ライフサイエンスコーパス: clinical significance

1 s were benign polymorphisms with no apparent clinical significance.

2 to replicate these findings and assess their clinical significance.

3 the overemphasis on statistical rather than clinical significance.

4 proved downstream annotation and analysis of clinical significance.

5 asic scientific interest, but also of direct clinical significance.

6 3%]) participants had results with potential clinical significance.

7 h the magnitude of change was on the cusp of clinical significance.

8 l processes, and their modulation is of high clinical significance.

9 rus (LCMV), is a neglected human pathogen of clinical significance.

10 with modest short-term benefit of uncertain clinical significance.

11 s aeruginosa is a Gram-negative bacterium of clinical significance.

12 and the BRAF(V600) activating mutation have clinical significance.

13 recent advances in defining and quantifying clinical significance.

14 erapy and bone marrow transplantation, is of clinical significance.

15 The transition of AKI to CKD has major clinical significance.

16 l samples warrants further evaluation of its clinical significance.

17 f promising anticancer agents with potential clinical significance.

18 line, although the findings are of uncertain clinical significance.

19 o distinguish functionally distinct DSA with clinical significance.

20 irus (LCMV) is a neglected human pathogen of clinical significance.

21 rse events associated with smoking limit its clinical significance.

22 sitive and Low Positive antibodies can be of clinical significance.

23 used to reveal interactions of biological or clinical significance.

24 irus (LCMV) is a neglected human pathogen of clinical significance.

25 remains poorly understood, yet has definite clinical significance.

26 essive disorder, raising questions about its clinical significance.

27 d small airways, appears to have independent clinical significance.

28 Center from 2001 to 2010 and assessed their clinical significance.

29 ve differing site associations and levels of clinical significance.

30 we interpreted three SVs to be of potential clinical significance.

31 standing the regulation of OAT1 has profound clinical significance.

32 es, indicating the importance of considering clinical significance.

33 the respective knowledge to interpret their clinical significance.

34 tiating cell (LIC) function are of important clinical significance.

35 nintentional discrepancies identified had no clinical significance.

36 regulation of this transporter has profound clinical significance.

37 d for the lack of consensus concerning their clinical significance.

38 lute risk are likely to be of minor, if any, clinical significance.

39 arched for terms relating to statistical and clinical significance.

40 inct mutational processes, and explore their clinical significance.

41 le size, some statistical differences lacked clinical significance.

42 n EE at the present GCG dose was of marginal clinical significance.

43 nd unremarkable changes in the brain without clinical significance.

44 n regarding their persistence, activity, and clinical significance.

45 ia after ibrutinib is an issue of increasing clinical significance.

46 tatistically significant but of questionable clinical significance.

47 -R breast cancer as well as evidence for its clinical significance.

48 dow the original natural product in terms of clinical significance.

49 osomal aberration predicted to be of unknown clinical significance and another one predicted to be li

50 Herein, we describe the clinical significance and characteristics of Haemophilus

51 atients are dyslipidemic, this finding is of clinical significance and indicates that self-lipid-reac

52 should be applied to bridge the gap between clinical significance and limited understanding of the r

53 s complications, our finding is of potential clinical significance and may enable new therapeutic str

54 Here we show the clinical significance and metastatic mechanism of NIFK i

55 cations in these patients, such changes have clinical significance and might become targets for fetal

56 ave been identified in certain patients, the clinical significance and molecular mechanisms by which

57 Analysis of patient specimens confirmed the clinical significance and positive correlation between g

58 th IU can occur though bearing no functional clinical significance and spontaneously resolving within

59 enotypic clusters in asthmatic patients, the clinical significance and temporal stability of these cl

60 This study assessed the clinical significance and the frequency of occurrence of

61 As such, the clinical significance and therapeutic utility offered vi

62 Here, we review the epidemiology, clinical significance, and diagnostic and treatment stra

63 support; however, its long-term prevalence, clinical significance, and efficacy of potential interve

64 to replicate these findings, determine their clinical significance, and identify the underlying mecha

65 ture on observed deviations from guidelines, clinical significance, and initiatives to improve timely

66 kers of numerous diseases, lipoproteins have clinical significance, and this workflow can be used at

67 eal (non-OPSCC), but its pathogenic role and clinical significance are unclear.

68 However, its prevalence and clinical significance are unknown.

69 ochenodeoxycholic acid (GCDC) in serum has a clinical significance as an inductor of pathological hep

70 ity in critically ill patients has a similar clinical significance as lateralized periodic discharges

71 significant signal changes at levels of high clinical significance as well as sensitivity to sub-leth

72 Such differences may have clinical significance, as therapeutic targeting of a sig

73 However, these are of limited clinical significance because they are effectively eradi

74 These findings have clear clinical significance because they may point to a new cl

75 tive LA mechanical assessment has proven its clinical significance beyond volume measures; however, t

76 ical significance should not be equated with clinical significance, but the topic of clinical signifi

77 ignificant in most studies, and of uncertain clinical significance (difference, -0.7 to 0 mmol/L [-28

78 irus 1 (HSV-1) is a common human pathogen of clinical significance due to its association with vision

79 erview covers both group-level indicators of clinical significance (e.g., effect size indexes), and i

80 can be considered a normal variation without clinical significance, especially in younger populations

81 were used as the gold standard criterion of clinical significance for comparison against the partici

82 these articles and selected 134 of possible clinical significance for further review.

83 The existence of clinical significance for positive nonsentinel lymph nod

84 rest in conceptualizing and operationalizing clinical significance has been a "hot topic" in other he

85 ection in MAC lung disease (MAC-LD), but its clinical significance has not been investigated.

86 with clinical significance, but the topic of clinical significance has not received much attention in

87 describe the extent to which developments in clinical significance have penetrated the nursing litera

88 These lesions have clinical significance; hyperdiploidy or the presence of

89 everal cancers, but PD-L1 expression and its clinical significance in basal cell carcinoma (BCC) are

90 mmune response, a finding that has potential clinical significance in combating infection in aged ind

91 mechanisms of CNTFRalpha regulation and its clinical significance in glioma remain largely unknown.

92 Retn in blocking LPS function with important clinical significance in helminth-induced immunomodulati

93 f multiple circRNAs in HCC tissues and their clinical significance in hepatitis B-related HCC patient

94 The associations were of low to moderate clinical significance in many studies.

95 ed to improve the visibility and salience of clinical significance in nursing science.

96 uRF1, which is of biological and potentially clinical significance in patients with lung diseases and

97 and identified SOX9-related genes and their clinical significance in patients with PDAC.

98 age of bleeding (hemostasis) is of paramount clinical significance in prophylactic, surgical, and eme

99 pathy in several patients may have potential clinical significance in spite of low risk of malignancy

100 ignaling in early-onset PCas, implying their clinical significance in the disease.

101 (epidermal growth factor receptor) may be of clinical significance in the treatment of epithelial tum

102 in antibiotic resistance patterns and their clinical significance in the treatment of severe pediatr

103 Clinical significance is calculated for the aggregate re

104 assessment is a matter of debate, and their clinical significance is not clearly established.

105 utcomes in mostly white populations, but its clinical significance is not well established for other

106 ome Variation Society) expressions; however, clinical significance is reported directly from submitte

107 of DAs should be viewed with caution as its clinical significance is still uncertain.

108 ient with breast and ovarian cancer, but its clinical significance is still unknown.

109 r, the optimal approach to its diagnosis and clinical significance is uncertain.

110 Its clinical significance is unclear.

111 t EPgV causes persistent viremia whereas its clinical significance is undetermined.

112 hout hepatitis B or C coinfection, but their clinical significance is unknown.

113 ith idiopathic pulmonary fibrosis, but their clinical significance is unknown.

114 titers as 3 doses for 6 years, although the clinical significance is unknown.

115 , "does not require further inspection", "no clinical significance", "MRI is not the first study in t

116 Determine the clinical significance of [(18)F]fluorodeoxyglucose (FDG)

117 The biological and clinical significance of a clonal B-cell lymphocytosis w

118 The trial independently confirms the clinical significance of a novel, minimal residual disea

119 irst study that evaluates the functional and clinical significance of a signaling molecule, Pak1, in

120 ghly sensitive to HER2-targeted therapy, the clinical significance of acquired HER2 heterogeneity dur

121 renal function seem dissociated; hence, the clinical significance of albuminuria in this setting is

122 The clinical significance of Alloscardovia omnincolens in th

123 Until the clinical significance of anti-PX2 is known, we also reco

124 The clinical significance of antibodies directed against ant

125 The clinical significance of antineutrophil cytoplasmic anti

126 Data regarding the prevalence and clinical significance of asymptomatic bacteriuria (AB) i

127 Further studies need to determine the clinical significance of asymptomatic CMV shedding.

128 The clinical significance of asymptomatic respiratory viral

129 The potential clinical significance of B7-H4 is supported by the high

130 finding that points to more research on the clinical significance of bacterial infection in symptoma

131 Despite the clinical significance of balanced chromosomal abnormalit

132 The clinical significance of BMI1 as a biomarker could be as

133 The present study aimed to validate the clinical significance of CACS in predicting coronary art

134 ical cohorts can be used to infer the likely clinical significance of CNVs in ASD.

135 , aetiology, prevalence, pathophysiology and clinical significance of cortical superficial siderosis,

136 ociated with poor survival, highlighting the clinical significance of CUX1 loss.

137 cerous cells under stress conditions and the clinical significance of CYGB expression and promoter me

138 We aimed to assess the clinical significance of DDI between the regular outpati

139 We studied the clinical significance of detecting EBV DNA in the plasma

140 We investigated the frequency and clinical significance of diagonal earlobe crease (DELC)

141 The clinical significance of diaphragm weakness in criticall

142 RATIONALE: The clinical significance of diaphragm weakness in criticall

143 the late 1970s, only partially confirmed the clinical significance of diaschisis.

144 urther studies are necessary to evaluate the clinical significance of differences between the results

145 The clinical significance of discordant serology (CIA(+)/RPR

146 Approach to interpretation of the clinical significance of drug interactions during target

147 Prevalence and clinical significance of dual pathology are unknown.

148 Thus determining the clinical significance of each nsSNP is of great importan

149 component, does not distinguish the relative clinical significance of each, and counts only the first

150 Our study may also imply the clinical significance of early detection and prophylacti

151 ntroduction of breast-screening methods, the clinical significance of early detection and treatment f

152 cognitive function, or quality of life, the clinical significance of embolic protection devices has

153 The clinical significance of extratumoral tryptophan metabol

154 of this study was to describe and assess the clinical significance of extravascular lung water variat

155 Furthermore, we evaluated the clinical significance of FO-enriched nutrition and clari

156 n effective approach to assess and interpret clinical significance of genetic mutations, as shown in

157 and clinician-scientists in determining the clinical significance of genetic variations.

158 e challenge of interpreting the biologic and clinical significance of germline TP53 mutations in fami

159 prospectively the incidence, predictors, and clinical significance of HCV reactivation during cancer

160 The present study aimed to evaluate the clinical significance of HDAC-1, -2, -4 and -6 protein e

161 ebral hemorrhage; however, the frequency and clinical significance of hematoma expansion after childh

162 a defining the virologic characteristics and clinical significance of human rhinoviruses, human coron

163 hermore, we review available evidence on the clinical significance of hyperfiltration in diabetes and

164 Although the clinical significance of IGRA conversions and reversions

165 the anatomy, underlying pathomechanisms and clinical significance of individual genomic lesions and

166 by-specialty understanding of the nature and clinical significance of informatics variability and ado

167 The mechanism and clinical significance of low circulating 25-hydroxyvitam

168 medium VGKC complex IgG values supports the clinical significance of low values in clinical evaluati

169 The clinical significance of low-positive (<0.6 ng/ml) UAg r

170 Future studies should attempt to clarify the clinical significance of lower VMAT2 in cocaine abusers,

171 and provide new insight into the nature and clinical significance of marrow involvement.

172 METHODS AND To assess the clinical significance of measured cardiopulmonary hemody

173 NDM may evolve into MVP, highlighting the clinical significance of mild MVP expression.

174 We determined the clinical significance of minimal residual disease (MRD)

175 We aimed to establish the clinical significance of minimal residual disease in a p

176 rosis; however, the extent, persistence, and clinical significance of molecular change during lifesty

177 The clinical significance of MYC and BCL2 genetic alteration

178 tudinal study to investigate the yet unknown clinical significance of myocardial fibrosis in patients

179 e genetic substrate of MVP and the potential clinical significance of NDMs in the community.

180 regenerative medicine including the current clinical significance of NDs, as well as the challenges

181 The clinical significance of non-alcoholic fatty pancreatic

182 d highlight the challenges in predicting the clinical significance of novel missense variants.

183 therefore aim to evaluate the frequency and clinical significance of ocular findings in ochronosis a

184 Clinical significance of only 9.56% of the SNVs is known

185 cused on CT infection risk factors in women, clinical significance of oropharyngeal CT detection, acc

186 and reduced overall survival, confirming the clinical significance of our observations.

187 Finally, to establish the clinical significance of our results, we analyzed malign

188 The incidence and clinical significance of persistent T2 hyperintensity af

189 The clinical significance of polymicrobial interactions, par

190 haracteristics of the TCR repertoire and the clinical significance of repertoire reformation througho

191 The prevalence and clinical significance of right ventricular (RV) systolic

192 vement of RPS15A in HCC pathogenesis and the clinical significance of RPS15A expression remain unclea

193 ere retrospectively reviewed to evaluate the clinical significance of S. lugdunensis isolation, the a

194 The clinical significance of SCPN detected by routine preope

195 ificantly reducing the time to interpret the clinical significance of sequence variants.

196 The profile and clinical significance of serum hepatitis B surface antig

197 the major focus has been concentrated on the clinical significance of serum sodium levels.

198 c basis for understanding the biological and clinical significance of SIRT2 mutations in genome maint

199 The clinical significance of subsegmental pulmonary embolism

200 Determination of the clinical significance of such interactions between PrP(C

201 study aimed to investigate the pathology and clinical significance of sudomotor denervation.

202 : To characterize the incidence, course, and clinical significance of symptom exacerbations (spikes)

203 positive/negative) as well as the nature and clinical significance of the association of autoimmune t

204 o replicate these findings and determine the clinical significance of the association.

205 options for newly infected individuals, the clinical significance of the detection of minority DRM r

206 Uncertainty about the incidence and clinical significance of the findings is the basis of 2

207 or on parent-reported outcomes, although the clinical significance of the improvement is unclear.

208 identification is required to establish the clinical significance of the isolate and facilitate opti

209 While the clinical significance of the isolate in this case is unc

210 Given this research attention and the clinical significance of the issue, this article analyze

211 The long-term clinical significance of the lipid changes noted with th

212 While promising, the clinical significance of the newer mapping techniques wi

213 We sought to evaluate the prevalence and clinical significance of the newest immune checkpoint, H

214 Despite eminent clinical significance of the obesity led gut barrier abn

215 Furthermore, the clinical significance of the retained gadolinium in the

216 The clinical significance of the small benefit of medication

217 We evaluated the clinical significance of the spontaneous histamine relea

218 This study underlines the clinical significance of the VWFpp assay in the diagnosi

219 side rare syndromes, the nature, extent, and clinical significance of their genetic origins are not k

220 However, the clinical significance of these abnormalities is poorly u

221 To investigate the clinical significance of these altered pathways, we perf

222 Studies on human subjects establish the clinical significance of these devices for rapid and non

223 h probably blinded assessments, although the clinical significance of these effects remains to be det

224 tional studies are needed to investigate the clinical significance of these findings and the generali

225 The clinical significance of these findings for cardiac reco

226 The clinical significance of these findings has been substan

227 The clinical significance of these findings is uncertain, an

228 Although the clinical significance of these findings is yet to be det

229 The clinical significance of these findings needs further in

230 The clinical significance of these findings should be addres

231 To translate the clinical significance of these findings, WDR1 expression

232 The clinical significance of these interactions is underscor

233 ective studies will be needed to examine the clinical significance of these low-level viral loads.

234 The clinical significance of these motors emphasizes the imp

235 The clinical significance of these other fungal species rema

236 The clinical significance of these potential biomarkers was

237 We also discuss the potential clinical significance of these studies and outline the r

238 However, the biological and clinical significance of this age-associated epigenetic

239 We confirmed the clinical significance of this by ex vivo analysis of nor

240 However, the clinical significance of this change in mortality should

241 To assess the clinical significance of this change, TURQUOISE-I, Part

242 nd etoposide-based chemotherapy, pointing to clinical significance of this chemoresistance mechanism.

243 However, the clinical significance of this drug-drug interaction on t

244 ower intraoperative blood loss, although the clinical significance of this finding is uncertain given

245 ss T-cell-associated antigens (TCA), but the clinical significance of this finding is uncertain.

246 he administration of MMC during surgery, the clinical significance of this finding remains uncertain,

247 The duration and clinical significance of this finding should be evaluate

248 eed for longitudinal studies to evaluate the clinical significance of this finding.

249 upstream, respectively, thus confirming the clinical significance of this mutational mechanism.

250 Finally we highlight the clinical significance of this pathology by demonstrating

251 als report conflicting results regarding the clinical significance of this pharmacological interactio

252 While the clinical significance of this phenomenon is uncertain it

253 The clinical significance of this small decrease remains to

254 in radiation exposure narrow over time, the clinical significance of this small increase is uncertai

255 The clinical significance of this variation is related to lo

256 The clinical significance of this warrants further investiga

257 However, the clinical significance of troponin elevation in the setti

258 the Merkel cell polyomavirus (MCPyV) and the clinical significance of tumor viral status.

259 The true clinical significance of variant histology is controvers

260 The clinical significance of variant histology is controvers

261 ely available archive for interpretations of clinical significance of variants for reported condition

262 terVar to help human reviewers interpret the clinical significance of variants.

263 We review the clinical significance of various cytogenetic and molecul

264 , these results provide new evidence for the clinical significance of VBNC and persister cells.

265 evidence for the direct impact and potential clinical significance of VCSL on the generation of "sele

266 However, the biological and clinical significance of VGLL dysregulation in human bre

267 tudy aimed to investigate the prevalence and clinical significance of viral persistence and antiviral

268 The clinical significance of viruses detected in patients wi

269 smembrane (6TM) isoforms, the biological and clinical significance of which remains unclear.

270 , which can be attenuated by sildenafil, the clinical significance of which warrants further study.

271 Despite their biological and clinical significance, only the IRAK4 kinase domain stru

272 limited by intermediate outcomes of unclear clinical significance or narrow eligibility criteria tha

273 By contrast, the term "clinical significance" or related surrogate terms were f

274 ormalities and their incidence, time course, clinical significance, predisposing factors, optimal ima

275 BRAF(V600E) mutation occurs frequently, but clinical significance remains to be determined.

276 detection of respiratory viruses, but their clinical significance remains unclear in pediatric lower

277 gG aCL prevalence has been reported, but the clinical significance remains unknown.

278 ly reversible with treatment, although their clinical significance remains unproven.

279 However, the clinical significance, reproducibility, and causality of

280 ard in self research, but also has important clinical significance, resonating recent efforts in comp

281 Because of its biological and clinical significance, several methods have been develop

282 Raising consciousness about clinical significance should be an important priority am

283 phocyte exhaustion/suppression showed higher clinical significance than those related to activation o

284 Despite its clinical significance, the genetic and developmental pat

285 Despite the potential clinical significance, the mechanism by which stress mod

286 rge-scale study will be necessary to confirm clinical significance, the set of vibratory measures der

287 Therefore, it is of a great biological and clinical significance to dissect the molecular mechanism

288 To impart functional and clinical significance to MTA1, we analyzed MTA1 and TH l

289 Our finding has important clinical significance to PD because it identifies Fyn as

290 Despite this basic and clinical significance, understanding of the developmenta

291 ever, these differences are unlikely to have clinical significance until the density decreases to bel

292 thogenic mutations and variants of uncertain clinical significance (VUS).

293 Clinical significance was investigated by using saphenou

294 Clinical significance was measured by a 50% or greater r

295 degree of improvement was not large, and its clinical significance was uncertain.

296 ally significant difference, but with little clinical significance, was observed in gingival conditio

297 Of clinical significance, we verified elevated PRL-3 expres

298 ce of MYC/BCL2 genetic alterations and their clinical significance were largely dependent on COO subt

299 s, but to diagnose cancers that have reached clinical significance, while avoiding unnecessary tests

300 antigen (ZIKV NS1) coincides with levels of clinical significance with detection of antigen in buffe