ライフサイエンスコーパス: clinical investigation

1 than the MTD regimen, justifying its further clinical investigation.

2 le isotopically labeled ones, even for adult clinical investigation.

3 inhibitor of the target or pathway is under clinical investigation.

4 s of promising antitumor therapies in active clinical investigation.

5 ment of MLL-rearranged leukemia and is under clinical investigation.

6 ibitors (NRTIs) is an important strategy for clinical investigation.

7 nts in the last decade and highlight ongoing clinical investigation.

8 or beta-blockers in PH that warrants further clinical investigation.

9 otherapeutics for cancer and many more under clinical investigation.

10 acokinetics, and adolescent compliance merit clinical investigation.

11 implications of these investigators' role in clinical investigation.

12 mitations of RF ablation and warrant further clinical investigation.

13 network, threatening the cause of legitimate clinical investigation.

14 eutics as well as the nanotherapeutics under clinical investigation.

15 ome to reach this goal and the next steps in clinical investigation.

16 activity are currently in advanced stages of clinical investigation.

17 ective in reducing pain and warrants further clinical investigation.

18 fficient potency and acceptable toxicity for clinical investigation.

19 sis of the four metabolites in a large-scale clinical investigation.

20 ombinant chaperoning-based vaccine to future clinical investigation.

21 e need for detailed further experimental and clinical investigation.

22 a nuanced understanding of epidemiology and clinical investigation.

23 Soluble Dll4 is thus a candidate for clinical investigation.

24 pilot study suggests important new areas for clinical investigation.

25 e ASCI started a new journal, the Journal of Clinical Investigation.

26 rategies for optimal training, staffing, and clinical investigation.

27 s, show antitumor efficacy and are now under clinical investigation.

28 ts potential as a prototype virus for future clinical investigation.

29 lar targeted therapies under preclinical and clinical investigation.

30 tions--the annual meeting and The Journal of Clinical Investigation.

31 Cs) following myocardial infarction is under clinical investigation.

32 ne therapy remains an appropriate subject of clinical investigation.

33 or activity and PD in tumors require further clinical investigation.

34 resistance and is thus worthy of prospective clinical investigation.

35 there has been a dramatic expansion of HDACi clinical investigation.

36 dextrin, a promising therapy currently under clinical investigation.

37 y it highlights areas which need further pre-clinical investigation.

38 human trials and suggests avenues for future clinical investigation.

39 CRC mouse models for genetic studies and pre-clinical investigation.

40 , patient-friendly Hsp90-directed agents for clinical investigation.

41 therapy or novel anticancer agents are under clinical investigation.

42 propriate patient selection currently hamper clinical investigation.

43 and the flagship of the American Society for Clinical Investigation.

44 y that remains unexplained following routine clinical investigation.

45 of low-dose aspirin in T1DM warrant further clinical investigation.

46 stomosis and hyperbaric oxygen therapy merit clinical investigation.

47 for TP53- or ATM-defective CLL that warrants clinical investigation.

48 commercially available (in Europe) or under clinical investigation.

49 nologic checkpoint blocking antibodies begin clinical investigation.

50 idering compounds at various stages of (pre-)clinical investigation.

51 inumab might be possible and warrant further clinical investigation.

52 ially cost-effective, candidates for further clinical investigation.

53 ising, novel antimicrobial agent that merits clinical investigation.

54 sy, thereby overcoming critical obstacles to clinical investigations.

55 multicenter efforts to conduct the necessary clinical investigations.

56 in glioblastoma through both preclinical and clinical investigations.

57 available at the end of synthesis for use in clinical investigations.

58 time-both of which are necessary for future clinical investigations.

59 against PC that warrants further in vivo and clinical investigations.

60 rphologies consistent with those reported in clinical investigations.

61 decades has emerged as a result of organized clinical investigations.

62 monly used for epidemiological, forensic and clinical investigations.

63 acy observed in pre-clinical and small-scale clinical investigations.

64 linical trials and to summarize results from clinical investigations.

65 s essential to guiding the design of further clinical investigations.

66 ress in this field and priorities for future clinical investigations.

67 ide a new foundation for future research and clinical investigations.

68 in cancer with several new drugs undergoing clinical investigations.

69 n provide a basis for further biological and clinical investigations.

70 devices that have been approved or are under clinical investigations.

71 radionuclide therapy and (166)Ho-phosphonate clinical investigations.

72 is unknown despite extensive preclinical and clinical investigations.

73 liant study was approved by the committee on clinical investigations.

74 field and to identify gaps in molecular and clinical investigations.

75 es are proving relevant to epidemiologic and clinical investigations.

76 as been the subject of significant basic and clinical investigations.

77 t also demonstrate functional utility in pre-clinical investigations.

78 sibility to apply the QD-based biosensor for clinical investigations.

79 n of F8-IL4 is currently being developed for clinical investigations.

80 gression and regression in basic science and clinical investigations.

81 Despite extensive clinical investigations, a standard systemic therapy for

82 Limited information is available from large clinical investigations about the agreement among source

83 tely, current implementations, in animal and clinical investigations, activate both afferent and effe

84 history, examination and routinely available clinical investigations) against a new 'gold standard' f

85 This has translated to clinical investigations aimed at the safe and controlled

86 ro and in vivo, establishing a rationale for clinical investigation and further motivation to underst

87 e Duke-UNC Editorial Board of the Journal of Clinical Investigation and have had the privilege of pub

88 al myocardial function have also evolved for clinical investigation and hold the promise of enhanced

89 Generally, the tension between clinical investigation and individual care can be framed

90 13 patients for up to 37 years, extended the clinical investigation and monitoring to living relative

91 ell lymphoma and identifies ongoing areas of clinical investigation and new treatment approaches.

92 toxic effects encountered and anticipated in clinical investigation and practice with antiangiogenic

93 9 has advanced to clinical investigation and successfully suppressed postp

94 ) mouse, thereby providing opportunities for clinical investigation and therapeutic intervention in R

95 contradictory results compared to those from clinical investigations and animal models.

96 This review summarizes the data from various clinical investigations and highlights the impact of len

97 Most of these enzymes are currently under clinical investigations and if successful will potential

98 perspective to use stochastic pacing during clinical investigations and in patients with implanted p

99 asures of myocardial strain and synchrony in clinical investigations and in practice; data are limite

100 This finding compels additional clinical investigations and pharmacovigilance directed t

101 The study was approved by the committee on clinical investigations and was HIPAA compliant.

102 Scientists Association, American Society of Clinical Investigation, and Association of American Phys

103 Clinical Research, the American Society for Clinical Investigation, and the Association of American

104 s mild AD in a large, multisite, prospective clinical investigation, and this signature appears to pr

105 e prospective studies (IDE [S-ICD System IDE Clinical Investigation] and EFFORTLESS [Boston Scientifi

106 The institutional review board for clinical investigations approved the protocols for each

107 l trials, and human data from several of the clinical investigations are compared with results from m

108 Clinical investigations are focused on development of ef

109 Further clinical investigations are needed to determine its clin

110 Encouraging results from some of these clinical investigations are summarized in this review.

111 MI-219 warrants clinical investigation as a new agent for cancer treatme

112 ostimulatory saponin that is currently under clinical investigation as an adjuvant in various vaccine

113 n Hh pathway inhibitor (HPI) currently under clinical investigation as an anticancer agent.

114 rpes simplex type 1 viruses are under active clinical investigation as oncolytic therapy for cancer.

115 Chk1 kinase inhibitors are currently under clinical investigation as potentiators of cytotoxic chem

116 biosynthesis inhibitors are currently under clinical investigation as treatments for respiratory and

117 ate hepatitis C virus antiviral therapies in clinical investigation as well as the associated clinica

118 dy suggests that ROR1 merits preclinical and clinical investigations as a novel target for mAb-based

119 years ago, in 1909, the American Society for Clinical Investigation (ASCI) held its first annual meet

120 The American Society for Clinical Investigation (ASCI) was started a century ago

121 Urine is considered an ideal biofluid for clinical investigation because it is obtained noninvasiv

122 ra (MVA) is a useful viral-based vaccine for clinical investigation, because of its excellent safety

123 t at the stage where it can enter widespread clinical investigations, because the technology is stabl

124 Clinical investigation, blinded to lyso-Gb3 results, rev

125 Research Council Scale) and associated with clinical investigations (brain magnetic resonance imagin

126 Genetic predictive testing and clinical investigation by imaging from neck to pelvis wa

127 tments of Ophthalmology and their associated clinical investigation centers.

128 (ABSORB Clinical Investigation, Cohort B [ABSORB B]; NCT00856856

129 fer preclinical rationale warranting further clinical investigation combining HDACi with EGFR and HER

130 Clinical investigations confirmed sclerotic skin, joint

131 With continued clinical investigation, CU imaging of the carotid artery

132 After extensive clinical investigation, direct sequencing and mutation a

133 Clinical investigations discovered that levels of patien

134 ns and ESR1 gains deserving urgent dedicated clinical investigation, especially in the context of end

135 tissues has led to the rapid development of clinical investigations exploring their anti-inflammator

136 ing mechanisms are poorly defined, with most clinical investigations focused on humoral autoimmunity

137 tase enzyme (BACE1) are under preclinical or clinical investigation for Alzheimer's disease (AD).

138 ancer cells by replicating viruses, is under clinical investigation for cancer therapy.

139 tein kinases (MAPKs) that is currently under clinical investigation for human malignancies.

140 , facilitates improved screening and focused clinical investigation for PH diagnosis and management.

141 nd a number of therapeutic options are under clinical investigation for the management of patients wi

142 sue-derived cells (hUTC) are currently under clinical investigation for the treatment of geographic a

143 Smoothened (SMO) inhibitors are under clinical investigation for the treatment of several canc

144 ry arterial hypertension and have been under clinical investigation for the treatment of several othe

145 ransplantation is a cell-based therapy under clinical investigation for the treatment of type 1 diabe

146 giogenesis and has since undergone extensive clinical investigation for the treatment of various soli

147 he novel Hsp90 inhibitor XL888 is undergoing clinical investigation for use in conjunction with the r

148 Nevertheless, clinical investigations for atherosclerosis still focus

149 ffers a novel combination regimen for future clinical investigations for prevention of prostate cance

150 using the standard World Health Organization clinical-investigation form for viral hemorrhagic fevers

151 Our clinical investigations further indicate that high tumor

152 on-like peptide-1 (GLP-1), and the target of clinical investigation, gastric inhibitory polypeptide (

153 Human satellite cells are scarce; therefore, clinical investigation has been limited.

154 The American Society for Clinical Investigation has supported the career developm

155 use and in vitro cell systems, together with clinical investigations, has provided insight into the m

156 iety, its annual meeting, and The Journal of Clinical Investigation have had on them.

157 entative of the class of dietary flavonoids, clinical investigations have been considered as a means

158 Laboratory and clinical investigations have clearly shown that endothel

159 However, data from several clinical investigations have consistently implicated an

160 al antibodies to NKG2D that are suitable for clinical investigations have not been published yet.

161 Clinical investigations have revealed that infusion of i

162 Clinical investigations have suggested that repression o

163 Experimental and clinical investigations have tested the hypothesis that

164 Clinical investigations highlight the increased incidenc

165 ng founders when they created the Journal of Clinical Investigation in 1924.

166 revious data, enzastaurin is currently under clinical investigation in a variety of hematologic malig

167 Combining VXL with a BH3-mimetic warrants clinical investigation in ALL at relapse and potentially

168 geting arginine is safe and warrants further clinical investigation in arginine-dependent cancers.

169 privation combined with antifolates warrants clinical investigation in ASS1-negative urothelial and r

170 Therefore, epigenetics is a key area of clinical investigation in diagnosis, prognosis, and trea

171 minal infusion of AAV2-GDNF and suggest that clinical investigation in PD patients is warranted.

172 prostate cancer models and, therefore, merit clinical investigation in this setting.

173 The results were compared with subsequent clinical investigations in human volunteers.

174 ing pharmacological profile supports further clinical investigations in hypertriglyceridemic subjects

175 Epidemiologic and clinical investigations in many settings should now incl

176 Research and clinical investigations in psychiatry largely rely on th

177 More than 20 years ago clinical investigations in the immunotherapy of cancer r

178 l proof-of-principle to repurpose l-NAME for clinical investigations in treatment of PDACs and possib

179 Clinical investigations included electro-oculography, fu

180 Clinical investigations included eye examination with co

181 Clinical investigations included fundus photography, opt

182 Clinical investigations included visual field testing, f

183 om LSC would enable important scientific and clinical investigation including the possibility of purg

184 approaches that are in preclinical or early clinical investigation, including modified protein immun

185 Randomized clinical investigation indicates that ACEI and a BP goal

186 mulating evidence from both experimental and clinical investigations indicates a tight interaction be

187 these trials and have warranted intense pre-clinical investigation into defining the tendencies of d

188 (TRIUMPH I: Double Blind Placebo Controlled Clinical Investigation Into the Efficacy and Tolerabilit

189 further study, including epidemiological and clinical investigations into laxative prescriptions cons

190 Our findings indicate further need for clinical investigations into the effects of OLZ, but not

191 A new anthrax vaccine under clinical investigation is based on recombinant Bacillus

192 However, further rigorous clinical investigation is necessary in order to prove th

193 Additional comprehensive and disciplined clinical investigation is needed to carefully characteri

194 Further clinical investigation is needed to confirm these result

195 Innovative basic and clinical investigation is urgently needed to improve tre

196 atinine are observed postoperatively, timely clinical investigation is warranted to maximize renal re

197 Further clinical investigation is warranted.

198 Further clinical investigation is warranted.

199 to antitumor effects to be gauged in future clinical investigations justified by our findings.

200 This edition of the Journal of Clinical Investigation marks the transition to a new edi

201 alignancies and pediatric-specific issues in clinical investigation may make translating genomic disc

202 , the most readily available human cells for clinical investigation, may provide a powerful tool for

203 Early clinical investigations noted its efficacy in relapsed a

204 American Physicians could unite the whole of clinical investigation, now stand many organizations and

205 Parallel clinical investigation of 6 patients with IWC revealed a

206 These data support clinical investigation of adjunctive deferasirox therapy

207 load" in neurodegeneration and the potential clinical investigation of agents that are effective trap

208 bserved in this patient suggest that further clinical investigation of alemtuzumab in ATL is warrante

209 , we applied our model to data obtained in a clinical investigation of an allogeneic whole-cell thera

210 tic cholesterol metabolism, which led to the clinical investigation of ASBT inhibitors as lipid-lower

211 These results warrant the clinical investigation of ATO for tumors with activated

212 , the present data do not support additional clinical investigation of combined paclitaxel/bevacizuma

213 cells and provide the rationale for further clinical investigation of DIM.

214 HER2-amplified breast cancers, rationalizing clinical investigation of dual mTORC1/2 kinase inhibitor

215 Results will inform clinical investigation of EGFR-targeting therapeutics in

216 Our results support the clinical investigation of FTC/TAF for PrEP.

217 cancers expressing AR-V7, supporting further clinical investigation of HSP90 inhibitors in malignanci

218 d they offer a mechanistic rationale for the clinical investigation of Jak and STAT3 inhibitors as th

219 These results support the clinical investigation of nelfinavir in combination with

220 des have brought an accelerating pace to the clinical investigation of new molecular targeted agents,

221 ene-driven lymphomas, and this work supports clinical investigation of NKT cell-based immunotherapy i

222 Clinical investigation of novel therapies in immune thro

223 Further clinical investigation of PARP-1 inhibitors is warranted

224 The study was conducted in the Center for Clinical Investigation of Quinze-Vingts National Ophthal

225 hese findings provide a strong rationale for clinical investigation of rhApo2L/TRAIL in combination w

226 wrisk MDS and provide a strong rationale for clinical investigation of SCIO-469 in MDS.

227 These findings warrant further clinical investigation of selumetinib plus docetaxel in

228 These recent advances bode well for the clinical investigation of stem cell-based gene therapy i

229 t of PI3K inhibitors, and strategies for the clinical investigation of such drugs in hormone receptor

230 These results warrant the clinical investigation of suicidal CD44v6-targeted T cel

231 ertension Study (n = 811), a cross-sectional clinical investigation of systematic differences between

232 TACE inhibitor and continues to obstruct the clinical investigation of TACE activity.

233 Clinical investigation of TDT 067 for the topical treatm

234 Clinical investigation of the homozygous Arg133Trp carri

235 Clinical investigation of the manifestations observed in

236 dontal health and disease, paving the way to clinical investigation of the possibility of using the W

237 with DLD; (3) recommend methods for further clinical investigation of the remaining infants, who are

238 ifferent experimental models, leading to the clinical investigation of the TGF-beta inhibitor LY21572

239 Clinical investigation of these radiopharmaceuticals req

240 Our results warrant the clinical investigation of this combination therapy in pa

241 These studies provide a rationale for clinical investigation of this novel redox-mediating age

242 umors via a variety of mechanisms, prompting clinical investigation of this potentially promising tre

243 rends in DTI applications for biomedical and clinical investigation of various brain diseases and dis

244 nd retrospective analyses ranging from small clinical investigations of 42 participants to large, mul

245 esents a novel PET radiotracer to facilitate clinical investigations of anti-GD2 immunotherapies and

246 itizes tumors, providing a new rationale for clinical investigations of As(2)O(3) in irradiation prot

247 inding is relevant to future preclinical and clinical investigations of cell transplantation and the

248 eomics and may be of value in biological and clinical investigations of cervical carcinogenesis.

249 his model, further supporting the concept of clinical investigations of combination therapy for HCV i

250 ween animal groups in toxicology studies and clinical investigations of liver disease.

251 dies exploring xenobiotic hepatotoxicity and clinical investigations of liver disease.

252 Clinical investigations of muscles from patients with a

253 Clinical investigations of neuromuscular diseases routin

254 Clinical investigations of novel drugs and biological ag

255 SCCs from HIV-positive patients and support clinical investigations of PD-1/PD-L1 checkpoint blockad

256 Clinical investigations of peripheral nerve lesions rout

257 Although clinical investigations of the RV have been focused on t

258 widespread problem in this tumor, prompting clinical investigations of the use of FGFR1 inhibitors f

259 y and will inform additional preclinical and clinical investigations of these constructs.

260 Here, we review data from clinical investigations of these virotherapeutic agents,

261 Clinical investigations of von Willebrand disease type 1

262 elopment and are either in various phases of clinical investigation or have received marketing author

263 e, and stem cell delivery is still under pre-clinical investigation or in clinical trials.

264 ze remains one of the key features of costly clinical investigations or of microarray studies that ha

265 Clinical investigations provide evidence that N-BP inhib

266 ay explain variation in the results of prior clinical investigations relating IS to hypertension inci

267 Clinical investigations reveal the overexpression of spe

268 esults from our studies suggest that further clinical investigation should be warranted to apply soy

269 Larger clinical investigations should include remodeling metric

270 A wealth of experimental and clinical investigations show that individual differences

271 ysician-scientists, the American Society for Clinical Investigation spring meetings are the backdrop

272 New clinical investigations suggest that CD may be caused by

273 Preclinical and clinical investigations suggest that phenylalanine ammon

274 isorder deepens through basic laboratory and clinical investigations, swift implementation of new eff

275 public health emergency, multi-institutional clinical investigation systems must be in place to rapid

276 epatitis and to illustrate the principles of clinical investigation that can be applied broadly to ot

277 ty of data, and trust in entities conducting clinical investigation that may represent barriers both

278 Fortunately, clinical investigations that have assessed the efficacy

279 otics are described, along with the types of clinical investigations that have been done.

280 Rather than relying on well conducted clinical investigations, the Food and Drug Administratio

281 gested by pathology studies and confirmed by clinical investigations, these results are not surprisin

282 overy Institute and the American Society for Clinical Investigation, this clinical advance has depend

283 riate etiologic evaluation and comprehensive clinical investigation to define the range of anomalies

284 The apelin-APJ system merits further clinical investigation to determine its role in cardiova

285 highly effective ROS1 inhibitor, and further clinical investigation to evaluate its potential therape

286 ithm that would allow patients in subsequent clinical investigations to be treated with a dose of PNU

287 Our findings warrant onward clinical investigations to examine the clinical efficacy

288 Our results may help guide future clinical investigations to promote functional axon regen

289 portion of OD patients despite the extensive clinical investigation used to assign each patient to th

290 Our findings prompt prospective clinical investigations using BH3-mimetics combined with

291 result in a fundamental change in how human clinical investigation was conducted, with the eventual

292 aim of this randomized, controlled, blinded, clinical investigation was to compare the coronally posi

293 The purpose of this prospective, human clinical investigation was to evaluate a large number of

294 primary aim of this randomized, controlled, clinical investigation was to evaluate the differences i

295 edth anniversary of the American Society for Clinical Investigation, we have invited various members

296 sfunction affecting the prefrontal cortex in clinical investigations, we targeted prefrontal cortex i

297 Clinical investigations were not contributory.

298 This work provides a foundation for clinical investigations whereby lymphedema etiogenesis a

299 These therapies are in various stages of clinical investigation, with some successes noted in cli

300 biomarkers that are useful in laboratory and clinical investigations, with particular focus on new pr