ライフサイエンスコーパス: clioquinol

1 elevant bioactive metal chelators related to clioquinol.

2 c metal chelating agents desferrioxamine and clioquinol.

3 howed decreased cell death when treated with clioquinol.

4 ch was inhibited by Cu2+ chelators including clioquinol.

5 brain rose by about 15% in mice treated with clioquinol.

6 n, cholesterol, and the proposed efficacy of clioquinol.

7 led trial in 36 patients with AD showed that clioquinol (250-750 mg daily) reduced plasma concentrati

8 xin rotenone and opposed by those induced by clioquinol, a compound with demonstrated therapeutic eff

9 tion (iAbeta5, a beta-sheet breaker peptide; clioquinol, a copper-zinc chelator) on the ability of is

10 mproved potencies up to 86-fold greater than clioquinol, a known cytotoxic compound.

11 The MFAO-2s outperform clioquinol, a metal attenuator that has been investigate

12 ly, in a tissue culture model, we found that clioquinol, a metal chelator in clinical trials for AD t

13 Clioquinol, a metal chelator, has been used for many yea

14 ington's disease, we examined the effects of clioquinol, a metal-binding compound currently in clinic

15 evels of intracellular zinc, indicating that clioquinol acts as a zinc ionophore.

16 In addition, clioquinol alone exhibits similar effects in prostate ca

17 view examines the recent studies relating to Clioquinol and AD, and anticipates the imminent results

18 Finally, the Abeta aggregation inhibitor clioquinol and gamma-secretase inhibitor L-685,458 atten

19 ell death, and contrary to previous reports, clioquinol and other hydroxyquinoline compounds do not a

20 4 and 3.2 microM, respectively) compared to clioquinol and pyrrolidine dithiocarbamate (IC50 of 10 a

21 ation for the current clinical assessment of clioquinol as an antineoplastic agent.

22 We report here that after binding to copper, clioquinol can inhibit the proteasomal chymotrypsin-like

23 The finding that clioquinol could modulate plasma concentrations of amylo

24 The 8-hydroxyquinolines (8-HQ) clioquinol (CQ) and PBT2 were developed for their abilit

25 Clioquinol (CQ) is shown to sequester Cu(2+) more effect

26 istration of the bioavailable metal chelator clioquinol (CQ) on susceptibility to the Parkinson's-ind

27 The antiparasitic clioquinol (CQ) represents a class of novel anticancer d

28 The antifungal and amoebicidal drug clioquinol (CQ) was withdrawn from the market when it wa

29 Clioquinol (CQ), an 8-OHQ previously reported to reduce

30 istration of the bioavailable iron chelator, clioquinol (CQ), to older mice was found to protect agai

31 on the cytotoxic activity of 5-Cl-7-I-8-HQ (clioquinol, CQ) copper complex (Cu(CQ)).

32 ed 9 week study of a mouse model of AD, oral clioquinol decreased brain Abeta by 49% without systemic

33 Clioquinol exerts its anti-parasitic actions by acting a

34 s, such as desferrioxamine (Fe chelator) and clioquinol (Fe, Cu, and Zn chelator), which reduce Abeta

35 ises the issue of specific iron chelators or clioquinol for control of oxidative damage in Parkinson'

36 Our results show that clioquinol has anticancer effects both in vitro and in v

37 mplexes were also >100-fold more potent than clioquinol in a tumor spheroid model, with values simila

38 the imminent results of a Phase II trial of Clioquinol in AD, due in March 2002.

39 Biochemical analysis revealed that clioquinol induced cancer cell death through apoptotic p

40 Although clioquinol induced modest inhibition of SOD1 activity in

41 ver, dihydrotestosterone partially inhibited clioquinol-induced AR suppression and apoptosis only in

42 In an in vivo xenografts mouse model, clioquinol inhibited tumor growth of xenografts over a 6

43 ain deposits in vitro and one such compound, clioquinol, inhibits Abeta deposition in the Tg2576 mous

44 Our results suggest that clioquinol is a candidate therapy for Huntington's disea

45 Clioquinol is a drug that acts on amyloid by perturbing

46 Our study provides strong evidence that clioquinol is able to target tumor proteasome in vivo in

47 Clioquinol is capable of forming stable complexes with c

48 The metal chelator, clioquinol, is reported by Cherny et al. to reduce Abeta

49 The zinc-binding 8-OH-quinoline clioquinol markedly reduced AbetaO synaptic targeting, w

50 dition of dihydrotestosterone did not affect clioquinol-mediated proteasome inhibition in both prosta

51 To test if clioquinol might act as an ionophore, a fluorescent prob

52 effect was rescued with the Zn(2+) chelators clioquinol or TPEN.

53 Most recently, it has been reported that clioquinol possesses antitumor effects.

54 by ferritin transgene or the metal chelator clioquinol prevent oxidative damage and MPTP toxicity in

55 Treatment with clioquinol reduced the viability of eight different huma

56 he reduced heme site, and (3) chelators like clioquinol remove Cu from these aggregates, while drugs

57 heet breaker peptide iAbeta5 or the chelator clioquinol, respectively.

58 The addition of clioquinol resulted in elevated levels of intracellular

59 he Abeta aggregation inhibitors, iAbeta5 and clioquinol, selectively attenuated caspase-3 activation

60 perturbing amyloid's metallo-chemistry, and Clioquinol treatment has been shown to be beneficial in

61 Clioquinol treatment of transgenic Huntington's mice (R6

62 Animal studies show that clioquinol treatment significantly inhibits the growth o

63 Clioquinol was identified as a prototype metal-protein-a

64 Clioquinol was withdrawn because of concerns of its asso

65 Moreover, the Abeta aggregation inhibitor, clioquinol, was able to attenuate isoflurane-induced cas

66 ease was inhibited by in vivo treatment with clioquinol, which suggests that brain Abeta accumulation