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1 t (P = 0.007 in early and P = 0.0048 in late clinical stages).
2 er at the target site, are mostly at the pre-clinical stage.
3 036 was associated with N classification and clinical stage.
4 for these patients based on the pretreatment clinical stage.
5 ere positively correlated with pN status and clinical stage.
6 antigen level, Gleason grade at biopsy, and clinical stage.
7 tion drug candidates from the preclinical to clinical stage.
8 disease progression shown to correlate with clinical stage.
9 y, the infection is chronic, with subsequent clinical stages.
10 ich side effect information for drugs at all clinical stages.
11 is, on the basis of the subclassification in clinical stages.
12 t differed considerably among treatments and clinical stages.
13 ne of these products has yet progressed into clinical stages.
14 from mechanical tissue substrates among ARVC clinical stages.
15 World Health Organization classification and clinical staging.
16 gible for sphincter-sparing surgery based on clinical staging.
17 phocytes of OSCC patients with early or late clinical staging.
18 men included in the study, 363 (98%) had WHO clinical stage 1 disease, 364 (99%) had high functional
19 tre, prospective, cohort study patients with clinical stage 1 endometrial cancer of all histologies a
20 ll tolerated when given to children with WHO clinical stage 1 or 2 HIV disease along with high antire
23 on activity of most other HAP, including the clinical stage 2-nitroimidazole mustard TH-302, dinitrob
24 (> or = IIB), sensitivity was poor for FIGO clinical staging (29%), CT (42%), and MRI (53%); specifi
25 es were eligible if they reported death, WHO clinical stage 3 or 4 events, admittance to hospital, se
31 endpoint of death, World Health Organization clinical stage 4 disease, or CD4(+) counts of <200/mm(3)
32 s (54 died, 45 had World Health Organization clinical stage 4 events, and 49 had poor immunological r
33 d new or recurrent World Health Organization clinical stage 4 events, or had poor immunological respo
34 and MRI (53%); specificity was 99% for FIGO clinical staging, 82% for CT, and 74% for MRI; and negat
36 rom LRR at 5 years ranged from 86% to 97% by clinical stage, 86% to 97% by pathologic stage, and 71%
38 We compared the distribution of grade and clinical stage across the pre-PSA and PSA screening eras
39 c physiological and HRCT variables to form a clinical staging algorithm predictive of mortality in a
41 was significantly higher with more advanced clinical stage (Alzheimer's disease > mild cognitive imp
42 -to-lead and lead optimization campaigns and clinical stage and approved drugs, reflecting their incr
43 arian cancer patients present at an advanced clinical stage and develop resistance to standard of car
44 d remained significant after controlling for clinical stage and Gleason grade and was stronger for pr
47 omarker of GI GVHD that can be combined with clinical stage and histologic grade to improve risk stra
50 ency of lymph node metastasis increased with clinical stage and was similar to that in historical sur
51 ifferences of clinical outcome in respective clinical stages and individual 'stage, size, grade and n
52 can progress over years through a series of clinical stages and lead to irreversible neurological or
53 grative topological measures correlated with clinical stages and prognosis, which was further validat
55 e findings may potentially contribute to the clinical staging and monitoring of Stargardt disease.
56 for glucose, a feature that is exploited in clinical staging and response monitoring by using (18)F-
57 m prostate-specific antigen, tumor grade and clinical stage) and by treatment type (radical prostatec
58 or relapsed HL (duration of first remission, clinical stage, and anemia at relapse), patients with tw
60 correlated with larger tumor size, advanced clinical stage, and low survival rate in OSCC patients.
61 for adjuvant hormonal treatment, HR status, clinical stage, and nuclear grade, patients who achieved
64 ng centre, largest radiological tumour size, clinical stage, and prespecified chemotherapy regimen.
65 r, human epidermal growth factor receptor 2, clinical stage, and regional lymph node metastasis statu
68 m SUV, performance status, T stage, N stage, clinical stage, and treatment type (surgery vs other) we
69 e, race, marital status, educational status, clinical stage, and tumor characteristics, increasing pa
72 ntification and treatment of AD in the early clinical stages as well as before cognitive symptoms eme
74 characteristics including ethnicity, age and clinical stage at diagnosis, age at parity, number of fu
75 destructive v metastatic) were unrelated to clinical stage at initial presentation, treatment histor
77 o test a method of brief pain assessment and clinical staging based on recognized focal features of c
78 therapy determines prognosis rather than the clinical stage before neoadjuvant chemotherapy, indicati
79 er investigator compiled data about baseline clinical stage, biopsy findings, and serum PSA measureme
80 prognostic models: one with CD4 cell count, clinical stage, bodyweight, age, and sex (CD4 count mode
81 to improve the decision making at the early clinical stage by using innovation and the high-profile
83 for non-Hodgkin lymphomas are not useful for clinical staging classification of most primary cutaneou
86 ing for known survival covariates, including clinical staging criteria, the IHC panel remained an ind
87 equipoise regarding the optimal treatment of clinical stage (CS) I nonseminomatous germ cell testicul
89 nt chemotherapy on the basis of pretreatment clinical stage (CS), estrogen receptor status (E), grade
90 ating the American Joint Committee on Cancer clinical stage (CS), final pathologic stage (PS), estrog
91 en (</=80 years) diagnosed in 2011-2012 with clinical stage cT1-2, localized prostate cancer, with pr
92 n of CRT to surgical resection, adjusted for clinical stage, demographic information, and CRT regimen
93 staging for breast cancer has a pretreatment clinical stage designation that is determined by clinica
94 strains and are constituents of vaccines in clinical-stage development, these findings will aid in r
95 sms in common, and then assesses the various clinical-stage diabetes drugs for their potential activi
99 have delivered inhibitors reaching advanced clinical stages due to several challenges in the discove
100 none of the evaluated risk factors (ie, age, clinical stage, elevated erythrocyte sedimentation rate,
101 us knowledge, and linkage to care) and three clinical stages (eligibility for antiretroviral therapy
102 relation to Parkinson disease diagnoses at 3 clinical stages: established (cases diagnosed before 199
103 iding preclinical support for the use of the clinical stage FAK/PYK2 inhibitors for treatment of MM,
104 ls of p-IRAK-4 levels did not correlate with clinical stage, gender, or age, but attenuated IRAK-1,-4
105 found with estimated dose or type of statin, clinical stage, Gleason score, or with prediagnosis stat
106 t association was found between the baseline clinical stage, Gleason score, serum PSA level, or the p
107 specific antigen [PSA] level, Gleason grade, clinical stage, greatest percentage of cancer in all bio
109 , histologic type of the tumor, T stage, and clinical stage had no influence on relapse (P = 0.180, P
110 gence of resistance observed for the current clinical-stage hepatitis C virus (HCV) NS3 protease inhi
111 ong DT patients included younger age, higher clinical stage, higher Gleason score, and higher prostat
112 ggressive disease features, such as advanced clinical stage, higher white blood cell counts, and shor
113 abnormalities included CD4 cell count nadir, clinical staging, history of AIDS-defining events, infec
114 ariate model that included age, pretreatment clinical stage, hormone receptor status, hormone therapy
115 zard ratio [HR] = 2.33, P < .0001), advanced clinical stage (HR = 2.75, P = .0025), poor risk cytogen
116 several management options for patients with clinical stage I (CS1) nonseminomatous germ cell tumors
117 etrospective study including data from 2,483 clinical stage I (CSI) patients, 1,139 CSI nonseminoma a
118 n 1997 and 2002, 502 patients with suspected clinical stage I (T1-2N0M0) NSCLC were prospectively enr
119 y 1999, 636 women (age >/= 70 years) who had clinical stage I (T1N0M0 according to TNM classification
126 nd retroperitoneal lymph node dissection for clinical stage I disease in January 2010, which revealed
127 ecific survival rate among participants with clinical stage I lung cancer that was detected on CT scr
131 ts and Methods Adult patients with resected, clinical stage I or II adenocarcinoma of the head of the
132 Results We identified 15,237 patients with clinical stage I or II resected pancreatic head adenocar
134 nce a relapse after adjuvant carboplatin for clinical stage I seminoma can be successfully treated wi
136 urveillance is a widely accepted strategy in clinical stage I testicular cancer treatment in the comm
138 s) with limited-stage small-cell lung cancer clinical stage I to III who received CT or CRT were iden
139 isease in 1 of 20 (5%) patients with initial clinical stage I, 2 of 44 (5%) stage IIA, 8 of 47 (17%)
141 titutions was used to identify patients with clinical stage I-III rectal cancer undergoing surgery (n
144 ment resulted in fewer early progressions in clinical stage I/II HL, although early outcome was excel
147 atients were identified: 8,073 patients with clinical stage IA and 8,525 patients with clinical stage
148 B use was reported in 13.3% of patients with clinical stage IA melanoma and was more likely in patien
150 vival rates of patients with first, primary, clinical stage IA nonsmall cell lung cancer from a large
151 l study of 787 patients with newly diagnosed clinical stage IB or II melanoma, we estimated odds rati
156 l lymph node biopsy (SLNB) for patients with clinical stage IB/II melanomas, but not clinical stage I
159 2 trial of neoadjuvant therapy for high-risk clinical stage II or III breast cancer, evaluated multip
164 ts in the independent validation cohort (99% clinical stage II-III) who were predicted to be treatmen
166 erapy achieves low local recurrence rates in clinical stages II to III rectal cancer, it delays admin
168 the role of FDG PET/CT in initial staging of clinical stage IIA and IIB and primary operable stage II
172 uld be considered for those who present with clinical stage III disease or have histologically positi
173 receiving CRT decreased with increasing age, clinical stage III disease, female sex, and the presence
176 variate analysis, an age less than 50 years, clinical stage III, grade 3, estrogen receptor (ER)-nega
177 re with risk factors (RFs) of early relapse, clinical stage III/IV, and anemia identified patients wi
179 ditional prognostic information over TLG and clinical staging in patients with advanced T-stage OPSCC
180 er MTV and TGA add prognostic information to clinical staging in patients with oral and oropharyngeal
182 ck of a suitable animal model, mimicking all clinical stages, in particular the healing process, rema
183 id sequences from 137 antibodies in advanced clinical stages, including 48 approved for therapeutic u
185 ted by FDG-PET in cervical cancer relates to clinical stage, is comparable to historical data, and st
187 n and their contribution to pathological and clinical stages leading to vision loss in diabetic retin
188 o detect MGA expression, especially in early clinical stage, low grade and lymph node metastasis-nega
189 ate cancer, as assessed by low-risk disease (clinical stage </=T2a, biopsy Gleason score </=6, and pr
190 l in prostate adenocarcinoma correlated with clinical stage, lymph node status, and Gleason score.
193 NFL concentration is increased by the early clinical stage of AD and is associated with cognitive de
194 dysfunction and SR Ca(2+) leak depend on the clinical stage of AF or specific animal model studied.
195 eurogranin is increased already at the early clinical stage of Alzheimer's disease and predicts cogni
199 e of HCC patients, and which correlated with clinical stage of HCC, were NAA, dimethylglycine, 1-meth
201 een the loss of Hcrt and MCH neurons and the clinical stage of PD, in contrast to the lack of a relat
202 eurons are significantly correlated with the clinical stage of PD, not disease duration, whereas the
204 ation carriers, in the later preclinical and clinical stages of ADAD, mutation-carrying children were
215 these changes are present from the earliest clinical stages of multiple sclerosis; (ii) they occur i
217 the relationships between age, the advanced clinical stages of Parkinson's disease and neuropatholog
219 of 12-HETER1 positively correlates with the clinical stages of prostate cancers and Gleason scores.
220 rbation, is affected at the pre-clinical and clinical stages of spinocerebellar ataxia type 6 (SCA6),
222 entified as a good tumor-specific marker for clinical staging of cervical sentinel lymph nodes in hea
225 g has allowed for more accurate preoperative clinical staging of renal tumors, and the necessity of c
227 epithelial neoplasia lesions correlated with clinical staging of the tumor (rho = -0.4, P = 0.0474) w
230 sion levels of KISS1 in PCas correlated with clinical stage (P < 0.01) and with KISS1R expression (P
231 gnosis (P = .01), tumor stage (P = .01), and clinical stage (P = .001) were found to be significant p
235 omes derived from multivariate analysis were clinical stage (P<0.0001), location of the tumor (P=0.02
237 NMRP expression were evident at the earliest clinical stages (p < 0.05), which progressed significant
239 expression was significantly associated with clinical stage, pathologic tumor status, distant metasta
241 neoadjuvant chemotherapy using pretreatment clinical stage, posttreatment pathologic stage, estrogen
242 score, prostate-specific antigen level, and clinical stage--predicts progression-free survival among
243 These results should improve MRI-guided clinical staging, presurgical planning, and intraoperati
244 1 scans: range 3-8 per patient) at different clinical stages (presymptomatic, mild cognitive impairme
246 nostic factors including high Gleason score, clinical stage, prostate-specific antigen (PSA) and exte
247 a correlation between staining intensity and clinical stage; PTEN expression was decreased in the col
250 DM was compared controlling for patient age, clinical stage, serum prostate-specific antigen level, b
252 ariable analysis adjusting for extent of RT, clinical stage, sex, and use of chemotherapy confirmed t
253 ed hazard ratio 0.21, 95% CI 0.17-0.27), WHO clinical stage (stages III-IV vs I-II; 3.45, 2.43-4.90),
254 ed system based on World Health Organization clinical staging, standardized first-line ART regimens,
255 ed, with the same number of patients in each clinical stage subgroup (12 stage I patients, 32 stage I
257 seventh edition tumor-node-metastasis (TNM) clinical staging system for OAL and followed every 6 to
258 sus-host disease (GvHD) is based on either a clinical staging system or histological or endoscopic fi
259 he American Joint Committee on Cancer (AJCC) clinical staging system, T3 and T2 lesions portended a h
260 40 to 80 years with a GS between 2 and 6 and clinical stage T1 or T2 prostate cancer enrolled between
261 CI, 0.94-2.03), as did current smokers with clinical stage T1 through T3 (HR, 1.41; 95% CI, 0.80-2.4
262 CI], 1.11-2.32), as did current smokers with clinical stage T1 through T3 (HR, 1.80; 95% CI, 1.04-3.1
266 cohort study of Medicare beneficiaries with clinical stage T1a kidney cancer treated with partial or
269 with esophageal adenocarcinoma histology and clinical stage T1bN1-N3 or T2-T4aN-/+M0 were divided int
270 R imaging may help to stratify patients with clinical stage T1c disease for appropriate clinical mana
271 e, 58 years; age range, 40-76 years) who had clinical stage T1c prostate cancer, had not been treated
273 t, 2 cm or greater in diameter by palpation, clinical stage T1c-3, cN0, cN1, or cN2a, without metasta
274 ed from 2004 to 2007 with low-risk prostate (clinical stage T1c/T2a; Gleason score, </=6; and prostat
276 a were for very-low-risk cancers, defined by clinical stage (T1c), prostate-specific antigen density
277 ery-low-risk (subset of the low-risk group) (clinical stage, T1c; Gleason score, </=6; prostate-speci
279 reated low-volume low-grade prostate cancer (clinical stage T2a or lower; Gleason score, 3+3; index t
280 Gleason score >7, locally advanced disease (clinical stage T3/T4), and extensive disease on prostate
282 otential advantage of extended resection for clinical stage T4b gastric adenocarcinoma with good long
283 th higher odds of Parkinson disease at all 3 clinical stages: the odds ratios comparing long nappers
285 astasis suppressive activity of entolimod, a clinical stage TLR5 agonist that activates NF-kappaB-, A
287 , and we classified patients by tumour site, clinical stage (TNM system), and post-surgical stage (In
288 SA) concentration, biopsy Gleason grade, and clinical stage to classify patients as low, intermediate
289 ected included demographics, diagnosis date, clinical stage, treatment, and outcome 1,082 patients me
290 th tGIV and pYGIV showed no correlation with clinical stage, tumor size, pathologic type, lymph node
291 (24%) had germline BRCA1 or BRCA2 mutations; clinical stage was I (13%), IIA (36%), IIB (36%), and II
299 utation status, CD38 or ZAP-70 cytogenetics, clinical stage) were significantly associated with time
300 ups (PSA concentration, Gleason grading, and clinical stage) were then used to sub-stratify within ea
301 e primarily associated with tumor burden and clinical stage, whereas tumor TLG is the best predictor
302 ul as it provides an opportunity to assess a clinical stage which in most subjects represents prodrom
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