ライフサイエンスコーパス: clomipramine

1 alopram) and tricyclic antidepressants (e.g. clomipramine).

2 f inadequate response or intolerance to oral clomipramine.

3 disorder (OCD) who are nonresponsive to oral clomipramine.

4 the allosteric potency of (S)-citalopram and clomipramine.

5 s and 172 patients), behavioural therapy and clomipramine (-12.97 [-19.18 to -6.74]; one trial and 31

6 Pulse clomipramine (200 mg i.v.) is associated with dramatic r

7 18) were randomly assigned to receive either clomipramine (200 mg i.v., N = 8) or saline (N = 8).

8 e present study a single intravenous dose of clomipramine (200 mg) was compared with saline placebo i

9 10 to -1.63]; nine trials and 231 patients), clomipramine (-4.72 [-6.85 to -2.60]; 13 trials and 831

10 osure and ritual prevention, 42% and 48% for clomipramine, 70% and 79% for exposure and ritual preven

11 eek, double-blind, crossover-design study of clomipramine, a potent serotonin reuptake inhibitor, and

12 by eight weekly maintenance sessions, and/or clomipramine administered for 12 weeks, with a maximum d

13 Cocrystal structures show that clomipramine, along with two other TCAs, binds in an ext

14 o test the relative and combined efficacy of clomipramine and exposure and ritual prevention in the t

15 of 21 patients initially randomized to i.v. clomipramine and treated subsequently with oral clomipra

16 ure and ritual prevention may be superior to clomipramine and, by implication, to monotherapy with th

17 xetine, citalopram, reboxetine, venlafaxine, clomipramine) and atypical antidepressants (agomelatine,

18 ination (exposure and ritual prevention plus clomipramine), and pill placebo was conducted at one cen

19 79% for exposure and ritual prevention plus clomipramine, and 8% and 10% for placebo.

20 that of exposure and ritual prevention plus clomipramine, and both were superior to clomipramine onl

21 exposure to the 5-HTT inhibitors fluoxetine, clomipramine, and citalopram from postnatal day 4 (P4) t

22 e-blind oral or intravenous pulse loading of clomipramine, and patients were then given 150 mg/day of

23 ose, six of seven patients given intravenous clomipramine but only one of eight given oral medication

24 of mice for 3 weeks with one of these drugs, clomipramine, causes nearly 50% reduction in the levels

25 Previous research found that clomipramine (CLI) treatment of neonatal rats produced,

26 ression, produced by neonatal treatment with clomipramine (CLI).

27 nts reboxetine (REB), paroxetine (PAROX) and clomipramine (CLOM) on extracellular DA in rats using mi

28 Patients taking antidepressants, including Clomipramine (CLP), have an increased risk of osteoporot

29 Chronic postnatal exposure to clomipramine (CMI), a monoamine uptake inhibitor, result

30 ys, we showed that inhibiting autophagy with clomipramine (CMI), chloroquine or metformin increased a

31 ix patients who had responded to intravenous clomipramine continued their improvement, but those who

32 evious open-label trial of pulse intravenous clomipramine demonstrated rapid relief of depressive sym

33 ncluded trials of amitriptyline, citalopram, clomipramine, desipramine, duloxetine, escitalopram, flu

34 Amitriptyline, nortriptyline, desipramine, clomipramine, dothiepin, and sertraline were not found i

35 : amitriptyline, nortriptyline, desipramine, clomipramine, doxepin, dothiepin, fluoxetine, sertraline

36 Clomipramine, exposure and ritual prevention, and their

37 fluoxetine, fluvoxamine, and sertraline) and clomipramine, four study designs, four dependent outcome

38 ncontrolled reports suggest that intravenous clomipramine hydrochloride may be effective for patients

39 to receive 14 infusions of either placebo or clomipramine hydrochloride, starting at 25 mg/d and incr

40 of intravenous versus oral pulse loading of clomipramine in patients with obsessive-compulsive disor

41 A tricyclic antidepressant, clomipramine, instead mirrored the behavior of the selec

42 Clomipramine is more effective than desipramine in the t

43 Intravenous clomipramine is more effective than i.v. placebo for pat

44 it mammalian ASM activities, desipramine and clomipramine, markedly extend the lifespan of wild-type

45 Intravenous pulse loading of clomipramine may be a valuable new treatment for obsessi

46 show that the tricyclic antidepressant (TCA) clomipramine noncompetitively inhibits substrate uptake.

47 plus clomipramine, and both were superior to clomipramine only.

48 Off-rate assays establish that clomipramine reduces the rate at which leucine dissociat

49 Fifty-four patients with oral clomipramine-refractory OCD were randomized to receive 1

50 quently with several days of open-label i.v. clomipramine responded (df = 1, P<.002).

51 cy for multiple inhibitors such as (RS)-CIT, clomipramine, RTI-55, fluoxetine, cocaine, nisoxetine, m

52 These data suggest that clomipramine's possibly superior efficacy in the treatme

53 After 8 weeks of oral clomipramine, the results partially supported the second

54 al comparing exposure and ritual prevention, clomipramine, their combination (exposure and ritual pre

55 Seven of the clomipramine-treated patients and three of the saline-tr

56 The adolescents who received pulse clomipramine treatment demonstrated significant decrease

57 Intravenous clomipramine treatment was safe with no serious adverse

58 l continue to improve during 8 weeks of oral clomipramine treatment.

59 nts randomized to receive intravenous (i.v.) clomipramine vs 0 of 25 patients given i.v. placebo were

60 Clomipramine was also superior to desipramine in improvi

61 Likewise, clomipramine was equally effective regardless of whether

62 Clomipramine was not better than were SSRIs (-1.23 [-3.4

63 with other variables controlled showed that clomipramine was significantly superior to each of the S

64 Clomipramine was superior to desipramine in the acute tr

65 mipramine and treated subsequently with oral clomipramine were responders, whereas 0 of 18 patients i

66 patients were then given 150 mg/day of oral clomipramine with increases of 25 mg every 4 days to 250

67 uld adolescents who received saline and that clomipramine would be superior to saline in terms of ant

68 that adolescents who were treated with pulse clomipramine would exhibit lower scores on the Hamilton