ライフサイエンスコーパス: clock gene

1 by a family of transcription factors called "clock genes".

2 nd regulates the promoter activity of a core clock gene.

3 king the circadian transcriptional activator clock gene.

4 regulating both the morning and the evening clock genes.

5 markers, they exhibit robust oscillations of clock genes.

6 ely disrupts transcriptional rhythms of core clock genes.

7 echanism of cytokine-regulated expression of clock genes.

8 positive genetic feedback loops composed of clock genes.

9 he additional absence of canonical circadian clock genes.

10 l as in the mRNA levels of several canonical clock genes.

11 e that eam5 disrupts circadian expression of clock genes.

12 ations, which could trigger transcription of clock genes.

13 ing on posttranscriptional regulation of key clock genes.

14 was in approximate antiphase with the other clock genes.

15 GABA circuit maturation, BDNF, and circadian Clock genes.

16 NA splicing of light signaling and circadian clock genes.

17 not affect the expression of core circadian clock genes.

18 ntal inputs and the direct regulation of key clock genes.

19 ession levels of only a small number of core clock genes.

20 teraction between JH signaling and circadian clock genes acting independently of the daily cycle.

21 mponents, a chromatin-dependent mechanism of clock gene activation appears to be common to both plant

22 released from the gut after a meal can reset clock gene activity in the liver.

23 Circadian rhythms controlled by clock genes affect plasma lipids.

24 n the transcript abundance of core circadian clock genes also became arrhythmic in the rNAD-ME1 line,

25 es the expression of Rev-erb alpha-regulated Clock gene and circadian function in mouse hepatoma cell

26 clusion that Bmal1 is a singularly essential clock gene and that Bmal2 has a minimal role in the cloc

27 are circadian clock networks comprising core clock genes and an ever-expanding list of clock-controll

28 The expression levels of clock genes and Aqp5 showed regular oscillatory patterns

29 articular, GEMIN2 controls the AS of several clock genes and attenuates the effects of temperature on

30 C57BL6J mice upon rhythmic transcription of clock genes and diurnal variation in vascular and metabo

31 s revealed extensive alternative splicing in clock genes and dynamic changes in alternatively spliced

32 m rhythmically expresses molecular circadian clock genes and genes controlling serotonin biosynthesis

33 h attenuation of rhythmic expression of core clock genes and impaired phase resetting of circadian cl

34 Chrono KO also alters the expression of core clock genes and impairs the response of the circadian cl

35 conclude that astrocytes depend on circadian clock genes and IP(3) signaling to express daily rhythms

36 d inhibition of high amplitude expression of clock genes and modulates the TNF-induced cytokine respo

37 of FBXW7 alters circadian expression of core clock genes and perturbs whole-body lipid and glucose le

38 been difficult to dissect because identified clock genes and proteins are not conserved across the do

39 human HFs and epidermal melanocytes express clock genes and proteins, and given that core clock gene

40 xpression phase and reduced the amplitude of clock genes and repressed the floral integrator gene FLO

41 xplained by phase differences in oscillating clock genes and suggest that variation in the molecular

42 isms in homologs of evolutionarily conserved clock genes and the timing of behavioral rhythms measure

43 mine whether gastric vagal afferents express clock genes and whether their response to mechanical sti

44 The rhythms in the expression of circadian clock genes are affected by calorie restriction (CR), a

45 ed changes in the rhythmic expression of SCN clock genes are believed to be a critical step in this p

46 ght and feeding-time cues to test which core clock genes are controlled by CREM/ICER in the liver and

47 ions in homologs of evolutionarily conserved clock genes are found in select pedigrees with extreme s

48 We find that circadian clock genes are preferentially retained relative to comp

49 Clock genes are transcriptional regulators engaged in th

50 ed in control of phototropic growth, but not clock genes, are differentially expressed on the opposit

51 ate biological systems such as the GRIK2 and CLOCK genes, as well as the extracellular signal-related

52 Genetic ablation of the clock gene Bmal1 (also called Arntl or MOP3) in bronchio

53 rrying a conditional allele of the circadian clock gene Bmal1 and expressing Cre recombinase under th

54 Whole-body knockout of the circadian clock gene Bmal1 in mice affects several aspects of slee

55 NA to knock down expression of the essential clock gene Bmal1 into the brain's master circadian pacem

56 Ablating the essential clock gene Bmal1 specifically in SCN astrocytes lengthen

57 smoke (CS) modulates expression of the core clock gene BMAL1, through Sirtuin1 (SIRT1) deacetylase d

58 for assessment of rhythmic expression of the clock genes BMAL1 and PER2, and by estimation of salivar

59 top-ranked rhythmic genes were the canonical clock genes BMAL1(ARNTL), PER1-2-3, NR1D1(REV-ERBa), DBP

60 ne system) by conditional targeting of a key clock gene (bmal1) removed all temporal gating of endoto

61 d protein expression and localization of key clock genes (Bmal1, Clock, Per1, and Per2), ion and aqua

62 Deletion of the core clock gene, Bmal1, ablates circadian rhythms and acceler

63 The central circadian clock genes, BMAL1/CLOCK (NPAS2), bind to Enhancer Boxes

64 Here we report that disruption of the clock gene, brain and muscle Arnt-like 1 (Bmal1), in mic

65 ted to the ROR response element sites of the clock genes, brain and muscle Arnt-like protein 1 (Bmal1

66 epithalamic medial habenula (MHb) expresses clock genes, but little is known about the bioelectric p

67 Period-altering mutations in clock genes can affect any of multiple regulated steps i

68 Plants that constitutively overexpress the clock gene CCA1 showed phase shifts in peak translation,

69 hat binds in vivo to the promoter of the key clock gene circadian clock-associated 1 (CCA1) and regul

70 and PRR9 can bind the promoters of the core clock genes circadian clock associated 1 (CCA1) and late

71 , and we measured the rhythmic expression of clock genes, circadian rhythms of locomotor activity, lu

72 The clock gene circuit in plants comprises interlocking tran

73 The circadian clock genes Clock (Clk) and cycle (cyc) are critical for

74 In this study, we examine expression of the clock genes Clock, Bmal, Per1, Per2, Cry1, and Cry2 in C

75 s in the gene and protein expression of core clock genes (CLOCK, BMAL1, and Period1) and clock-contro

76 the cornea, and the expression of main core clock genes (Clock, Bmal1, Per2, Cry1, and Rev-erbalpha)

77 of DVM, metabolism, and most core circadian clock genes (clock, period1, period2, timeless, cryptoch

78 eported a latitudinal cline in the circadian clock gene, Clock, which influences rhythms in both phys

79 its phase angle with the expression of core clock genes, Clock1 and Per1, are preserved in constant

80 Mice with a mutation in the Clock gene (ClockDelta19) exhibit increased preference f

81 d that mice with a mutation in the circadian Clock gene (ClockDelta19) exhibit rapid mood-cycling, wi

82 Mice with a mutation in the Clock gene (ClockDelta19) have been identified as a mode

83 ers experiencing a deregulation of circadian clock genes compared to a control group.

84 Mutants defective in specific clock gene components were resistant to the change in pe

85 Here, we show that circadian clock genes control the onset of critical period plastic

86 therefore developed FLYGLOW, an assay using clock gene controlled luciferase expression detected by

87 inant coding variation in the core circadian clock gene CRY1, which creates a transcriptional inhibit

88 mRNA oscillations of the central clock genes cryptochrome-m and period were delayed by 4.

89 aluated in flies with a null mutation in the clock genes cycle and period.

90 in response to light, we imaged period (per) clock gene cycling for up to 6 days at single-neuron res

91 Because the expression of circadian clock genes differs in male and female mice infected wit

92 In order to further accelerate clock gene discovery, we utilized a computer-assisted ap

93 Across tissues, clock gene disruption was associated with local inflamma

94 ues - the rapid induction of these circadian clock genes drives the resetting process.

95 Arabidopsis (Arabidopsis thaliana) circadian clock genes EARLY FLOWERING3 (ELF3), ELF4, and LUX ARRHY

96 lticellular model that allows the effects of clock genes, electrical firing, Ca(2+), GABA, and VIP on

97 re all these regulatory interactions between clock genes equally crucial for the establishment and ma

98 e focus here is on three groups of circadian clock genes essential to clock function in Arabidopsis t

99 2 000 transcripts and observed that the core clock genes, essential for controlling virtually all rhy

100 nd regulates transcription of core circadian clock genes even in the absence of pathogen challenge.

101 suggest deregulated expressions of circadian clock genes exist in GC and circadian rhythm disturbance

102 A clock gene expressed in skeletal muscle plays a bigger r

103 ponents and positively affects expression of clock genes expressed at dawn.

104 These changes are likely controlled by clock genes expressed in the intestine that are probably

105 of serum cortisol, melatonin, and peripheral clock gene expression (Bmal1, Per2, and Rev-Erbalpha).

106 Clock gene expression analysis shows that the underlying

107 Because astrocytes have persistent circadian clock gene expression and ATP release in vitro [5-8], we

108 so termed mat-a, are severely compromised in clock gene expression and clock outputs.

109 kedly impaired central and hepatic circadian clock gene expression and do not gain weight compared to

110 this cell type displays circadian rhythms in clock gene expression and extracellular accumulation of

111 nerate independent circadian oscillations of clock gene expression and neuronal firing.

112 lts imply a high degree of causality between clock gene expression and one of the planet's largest da

113 osure (100-300 mg/m(3) particulates) altered clock gene expression and reduced locomotor activity by

114 ned with IAV infection altered the timing of clock gene expression and reduced locomotor activity in

115 We found robust rhythms of clock gene expression as well as, after stimulation, IL-

116 dian rhythms of immune function, we analyzed clock gene expression by qPCR in unstimulated CD4+ T cel

117 to a daily temporal program that depends on clock gene expression cycles in most mammalian cell type

118 s, there may be a circadian dysregulation in clock gene expression in a subgroup of MDDs.

119 the neuronal dual oscillator model in which clock gene expression in key cells generates the circadi

120 Consistent with disturbed hepatic clock gene expression in MLL4 mutant mice, we found that

121 BaP-induced Cyp1A1 and Cyp1B1 and molecular clock gene expression in mouse mammary glands.

122 o this molecule, SCN astrocytes can modulate clock gene expression in other cells and tissues, and in

123 We developed an imaging system to monitor clock gene expression in shoots and light- or dark-grown

124 suggest the possibility that attenuation of clock gene expression in some brain regions (the hippoca

125 arkedly to functionally important changes in clock gene expression in temperature transitions by prod

126 behaviour and the circadian pattern of core clock gene expression in the hypothalami of mice.

127 ng infection, we measured diurnal rhythms of clock gene expression in the lung, locomotor activity, p

128 strocytes lengthened the circadian period of clock gene expression in the SCN and in locomotor behavi

129 cumulation were in phase coherence with core clock gene expression in vivo and in vitro.

130 onin and cortisol), plasma triglycerides, or clock gene expression in whole blood.

131 er they persist during acute illnesses where clock gene expression is disrupted by systemic inflammat

132 s and clear-painted antennae, while rhythmic clock gene expression is disrupted in black-painted ante

133 Rhythmic activation and repression of clock gene expression is essential for the eukaryotic ci

134 Rhythms of clock gene expression occur in brain regions that are ou

135 triction and blood pressure and suggest that clock gene expression outside of the SCN should be furth

136 Dysregulation of clock gene expression results in diverse human pathologi

137 or axis, which results in traveling waves of clock gene expression sweeping in the unsegmented tissue

138 ayed the daily, dorsal-ventral phase wave in clock gene expression typical of the adult SCN.

139 CR-dependent effects on some clock gene expression were impaired in the liver of mice

140 F) mice display altered daily oscillation of clock gene expression with a concomitant change in the e

141 ake is coordinated to cellular metabolism by clock gene expression with a master clock in the suprach

142 ydrogen sulfide, directly modulate circadian clock gene expression within hepatocytes.

143 various circadian output rhythms and central clock gene expression, demonstrating that the cka1a2a3 t

144 causes core oscillator failure by perturbing clock gene expression, rescuing oscillator function does

145 a certain degree of redundancy in regulating clock gene expression.

146 al Wnt3a gradient into a temporal pattern of clock gene expression.

147 program and synergizes with Notch to trigger clock gene expression.

148 show for the first time altered waveforms of clock gene expressions in all tissues in parallel with b

149 transcription-translation feedback loops of clock genes for rhythm generation.

150 k of coupled circadian oscillators where the clock genes form a major hub.

151 lation of codons in the Neurospora circadian clock gene frequency (frq).

152 ting the Bmal1 (also known as Arntl or Mop3) clock gene from histaminergic cells removes this variati

153 In obesity, clock gene function and physiological rhythms were prese

154 hese results demonstrate that disruptions of Clock gene function are sufficient to promote alteration

155 ene expression caused by the perturbation of clock gene function can have large effects on the growth

156 bral redox homeostasis and connects impaired clock gene function to neurodegeneration.

157 and peripheral circadian rhythms, circadian clock gene function, and sleep in maintaining brain home

158 ck, indicative of a reactivation of abnormal clock gene function.

159 Further, peak expressions of clock genes generally occurred at either sunset or sunri

160 old response to temperature in the circadian clock gene GIGANTEA-5 (GI5), suggesting that this gene h

161 Although several clock genes have been extensively characterized, a funda

162 examines the roles that alleles of circadian clock genes have played in domestication and improvement

163 can impact mood by noncircadian mechanisms; clock genes have pleiotropic, clock-independent function

164 eractions between SN and two other circadian clock genes, HIGH RESPONSE TO PHOTOPERIOD (HR) and DIE N

165 ) mouse lines with targeted deletions of the Clock gene in excitatory and parvalbumin (PV)-expressing

166 ing one of the first field investigations of clock genes in a marine species [5, 7], this study coupl

167 ings establish a role for the core circadian clock genes in AML.

168 ession and alternative splicing of some core clock genes in Arabidopsis lsm5 mutants, the precise mol

169 ith controls, the expression patterns of the clock genes in brain were significantly dysregulated.

170 cts the alternative splicing (AS) of several clock genes in fungi, plants, and flies, but the splicin

171 However, the expression of circadian clock genes in GC remains unexplored.

172 ny clear loss of rhythm in the expression of clock genes in ICCV 96029 grown under continuous light,

173 e and SD may act, in part, to reset abnormal clock genes in MDD to restore and stabilize circadian rh

174 metabolic circadian rhythms and adipose core clock genes in mice and characterization of 24-h circula

175 d the rhythms in the expression of circadian clock genes in mice on the mRNA and protein levels, sugg

176 Genetic disruption of clock genes in mice perturbs metabolic functions of spec

177 te metabolic rhythms and adipose tissue core clock genes in mice.

178 o evaluate the expression and periodicity of clock genes in salivary glands.

179 ion of both drought responsive and circadian clock genes in soybean.

180 ION/PSEUDO RESPONSE REGULATOR family of core-clock genes in the afternoon and early night.

181 ed or abolished rhythms in the expression of clock genes in the central clock, liver, thymus, and per

182 lvement and contribution of these peripheral clock genes in the circadian rhythm of blood pressure re

183 summarizes current knowledge of the roles of clock genes in the formation and maintenance of oral tis

184 Most of the central circadian clock genes in the mouse exist as paralog pairs (Per1 an

185 p75(NTR) alters the circadian oscillation of clock genes in the SCN, liver, and fibroblasts.

186 nding decidual cells, but the involvement of clock genes in this process is incompletely understood.

187 the muscle followed the patterns of internal clock genes in this tissue, and coincided with enhanced

188 tional loops in the expression of a panel of clock genes in various brain and peripheral sites.

189 sequencing, we found minimal effects on core clock genes in Zfhx3(Sci/+) SCN, whereas the expression

190 Specifically, there is downregulation of clock genes including Ciart, Per2, Npas4, Dbp, and Rorb

191 ld inducible RNA-binding proteins), and core clock genes including CLOCK and ARNTL (BMAL1).

192 k, controls circadian oscillation of several clock genes, including Bmal1 Rev-erb alpha protein degra

193 Rhythmic expression of other clock genes, including LHY, GIGANTEA (GI), and TIMING OF

194 Clock genes involved in this response were identified by

195 The preferential retention of clock genes is consistent with the gene dosage hypothesi

196 s, it is unclear whether our current list of clock genes is exhaustive.

197 The rhythmic expression of core clock genes is regulated at the transcriptional level, a

198 Transcription of clock genes is sensitive to metabolic changes in reducti

199 ranscripts with altered expression following CLOCK gene knockdown.

200 common rodent models of arrhythmia caused by clock gene knockouts or surgical ablation of the suprach

201 anges, notably those affecting the circadian clock genes late elongated hypocotyl (LHY) and pseudo re

202 nd immunohistochemistry to estimate striatal clock gene levels and found that PER2 expression in the

203 These rhythms are modulated by the clock gene machinery and its products.

204 dramatically effective suggests that altered clock gene machinery may represent a core pathophysiolog

205 ng recovery night sleep reactivates abnormal clock gene machinery, and that supplemental chronotherap

206 It is hypothesized that SDT resets abnormal clock gene machinery, that relapse of depressive symptom

207 ral role in determining how mutations of the Clock gene manifest themselves in the behaviour of diffe

208 a marine species [5, 7], this study couples clock gene measurements with laboratory and field data o

209 This provides evidence that peripheral core clock genes modulate human HF cycling and are an integra

210 ot to circadian phase, and also that two key clock genes monitored in reindeer fibroblast cells displ

211 with mutations in other essential circadian clock genes, mPeriod and Bmal1.

212 A small number of core clock gene mRNAs and a much larger number of output mRNA

213 Clock gene mRNAs and clock proteins were found different

214 The same comparison for core clock gene mRNAs gives rise to a qualitatively similar c

215 In this study, we assessed whether Per2 clock gene-mutant mice exhibit a vascular phenotype simi

216 nes TNF and TGFbeta impair the expression of clock genes, namely the period genes and the proline- an

217 t of CD34(+) cells revealed Per2 as the only clock gene necessary to maintain the undifferentiated st

218 egulation involves interactions of D4Rs, the clock gene Npas2, and the clock-controlled gene adenylyl

219 ight/dark manipulations, global mutations of clock genes, or brain area lesions.

220 rcadian cycle we show that the expression of clock genes oscillates with a 24-h period.

221 sing human macrophages, which show circadian clock gene oscillations and rhythmic endotoxin responses

222 monstrate a developmental role for circadian clock genes outside the suprachiasmatic nucleus, which m

223 Here we demonstrate that the circadian clock gene P. hybrida LATE ELONGATED HYPOCOTYL (LHY; PhL

224 149* and intronic miRNA-6883-5p encoding the clock gene PER1 in colorectal cancer patient samples.

225 nscription rhythms via induction of the core clock genes Per1 and 2.

226 ffect of a heat stimulus (39.5 degrees C) on clock gene (Per1 and Bmal1) expression in cultured murin

227 lock genes and proteins, and given that core clock genes (PER1, BMAL1) modulate human HF cycling, we

228 , the expression profiles of eight circadian clock genes (PER1, PER2, PER3, CRY1, CRY2, CKI, CLOCK, a

229 ulted in fine-tuning of all measured adrenal clock genes (Per1/2/3, Cry1/2, Bmal1, and Rev-erbalpha),

230 hift-lag altered the circadian expression of clock genes, Per2 and Bmal1, and cytolytic factors, perf

231 -42a, which is related to the core circadian clock gene PERIOD (PER), results in arrhythmic molts and

232 ocks by regulating transcription of the core clock gene period (per).

233 Using spatially restricted expression of the clock gene period, we show that dorsally located clock n

234 CN neurons, auto-regulatory feedback on core clock genes Period (Per) and Cryptochrome (Cry) followin

235 xpression of the photoinducible and rhythmic clock genes Period 1 and 2 (Per1 and Per2) in the SCN re

236 tennae and brain of T. saltator and show the clock genes period and cryptochrome 2 are rhythmically e

237 ption of all three paralogs of the canonical clock gene, Period, revealed unique and convergent findi

238 ed by changes in expression of the canonical clock genes Period1 and Period2 (Per1 and Per2), as well

239 that DA-induced expression of core circadian clock genes Period1 and Period2 accompanied both phase a

240 The circadian clock gene Period2 (PER2) has been suggested to be a tum

241 hin the dorsal striatum, the daily rhythm of clock gene period2 expression was markedly suppressed in

242 dentified two rare variants in the circadian clock gene PERIOD3 (PER3-P415A/H417R) in humans with fam

243 challenged by the discovery that each of the clock genes present in the SCN is also expressed and fun

244 n to possess a small number of non-redundant clock genes, presents an attractive alternative target f

245 oxetine treatment across 7 days on circadian clock gene product expression across numerous brain regi

246 dback loops, whereby rhythmic expression of 'clock' gene products regulates the expression of associa

247 In an unbiased search of core clock gene promoters from 12 species of Drosophila, we d

248 ation of transcription from E-box-containing clock gene promoters within key pacemaker neurons.

249 verely compromises the oscillation of "core" clock gene promoters, including Bmal1, mCry1, mPer2, and

250 Clock gene protein expression in the brain was measured

251 ect of aging on the daily oscillation of two clock gene proteins (CLOCK, BMAL1) in the mouse brain.

252 ck loop (TTFL) made up of the so-called core clock genes/proteins.

253 associated with the regulation of circadian clock genes, providing the first cis-regulatory link bet

254 This revealed direct effects on the morning clock gene PRR9, and we determined association of ELF3 t

255 m, we show that transient knockdown of known clock genes recapitulates the same circadian phenotypes

256 The Clock gene regulates diurnal plasma triglyceride fluctua

257 Our analysis of cellular circadian clock gene reporters further differentiated between the

258 Mice lacking the clock gene repressors period circadian clock 1 (Per1) an

259 ss autonomous clocks, and that disruption of clock genes results in metabolic dysregulation have reve

260 Global deletion of Bmal1, a core clock gene, results in beta-cell dysfunction and diabete

261 lesterol-activated nuclear receptor and core clock gene retinoic acid-related orphan receptor alpha (

262 lon circadian 24-hour expression patterns of clock genes Rev-erbalpha and Bmal1 best discriminated th

263 sues and suggest that cellular disruption of clock gene rhythmicity may occur by mechanisms shared wi

264 Retinal inputs appear normal in mutants, and clock gene rhythms within the suprachiasmatic nucleus (S

265 ell lines with defined knockout mutations in clock genes, RNA-seq, ChIP-seq, and reporter gene assays

266 Genotype data for the selected 23 CLOCK gene SNPS was obtained by imputation with IMPUTE2

267 Most of the clock genes studied (Clock, Bmal1, and Per2) displayed a

268 The liver expression of some circadian clock genes such as Bmal1 and three Periods (Per1, Per2

269 ce, is E-box dependent, and is in phase with clock genes, such as Per1 and Per2.

270 transcript abundance of many core circadian clock genes, suggesting that perturbing the only known l

271 EARLY FLOWERING3 (ELF3) is a circadian clock gene that contributes to photoperiod-dependent flo

272 ng parts of Drosophila period (dper), a core clock gene that encodes a critical component of the circ

273 Intracellular circadian clocks, composed of clock genes that act in transcription-translation feedba

274 niloticus), the hippocampus shows rhythms of clock genes that are 180 degrees out of phase with those

275 es, researchers have characterized a set of "clock genes" that drive daily rhythms in physiology and

276 ms by inhibiting expression of the important clock gene timeless (tim).

277 LMD depends on the circadian clock genes timeless and period, but not Clock or cycle,

278 ergic coactivating role of evening-expressed clock genes to a repressive antagonistic function modula

279 lecules capable of resetting and stabilizing clock genes to evaluate if they can rapidly relieve symp

280 obiota regulates the expression of circadian-clock genes to impact host lipid metabolism and body com

281 The effect of PDF on clock gene transcription and the known role of PDF in en

282 rhythms are abolished by disrupting the key clock gene transcription factor Bmal1.

283 hythms were preserved in the vasculature but clock gene transcription in metabolic tissues and rhythm

284 protein (PER) is a well-studied repressor of clock gene transcription, and the per(S) protein (PERS)

285 zed mechanism for enhancing the amplitude of clock gene transcription.

286 ay and reduction in levels of evening-phased clock gene transcripts and significant lengthening of cl

287 substantially phase shift the oscillation of clock gene transcripts in the absence of PKCgamma.

288 es upregulation of LUX and also alters other clock gene transcripts.

289 e or arrhythmic expression of core circadian clock genes under cool ambient temperature cycles, but n

290 ver and highlight the functions of circadian clock genes under physiological and pathological conditi

291 In this work, CLOCK gene variants were associated with sleep duration

292 repressor recruited to the promoters of core clock genes via interaction with two MYB transcription f

293 echanism is the repression of evening-phased clock genes via the binding of morning-phased Myb-like r

294 Several clock genes were disrupted in the early stages of cartil

295 Twenty-five miRNAs targeting clock genes were identified.

296 ed between the humanized mice, but circadian clock genes were not.

297 Circadian clock genes were overrepresented among the top markers.

298 Nearly all core circadian clock genes were up-regulated upon exposure to light dur

299 series of transcriptional feedback loops of clock genes, which in turn produce endocrine, physiologi

300 se shift protocol that eliminates cycling of clock genes within the suprachiasmatic nucleus (SCN), bu