ライフサイエンスコーパス: clinically

1 nterventions to restore perceptual abilities clinically.

2 ical appropriateness has not yet been proven clinically.

3 lve-year follow-up period and demonstrated a clinically acceptable safety profile.

4 Thanks to clinically accessible biopsy samples, high-quality molec

5 o pretreatment disease burden, we identify a clinically accessible potential on-treatment predictor o

6 ional model simulations indicate that within clinically achievable PTX concentrations, the contributi

7 hensive molecular analysis is available from clinically acquired metastatic cancers.

8 to draw comparisons and identify potentially clinically actionable alterations.

9 d expression changes (<2-fold or >2-fold) in clinically actionable genes including gains of FGFR4 (n

10 tic testing based on family history may miss clinically actionable genetic changes with established i

11 e EGFR signaling pathway, since they provide clinically actionable information as negative predictors

12 In addition, we find potentially clinically actionable PI3K signalling mutations in 16% o

13 med on glutaraldehyde-fixed thin sections of clinically acute and pathologically active cases of MS.

14 aches, with a focus on agents that have been clinically adopted.

15 obligate C9orf72 carriers), of whom 147 were clinically affected (89 proven or obligate C9orf72 carri

16 To investigate the ability of clinically and biologically relevant genes and gene sign

17 AD is a heterogeneous disease both clinically and biologically.

18 uencies of specific morphologic patterns of (clinically and dermoscopically) SK-like melanomas, patie

19 The study confirms the occurrence of clinically and environmentally relevant mycobacteria in

20 be attributed to the virus is important both clinically and epidemiologically.

21 report that monoamine oxidase A (MAOA) is a clinically and functionally important mediator of PCa bo

22 Intellectual disability (ID) is a clinically and genetically heterogeneous disorder, affec

23 the categories of patients with CIDs in Iran clinically and genetically.

24 nd that axillary lymph node dissection, both clinically and in a mouse model, results in a marked inc

25 Follicular lymphoma (FL) is a clinically and molecularly highly heterogeneous disease,

26 ng the thalamus were prospectively evaluated clinically and with magnetic resonance imaging to quanti

27 and malaria can be difficult to distinguish clinically, and rapid testing was not available in many

28 allenging when evaluating diastolic function clinically; and 5) their usefulness in guiding therapeut

29 Patients with Coats' disease diagnosed clinically, angiographically, or both from 1995 through

30 necrotic regions of 13 previously untreated, clinically-annotated and genetically-defined high grade

31 he signal of fluorinated cells detected by a clinically applicable (19)F MRI method correlated with t

32 The aim was to develop a clinically applicable risk prediction tool.

33 corrected by ivacaftor (VX-770; Kalydeco), a clinically approved CFTR potentiator.

34 tide antibiotics structurally related to the clinically approved daptomycin.

35 Clinically approved inhibitors of MBLs are currently una

36 Omalizumab, a clinically approved therapeutic antibody, inhibits the i

37 Triple-negative breast cancer is viewed clinically as an aggressive subgroup of breast cancer.

38 Glucocorticoids (GCs; referred to clinically as corticosteroids) are steroid hormones with

39 EVs which can be employed for liquid biopsy clinically as well as for the study of intercellular sig

40 win studies, but the genetic overlap between clinically ascertained ASD and ADHD remains largely uncl

41 Blockade of AhR using a clinically available AhR antagonist greatly enhanced the

42 aromatic carbamate derivatives based on the clinically available drug flupirtine was synthesized to

43 ltidrug resistance is a global threat as the clinically available potent antibiotic drugs are becomin

44 14 is not clinically available, however, because its development w

45 astases are usually missed and most patients clinically classified as a complete responder eventually

46 posed individuals developed an acute illness clinically compatible with trichinellosis, characterized

47 nts and standing in individuals with chronic clinically complete SCI.

48 lation, 199 (77.4%) of 257 participants were clinically cured in the ceftazidime-avibactam group, com

49 eceding transient ischaemic attack, which is clinically defined as focal neurological symptoms of isc

50 n genetic basis of salutary social bonds and clinically defined psychiatric disorders.

51 tients at risk for short-term development of clinically defined synucleinopathy.

52 -78.4]), 189 (51%) of 368 patients developed clinically definite multiple sclerosis.

53 determined based on analysis of 34 eyes with clinically definite ONHD.

54 Patients with clinically designated multiple primary MCC were identifi

55 Forty-one eyes of 36 patients with clinically diagnosed ARN, PCR-positive for herpes simple

56 a measurable decline in IP-10 at day 7 than clinically diagnosed cases (48/77 (62.3%) vs 13/41 (31.7

57 levels at D0 and had a steeper decline than clinically diagnosed cases (mean decline difference 2231

58 c MDR-TB, we surveyed high-burden states for clinically diagnosed cases treated for MDR-TB.

59 seven consecutive eyes of 57 patients with a clinically diagnosed choroidal melanoma underwent comple

60 Clinically diagnosed eating disorders may have adverse c

61 istance adipose arteries of non-diabetic and clinically diagnosed type 2 diabetic patients.

62 Currently, these cancers are clinically diagnosed using invasive biopsy-based tests,

63 A clinically directed tiered testing strategy can increase

64 ples with NOTCH pathway activation were also clinically distinct and were associated with better over

65 of patients with metastatic CRC and define a clinically distinct subtype of CRC with an excellent pro

66 Although these two syndromes are clinically distinct, there is significant phenotypic ove

67 Clinically driven target lesion revascularization occurr

68 predict whether an antifungal agent will be clinically effective against a particular fungal isolate

69 more than three decades of research effort, clinically effective anti-RAS therapies have remained el

70 gly antibiotic resistant, and development of clinically effective antibiotics is lagging.

71 (HER2)-positive metastatic breast cancer; a clinically effective biosimilar may help increase access

72 for the treatment of psoriasis has not been clinically effective.

73 S) (USMG: 22.7%, IMG: 22.8%; P = 0.352) were clinically equivalent.

74 Using the clinically established PRETEXT groups I, II, III, and IV

75 In the clinically evaluable population, 199 (77.4%) of 257 part

76 le a number of pan-FGFR inhibitors are being clinically evaluated, their application to FGF19-driven

77 was up to 20 days before engraftment became clinically evident.

78 ascertaining dementia diagnoses, those which clinically examined all participants found higher risk f

79 Tackling PPIs, particularly by stabilizing clinically favored conformations of target proteins, wit

80 pedance tomography-derived maps might become clinically feasible and relevant, being simpler than cur

81 To derive a clinically feasible risk index for firearm violence.

82 In this Seminar, we provide a clinically focused overview of asthma, including epidemi

83 Performing the testing in a clinically focused tiered fashion would be 6.1% more sen

84 d on a patient with a full deletion of IGSF1 clinically followed from neonate to adulthood, we invest

85 ereas for normal responders <65 years old, a clinically guided protocol was necessary to achieve well

86 evaluation and testing men at risk for PCA-a clinically heterogeneous disease.

87 pment, metaplastic breast cancer serves as a clinically identifiable surrogate to evaluate potential

88 d absolute risk for psychiatric disorders in clinically identified individuals with 22q11.2 deletion

89 Clinically, IgE-anti-IL-24 levels showed an association

90 Here we show that clinically ill transgenic mice overexpressing hamster pr

91 INTERPRETATION: Our findings show a clinically important benefit of enhanced social recovery

92 range, 0 [no symptoms] to 6 [death]; minimum clinically important difference, 1 point), assessed at 9

93 hange in letters read, -121 to +101; minimal clinically important difference, 7 letters), analyzed by

94 , there were no statistically significant or clinically important differences in pain reduction at 2

95 events and predisposes to the development of clinically important mitral valve regurgitation and mitr

96 retome and analyzed the transcriptome of the clinically important PMEN1 lineage to identify which pep

97 Purpose To characterize clinically important prostate cancers missed at multipar

98 uction in critical care patients, along with clinically important reductions in blood pressure.

99 s on precise breakpoint prediction, which is clinically important.

100 s that are statistically significant but not clinically important.

101 To clinically improve FDH by using AFR to characterize the

102 ctively identified 10 patients who underwent clinically indicated (18)F-fluciclovine PET/CT prior to

103 We quantified serum miRNA at clinically indicated and/or protocol biopsy events (n =

104 Clinically indicated elective revascularizations perform

105 monitored regularly posttransplant and when clinically indicated using the single-antigen bead Lumin

106 n, is associated with faster conversion from clinically isolated syndrome (CIS) to multiple sclerosis

107 tients with relapsing-remitting MS (RRMS) or clinically isolated syndrome (CIS) with disease onset be

108 a first demyelinating event (also known as a clinically isolated syndrome) to multiple sclerosis.

109 34 with the relapsing-remitting form, 2 with clinically isolated syndrome) with and without disease-m

110 iomarkers of subclinical cardiac disease and clinically manifest cardiac diseases with CMIs graded on

111 ernalization, impairing the iron absorption; clinically manifested as anemia of inflammation (AI).

112 aocular involvement is frequent in PCNSL and clinically marked by slowly progressive visual deteriora

113 Purpose Measures of response that are clinically meaningful and occur early are an unmet need

114 monstrated partial response also experienced clinically meaningful and statistically significant impr

115 This study aims to validate and apply clinically meaningful bands to the ItchyQuant, an illust

116 support the value of sNfL as a sensitive and clinically meaningful blood biomarker to monitor tissue

117 nment need multifaceted strategies to invoke clinically meaningful change in BMI among adult patients

118 The algorithm extracted clinically meaningful clusters with significantly differ

119 % confidence interval, 1.3%-6.7%), there was clinically meaningful diagnostic discordance, with the F

120 There were no clinically meaningful differences in HRQoL between lenal

121 ust and significant independent indicator of clinically meaningful measures of COPD.

122 omote appropriate allocation of MAC based on clinically meaningful patient factors.

123 out ET) given for only 12 weeks results in a clinically meaningful pCR rate.

124 TION: Carfilzomib provided a significant and clinically meaningful reduction in the risk of death com

125 Ibrutinib resulted in clinically meaningful responses with acceptable safety i

126 We found no evidence to support a clinically meaningful role of CYP2C19 polymorphisms and

127 ing the skills they learned in the museum in clinically meaningful ways at medical school.

128 of baseline participant characteristics and clinically meaningful worsening in menopause-specific qu

129 .0% was selected to allow for no more than a clinically negligible 6.0% breakthrough reaction rate in

130 oroparietal and occipital cortex compared to clinically normal controls, and in probable DLB, the upt

131 on, our study delivers the rationale for the clinically observed phenomenon of residual terminal path

132 tion in the Pittsburgh Specialized Center of Clinically Oriented Research cohort.

133 uals in the Pittsburgh Specialized Center of Clinically Oriented Research cohort.

134 line, published in 2016, is clear, thorough, clinically practical, and helpful, despite the limited a

135 pursuing basic investigation: pressure to be clinically productive, excessive administrative responsi

136 T-cell responses in children and may have a clinically protective effect at the population level.

137 f ZIKV non-structural-1 (NS1) protein from a clinically proven safe, Modified Vaccinia Ankara (MVA) v

138 ontacts' maps could uncover functionally and clinically related genes.

139 Fewer than half of funded grants aimed for clinically related targets (eg, sunburn reduction).

140 continuum, measuring interventions that hit clinically related targets, and leveraging technology, t

141 rpolarized [(13)C]-Glyc as a novel agent for clinically relevant (13)C MRS studies of energy metaboli

142 lic forms of RP in dogs, rcd1 and xlpra2, at clinically relevant advanced stages of the two diseases.

143 We have previously presented simulations of clinically relevant amounts of intraperitoneal (90)Y-mAb

144 We characterized 11 clinically relevant and 5 nonclinical Fpn mutations usin

145 igration protein Tetraspanin 1 (TSPAN1) as a clinically relevant androgen regulated target in prostat

146 iated with resistance of the gonococcus to a clinically relevant antibiotic.

147 ured mutant depletion upon exposure to three clinically relevant antimicrobials (colistin, imipenem o

148 Even though this site is present in clinically relevant AR-variants it can only be ubiquitin

149 evolved a unique cell division cycle in the clinically relevant asexual blood stage of infection(1).

150 We defined five clinically relevant backbone groups on the basis of esta

151 These findings provide clinically relevant biological insight into heritable va

152 tiparametric diagnostics could help discover clinically relevant biomarker combinations pivotal for u

153 inical resistance, and inform development of clinically relevant biomarkers and trials of combination

154 erstood and often overlooked when developing clinically relevant bispecific therapeutics.

155 There was a small non-clinically relevant but statistically significant (0.2 [

156 Clinically relevant cataract surgical skills can be impr

157 ) PCs (60 and 234.4 days, respectively), and clinically relevant cell-bound IgE (67.3 days).

158 d victimization had pervasive impairments in clinically relevant cognitive functions, including gener

159 l sensor characteristics and assays covering clinically relevant concentrations in physiological sali

160 atory strains in the presence and absence of clinically relevant concentrations of 3 commonly used an

161 tics and, as shown here, to barbiturates, at clinically relevant concentrations.

162 eaningful changes in ion channel function at clinically relevant concentrations.

163 achieving precise molecular measurements at clinically relevant detection limits and high (3 s) temp

164 We aimed to establish an endpoint capturing clinically relevant deteriorations (diary events) that,

165 scale, with the predefined hypothesis of no clinically relevant differences after induction between

166 , we have shown that cancer cells respond to clinically relevant doses of sunitinib by enhancing the

167 ncies, block BCR-mediated lytic induction at clinically relevant doses.

168 low potential as a perpetrator or victim of clinically relevant drug interactions-coformulated with

169 therapy for nAMD was evident across multiple clinically relevant end points.

170 e-based design of potent modulators of these clinically relevant enzymes.

171 Clinically relevant Ezh2 inhibitors restore androgen rec

172 luence corneal biomechanics and represents a clinically relevant factor that needs further investigat

173 These clinically relevant findings should have significant inf

174 tenuated vaccine platform for ZIKV and other clinically relevant flaviviruses.

175 ch collaborations, we recommend prioritizing clinically relevant genes for functional studies, develo

176 For proof-of-principle, the clinically relevant glucagon-like peptide 1 (GLP-1) was

177 assign antibiotic susceptibility profiles of clinically relevant Gram-negative bacteria within two ho

178 To neutralize inhibitory RGMa, clinically relevant human monoclonal antibodies were sys

179 Changes in HVPG and BW were predefined as clinically relevant if >/=10% and >/=5%, respectively.

180 dly upregulated in multiple cell types after clinically relevant impact-compression SCI in rats, and

181 ER and CA-IKKbeta-driven gene expression and clinically relevant invasion and metastasis gene signatu

182 nule cell neurons of the hippocampus after a clinically relevant isoflurane anesthesia exposure condu

183 ox thiol, both markers are detectable across clinically relevant levels by label free impedance deriv

184 ach for the routine analysis of uric acid at clinically relevant levels in urine patient samples.

185 tic studies of initiation and progression of clinically relevant lower urinary tract symptoms.

186 cal and biochemical cues on the surface of a clinically relevant material such as titanium.

187 osophila nephrocyte can be used to elucidate clinically relevant molecular mechanisms underlying the

188 The parallel development of clinically relevant mouse models of fungal disease and t

189 -Gbetagamma inhibition in CKD developed in a clinically relevant murine model of nonischemic hypertro

190 Here, three clinically relevant nanomedicines, i.e., high-density li

191 In this systems-based review, we describe clinically relevant neuroendocrine abnormalities in Park

192 The definition, etiology, and clinically relevant outcomes associated with malnutritio

193 iveness compared with standard care improves clinically relevant outcomes in adults admitted to the I

194 vascular expertise on big data approaches to clinically relevant paradigms.

195 laboratories that summarizes new and revised clinically relevant parasite taxonomy from January 2012

196 ations with the adjusted model generated the clinically relevant prediction that the slow delayed rec

197 ssment of blood-brain barrier pathology as a clinically relevant predictive, diagnostic and pharmaco!

198 allel with insulin resistance and could be a clinically relevant predictor of MS development.

199 prevalence, strength and cross-reactivity to clinically relevant profilins.

200 and its interaction with sodium did not add clinically relevant prognostic information on top of oth

201 sting using representative animal models and clinically relevant quantitative biomarkers.

202 However, a remaining clinically relevant question is whether early post-statu

203 ll answer exciting basic microbiological and clinically relevant questions.

204 a distinct responsiveness of CRAF fusions to clinically relevant RAFi.

205 nt biomarker data are summarized here, using clinically relevant scenarios in which biomarkers could

206 ed treated wastewater showed the presence of clinically relevant slow growers like M. kansasii, M. sz

207 These findings suggest a clinically relevant spectrum of subclinical primary aldo

208 e positive results on skin prick testing and clinically relevant symptoms of rhinitis related to thei

209 an initial hypervigilance or facilitation to clinically relevant threats and consequent defensive avo

210 antisense oligonucleotides into the LV in a clinically relevant time frame significantly inhibits TR

211 sient ischaemic attack, and that it would be clinically relevant to develop non-invasive in vivo imag

212 ng a dual-transducer system operating at the clinically relevant ultrasound frequency of 274.3 kHz.

213 important determinants of antigenicity in a clinically relevant xenogeneic biomaterial (i.e. BP) and

214 dient occurs early in multiple sclerosis, is clinically relevant, and may arise from one or more mech

215 This is clinically relevant, as overly softened and stiffened cl

216 R-32, we identified RAC2 as a potential, and clinically relevant, target of miR-32.

217 urovascular function during cold exposure is clinically relevant.

218 ens and non-locum tenens physicians were not clinically relevant.

219 such patterns might be more biologically and clinically relevant.

220 ical response, and hence their monitoring is clinically relevant.

221 Thus, we developed a clinically-relevant animal model for TON using a novel u

222 We therefore sought to determine how a clinically-relevant dose of cryotherapy would impact the

223 unomide could suppress SOCE significantly at clinically-relevant doses and this provides for an addit

224 lar vaccine incorporating a peptide from the clinically-relevant human papilloma virus (HPV) 16 E7 on

225 trointestinal biomass can be induced using a clinically-relevant iso-osmotic agent.

226 g facilitates non-invasive identification of clinically-relevant mutations in lung adenocarcinoma.

227 Our study introduces a clinically-relevant neuroimaging ageing biomarker and de

228 Larger clinically-relevant vectors are needed.

229 lity also offers a simple explanation of the clinically reported difference in surgical outcomes.

230 e acquired in individual infants following a clinically required heel lance.

231 ultiple primary MCCs from progression of MCC clinically resembling multiple primaries, allowing appro

232 bacterial or fungal growth, with 342 (6.0%) clinically significant and 83 (1.5%) contaminated.

233 idence of campylobacteriosis, outbreaks, and clinically significant antimicrobial resistance increase

234 riable, and timely and accurate detection of clinically significant cancer is critical in positively

235 Patients were more likely to report a clinically significant decline in self-reported cognitiv

236 ld to moderate intellectual disabilities and clinically significant depression were recruited from he

237 cile testing of stools from patients without clinically significant diarrhea and in patients with rec

238 Extracts of the clinically significant ESKAPE pathogens: E nterococcus f

239 anomalies in functional connectivity tied to clinically significant inattention centered on midline r

240 s randomized to UC + PAL versus UC alone had clinically significant incremental improvement in KCCQ a

241 nd to acquire a snapshot of the frequency of clinically significant levels of depression, anxiety, an

242 e tests used to stratify patients at risk of clinically significant liver disease in a general popula

243 ion to proliferative diabetic retinopathy or clinically significant macular edema was limited to appr

244 Clinically significant myelosuppression occurred in less

245 TA autoantibodies are present in a clinically significant number of individuals and could s

246 single institution, including data regarding clinically significant PF (International Study Group on

247 Clinically significant POPF occurred in 45 of the 300 ra

248 The mean cost for those who developed clinically significant POPF was MP$39,700 (MP$13,800 - M

249 ose To determine the diagnostic accuracy for clinically significant prostate cancer achieved with abb

250 Conclusion For the detection of clinically significant prostate cancer, no difference wa

251 this cartridge to perform rapid detection of clinically significant proteoforms from plasma samples.

252 ng anakinra for 4 weeks does not result in a clinically significant reduction in fatigue severity in

253 oms was administered bimonthly, and rates of clinically significant symptom elevations were compared

254 n methods to understand the modes underlying clinically significant tissue reactions to Co, Cr and Ti

255 ion to a particular phase of tremor afforded clinically significant tremor relief (up to 87% tremor s

256 is not easily predicted from BP, and may be clinically significant.

257 These findings reveal a clinically-significant role for RPGR in the activation o

258 Undiagnosed celiac disease appeared to be clinically silent and remained undetected, but long-term

259 ing as a first-hit mutation that initiates a clinically silent pre-leukemia in utero.

260 ectly affect CTLA-4 expression, resulting in clinically similar disorders.

261 We studied 205 participants followed clinically since childhood.

262 Aortic dissection was suspected clinically, so the patient was referred for imaging.

263 hniques and MRI studies were performed in 97 clinically stable children with CF across the pediatric

264 The patients were clinically stable on fingolimod.

265 Clinically stable patients with ACHD who routinely visit

266 Currently, this is clinically studied for treatment of chest wall recurrenc

267 aly are highly suggestive of dengue fever in clinically suspected cases.

268 A total of 250 clinically suspected ocular toxocariasis cases referred

269 ed high seroprevalence of toxocariasis among clinically suspected OLM cases confirming the toxoplasmi

270 A recent quantitative clinically-targeted MRI method, fast macromolecular prot

271 Two other clinically tested sulfonamides, tasisulam and chloroquin

272 limitations of current therapies and may be clinically translatable for patients with therapy-sensit

273 AID/RAD51 axis as a target for a potentially clinically translatable pharmacological approach that ca

274 ABSTRACT: There is a need for developing clinically translatable therapy for preventing fetal ori

275 rties, and critically their likelihood to be clinically translated.

276 fluorescence biopsies (DIF) in patients with clinically typical ocular mucous membrane pemphigoid (MM

277 able visual fields (VFs) that are defined as clinically unaffected based on summary indices were extr

278 At histopathologic examination, 80 clinically unimportant lesions (<5 mm; Gleason score, 3+

279 ound to have disseminated tuberculosis and a clinically unsuspected partial thrombus in the splenic v

280 Additionally, utilization of IMI clinically upstaged 6 (12%) subjects and improved manage

281 ndins stimulate uterine contractions and are clinically used for cervical ripening during pregnancy.

282 pletion impaired the ability of exendin-4, a clinically used GLP-1 analog, to reduce body weight in r

283 ion of nifedipine, a calcium-channel blocker clinically used in patients with cardiovascular disease.

284 ore and lipid layer containing docetaxel and clinically used inhibitor of sphingosine kinase 1 (SK1)

285 Antifolates have a proven record as clinically used oncolytic agents.

286 We determined that lithium, a clinically used therapeutic, induced high AID pS38 level

287 the identification of novel targets for two clinically used tyrosine kinase inhibitors, nilotinib an

288 sign principles that defined success for the clinically-used cancer nanomedicines can enable the desi

289 ly employed the gem-dimethyl group to obtain clinically useful drugs and to provide synthetic methods

290 ng PET has the potential to translate into a clinically useful imaging tool for individual patients.

291 have been made to target oncogenic KRAS, no clinically useful therapies currently exist.

292 ge in the near future, with the emergence of clinically useful tyrosine kinase inhibitors.

293 Clinically, vaginal-douche BD2 concentrations were reduc

294 , offer to return to individual participants clinically valid, medically important and medically acti

295 ses on anatomical and functional MRI contain clinically valuable information.

296 loss after macular laser photocoagulation is clinically valuable.

297 ncy is the most biologically interesting and clinically vexing feature of the virus.

298 d pluripotent stem cells were derived from a clinically well-characterized cohort of three individual

299 in receptor (SSTR) antagonists compared with clinically widely used agonists.

300 ma was ultimately ruled out were followed up clinically with repeated bronchial challenge tests over