ライフサイエンスコーパス: clinical utility

1 novel predictive score is needed to confirm clinical utility.

2 rker in prospective studies will further aid clinical utility.

3 y in an office setting, and determination of clinical utility.

4 al and drug resistance hampers their further clinical utility.

5 olation and analysis and challenges to their clinical utility.

6 eak, backwards expansion wave (BEW) may have clinical utility.

7 nt of antibody assays needs to reflect their clinical utility.

8 tration in tissue is a serious constraint to clinical utility.

9 low sensitivity and specificity limit their clinical utility.

10 illiliters to microliters provides increased clinical utility.

11 edict human traits, with the aim of eventual clinical utility.

12 act of the p53 pathway are needed to achieve clinical utility.

13 dol-induced toxicity (HIT), which limits its clinical utility.

14 r functions in vivo, with likely significant clinical utility.

15 trance of identified mutations and determine clinical utility.

16 thrombin generation that have potential for clinical utility.

17 dicine paradigm, but have yet to demonstrate clinical utility.

18 cludes inferences about causal direction and clinical utility.

19 al properties, thus limiting their potential clinical utility.

20 xes, as derived from eye models, limit their clinical utility.

21 anoma skin cancers, to demonstrate potential clinical utility.

22 ysis of clinical validity and by determining clinical utility.

23 t is stable, reproducible, and has potential clinical utility.

24 mortality risk stratification with possible clinical utility.

25 a preliminary evaluation of the instrument's clinical utility.

26 nd 10(4) virus particles/mL, consistent with clinical utility.

27 t of action, and side effects restrict their clinical utility.

28 sting in other disease cohorts to assess its clinical utility.

29 reveals new molecular findings of uncertain clinical utility.

30 e MammaPrint assay to assess for evidence of clinical utility.

31 erial (vs other) infections would have great clinical utility.

32 index by balancing statistical accuracy with clinical utility.

33 vements to these mAbs to better ensure their clinical utility.

34 ts with broad-spectrum and targeted-spectrum clinical utilities.

35 of their molecular mechanisms and potential clinical utilities.

36 to define its therapeutic applicability and clinical utilities.

37 To test for protein measurement, rather than clinical utility, a PD-L1 index tissue microarray, inclu

38 The performance, clinical utility (AII duration and survival), and cost-e

39 ility of GLP-1 has significantly limited its clinical utility, although many studies are focused on e

40 performance approached WHO TPP criteria for clinical utility among HIV-uninfected adults with presum

41 , the provision of a checklist increases the clinical utility and accessibility of these recommendati

42 dologies for IRD and thereby demonstrate the clinical utility and additional value of WGS.

43 e rhesus macaque animal model where both the clinical utility and biological role of neutralizing MAb

44 This study investigated the clinical utility and combined yield of post-mortem genet

45 Further research is needed to assess the clinical utility and cost-effectiveness of this addition

46 Further research is needed to understand the clinical utility and cost-effectiveness of this approach

47 and when it should be performed to maximize clinical utility and cost-effectiveness.

48 the metrics by using additional measures of clinical utility and data from phase III trials.

49 Thus, the clinical utility and feasibility of passive antibody tra

50 hort and has test characteristics supporting clinical utility and further prospective evaluation.

51 frail patients, though they differ in their clinical utility and prognostic ability.

52 inical trials in pediatric PAH, although its clinical utility and prognostic value need to be further

53 For the long run, in addition to clinical utility and scientific validity, new diagnostic

54 cussion among frontline clinicians about the clinical utility and specific indications for testing.

55 We suggest that this analysis has clinical utility and that there is limited room for furt

56 oward potentially safer PAR4 antagonists for clinical utility and the development of tools such as ra

57 tial to serve as a prognostic biomarker with clinical utility and to reduce the overall burden associ

58 of this tool to the clinic in 2004, further clinical utility and widespread adoption have been limit

59 symptom criteria do not seem to have greater clinical utility, and a high percentage of soldiers who

60 Alterations in genes with potential clinical utility are observed in more than three quarter

61 ability of PD-MCI over time to determine its clinical utility as a marker of disease.

62 uggest that AKAP7 expression levels may have clinical utility as a prognostic biomarker for post-stro

63 TgAb trends appear to have clinical utility as a surrogate tumor marker in the surv

64 gest that targeted TTK inhibition might have clinical utility as an adjunct therapy in management of

65 -3p) associates with acute IS and might have clinical utility as an early diagnostic marker.

66 ic and predictive biomarkers that might have clinical utility as biomarkers for combination cytotoxic

67 ing that these miRNA may have some potential clinical utility as biomarkers.

68 rystal microbalance (QCM) devices, have good clinical utility as fast diagnostic tools for the detect

69 ring sepsis with an investigation into their clinical utility as markers for sepsis through measureme

70 effective antimicrobial NPs, which may have clinical utility as mucus-penetrating tobramycin deliver

71 ion of prosthetic valves, and have potential clinical utility as therapeutic targets for tailored med

72 ive studies were found to have evaluated the clinical utility, as defined by the guideline, of specif

73 ators and drivers of disease and have proven clinical utility at initial diagnosis.

74 However, the genetic landscape and its clinical utility at relapse are less well understood and

75 that this classification scheme has limited clinical utility based on its lack of reproducibility in

76 Many powerful drugs have limited clinical utility because of poor water solubility and hi

77 on, but further research is needed to assess clinical utility before they are incorporated into pract

78 Local drug delivery depots have significant clinical utility, but there is currently no noninvasive

79 ty using PCa cell line models, and showcased clinical utility by accurately detecting TMPRSS2:ERG in

80 e translation of these molecular findings to clinical utility, by enabling novel strategies for early

81 Somatic mutations of established clinical utility (category I) were reported in 4 (3%) of

82 Clinical utility data on HDT benefit in these patients a

83 of evidence that would support study of the clinical utility, describes the outcomes that should be

84 lth technologies, and may increase mHealth's clinical utility, especially for telemedicine and for re

85 eloping novel D3R-selective compounds toward clinical utility, especially for treatment of cocaine ab

86 The TVI has clinical utility, especially in node-negative disease, i

87 ly, there are no blood-based biomarkers with clinical utility for acute ischemic stroke (IS).

88 Ultrasound provides clinical utility for assessing the trajectory of change

89 s demonstrate that risk alleles of potential clinical utility for both Mendelian and complex traits a

90 ining 10% of phenotypic variation could have clinical utility for deciding which single-seizure indiv

91 The signature may have clinical utility for differentiating host systemic infla

92 ted screening tools to report calibration or clinical utility for improving health outcomes.

93 research suggests that NOP agonists may have clinical utility for pain treatment and substance abuse

94 nts on tumor phenotypes can be translated to clinical utility for patient prognosis and choices of ma

95 in an unbiased analysis of cfDNA, suggesting clinical utility for predicting chemotherapy response in

96 DNAm biomarkers with clinical utility for predicting food challenge outcomes

97 dge of SLCO1B1 genotypes is believed to have clinical utility for predicting myopathy risk and ensuri

98 blood cultures, demonstrating the potential clinical utility for real-time plasmid tracking in an ou

99 ur findings suggest that R-baclofen may have clinical utility for some of the core symptoms of human

100 pecificity, Ig-HTS from plasma has potential clinical utility for surveillance after complete remissi

101 or 2, the panel found sufficient evidence of clinical utility for the biomarker assays Oncotype DX, E

102 rs with narrow selectivity profiles can have clinical utility for therapy based on individual tumor g

103 ls suggesting that these approaches may have clinical utility for treatment or prevention of chronic

104 be the most expeditious path toward deriving clinical utility from these GWAS findings.

105 tabilizing DNA-cleavage complexes, but their clinical utility has been compromised by resistance.

106 will affect estimates of prevalence, whether clinical utility has been improved, and how many individ

107 omise for the treatment of many cancers, its clinical utility has been limited by problems in deliver

108 ility of GLP-1 has significantly limited its clinical utility; however, many studies are focused on e

109 ng echocardiography) have been shown to have clinical utility in a variety of settings.

110 y low functional avidity, which limits their clinical utility in adoptive cell transfer approaches.

111 The assay of plasma VWFpp has clinical utility in assessing acute and chronic vascular

112 , likely due to bone turnover, which impairs clinical utility in children.

113 sults suggest that PDE4 inhibitors may be of clinical utility in CLL or autoimmune diseases that are

114 d excellent antiviral activity and potential clinical utility in combination with other direct acting

115 dysfunction associated with FGR and may have clinical utility in correctly identifying FGR among fetu

116 rate of phoria adaptation may have potential clinical utility in differentiating which patients may a

117 ative accuracy may not yet be sufficient for clinical utility in FEP.

118 rognostic classification models and may have clinical utility in guiding therapeutic options for pati

119 radionucleotide angiography, has also shown clinical utility in identifying early-onset cardiotoxici

120 e prospective studies and may have potential clinical utility in improving CVD risk classification.

121 This may have important clinical utility in improving diagnostic accuracy, allow

122 cardiac troponin (cTn) assays maintain their clinical utility in patients with renal dysfunction.

123 ur scalp-negative seizure detector has clear clinical utility in patients with temporal lobe epilepsy

124 iome project, now stands at the threshold of clinical utility in regards to risk stratification and t

125 have unique properties that may translate to clinical utility in several key cardiovascular imaging n

126 herefore, the MammaPrint assay does not have clinical utility in such patients.

127 ed preliminary evidence for the instrument's clinical utility in that knowledge of ICS beliefs and CA

128 Evaluation of OCTA may be of clinical utility in the evaluation and grading of diabet

129 s, magnitude-based MRI has the potential for clinical utility in the evaluation of NAFLD, but at this

130 This suggests that SP has limited clinical utility in the overall prevention of recurrent

131 laque, and suggest that this effect may have clinical utility in the prophylaxis of inflammatory athe

132 and suggests that sequencing of APC may have clinical utility in the routine staging and potential th

133 lifetime risk in persons with HIV, may have clinical utility in this population.

134 rapeutics targeting the Maresin pathway have clinical utility in treating LAP and other oral diseases

135 Regarding clinical utility, increasing evidence points to a change

136 learly demonstrated analytical validity, its clinical utility is debated.

137 regulates many biological processes, but its clinical utility is limited by its hypercalcemic effect.

138 tin is an important antitumor agent, but its clinical utility is often limited by multifactorial mech

139 after kidney transplantation; however, their clinical utility is still undefined.

140 ified for circulating tumor cells (CTCs) and clinical utility is typically limited to cell enumeratio

141 Tissue sampling has limited clinical utility, mainly because it requires an invasive

142 To give this information clinical utility, new methods of detecting nucleic acid

143 These studies strongly suggest the clinical utility of (124)I-MORAb-004 immuno-PET in asses

144 his study was to prospectively determine the clinical utility of (68)Ga-DOTATATE positron emission to

145 Overall, these results do not support the clinical utility of 5-HT2C agonists and 5-HT2A inverse a

146 In this multicenter study, we examined the clinical utility of 7 more sensitive cTn assays (3 sensi

147 The study examined the clinical utility of a molecular diagnosis and the cost-e

148 into five phases, designed to establish the clinical utility of a new diagnostic test--the index tes

149 In summary, these data support the clinical utility of ACMG variant-classification guidelin

150 in breast cancer recurrence and suggest the clinical utility of agents targeted against this prosurv

151 There is uncertainty about the accuracy or clinical utility of all potential screening tools.

152 However, the clinical utility of all tools was modest for case-findin

153 More work is also required to determine the clinical utility of amyloid imaging specifically in subj

154 This study demonstrated the clinical utility of an app for successful weight reducti

155 porting the further evaluation and potential clinical utility of an effective heroin vaccine in treat

156 ciparum malaria that threatens the long-term clinical utility of artemisinin-based combination therap

157 These data suggest clinical utility of baseline WBMRI in TP53 germline muta

158 actical and technical details as well as the clinical utility of BAT in diagnosis and management of a

159 ndividual CTC could dramatically enhance the clinical utility of BBBs, allowing in depth interrogatio

160 We assessed the clinical utility of beta-amyloid (Abeta) imaging with (1

161 ive-retrospective studies that evaluated the clinical utility of biomarkers.

162 is and degradation of proteins increases the clinical utility of biomarkers.

163 routine TBI patient management may limit the clinical utility of blood-based biomarkers because their

164 Future work will test the clinical utility of body composition monitoring for impr

165 adherence to these guidelines and assess the clinical utility of brain imaging.

166 t is unclear whether this will impact on the clinical utility of CDK8/19 inhibitors.

167 research directions will refine measures of clinical utility of CGES in both germline and somatic te

168 ospective patient studies for evaluating the clinical utility of computational models.

169 The results strongly support the safety and clinical utility of CPC therapy.

170 Our data suggest the clinical utility of evaluating body composition by age g

171 s, which limits the detail, specificity, and clinical utility of fMRI resting-state functional connec

172 e of Blood, Kurtz et al report the potential clinical utility of immunoglobulin high-throughput seque

173 The clinical utility of inhibiting cytochrome P450 17A1 (CYP

174 This study demonstrates the clinical utility of inhibiting the PI3Kdelta pathway wit

175 creasing technology could ultimately enhance clinical utility of intravenously delivered nanoscale me

176 herapeutic outcomes, but also maximizing the clinical utility of LDV and SOF combination regimens.

177 The clinical utility of limited-channel sleep studies (which

178 pediatric populations are discussed and the clinical utility of mechanical circulatory support devic

179 Resampling methods were used to assess the clinical utility of metrics to predict phase III outcome

180 Clinical utility of MFCT has been identified in prenatal

181 ts and values essential to understanding the clinical utility of molecularly targeted therapies in on

182 The clinical utility of monitoring behavioral changes during

183 To determine the role on the clinical utility of MYXV therapy for glioma, we used a c

184 s contribute to the growing evidence for the clinical utility of neonatal magnetic resonance imaging

185 basic science discoveries remain promising, clinical utility of neuroprotection is still quite limit

186 ealthcare stakeholders are unclear about the clinical utility of NGS and are concerned it could be an

187 To extend the clinical utility of our findings, we applied a mathemati

188 h trials and practice to begin to define the clinical utility of percutaneous leaflet repair, and ann

189 ectrum of RAD21 mutations and emphasizes the clinical utility of performing RAD21 mutation analysis i

190 Our results demonstrate the potential clinical utility of pharmacologic ascorbate as a radiose

191 In practice, clinical utility of potent radiosensitizing drugs is cur

192 es and additional biomarkers will expand the clinical utility of predictive algorithms for pharmaceut

193 Evidence supporting the clinical utility of predictive biomarkers of anthracycli

194 , this is the first study to demonstrate the clinical utility of predictive genetic testing for MYOC

195 ocognitive deficits and thus has a potential clinical utility of proper concussion assessment and man

196 the feasibility, reliability, validity, and clinical utility of proposed changes that can assist in

197 measures may be used to rapidly identify the clinical utility of prospective addiction treatments.

198 rity System is necessary when evaluating the clinical utility of readings.

199 bstrate of RSNs and encourage testing of the clinical utility of resting-state connectivity in PET da

200 estimates of test accuracy and to assess the clinical utility of RNA biosignatures in practice.

201 y reproducibility are required to expand the clinical utility of RNA-seq.

202 rtiary care medical center and to assess the clinical utility of routinely querying for anaerobes in

203 The clinical utility of serum periostin as a type 2 biomarke

204 ew describes the mechanism of action and the clinical utility of some of the older inotropic agents,

205 To evaluate the clinical utility of spectral analysis of intraocular pre

206 Given the potential clinical utility of such biomarkers, we sought to valida

207 ol isomerases control vascular function, the clinical utility of targeting them in thrombotic disorde

208 points and continues to add insight into the clinical utility of tedizolid phosphate.

209 roidal anti-inflammatory drugs; however, the clinical utility of testing for these genetic associatio

210 The clinical utility of the addition of electrolytes to poly

211 ought to provide prospective evidence of the clinical utility of the addition of the 70-gene signatur

212 The clinical utility of the adeno-associated virus (AAV) gen

213 r time and may compromise the properties and clinical utility of the cells.

214 ver, predictive accuracy was modest, and the clinical utility of the CHA2DS2-VASc score in patients w

215 nd can be useful to the WHO in improving the clinical utility of the classification and its global ac

216 This study aims to examine the clinical utility of the combination of TNM stage and mod

217 To demonstrate the clinical utility of the diagnostic assay presented, a pa

218 Analysis of the clinical utility of the effect size of plasma CXCL8 in h

219 To establish clinical utility of the identified biomarkers, a placebo

220 Several illustrations of the clinical utility of the information obtained for improvi

221 display at video-rate speed are critical for clinical utility of the IVPA-US imaging technology.

222 absence of studies designed to evaluate the clinical utility of the markers.

223 rmed decision curve analysis to evaluate the clinical utility of the model by calculating its net ben

224 We validated the clinical utility of the MTB-ISAD assay by detecting MTB

225 nrolled subjects to correctly appreciate the clinical utility of the novel lymphocyte-adenosine proto

226 greater than or equal to 2, may diminish the clinical utility of the quick Sequential Organ Failure A

227 ual crossmodal connectivity, and promote the clinical utility of the resting paradigm for single-pati

228 primary lung cancer (IPLC) and evaluated the clinical utility of the risk prediction model for select

229 Future work is needed to validate potential clinical utility of the RNA species described.

230 40-73 years]) were assessed to ascertain the clinical utility of the sign to detect likely pharmacolo

231 We aim to assess the clinical utility of the SITA algorithm for accurately ma

232 We further compared the clinical utility of the targeted NGS panel test with tha

233 fs and CAM endorsement and (2) evaluated the clinical utility of the tool as a communication prompt i

234 inical relevance both in terms of the direct clinical utility of the vaccine studied and in illustrat

235 We end with case scenarios to illustrate the clinical utility of the website.

236 ntional therapy are required to evaluate the clinical utility of these agents in the treatment of Ph-

237 xic agents are available to oncologists, the clinical utility of these agents is limited due to their

238 s perturbed, which significantly reduces the clinical utility of these agents.

239 y and composite histological scores, and the clinical utility of these biopsies.

240 tablish the biological context and potential clinical utility of these findings.

241 However, the clinical utility of these measures may only become appar

242 ies, such as bevacizumab, greatly limits the clinical utility of these promising approaches.

243 The clinical utility of these techniques is increasingly bei

244 esistance mutations are needed to ensure the clinical utility of these tools.

245 and identify strategies that may enhance the clinical utility of these unique targeted therapies.

246 In addition, the practicability and clinical utility of this approach has also been demonstr

247 ies are needed to demonstrate the safety and clinical utility of this approach, our results suggest t

248 tive validation is required to better assess clinical utility of this approach.

249 nt, whereas subsequent studies confirmed the clinical utility of this approach.

250 pective testing is required to determine the clinical utility of this assay, particularly for the dia

251 repeated administration leaves the potential clinical utility of this class of drugs in question.

252 The potential clinical utility of this common laboratory test in predi

253 ore, the goal of our study was to assess the clinical utility of this functional imaging modality in

254 currently available data point to a relevant clinical utility of this imaging technique.

255 anine intake, thereby reducing the perceived clinical utility of this inhibitor class.

256 minutes of MAPS injection, in support of the clinical utility of this method.

257 We demonstrate the clinical utility of this model by predicting three impor

258 DCC)-mediated internalization of Mn(2+), the clinical utility of this technique is limited by the cyt

259 Clinical utility of this technology was shown through th

260 se groups of patients to assess accuracy and clinical utility of this test in different clinical sett

261 This analysis demonstrates the clinical utility of this test, providing examples where

262 To provide an overview of the clinical utility of thyroglobulin antibody (TgAb) measur

263 In conclusion, the clinical utility of urine Gram stain does not warrant th

264 The clinical utility of using a 4-BRS for risk prediction an

265 Recent studies point to the clinical utility of using peri-implant sulcular fluid (P

266 To assess the clinical utility of WBMRI in germline TP53 mutation carr

267 Our findings demonstrate the clinical utility of WES to identify causative mutations

268 The clinical utility of whole genome sequencing projects wil

269 The clinical utility of wPRx should be explored in prospecti

270 therapeutic glycoproteins that possess wide clinical utility owing to their biocompatibility, high a

271 broadly neutralizing members with potential clinical utility, particularly in areas where clade C is

272 broadly neutralizing members with potential clinical utility, particularly in areas where clade C is

273 their clinical validity (phases 2 and 3) and clinical utility (phases 4 and 5) are incomplete.

274 ecommendations, which cover establishment of clinical utility, regulatory oversight, coverage and rei

275 lack of replicable prospective evidence for clinical utility required for altering medical care.

276 ems for identifying at-risk individuals, its clinical utility requires further comparison with other

277 b, a selective inhibitor of RAF kinases, has clinical utility restricted to BRAF-mutant tumors.

278 This investigation evaluated the clinical utility, sensitivity, and specificity of urine

279 These results demonstrate the clinical utility, specificity, and sensitivity of urine

280 al studies have been promising, but proof of clinical utility still requires prospective multicenter

281 types of incidental results (with potential clinical utility) that could be offered for return to an

282 ssified PDACs into 4 subtypes with potential clinical utility: the subtypes were termed stable, local

283 sing the vast array of genetic discovery for clinical utility through emerging precision medical init

284 Clinical performance and clinical utility (time to positivity) were calculated fo

285 test must have high analytical validity and clinical utility to be used to guide clinical care in st

286 d discrimination and calibration, suggesting clinical utility to improve individualized predictions o

287 n and Yahr stage at baseline, suggesting its clinical utility to monitor disease severity.

288 istribution on SPECT systolic images may add clinical utility to whole-cycle images and wall motion.

289 f aGPCR synthetic modulators that could find clinical utility toward aGPCR-directed disease.

290 ssure regulation with age, thus, a potential clinical utility towards detection of fall proneness.

291 Clinical utility was assessed by positive predictive val

292 As a demonstration of clinical utility, we characterize exosomes directly from

293 Finally, in order to demonstrate clinical utility, we have used our platform for the succ

294 To establish clinical utility, we need to understand the consequences

295 to demonstrate the system functionality and clinical utility, we present images of the photoreceptor

296 No studies that met guideline criteria for clinical utility were found to guide choice of specific

297 t broad-spectrum MMP inhibitors have limited clinical utility, which has spurred the development of i

298 To demonstrate its clinical utility, whole blood samples with clinically-re

299 ant disease progression, being considered of clinical utility with potential use as therapeutic targe

300 Testing its clinical utility with The Cancer Genome Atlas data demon