ライフサイエンスコーパス: clinical observation

1 ormalities are evident from both parents and clinical observation.

2 y limited and has largely been obtained from clinical observation.

3 as confirmed by pathology, bacteriology, or clinical observation.

4 fe without improving survival, compared with clinical observation.

5 was open-minded, exploratory, comprehensive, clinical observation.

6 ning, and show a remarkable coincidence with clinical observations.

7 to collect participants' characteristics and clinical observations.

8 nt mice that have recapitulated and informed clinical observations.

9 ts vs. several decades of animal studies and clinical observations.

10 l of blood clot dissolution, as well as with clinical observations.

11 previously defined in vitro measurements and clinical observations.

12 imate (NHP) model of SSIOAC and reported our clinical observations.

13 ls, in vitro human cell culture systems, and clinical observations.

14 blood and bone marrow and to correlate with clinical observations.

15 th of susceptible virus, explaining puzzling clinical observations.

16 y provides a molecular explanation for these clinical observations.

17 heightened interoception, described in some clinical observations.

18 respectively, accurately reflecting previous clinical observations.

19 gap between data from animal pain models and clinical observations.

20 them seems to fully account for the reported clinical observations.

21 from preclinical models and correlation with clinical observations.

22 ion predicted by simulation agreed well with clinical observations.

23 , these models do not entirely reproduce the clinical observations.

24 s, which is consistent with experimental and clinical observations.

25 This direct causality is incompatible with clinical observations.

26 mortality, which is consistent with current clinical observations.

27 nation in numeric simulations, referenced to clinical observations.

28 A (10%) and G (90%), which is in accord with clinical observations.

29 Similar to clinical observations, a robust vaginal polymorphonuclea

30 Two models have been forged on the basis of clinical observations: a first model proposes that the r

31 The flow of ideas from clinical observations about essential tremor, to their t

32 results provide a bridge between the current clinical observations about resection for temporal lobe

33 of PTGR2 in gastric cancer, but also provide clinical observations affirming the significance of PTGR

34 Consistent with clinical observations, all metreleptin signaling pathway

35 gies-based on viral load, CD4 cell count, or clinical observation alone-for determining when to switc

36 We stress the continuing relevance of clinical observations amid the increasing molecular comp

37 In addition to a number of very compelling clinical observations, an extensive body of extremely su

38 us of hollow viscus injury were selected for clinical observation and additional laparoscopy in 2.

39 nical benefit after 6 wk of therapy based on clinical observation and CT response by World Health Org

40 the pathogenesis of CHIKV infection through clinical observation and with animal models.

41 mics, evolution, metabolic network analysis, clinical observations and animal models that are in acco

42 Here, we summarise the published clinical observations and biology underlying tumours wit

43 Clinical observations and complete blood counts (CBC) we

44 In vitro studies confirm these clinical observations and demonstrate an anti-HIV replic

45 Clinical observations and epidemiologic studies suggest

46 Clinical observations and experimental evidence link bon

47 Through clinical observations and experimental models of AlloSCT

48 We have reported, based on clinical observations and in vitro models, that compleme

49 immunopathology, confirming 30 years of XLP clinical observations and indirect experimentation.

50 Clinical observations and laboratory evidence link bone

51 ncer has been postulated for many years, and clinical observations and laboratory experiments support

52 his review article presents some preliminary clinical observations and limitations that suggest a pot

53 acy of treatment, determined on the basis of clinical observations and microbiologic tests, was asses

54 Recent clinical observations and molecular studies have created

55 s of death are unknown, but a combination of clinical observations and pathological findings suggests

56 These findings are consistent with anecdotal clinical observations and postulated biological mechanis

57 eat example of research that originated from clinical observations and progressed in the last 50 year

58 Over the past decade, clinical observations and ray-tracing models have greatl

59 t candidates, the validation of research and clinical observations and the generation of unanticipate

60 rministic model has some deviations from the clinical observations and the growth term value is not w

61 However, investigations relevant to clinical observations and the natural history of the dis

62 Our prior clinical observations and those of other investigators s

63 nds in cancer, with reference to instructive clinical observations and translational approaches.

64 The data were compared with clinical observations and with a gene expression databas

65 iagnostic assessment, including standardised clinical observation, and parent interview assessments o

66 understanding of renal physiology, reported clinical observations, and individual experiences.

67 the importance of basic research, chairside clinical observations, and population-based studies in d

68 Based on reported clinical observations, and studies of mouse models of CM

69 ources including laboratory experimentation, clinical observation, animal models and a new computer s

70 ellular and molecular mechanisms behind this clinical observation are unclear.

71 Recent clinical observations are also changing how HLH is conce

72 Neuroimaging, neurophysiological and clinical observations are consistent with either or both

73 These clinical observations are well established, but the unde

74 id hormone action has been informed by these clinical observations as well as by animal models and ha

75 rstanding the molecular details underpinning clinical observations as well as to aid in the design of

76 Clinical observations, as well as data obtained from the

77 lude molecular biomarkers as a complement to clinical observations, as well as understand how these g

78 Knowledge about this disease is limited to clinical observations because there are no animal models

79 hemianopia in humans is well recognized from clinical observation but the findings in acquired lesion

80 l. provide a potential explanation for these clinical observations by examining IL-17C-driven psorias

81 However, clinical observations by immunohistochemistry studies in

82 creased levels of bound fatty acids, and all clinical observations can be rationalized by this molecu

83 Our work highlights how clinical observations can lead to the generation of a mo

84 roduce diverse sets of experimental data and clinical observations concerning the temporal sensitivit

85 Clinical observations corroborate previously reported cl

86 Based on clinical observations, data from accessible GWAS and exp

87 riguing example of such crosstalk comes from clinical observations dating from the 1930s: Patients wh

88 ear extinction suggests that, in accord with clinical observations, DBS could augment the effectivene

89 Preclinical as well as clinical observations demonstrate that lenalidomide down

90 However, our clinical observations do not support this premise.

91 driven by discoveries in animal studies and clinical observations (eg, oestrogen, calcitonin, and te

92 Clinical observations established that IL-12/23p40 is in

93 CLL) from its early stage and worsens during clinical observation, even in absence of disease progres

94 ersonality, and social psychology as well as clinical observations, expansions of the original cognit

95 Several mechanisms referenced to clinical observations explained termination of AF to sin

96 superior and inferior quadrants, supporting clinical observations for RNFL thinning in glaucoma.

97 Evidence from clinical observation (funduscopy) suggested that retrogr

98 The clinical observation has been made that there might be a

99 A long-standing clinical observation has been the delay between GC admin

100 similar in both groups despite the fact that clinical observation has consistently found evidence of

101 Translational research informed by clinical observations has the greatest potential for the

102 accumulation of patient reports, as well as clinical observations, has belatedly led to an interest

103 giographic intervention, serial imaging, and clinical observation have also changed over the years.

104 Clinical observations have been made that promise to pro

105 These clinical observations have been theoretically linked to

106 Clinical observations have documented substantial differ

107 Although many experimental and clinical observations have implicated gut microbiota in

108 underlying mechanisms responsible for these clinical observations have not been fully delineated.

109 Clinical observations have suggested that concurrent bac

110 While clinical observations have suggested that insulin action

111 Anecdotal clinical observations have suggested that poor oral heal

112 Disease manifestations were identified by clinical observation, histology, and measurement of cyto

113 Recent clinical observations, however, have suggested that ETV

114 gingivalis) in a manner consistent with the clinical observations (i.e., LPS upregulated Wnt5a and d

115 Epidemiologic and clinical observations identify obesity as an important r

116 Clinical observations imply that female cocaine addicts

117 role of serendipity coupled with meticulous clinical observation in drug development in medicine was

118 tion resulting in acanthosis is an important clinical observation in patients with atopic dermatitis,

119 review summarizes three major areas: first, clinical observation in patients; second, experimental m

120 The model's predictions accurately mimic clinical observations in ascites, including the magnitud

121 ATM in these processes has been suggested by clinical observations in ataxia telangiectasia patients

122 , current culture results do not explain all clinical observations in CF, including negative culture

123 ction in a tractable animal model to similar clinical observations in children with mitochondrial myo

124 We review important new clinical observations in chronic pancreatitis made in th

125 We review important new clinical observations in chronic pancreatitis made in th

126 We review important new clinical observations in chronic pancreatitis made in th

127 PURPOSE OF REVIEW: We review important new clinical observations in chronic pancreatitis reported i

128 We review selected important clinical observations in chronic pancreatitis reported i

129 p a diagnostic toolbox to capture and report clinical observations in double-blind placebo-controlled

130 New clinical observations in ESCS include (1) torpedo-like,

131 d cancer progression while, in contrast with clinical observations in humans, anti-RANKL therapy full

132 Here, we review clinical observations in offspring, noting that offsprin

133 This mimics clinical observations in patients with exacerbations, wh

134 ded because NK cell tolerance is relevant to clinical observations in patients with infections and ca

135 olecular basis of optic fissure closure with clinical observations in patients with uveal coloboma.

136 ry arterial muscularization, and support the clinical observations in pediatric patients and in compa

137 Our results for 8 seizures match with clinical observations in terms of seizure origin and ext

138 Clinical observations in these patients have varied from

139 etinal regions yielded results comparable to clinical observations in those regions.

140 Clinical observations included visual acuity, retinal de

141 logy have been accompanied by some important clinical observations including increased rates of C. di

142 can explain a number of previously published clinical observations including latent reservoir size an

143 quilibrium process was inferred largely from clinical observations, including reports of transplantat

144 Long-standing experimental and clinical observations indicate a key role for neurons wi

145 However, clinical observations indicate a spectrum of anorectal d

146 Recently, additional clinical observations indicate that AAG patients may als

147 ent survival are poorly understood; however, clinical observations indicate that EBOV viremia may be

148 However, this hypothesis is at odds with clinical observations indicating that bulky tumors can b

149 ression and are consistent with our previous clinical observations indicating that certain TMPRSS2/ER

150 ms (Autism Diagnostic Interview-Revised) and clinical observation instrument (Autism Diagnostic Obser

151 However, the mechanism underlying this clinical observation is not fully understood.

152 ent protocols; however, cautious and careful clinical observation is warranted to monitor for enhance

153 A theory for estimating Theta from scaled clinical observations is developed, and the hypothesis i

154 common discrepancy between experimental and clinical observations is the use of nonphysiologically r

155 Based on clinical observations, it is more appropriate in most ca

156 Clinical observations link respiratory virus infection a

157 Despite these clinical observations, little is known regarding the eff

158 Clinical observation may also serve as an adjunct to ini

159 Consistent with clinical observations, miR-1269a significantly increases

160 Here we report the clinical observation of 3 MCL patients with symptomatic

161 Finally, our findings may explain a past clinical observation of a GABAA-R PAM reducing HbA1c lev

162 In work arising from the clinical observation of a patient with ALK fusion-positi

163 ine to control ongoing pain, consistent with clinical observation of BTP.

164 a potential mechanistic explanation for the clinical observation of early adverse events to SSRI tre

165 dings suggest a possible explanation for the clinical observation of greater pain reporting and poore

166 Clinical observation of HR during anti-PD-1/anti-PD-L1 t

167 y providing mechanistic explanations for the clinical observation of immune dysfunction and tolerance

168 s is remarkable and may explain the reported clinical observation of improved HSCT outcome with young

169 After an initial clinical observation of isolated cases of pyridoxal-5'-p

170 non-small cell lung cancer, as implicated by clinical observation of mixed ADC and SCC pathologies in

171 The clinical observation of reduced ROP severity in prematur

172 rimental structural barrier findings and the clinical observation of T-wave alternans occurring at sl

173 m of rigorous science growing out of careful clinical observations of a rare disorder yielding both i

174 These findings are relevant to clinical observations of altered metabolic signaling in

175 ociate those mechanical findings with common clinical observations of disc fatigue and damage.

176 Despite clinical observations of enhanced bone healing in patien

177 Together, our findings link clinical observations of glucose uptake with a pathologi

178 Clinical observations of increased colon microvascular d

179 ctors and vascular occlusions, replicate key clinical observations of ischemia and macular edema in t

180 These findings are consistent with several clinical observations of luminal breast cancer sub-types

181 Clinical observations of migraine headache symptoms in p

182 metastasis are placed within the context of clinical observations of ovarian cancer to derive a step

183 Clinical observations of patients with central vision lo

184 These nerve-dependent phenotypes mimic clinical observations of patients with nerve damage resu

185 Sporadic clinical observations of periodontal regeneration treatm

186 Based on clinical observations of peripartum cardiomyopathy patie

187 ey provide a mechanistic explanation for the clinical observations of reduced albuminuria with atrase

188 l groups, which again is consistent with the clinical observations of reduced numbers of dendritic sp

189 In our clinical observations of severe generalized recessive dy

190 Our data support the clinical observations of strong RPE fluorescence, increa

191 Clinical observations of the apparently random responsiv

192 This finding is discussed in relation to clinical observations of the dependence of HED retention

193 us pathogenetic mechanisms and important new clinical observations of the disease course provide fres

194 ion has been substantially altered by recent clinical observations of thyroid signaling defects in sy

195 een the underlying molecular biology and the clinical observations of tumor (18)F-FDG accumulation in

196 The strongest evidence for this derives from clinical observations of tumor regressions upon antivira

197 This finding is in accordance with clinical observations of zoster virus reactivation from

198 fen resistance, which is consistent with the clinical observation on the association of ER-alpha36 ex

199 We detail clinical observations on VH in five macular degeneration

200 ppendicitis by surgical pathologic findings, clinical observation, or follow-up.

201 nireview examines both the basic science and clinical observations over the past 20 years to show how

202 pathy (AAG) including serological diagnosis, clinical observations, pathophysiology, and treatment.

203 Clinical observations point to immune defects in GD beyo

204 their reconciliation with epidemiologic and clinical observations poses a major challenge.

205 Hemodynamic and clinical observations provide direction toward additiona

206 btypes that are difficult to discern through clinical observations, providing impetus for deeper inve

207 Additional parameters, including clinical observations, radiographs, viral load in blood,

208 Nevertheless, these clinical observations raise the possibility for an ABC-D

209 ated diseases, but emerging commonalities in clinical observations recently led us to identify key pl

210 These findings reconcile preclinical and clinical observations regarding the development of morph

211 ally predominant in the airways and explains clinical observations relating to drug specificity in pa

212 ely common, but the etiology underlying this clinical observation remains elusive.

213 We review selected important clinical observations reported in 2012.

214 Clinical observations reveal that an augmented pace of T

215 Clinical observations revealed that a robust vaginal pol

216 nostic algorithm based on the combination of clinical observations, RT-qPCR in multiple diagnostic sp

217 Based on clinical observations, sensory over-responsivity is hypo

218 Clinical observations show that the relationship between

219 Clinical observations showing significantly less acute a

220 ng a prodrome requires techniques other than clinical observation such as monitoring endophenotypes t

221 Clinical observations suggest a relatively specific effe

222 Clinical observations suggest a role for donor MICA anti

223 Molecular and clinical observations suggest a role of sex steroid horm

224 Clinical observations suggest an even higher risk during

225 Because clinical observations suggest conventional sodium channe

226 Clinical observations suggest that anaphylaxis is more c

227 Animal studies and clinical observations suggest that epilepsy is associate

228 Preclinical and clinical observations suggest that even following the de

229 Although clinical observations suggest that humans with amygdala

230 Clinical observations suggest that local inflammation is

231 Clinical observations suggest that loss of MC4R function

232 Clinical observations suggest that patients with age-rel

233 Clinical observations suggest that RT may expand the the

234 Basic and clinical observations suggest that the caudal hypothalam

235 Clinical observations suggest that the development of SM

236 Clinical observations suggest that the monomorphic varia

237 However, recent clinical observations suggest that the survival of patie

238 Clinical observations suggest that there is individual v

239 Clinical observations suggest that tolerance to heat str

240 Clinical observations suggest that VZV-specific T cell i

241 microbiome of atopic patients and to review clinical observations suggesting that atopic patients mi

242 Clinical observation suggests that oral mucosal wounds h

243 Clinical observation suggests that patients with BDD foc

244 Because extrusion is a common form of PTM, clinical observations support the theory that eruption f

245 This effect was in line with clinical observations, supporting a correlation between

246 mized to postoperative IS (control group) or clinical observation (test group) at a single-center ter

247 mpared to B. multivorans, which supports the clinical observation that B. cenocepacia is more virulen

248 The clinical observation that discontinuation of treatment c

249 ndings establish a mechanistic basis for the clinical observation that drusen predispose to CNV, reve

250 iomagenesis, functionally substantiating the clinical observation that EGFR-positive GBMs from patien

251 This finding might help us understand the clinical observation that patients with atopic dermatiti

252 This study confirmed our clinical observation that patients with CS suffer from c

253 This finding was corroborated by clinical observation that PER2 down-regulation was assoc

254 In conjunction with the clinical observation that rare coding GLRB gene mutation

255 This dynamic analysis supports the clinical observation that the majority of vein grafts pr

256 ervable and predictable link with the common clinical observation that the posterior region of the di

257 e to in vivo irradiation are consistent with clinical observation that therapeutic ionizing radiation

258 Our data provide a mechanism to explain clinical observations that acute-phase viral loads predi

259 lts support a potential mechanism underlying clinical observations that allergic sensitization is ass

260 In addition, the model supports the clinical observations that antibiotic treatment quickly

261 ome chronically infected in combination with clinical observations that antibody responses after blad

262 th protective alleles, coupled with detailed clinical observations that EvC and BPI do not occur in t

263 cal microbiota transplantation and summarize clinical observations that have implicated the intestina

264 ent and provide a molecular basis for recent clinical observations that induction of mild hypothyroid

265 hus chronic exposure give credibility to the clinical observations that MI can be an important cause

266 Consistent with clinical observations that posterior uveitis frequently

267 Our findings provide the rationale for clinical observations that relate atopy with a lower ris

268 When data were required from both parent and clinical observation, the specificity of the DSM-5 crite

269 Consistent with clinical observations, the allodynia was unaffected by a

270 anagement of dacryocystitis is based on only clinical observation Therefore, this study attempted to

271 When combined with prior clinical observations, these analyses suggest the follow

272 Together with our clinical observations, this supports the need to optimiz

273 ational psychiatry accounts have linked this clinical observation to difficulties in making flexible

274 pathogenesis of AMD, having progressed from clinical observations to epidemiologic observations and

275 ative nature of therapeutic development from clinical observations to in vitro, in vivo, and clinical

276 We retrospectively report our clinical observations using 4 different treatment activi

277 Clinical observations, viral loads, immune responses, an

278 s, Kuhn's method of unfettered, exploratory, clinical observation was substandard, haphazard, even me

279 Although evidence from clinical observations was indirect, there is close corre

280 ning the underlying molecular basis for this clinical observation, we find that KSHV infection select

281 Working from this clinical observation, we find that wild-type mtsR functi

282 Based on this clinical observation, we investigated the potential of p

283 Starting with this clinical observation, we sought to model neonatal ABOi o

284 To explore mechanisms underlying these clinical observations, we backcrossed an established pso

285 Inspired by these clinical observations, we examined the anticancer potent

286 In agreement with clinical observations, we found that both genetic and bo

287 Based on clinical observations, we have previously shown in a mur

288 Based on clinical observations, we hypothesized that low condylar

289 Based on recent clinical observations, we hypothesized that the Hedgehog

290 To better understand these clinical observations, we investigated and compared the

291 Based on several clinical observations, we investigated the association b

292 Based on clinical observations, we systematically investigated wh

293 Based on these clinical observations, we wished to determine whether Gr

294 , classic pressure-flow physiology explained clinical observations well, with a coefficient of determ

295 oxicities occurred, and no treatment-related clinical observations were made in any of the studies.

296 Clinical observations were performed after grafting.

297 Clinical observations were recorded during hospitalizati

298 the activities of these compounds along with clinical observations, where available.

299 early detection and the need for correlating clinical observations with multimodal imaging, particula

300 nditioned fear and PTSD derives largely from clinical observations, with limited empirical work on th