is a pressing need for effect

285 However, despite its clinical importance, there remains limited understanding

286 In addition to their clinical importance, these results support the use of pe

287 Despite its basic and clinical importance, this process remains mysterious in

288 Identifying the HSV type is of clinical importance to determine proper treatment, as th

289 ombi after myocardial infarction would be of clinical importance to estimate the risk for embolizatio

290 s edema resolution, which is of biologic and clinical importance to patients with IAV-induced lung in

291 ating the mechanism underlying LTF can be of clinical importance to the patients suffering from sleep

292 ply sound scientific principles to issues of clinical importance was most apparent in his work in thr

293 gh cognitive improvements were modest, their clinical importance was suggested by relationships with

294 Of clinical importance, we observed that elevated MT1-MMP e

295 Few differences of clinical importance were found for core illness symptoms

296 Factors with a P value of less than 0.1 and clinical importance were included in the multivariable l

297 We conclude that secondary variants of high clinical importance will be detected at an appreciable f

298 y-resistant LSCs, a cellular entity of prime clinical importance, will be required to develop additio

299 e tolerance that was modest and of uncertain clinical importance, with a higher likelihood of major c

300 This might be of clinical importance within the context of neuronal disea