ライフサイエンスコーパス: clock

1 NA methylation can be used as an "epigenetic clock".

2 tion of CREBH are regulated by the circadian clock.

3 s to the recently described human epigenetic clock.

4 dating molecular mechanisms of the circadian clock.

5 e >24-h period length of the human circadian clock.

6 turally in a one-dimensional optical lattice clock.

7 edictor of age in mice, the mouse epigenetic clock.

8 etabolic control on the Neurospora circadian clock.

9 ribed role is as components of the circadian clock.

10 htly controlled by cell-autonomous circadian clock.

11 n ZEITLUPE, a key regulator of the circadian clock.

12 er light-dependent delays or advances to the clock.

13 that is normally controlled by the circadian clock.

14 neurons, each of which contains a molecular clock.

15 between sleep homeostasis and the circadian clock.

16 tion, and proteins involved in the circadian clock.

17 l repressors and components of the circadian clock.

18 is difficult because of their reliance on a clock.

19 r transcriptional regulator of the circadian clock.

20 e light schedule, may synchronize peripheral clocks.

21 the environment, courtesy of their circadian clocks.

22 precision timing signals furnished by atomic clocks.

23 and orchestrating synchrony among circadian clocks.

24 nta metabolic adjustments linked to internal clocks.

25 ssil record and estimates based on molecular clocks.

26 h the behavioral processes mediated by these clocks.

27 recision sensors and state-of-the-art atomic clocks.

28 o temperature shifts that entrain peripheral clocks [1-5].

29 hylation changes comprise a so-called aging "clock", a robust biomarker of aging.

30 arch turnover is controlled by the circadian clock acting as a dynamic homeostat responding to sucros

31 ction is also known to reciprocally modulate clock activity.

32 gs provide evidence that the human circadian clock adapts to seasonal changes in the natural light-da

33 ory studies have demonstrated that circadian clocks align physiology and behavior to 24-h environment

34 eatures were not rescued, revealing that the clock also regulates expansion growth more directly.

35 Ectopic clocks also require the blue light photoreceptor CRYPTOC

36 We present phylogenomic and molecular clock analyses, including data from cyanobacterial and c

37 nation of comparative genomics and molecular clock analyses, we show that phototrophic members of the

38 Molecular clock analysis estimated that crown eudicots originated

39 nctional variants in BBS1, BBS9, GNAS, MKKS, CLOCK and ANGPTL6.

40 ulting from cross-talk between the molecular clock and aryl hydrocarbon receptor.

41 ed affinity for circadian activator proteins Clock and Bmal1.

42 th, animal sleep is regulated by an internal clock and by the duration of prior wakefulness.

43 Together, these results establish circadian clock and cell cycle as interdependent coupled oscillato

44 n the molecular events linking the circadian clock and defense.

45 an s-LNv-specific regulator of the molecular clock and essential for the generation of circadian loco

46 for direct DA input to the master circadian clock and highlight the importance of an evolutionarily

47 Thus CRYs link the circadian clock and JAK-STAT signaling through control of STAT5B p

48 Radical clock and kinetic isotope experiments support a mechanis

49 yping(4D) to investigate the contribution of clock and light signaling to the diurnal regulation of r

50 light-dependent maturation of the circadian clock and light-independent refinement of retinogenicula

51 discuss the interplay between the circadian clock and metabolism, the importance of the microbiome,

52 The core clock and most output genes remained robustly rhythmic i

53 elay in meals on markers of the human master clock and multiple peripheral circadian rhythms.

54 plicating distinct elements of the circadian clock and processes involved in neuronal plasticity.

55 nstrated predictive utility as an epigenetic clock and prognostic of age-related morbidity and mortal

56 mportance in the fields of chip-scale atomic clock and quantum information.

57 um Likelihood, genetic divergence, molecular clock and S-DIVA.

58 contain an intracellular molecular circadian clock and the Cryptochromes (CRY1/2), key transcriptiona

59 e impact of desynchrony between the internal clock and the external light-dark (LD) cycle on mammalia

60 nt, synchrony, and amplitude of SCN cellular clocks and organizes circadian behavior [5-16].

61 lar link among the microbiota, the circadian clock, and host metabolism.

62 rincipal neurons with respect to this common clock, and the robustness of this synchronous oscillator

63 pe effects, stereochemical labeling, radical clock, and transient absorption studies support the elec

64 be applied in frequency metrology, precision clocks, and spectroscopy.

65 ssumption of a "universal" mitochondrial DNA clock are not valid.

66 tes for signal transduction to the circadian clock are the PHYTOCHROME INTERACTING FACTOR (PIF) famil

67 istics of circadian alpha-cell and beta-cell clocks are an important feature in the temporal coordina

68 Circadian clocks are autonomous daily timekeeping mechanisms that

69 These cell-autonomous clocks are composed of a transcription-translation-based

70 Thus, circadian clocks are mechano-sensitive, providing a potential mech

71 showed that alpha-cellular and beta-cellular clocks are oscillating with distinct phases in vivo and

72 The genomic targets of circadian clocks are pervasive and are intimately linked to the re

73 Circadian clocks are ubiquitous timing systems that induce rhythms

74 he dynamical structure of the cyanobacterial clock as an oscillator and explored the physiological re

75 le in timing because it has a more accurate "clock" as it integrates information across multiple cort

76 HOCK DOMAIN PROTEIN 3 (MdCSP3) and CIRCADIAN CLOCK ASSOCIATED 1 (MdCCA1) genes.

77 ntaining CAM pathway genes are enriched with clock-associated cis-elements, suggesting circadian regu

78 consensus sequence that we designated as the Clock-Associated Transcriptional Activation Cassette or

79 lants in which the oscillator gene CIRCADIAN CLOCK ASSOCIATED1 (CCA1) was overexpressed under the con

80 ial effects of TRF are mediated by circadian clock, ATP-dependent TCP/TRiC/CCT chaperonin and mitocho

81 CRY repression of CLOCK-BMAL1 and regulation of circadian period are propo

82 Prior to incorporation, CLOCK-BMAL1 exists in an approximately 750-kDa complex.

83 ssembly that quantitatively incorporates its CLOCK-BMAL1 transcription factor target.

84 x PAS domain (bHLH-PAS) transcription factor CLOCK:BMAL1 (brain and muscle Arnt-like protein 1) sits

85 Precise control of CLOCK:BMAL1 activity by coactivators and repressors esta

86 e of this interface for direct regulation of CLOCK:BMAL1 activity by CRY1.

87 he core clock proteins cryptochrome 1 (CRY1):CLOCK:BMAL1, plays an important role controlling the swi

88 ake affects various aspects of the circadian clock, but its effects on immune function are unknown.

89 that UNF interacts with the s-LNv molecular clocks by regulating transcription of the core clock gen

90 tudy provides insight into how the circadian clock can regulate hippocampus-dependent learning by con

91 nstrate how neuropeptides from two groups of clock cells appear to be responsible for the fly's circa

92 alth, deeper knowledge of how our biological clocks change with age may create valuable opportunities

93 The CLOCK (circadian locomotor output cycles protein kaput)

94 regulate the activity of the core circadian clock complex.

95 back loops driven by interacting networks of clock complexes.

96 We investigated whether the core clock component nuclear receptor subfamily 1 group D mem

97 BP as a molecular pathway by which circadian clock components anticipatorily regulate lipogenic respo

98 d Solanas et al. now reveal that, while core clock components remain nearly unaltered, aging is assoc

99 aintain passive membrane properties in a non-clock-containing peripheral tissue independent of light.

100 The circadian clock contributes to the regulation of photosynthesis, a

101 This work shows that clock control of KfPPCK1 prolongs the activity of PPC th

102 regulated posttranslationally by a circadian clock-controlled protein kinase called phosphoenolpyruva

103 ents a novel cis-regulatory element encoding clock-controlled regulation.

104 Clock-controlled timekeeping involves extensive regulati

105 examined to determine if a genomic molecular clock could be calculated.

106 a result of spontaneous symmetry breaking of clock/counterclockwise rotation of self-assembled partic

107 These feedback loops are initiated by CLOCK-CYCLE (CLK-CYC) heterodimers, which activate trans

108 for the core circadian transcription factor CLOCK/CYCLE (CLK/CYC), and CATAC-mediated expression rhy

109 s oxidative stress, and this upregulation is CLOCK-dependent.

110 The circadian clock directs many aspects of metabolism, to separate in

111 phenotypes and individuals with PER3-related clock disorders.

112 mutations at the interface on either CRY1 or CLOCK disrupt formation of the ternary complex, highligh

113 were strongly attenuated upon siRNA-mediated clock disruption in human primary myotubes.

114 Furthermore, dysregulation of CLOCK disrupts coexpressed networks of genes implicated

115 Circadian clocks drive approximately 24 h rhythms in tissue physio

116 Circadian clocks drive rhythmic physiology and metabolism to optim

117 ICANCE STATEMENT The intracellular molecular clock drives changes in SCN neuronal excitability, but i

118 The molecular clock drives circadian changes in the membrane propertie

119 es on a genetic oscillator (the segmentation clock) driving the rhythmic activity of signaling pathwa

120 pate pollen fossils and most other molecular clock estimates, and Pentapetalae sequentially diverged

121 Molecular clock estimation, together with analysis of their enviro

122 Y1 and CRY2 bind independently of other core clock factors to many genomic sites, which are enriched

123 oducts which are controlled by the circadian clock feedback to affect the circadian oscillator that g

124 Both neurons from Emx-Cre; Clock(flox/flox) mouse and human epileptogenic tissue ex

125 owever, excitatory neurons from the Emx-Cre; Clock(flox/flox) mouse have spontaneous epileptiform dis

126 The Emx-Cre; Clock(flox/flox) mouse line alone has decreased seizure

127 nce supports the importance of the circadian clock for plant health.

128 on upon re-oxygenation may act to 'reset the clock' for the rapid molecular changes and cell division

129 clock function, whether vri is required for clock function and/or output is not known.

130 In larval salivary glands, which lack clock function but are amenable to electrophysiological

131 mponents were proposed as modulators of core clock function in mammals (Per) and fungi (frq/qrf).

132 at DNA replication is required for circadian clock function in Neurospora.

133 h is required for both light entrainment and clock function in peripheral tissues.

134 Genetic ablation of circadian clock function or environmental CRD in mice increased su

135 disrupt activity rhythms without eliminating clock function, whether vri is required for clock functi

136 , play only minor roles in the regulation of clock function.

137 ffect of a heat stimulus (39.5 degrees C) on clock gene (Per1 and Bmal1) expression in cultured murin

138 Ablating the essential clock gene Bmal1 specifically in SCN astrocytes lengthen

139 inant coding variation in the core circadian clock gene CRY1, which creates a transcriptional inhibit

140 A clock gene expressed in skeletal muscle plays a bigger r

141 lts imply a high degree of causality between clock gene expression and one of the planet's largest da

142 BaP-induced Cyp1A1 and Cyp1B1 and molecular clock gene expression in mouse mammary glands.

143 strocytes lengthened the circadian period of clock gene expression in the SCN and in locomotor behavi

144 cumulation were in phase coherence with core clock gene expression in vivo and in vitro.

145 onin and cortisol), plasma triglycerides, or clock gene expression in whole blood.

146 ayed the daily, dorsal-ventral phase wave in clock gene expression typical of the adult SCN.

147 149* and intronic miRNA-6883-5p encoding the clock gene PER1 in colorectal cancer patient samples.

148 ocks by regulating transcription of the core clock gene period (per).

149 In an unbiased search of core clock gene promoters from 12 species of Drosophila, we d

150 Genotype data for the selected 23 CLOCK gene SNPS was obtained by imputation with IMPUTE2

151 The effect of PDF on clock gene transcription and the known role of PDF in en

152 of DVM, metabolism, and most core circadian clock genes (clock, period1, period2, timeless, cryptoch

153 ues - the rapid induction of these circadian clock genes drives the resetting process.

154 Arabidopsis (Arabidopsis thaliana) circadian clock genes EARLY FLOWERING3 (ELF3), ELF4, and LUX ARRHY

155 Further, peak expressions of clock genes generally occurred at either sunset or sunri

156 metabolic circadian rhythms and adipose core clock genes in mice and characterization of 24-h circula

157 the muscle followed the patterns of internal clock genes in this tissue, and coincided with enhanced

158 Specifically, there is downregulation of clock genes including Ciart, Per2, Npas4, Dbp, and Rorb

159 ed by changes in expression of the canonical clock genes Period1 and Period2 (Per1 and Per2), as well

160 that DA-induced expression of core circadian clock genes Period1 and Period2 accompanied both phase a

161 obiota regulates the expression of circadian-clock genes to impact host lipid metabolism and body com

162 its phase angle with the expression of core clock genes, Clock1 and Per1, are preserved in constant

163 A circadian clock governs most aspects of mammalian behavior.

164 latory mechanism through which the circadian clock governs skeletal muscle bioenergetics.

165 However, their photosensitive circadian clock had to adapt to extreme seasonal photoperiods duri

166 Strontium optical lattice clocks have the potential to simultaneously interrogate

167 Eating at a later clock hour is a newly described risk factor for adverse

168 between lean and nonlean individuals in the clock hour of food consumption (P = 0.72).

169 al controls, including mean number of limbal clock hours affected by OSSN (6 vs 4; P = .12), mean tum

170 Corneoscleral limbal dissection of >/=6 clock hours during wide excision of OSSN can cause LSCD.

171 Superior and inferior temporal clock hours had the largest differences.

172 (13 mm vs 8 mm; P = .11), and mean number of clock hours of corneoscleral limbal dissection owing to

173 n equilibrium, compliance with the molecular-clock hypothesis, or stability of the phenotypic profile

174 mmunoprecipitation sequencing for endogenous CLOCK in adult neocortices and RNA sequencing following

175 main gene BBX32 We showed that the circadian clock in Arabidopsis regulates BBX32 and expressed in th

176 stigated this novel transcriptional role for CLOCK in human neurons by performing chromatin immunopre

177 y highlights the importance of the circadian clock in maintaining vascular homeostasis and demonstrat

178 in that ultimately feeds the local circadian clock in mouse melanocytes and melanoma cells.

179 ate a potential involvement of the circadian clock in rapid antidepressant responses.

180 first time the involvement of the circadian clock in the host response following Giardia infection.

181 that expression of the transcription factor CLOCK in the human cortex might be relevant to human cog

182 der lighting conditions in which the central clock in the SCN is dampened, peripheral oscillators in

183 abolic cues, can also phase shift the master clock in the suprachiasmatic nuclei (SCNs) and/or reduce

184 the sleeping period phase shifts the master clock in the suprachiasmatic nuclei and/or slows down th

185 lation of its ticking rate and resetting the clock in vivo to study the impact on biological age.

186 been used to discern the functions of these clocks in humans outside of controlled settings.

187 g as a dominant agent that affects circadian clocks in metabolic organs.

188 atic genetic re-programming of intracellular clocks in SCN astrocytes was capable of remodeling circa

189 ay by which UNF interacts with the molecular clocks in the s-LNvs and highlight the mechanistic diffe

190 there is very little information on how the clock influences the performance of crop plants.

191 n circadian clock mutants suggested that the clock influences the timing of onset of degradation.

192 nscription factor of the molecular circadian clock influencing diverse metabolic pathways, including

193 y available datasets, we find that the mouse clock is accurate enough to measure effects on biologica

194 In Drosophila, the circadian clock is comprised of transcriptional feedback loops tha

195 Moreover, the mammary clock is controlled by the periductal extracellular matr

196 put to the suprachiasmatic nucleus circadian clock is critical for animals to adapt their physiology

197 system has been studied extensively, how the clock is driven thermodynamically has remained elusive.

198 The Drosophila circadian clock is extremely sensitive to light.

199 Circadian clock is known to adapt to environmental changes and can

200 The master circadian clock is located in the suprachiasmatic nuclei (SCN) of

201 Here, we reveal that the breast epithelial clock is regulated by the mechano-chemical stiffness of

202 The circadian clock is the endogenous timekeeper critical for multiple

203 also not been shown whether this epigenetic clock is unique to humans or conserved in the more exper

204 of Circadian Locomotor Output Cycles Kaput (CLOCK) is decreased in epileptogenic tissue.

205 N)-often referred to as the master circadian clock-is essential in generating physiologic rhythms and

206 ult neocortices and RNA sequencing following CLOCK knockdown in differentiated human neurons in vitro

207 igration, and a functional assay showed that CLOCK knockdown increased neuronal migratory distance.

208 of subjective hunger and sleepiness, master clock markers (plasma melatonin and cortisol), plasma tr

209 ulation of RGCs which regulate the circadian clock, masking behavior, melatonin suppression, the pupi

210 This misalignment of central and peripheral clocks may be involved in the development of disease and

211 (p < 0.01), indicating that human molecular clocks may be regulated by feeding time and could underp

212 of GPS satellites, extraordinarily accurate clocks measuring the difference between local time and a

213 mood by utilizing a comprehensive circadian clock model that accurately predicts the changes in circ

214 Circadian clocks must be able to entrain to time-varying signals t

215 Mouse models of clock mutants recapitulate these deficits, implicating m

216 Starch measurements in circadian clock mutants suggested that the clock influences the ti

217 Diurnal responses were modified in clock mutants.

218 cemaker of the locomotor rhythms, from other clock neuron subtypes.

219 4 (HDAC4), a SIK3 phosphorylation target, in clock neurons and that constitutive HDAC4 localization i

220 The mechanisms by which clock neurons in the Drosophila brain confer an approxim

221 ing circuits and show that both contact DN1p clock neurons, the output of which is also required for

222 Two distinct clusters of clock neurons-morning oscillators (M cells) and evening

223 Circadian clocks normally operate in approximately 150 brain pacem

224 The principal pacemaker of the circadian clock of the cyanobacterium S. elongatus is a protein ph

225 The master circadian clock of the suprachiasmatic nucleus synchronizes to lig

226 ing understanding of the impact of circadian clocks on mammalian transcription has sparked interest i

227 cycles relative to the endogenous circadian clock, on specific performance metrics in Major League B

228 Whether parasites have intrinsic molecular clocks or whether they simply respond to host rhythmic p

229 evidence suggests that the retinal circadian clock, or its output signals (e.g., dopamine and melaton

230 related genes, indicating that the circadian clock oscillators have been reset, was independent of it

231 onstrate that vri acts as a key regulator of clock output and suggest that the primary function of th

232 lower levels than AaCCA1, which could alter clock output traits.

233 cete Neurospora crassa affects the circadian clock output, yielding a pattern of asexual conidiation

234 le concept for encoding two bits of data per clock period opens exciting opportunities for data-carry

235 bolism, and most core circadian clock genes (clock, period1, period2, timeless, cryptochrome2, and cl

236 Circadian clocks play an important role in lipid homeostasis, with

237 r direction away from the inferior angle 6 o'clock position.

238 results therefore show that basic circadian clock properties are governed by dynamic interactions am

239 echanism is mediated not via cell-autonomous clock properties, but rather through altered networking

240 system stems from robust degradation of the clock protein PERIOD.

241 of a repressive complex, defined by the core clock proteins cryptochrome 1 (CRY1):CLOCK:BMAL1, plays

242 post-translational modification of molecular clock proteins influence the temporal expression of SCN

243 The circadian clock provides a mechanism for plants to anticipate even

244 -time simply by setting the amplitude of the clock pulse applied to the gate.

245 Without the SCN, these peripheral clocks rapidly become desynchronized.

246 e concept of frequency combs13-15 to optical clock rates, we show how the polarization and carrier-en

247 addition to direct retinal projections, the clock receives input from the visual thalamus, although

248 , although genetic deficits in the molecular clock regularly render mice with altered mood-associated

249 These data suggested that CLOCK regulates the expression of genes involved in neur

250 changing the neuronal expression of two key clock-related components.

251 Polymorphisms in a circadian clock-related gene, PER3, are associated with behavioral

252 ut pathway evoked larger shifts in molecular clock rhythms in Fbxl3(Afh/Afh) compared with Fbxl3(+/+)

253 lation, CAM productivity, and core circadian clock robustness.

254 s do not appear to possess a time-difference clock sense [2].

255 he hypothesis proposed is that an epigenetic clock serves to maintain the period of molecular rhythms

256 nfluences of light, metabolic, and circadian clock signaling on rates of cellulose biosynthesis and c

257 udy was to evaluate the associations between CLOCK single nucleotide polymorphisms (SNPs) and body ma

258 found a significant association between the CLOCK SNP rs2070062 and sleep duration, participants car

259 Here we show by means of core-hole clock spectroscopy that SnS2 exhibits spin-dependent att

260 We use clock spectroscopy to prepare lattice band populations,

261 rology, the qubit coherence time defines the clock stability, from which the spectral linewidth and f

262 nteractions have forced a compromise between clock stability, which benefits from a large number of a

263 e exceptionally long lifetime of the excited clock state (160 seconds) eliminates decoherence and ato

264 cilis, serving as an indicator of biological clock status, photosynthetic and respiratory capacity, c

265 ides the thermodynamic driving force for the clock, switching KaiC between an active conformational s

266 ight-Oxygen-Voltage(LOV) domain in circadian clock system.

267 Circadian clock systems help establish the correct daily phasing o

268 e that parasites have an intrinsic circadian clock that is independent of the host, and which regulat

269 ity are controlled by an intrinsic circadian clock that promotes approximately 24 hr rhythms in many

270 ility of key components of the intracellular clock, the cryptochrome proteins, unexpectedly increases

271 eurons constitute only one "half" of the SCN clock, the one metabolically active during circadian day

272 sory input to the master mammalian circadian clock, the suprachiasmatic nucleus (SCN), is vital in al

273 eletal muscle is controlled by the circadian clock, these results delineate an epigenomic regulatory

274 ehaviour, as well as coordinating peripheral clocks throughout the body.

275 advances and phase delays of the RPE-choroid clock, thus suggesting that - as in other tissues - the

276 SnapShot, we describe the basics of how the clock ticks.

277 s a strong modulator of the neural circadian clock, time of food intake is emerging as a dominant age

278 hting has caused the near-24-hour biological clock to be set to a later time and that humans physiolo

279 , the picture of space-time assigns an ideal clock to each world line.

280 a brain cooperate with the central circadian clock to help regulate body temperature.

281 re photoreceptors that entrain an organism's clock to its environment, whereas Type II (including mam

282 a linear peptidergic circuit that links the clock to motor outputs to modulate circadian control of

283 oice, participants adjusted the setting of a clock to the moment they felt they had reached a decisio

284 Most organisms use internal biological clocks to match behavioural and physiological processes

285 oundwork for using fermionic optical lattice clocks to probe new phases of matter.

286 Genome-wide analyses of the clock transcriptional feedback loop have revealed a glob

287 y limited by the flat slope of the so-called clock transition.

288 ting single nuclear spins, exploiting atomic clock transitions for robust qubits and, most recently,

289 signaling, photosynthesis, and the circadian clock under both dark and light conditions.

290 the differential regulation of the molecular clocks underlies the functional differences among the pa

291 in protein catabolism as one major source of clock variation in humans.

292 sion is regulated by CR and by the circadian clock, we found that rhythms in Igf-1 expression have se

293 y pregnancy are uncoupled from the circadian clock, whereas in late pregnancy, energy availability is

294 mplies gravitational interaction between the clocks, whereas the quantum mechanical superposition of

295 of human activities are marked by circadian clocks which in turn are entrained to different environm

296 mals are governed by an endogenous circadian clock, which is dependent on transcriptional regulation.

297 siology and behaviour generated by molecular clocks, which serve to coordinate internal time with the

298 iasmatic nuclei (SCN), the circadian "master clock," which is DNA methylated in region-specific manne

299 This clock will be instrumental for understanding the biology

300 o synchronize the SCN's endogenous circadian clock with local time and drive the diurnal variations i