ライフサイエンスコーパス: clonal

1 CA/Ph(-) into those in which -Y was the only clonal abnormality, and all others.

2 Quantitative analysis of clonal abundance in several anatomic sites identified 2

3 data to detect deletions and quantify their clonal abundances.

4 o be associated with DNA-(de)methylation and clonal age, which suggests that epigenetic changes assoc

5 ell carcinoma, 8 samples reduced the list of clonal alterations by 40% with respect to a single biops

6 probability of classifying clonal versus sub-clonal alterations from multi-region profiling of tumour

7 Clonal analysis during regeneration reveals local clonal

8 velop provide important context to interpret clonal analysis of repertoire sequencing data and allow

9 profiling of the tumours, including detailed clonal analysis, was performed to determine whether the

10 Here, we analyzed the clonal and genetic structure of the cyclical parthenogen

11 een able to detect the emergence of regional clonal and nonclonal resistance in several countries.

12 ssect the earliest phases of stem/progenitor clonal (and microenvironment) evolution/diversity with n

13 Here, we investigated the clonal architecture of the CD34(+)CD38(-) hematopoietic

14 f different functional categories, a complex clonal architecture, and disease evolution over time.

15 Increasing evidence shows that tumor clonal architectures are often the consequence of a comp

16 cell-related marker evaluation, single cell clonal assay and three-dimensional (3-D) culture.

17 Through the use of clonal assays, combined with statistical computation, to

18 a higher than anticipated frequency of large clonal autosomal mosaic events >2 Mb in size in the agin

19 ted the phenotypic and functional changes in clonal B cells of MC patients with sustained virologic r

20 ble disease characterized by accumulation of clonal B lymphocytes, resulting from a complex balance b

21 ion generates physiological heterogeneity in clonal bacterial infections and helps to determine the d

22 re, we use cellular barcoding to analyze the clonal behavior of patient-derived leukemia-propagating

23 A broad range of clonal behaviors characterized by contribution level and

24 in human and murine pancreatic islets and in clonal beta cells in a dose- and time-dependent manner.

25 The New Zealand population of Psa is clonal but has evolved rapidly since its introduction by

26 ere, we report clonal shifts (change >0.1 in clonal cancer cell fraction, Q < 0.1) in 31% of patients

27 Our indicator cell line, SupT1-CCR5 cells (a clonal cell line expressing CD4, CXCR4 and CCR5) provide

28 etuses (15 to 21 weeks postconception) using clonal cell populations.

29 of the c-subunit in the PTP, we generated a clonal cell, HAP1-A12, from near-haploid human cells, in

30 unit b and the OSCP in the PTP by generating clonal cells, HAP1-Deltab and HAP1-DeltaOSCP, lacking th

31 Clonal chromosomal abnormalities in Philadelphia chromos

32 loping limbs), the transverse integration of clonal columns determines the well-defined diameter and

33 rethral Nm isolates were nongroupable, ST-11 clonal complex (cc11), ET-15, and clustered together phy

34 onging to the hypervirulent sequence type-11 clonal complex (cc11), with a variant outbreak strain (t

35 WGS analysis differentiated ST382 from a clonal complex 1 outbreak strain co-contaminating the ca

36 the remaining discrepant results belonged to clonal complex 288 (CC288), comprising both S. boydii an

37 methicillin-resistant Staphylococcus aureus clonal complex 398 (LA-MRSA CC398) is causing an increas

38 neage of meningococci, known as serogroup A, clonal complex 5 (A:cc5), has caused three successive pa

39 nvolving KPC-producing Klebsiella pneumoniae clonal complex CC258.

40 es evidence that, within the same serotype 1 clonal complex, biological properties differ significant

41 African 1 was the dominant M. bovis clonal complex, with 97 unique genotypes including 19 no

42 S. aureus strains from clonal complexes 1 and 8 were more frequently isolated f

43 nal complexes identified fit to 12 different clonal complexes belonging to carriage strains.

44 Eleven of the 15 clonal complexes identified fit to 12 different clonal c

45 Within common MRSA clonal complexes, 3/14 MSSA and 2/21 PSSA isolates arose

46 The clonal complexity of adult stem cell pools is progressiv

47 which clonal composition was highly diverse, clonal composition in serial xenografts was highly simil

48 Second, clonal composition in the skeleton significantly differe

49 e it possible to comprehensively profile the clonal composition of lymphocyte populations.

50 The rate of resistance and clonal composition of PD are incompletely characterized.

51 In contrast to primary recipients, in which clonal composition was highly diverse, clonal compositio

52 By modeling DC generation in bulk and clonal cultures, we show here that Jagged1 (JAG1)-mediat

53 Here, we present molecular and clonal data showing that all type II neuroblasts form in

54 tion, Bim has been shown to be important for clonal deletion in several model systems, whereas Nur77

55 T cell receptor-Vbeta5.(1/2) and TCR-Vbeta11 clonal deletion was detected in host T cells in chimeras

56 fector function and proliferative potential, clonal deletion, and significantly decreased occurrence

57 hat, despite being dispensable for thymocyte clonal deletion, RasGRP1 is critical for agonist selecti

58 es was not solely due to reported defects in clonal deletion.

59 rtant mechanism of lymphocyte contraction is clonal depletion of activated T cells by cytokine withdr

60 ine-learning framework, we found significant clonal differences in the determinants most predictive o

61 Myelodysplastic syndrome (MDS) is clonal disorder characterized by ineffective hematopoies

62 Systemic mastocytosis is a clonal disorder of mast cells that may variably present

63 Chronic lymphocytic leukaemia (CLL) is a clonal disorder of mature B cells.

64 licing factors have been reported in several clonal disorders, including cancers.

65 ilure to respond and the development of late clonal disorders.

66 tions were subclonal, with a highly variable clonal distribution.

67 pair of clusters, which may range from fast clonal divergence with little interaction between the cl

68 Clonal diversity and T-cell repertoire, measured by vect

69 programs that restrict T cell expansion and clonal diversity during PD-1 blockade treatment.

70 ow individual SNP-arrays reveal intra-sample clonal diversity with moderate accuracy.

71 to intestinal microbes and determined their clonal diversity.

72 ted mutation load in combination with T cell clonal dominance among intratumoral lymphocytes prior to

73 g of the molecular mechanisms underlying the clonal dominance of MPN stem cells advances, this will h

74 One patient developed a benign clonal dominance that could not be attributed to inserti

75 We investigated clonal dynamics and diversity in a cohort of 15 ADA-SCID

76 ns in cancer impact drug sensitivity and the clonal dynamics of cancer evolution.

77 To gain insight into the clonal dynamics of multiple myeloma (MM) and its possibl

78 h pancreatic cancer have exposed the complex clonal dynamics that underlie the dissemination of cance

79 odysplastic syndromes (MDS), we investigated clonal dynamics using whole-exome and/or targeted sequen

80 s precludes high-resolution tracing of their clonal dynamics.

81 ematopoietic stem cells, and can be used for clonal engraftment and serial primary and secondary mult

82 f a selective sweep of specific var genes or clonal epidemic structure related to the incidence of un

83 inactive genes is indicative of a protracted clonal evolution and consequently, increased risk for tu

84 and the impact of mutation chronology on the clonal evolution and progression of CNL.

85 ve helped to understand the genetic basis of clonal evolution and relapse and the role of inherited g

86 al-time and noninvasive approach to tracking clonal evolution and the emergence of treatment-resistan

87 cing on bone marrow samples and investigated clonal evolution from clonal haemopoiesis to the develop

88 Patients showing clonal evolution had significantly shorter survival afte

89 ted and whole-exome sequencing and described clonal evolution in cases for whom paired CHIP and thera

90 , we present current concepts on the role of clonal evolution in lymphoid and myeloid leukemia as a d

91 Our results explain the genetic basis for clonal evolution of an ETV6-RUNX1 preleukemic clone to p

92 Here we study the clonal evolution of barcoded glioblastoma cells in an un

93 In addition, the results indicate that the clonal evolution of mutations that are seen within later

94 roup (*p = 0.018), indicative of a shortened clonal evolution treated sulindac.

95 Rates of relapse and clonal evolution were similar to our historical experien

96 A for the identification of DLBCL mutations, clonal evolution, and genetic mechanisms of resistance.

97 Multistage clonal expansion (MSCE) models are a class of continuous

98 s assess adequate nutrient supply to support clonal expansion and adaptive immune responses.

99 We found that Runx3 deficiency limited clonal expansion and impaired upregulation of cytotoxic

100 an advantage to mutant cells, driving their clonal expansion and potentially leading to leukemia.

101 ion or amplification of IDH1 was followed by clonal expansion and recurrence at a higher grade.

102 n, suggesting extensive and serial rounds of clonal expansion and selection.

103 t-7 expression in activated T cells enhances clonal expansion and the acquisition of effector functio

104 mutations may persist after therapy, lead to clonal expansion during hematologic remission, and event

105 and that the KDM5s are necessary for mitotic clonal expansion in 3T3-L1 cells, indicating that KDM5 K

106 distribution or the underlying mechanism of clonal expansion in vivo.

107 The two-stage clonal expansion model we propose is based on the thesis

108 iability of the two-, three-, and four-stage clonal expansion models given age-specific cancer incide

109 lammatory process, as well as activation and clonal expansion of B cells.

110 t were completely identical, consistent with clonal expansion of CD4+ T cells harboring intact HIV-1.

111 ramework for understanding the regulation of clonal expansion of CD8 T cells by subthreshold TCR sign

112 These results identify potential drivers of clonal expansion of HIV-1-infected cells in vivo.

113 mory T cells, and most recently appreciated, clonal expansion of HIV-infected cells.

114 ARCH is defined as the gradual, clonal expansion of HSPCs carrying specific, disruptive,

115 B cell-specific Fcmr(-/-) mice lacked robust clonal expansion of influenza hemagglutinin-specific B c

116 that disease flares were associated with the clonal expansion of the S. aureus population, occurring

117 mechanisms by which proviral integration and clonal expansion sustain the HIV reservoir.

118 Krt8(+) mammary luminal cells leads to their clonal expansion without directly affecting their lumina

119 B-cell responses result in clonal expansion, and can occur in a variety of tissues.

120 ndergo somatic hypermutation, affinity-based clonal expansion, and differentiation to produce plasma

121 69, CD25, CD154, NUR77), IL-2 production, or clonal expansion.

122 low-affinity B cell clones for proliferative clonal expansion.

123 y safely tolerated but also advantageous for clonal expansion.

124 mphocyte development, facilitating leukaemic clonal expansion.

125 equilibrium between immune surveillance and clonal expansion.

126 st of melanocytic nevi in vivo termed stable clonal expansion.

127 onfers a growth advantage to tumor cells for clonal expansion.

128 proteins, was upregulated during the T cell clonal-expansion phase, followed by inhibition of the tr

129 Clonal expansions have differentiated from a naive to ef

130 This review discusses the age-related clonal expansions in the human HSPC pool, which was term

131 l analysis during regeneration reveals local clonal expansions of hepatocyte stem/progenitors at inju

132 cile RT017 that contain multiple independent clonal expansions.

133 tant IDH1 and 2HG are not required for later clonal expansions.

134 ssion of mutant and wild-type KRAS modulates clonal fitness and sensitivity to MEK inhibitors in a mo

135 algorithm also yields accurate estimates of clonal frequencies.

136 Clonal frequency analyses of somatic mutations show that

137 Clonal genetic inactivation of KRas(G12D) in mouse lung

138 rtilage shape by experimentally manipulating clonal geometries.

139 by the introduction and subsequent spread of clonal group 258 (CG258) isolates containing blaKPC-3.

140 an effective treatment strategy against this clonal group in murine models of bacteremia that recapit

141 data and allow for rigorous testing of other clonal grouping algorithms.

142 ce screens and identified genes conferring a clonal growth advantage on normal and neoplastic (cutane

143 biology 402 (MCDB 402)] optimized for their clonal growth in minimal serum, they produced transforme

144 potential of stochastic fluctuations during clonal growth to rapidly generate phenotypically indepen

145 tion, decreases lactate production, inhibits clonal growth, migration and invasion of ovarian cancer

146 H3.3(K27M)-driven lesions are clonal, H3K27me3 depleted, Olig2 positive, highly prolif

147 rs was significantly higher in patients with clonal haemopoiesis (29%, 95% CI 8-53) than in those wit

148 rs was significantly higher in patients with clonal haemopoiesis (30%, 95% CI 16-51) than in those wi

149 To further clarify the association between clonal haemopoiesis and therapy-related myeloid neoplasm

150 Evidence suggests that individuals with clonal haemopoiesis have increased risk of developing ha

151 We detected clonal haemopoiesis in 17 (31%) of the 54 controls.

152 elopment, we also analysed the prevalence of clonal haemopoiesis in an external cohort of patients wi

153 Of the 14 cases, we detected clonal haemopoiesis in the peripheral blood samples of t

154 ased on the external cohort, the presence of clonal haemopoiesis significantly increased the risk of

155 mples and investigated clonal evolution from clonal haemopoiesis to the development of therapy-relate

156 treatment peripheral blood samples to detect clonal haemopoiesis.

157 groups: type I, which is seen exclusively in clonal hematologic diseases, and type II/III, which is c

158 tive neoplasms (MPNs) are a group of related clonal hematologic disorders characterized by excess acc

159 Primary myelofibrosis (PMF) is a clonal hematologic malignancy characterized by BM fibros

160 Clonal hematopoieses after chemotherapy, in marrow failu

161 ol, which was termed in the past age-related clonal hematopoiesis (ARCH).

162 Clonal hematopoiesis (CH) arises when a substantial prop

163 Clonal hematopoiesis (CH), as evidenced by recurrent som

164 deficient mice to generate genetic models of clonal hematopoiesis and neoplasia.

165 Age-associated clonal hematopoiesis caused by acquired mutations in mye

166 This clonal hematopoiesis correlates with an increased risk o

167 Conversely, clonal hematopoiesis due to mutations of CSF3R was prese

168 tion sequencing (NGS) discovered age-related clonal hematopoiesis of indeterminate potential (CHIP).

169 ave been characterized as frequent events in clonal hematopoiesis of indeterminate potential, suggest

170 These patients have BCR-ABL1-positive clonal hematopoiesis resembling a chronic myeloid leukem

171 Clonal hematopoiesis results from somatic mutations in h

172 ancies exist on a spectrum from asymptomatic clonal hematopoiesis to overt leukemia and exhibit subst

173 rom normal, healthy elderly individuals with clonal hematopoiesis who are at increased risk of subseq

174 ns in TET2 occur frequently in patients with clonal hematopoiesis, myelodysplastic syndrome (MDS), an

175 The acquisition of clonal hematopoiesis-driver mutations (CHDMs) occurs wit

176 progenitor cells (HSPCs) and/or by promoting clonal hematopoiesis.

177 isorders in which recurrent mutations define clonal hematopoiesis.

178 Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy that may deserve specifi

179 a diverse group of bone marrow disorders and clonal hematopoietic stem cell disorders characterized b

180 pecific perturbations can enhance fitness of clonal hematopoietic stem cells, which can impact outcom

181 tive neoplasms (MPNs) are a group of related clonal hemopoietic stem cell disorders associated with h

182 rmation found an inverse association between clonal heterogeneity and immune metagene expression (rho

183 High immune gene expression and lower clonal heterogeneity in TNBC and HER2(+) cancers suggest

184 In addition, because of the clonal heterogeneity of advanced disease, a single sampl

185 The study compared clonal heterogeneity, somatic total mutational load, neo

186 Here we examine if clonal heterogeneity, total mutation load, neoantigen lo

187 is to overt leukemia and exhibit substantial clonal heterogeneity.

188 These benign tumors represent clonal hyperproliferation of melanocytes that are in a s

189 though some of these genetic alterations are clonal in the PIPs, many of the mutations are subclonal

190 Furthermore, this bias in the clonal iNKT repertoire in type 1 diabetes was associated

191 granules in human beta cells and rat-derived clonal insulin 1 (INS1) cells for which localized Ca2+ i

192 resistances, and population bottlenecks and clonal interference can strongly influence resistance ev

193 the recombination event partially alleviates clonal interference.

194 clades and species, and to the avoidance of clonal interference.

195 pproach by deriving fibroblast subclones and clonal iPSC lines from the same fibroblast population an

196 Importantly, the clonal iPSCs and fibroblast subclones contained comparab

197 Intriguingly, cell kinetic analysis of clonal isolates derived from single and multiple donors

198 Sequencing of independent clonal isolates of replication-competent virus revealed

199 ells (DCs) have not been investigated at the clonal level.

200 Clonal LGL expansion arise from chronic antigenic stimul

201 tability are typically maintained during the clonal line-generation process.

202 Antibody clonal lineage analysis reveals that somatic hypermutati

203 USA300 is a pandemic clonal lineage of hypervirulent, community-acquired, met

204 the M. persicae genome and assessed how one clonal lineage responds to host plant species of differe

205 We describe here a human antibody clonal lineage, designated CL6649, members of which bind

206 tification of the starting point of a B-cell clonal lineage, the initial V(D)J rearrangement.

207 es across 40 families and single M. persicae clonal lineages can colonise distantly related plants.

208 This leads to multiple clonal lineages in the newly apomictic population, and t

209 Evidence of clonal lineages shared by some patients was observed, su

210 ccess of nosocomial and community-associated clonal lineages, aided by mechanisms of genetic plastici

211 b prophage (PhiSaeq1) found in six different clonal lineages, almost exclusively in strains cultured

212 e and evolved toward dominance of individual clonal lineages, indicating affinity maturation.

213 Final clonal lines corresponding to each of the 10 cellular st

214 , which may serve as the underlying basis of clonal maintenance at this locus, as well as other insta

215 Clonal mast cell disease was diagnosed in 14% of patient

216 e patients more likely to have an underlying clonal mast cell disorder (monoclonal mast cell activati

217 rvation has prompted the question of whether clonal mast cell disorders also occur in patients with i

218 Clonal mast cell disorders are known to occur in a subse

219 , and patients may present with unrecognized clonal mast cell disorders with KIT mutations may presen

220 pathology this randomness shifts to selected clonal microglial expansion.

221 Inhibition of KCC2 activity in clonal MIN6 beta-cells increases basal and glucose-stimu

222 Here, we performed clonal multicolor lineage tracing of skeletal muscle ste

223 icity is linked to the variant expression of clonal multigene families such as the var genes.

224 ed in patients with histiocytoses, which are clonal myeloid diseases associated with somatic mutation

225 ion to clinical outcome and to determine the clonal nature of driver events and evolutionary processe

226 lants, apomixis results in the production of clonal offspring via seed and can provide reproductive a

227 of B. anthracis, which is considered to be a clonal organism.

228 se in the number of stem cells with distinct clonal origins.

229 We investigated and mitigated a 2-phase clonal outbreak of M. abscessus linked to hospital tap w

230 with evidence of transmission beyond limited clonal outbreaks, points to multiple unsampled transmiss

231 Genetic barcoding allows monitoring of the clonal output of tumorigenic cells without prospective i

232 Fragaria spp), where they produce tubers and clonal plants, respectively.

233 etects extramedullary sites of proliferating clonal plasma cells while providing important prognostic

234 noglobulin light chains (LC) are produced by clonal plasma cells, but only in AL do they form amyloid

235 heir capability to create different sizes, a clonal population in a given environment maintains a uni

236 ysis, was performed to determine whether the clonal population in the xenograft recapitulated the pat

237 characterized by the presence of an enlarged clonal population of innate intraepithelial lymphocytes

238 cell states among individual cells within a clonal population.

239 sister cells and eventually gives rise to a clonal population.

240 ular analysis, have facilitated the study of clonal populations and their genetic and epigenetic evol

241 d recent, independent emergence of different clonal populations on 3 continents.

242 t cells produces tumors composed of multiple clonal populations, distinguished in part by rearrangeme

243 raising the possibility that an age-related clonal process of preleukemic cells could precede the de

244 inct splicing program shared across multiple clonal processes and define a biochemical mechanism for

245 T-cell immunity requires extremely rapid clonal proliferation of rare, antigen-specific T lymphoc

246 Lymphomas represent clonal proliferations of lymphocytes that are broadly cl

247 consumption, the concomitant bottleneck and clonal propagation have resulted in a large proportion o

248 among cultivars as well as within sources of clonal propagation of the same cultivar.

249 for investigating the mechanistic basis and clonal properties of human AML.

250 er helminthes prevent T cell priming or skew clonal recruitment and effector differentiation is not k

251 Clonal relationships are not directly measured, but they

252 We investigate clonal relationships of various NK-cell subsets, includi

253 mutations in tissues permitting inference of clonal relationships.

254 s, we postulate that vaccination establishes clonal relatives of GCTfh within the circulating memory

255 We investigate the clonal repertoire of 29 CTL responses against 23 HIV-1 e

256 may require coordinated direction of the CTL clonal repertoire to simultaneously block escape pathway

257 of these important fungi including sexual or clonal reproduction, similarity or dissimilarity of nucl

258 evoked by systemic endotoxin challenge, the clonal response of leukocytes in bone marrow of acute my

259 Colonization by clonal S. aureus populations was observed in both AE pat

260 drogen-independent cells that are poised for clonal selection after androgen-deprivation therapy.

261 well as for effective strategies to improve clonal selection against age related deterioration.

262 cytes that respond rapidly to stress without clonal selection and differentiation.

263 in the absence of a better understanding of clonal selection and evolution.

264 f cancer that is not subject to the blunting clonal selection effects that reduce the efficacy of oth

265 Tetrachimeric mice show clonal selection occurs during development with further

266 cellular origin of high affinity IgE and the clonal selection of high affinity memory B cells into th

267 cells undergo class switch recombination and clonal selection to generate high affinity neutralizing

268 a deterministic, clone-size-based model for clonal selection.

269 imensional compositional information of each clonal sequence (defined by CDR3), we detected predictiv

270 ic clones, which may be defined as Ab or TCR clonal sequences shared across individuals.

271 ively on large published datasets (3 million clonal sequences) and was sufficiently robust for public

272 Clonal sequencing and fluctuation tests have suggested t

273 Here, we report clonal shifts (change >0.1 in clonal cancer cell fractio

274 onse, indicating the lack of requirement for clonal skewing.

275 e sequencing, we validate the concordance of clonal somatic mutations (88%), copy number alterations

276 nto the molecular mechanisms responsible for clonal somatic structural events.

277 sonic hedgehog signaling activity influences clonal spatial distribution.

278 e most important feature of CWID and RICD is clonal specificity, which lends great appeal as a strate

279 The emergence and clonal spread of colistin resistance was analysed in 40

280 onsiderably in stability over time, although clonal stability (Sorensen index) was not significantly

281 Here, we demonstrate that the clonal stability and number of clones for the CTL respon

282 These findings demonstrate that clonal, stable GCRs can be produced by a single engineer

283 n a dilute collagen-type I hydrogel, a novel clonal strain of rat cancer-associated myofibroblasts (T

284 erprinting of clinical isolates identified 2 clonal strains of M. abscessus; 1 clone was isolated fro

285 early-stage breast cancer, we show that the clonal structure of the tumor is significantly different

286 fication of the pandemic multidrug-resistant clonal subgroup ST131-H30.

287 This has been observed in clonal subpopulations of larger size, especially when ge

288 murine model, there was little evidence for clonal succession after initial hematopoietic reconstitu

289 model for multiple myeloma progression with clonal sweeps in the early phase and regional evolution

290 useful tool for detecting and characterizing clonal TCR rearrangements in PTCL.

291 Compared with other approaches to clonal tracking, this approach is highly quantitative an

292 Reversible mutagenesis overcomes clonal variance by permitting functional annotation of t

293 y homogeneous cell populations exhibit large clonal variance that can confound analyses and undermine

294 ment resulted in the selective enrichment of clonal variants with high ST6Gal-I expression, further s

295 esting that chronic chemotherapy selects for clonal variants with more abundant ST6Gal-I.

296 The probability of classifying clonal versus sub-clonal alterations from multi-region p

297 nges in CD4+ T-cell population diversity and clonal viral sequence expansion during CD4+ T-cell recon

298 ntified as clonal with one biopsy proved sub-clonal when 8 samples were considered.

299 al cancers, 30% of alterations identified as clonal with one biopsy proved sub-clonal when 8 samples

300 As many as 40% of HCCs are clonal, with alteration of key tumor-suppressor pathways