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1 or the beta-chain, which hinders rescue from clonal deletion.
2 le dose was insufficient to achieve complete clonal deletion.
3 cross-react with self-peptides resulting in clonal deletion.
4 H-induced apoptosis with that induced during clonal deletion.
5 leading to Ag-specific T cell activation and clonal deletion.
6 echanisms of tolerance: receptor editing and clonal deletion.
7 l surface) to create an agent for CD8 T-cell clonal deletion.
8 al clonal exhaustion, followed by peripheral clonal deletion.
9 hese self-antigens within the thymus undergo clonal deletion.
10 responses involves both anergy induction and clonal deletion.
11 because all of these elements contribute to clonal deletion.
12 ay of self-peptides resulting in inefficient clonal deletion.
13 is attained by receptor editing, anergy, or clonal deletion.
14 orted roles in tissue-restricted Ag-mediated clonal deletion.
15 l superantigen induced a clan III-restricted clonal deletion.
16 that P1A-specific T cells are susceptible to clonal deletion.
17 ure CD4+CD8+ (DP) thymocytes, referred to as clonal deletion.
18 o autoreactivity in the periphery results in clonal deletion.
19 apoptosis in these immature B cell models of clonal deletion.
20 fic transplant tolerance analogous to thymic clonal deletion.
21 s developed, at least in part, by intragraft clonal deletion.
22 ved are, instead, attributable to effects of clonal deletion.
23 es was not solely due to reported defects in clonal deletion.
24 ation of T cells that would normally undergo clonal deletion.
25 +)Foxp3(+) Treg development without inducing clonal deletion.
26 cell autoreactivity in the absence of thymic clonal deletion.
27 lear quantitative defects in antigen-induced clonal deletion.
28 l tolerance enforced by receptor editing and clonal deletion.
29 ambda, in pAlb mice, kappa B cells underwent clonal deletion.
30 is largely unknown how these T cells escape clonal deletion.
31 w, via a combination of receptor editing and clonal deletion.
32 ood about the molecular mechanism leading to clonal deletion.
33 ork for understanding the molecular basis of clonal deletion.
34 th a conalbumin-specific TCR prone to thymic clonal deletion acquired peptide-specific T cell respons
35 p24 Ag in HIV-infected individuals and that clonal deletion alone does not explain this phenomenon.
37 s was associated with peripheral and central clonal deletion and a higher frequency of regulatory T c
40 ve B lymphocytes that escape inactivation or clonal deletion and are examples of "clonal ignorance."
41 d in many ways, does not require a thymus or clonal deletion and can spread to third-party antigens l
43 ed by large naive populations induce minimal clonal deletion and contain certain amino acids with the
44 , 2) unable to secrete Ab, 3) able to escape clonal deletion and develop into B1 B cells in the perit
45 signals results in outcomes as divergent as clonal deletion and differentiation to the unconventiona
46 1H3.1 alphabeta TCR Tg T cells have escaped clonal deletion and efficiently populated the periphery.
47 trating OT-I CD8(+) T cells that had escaped clonal deletion and gained effector functions before dev
48 Bim and Nur77 during ubiquitous Ag-mediated clonal deletion and highlight potential differences from
49 CD28KO pregnants in contrast to the partial clonal deletion and hyporesponsiveness of remaining T ce
50 CD28 as the intrathymic signal required for clonal deletion and identifies CD8alphaalpha(+) IELs as
51 th limited thymic expression induced partial clonal deletion and impaired effector T cell potential b
52 apoptosis pathway from that activated during clonal deletion and indicate that signaling cascades lea
53 fficient T cell apoptosis may interfere with clonal deletion and maintenance of tolerance, and result
54 mbles the signaling cascade activated during clonal deletion and modeled by B cell receptor cross-lin
55 article, I trace the historic background of clonal deletion and molecular mimicry, two major pillars
58 ion of antigen-specific T cells, followed by clonal deletion and survival of a small number of memory
59 sion activates apoptosis of B cell models of clonal deletion and that rescue from apoptosis by CD40 l
60 endent processes are thought to promote both clonal deletion and the development of Foxp3(+) regulato
61 raft survival correlated with donor-specific clonal deletion and the presence of donor class II mRNA
62 ays an important role in normal processes of clonal deletion and they indicate that the NF-kappaB/Ika
63 expression of nuclear hLa Ag induces thymic clonal deletion and tTreg selection, and lymphocytic inf
64 e spleens of mixed chimeras, suggesting that clonal deletion and/or receptor editing may maintain B-c
66 th production of donor T-cells and effective clonal deletion, and a significant reduction in activate
68 undergo tolerance, such as receptor editing, clonal deletion, and anergy, have been established in mi
70 and B7-2 and their receptor CD28 can promote clonal deletion, and limited in vivo studies have indica
72 at in mixed allogeneic chimeras, intrathymic clonal deletion, and not peripheral suppression or anerg
74 fector function and proliferative potential, clonal deletion, and significantly decreased occurrence
75 olerance to bone marrow transplants involves clonal deletion, and tolerance to heart allografts in th
78 nt functional CTL responses, arguing against clonal deletion as a mechanism for the decline of CTL re
80 one marrow has recently been associated with clonal deletion, as reported in fully allogeneic models
82 homa is used as a model of self-tolerance by clonal deletion because B cell receptor (BCR) ligation r
83 one of the principal mediators implicated in clonal deletion, Bim, is required for caspase-3 activati
84 ative selection of crossreactive TCRs led to clonal deletion but also recycling into intestinal CD4(-
85 the chromosome 3 (Chr3) regions that control clonal deletion, but mainly to two regions on Chr1 and C
86 nding in T cells leads to inefficient thymic clonal deletion, but T cell tolerance is maintained by F
87 eptors (TCR) can adopt differing cell fates: clonal deletion by apoptosis or deviation into alternati
88 cells, BM-derived cells extend the range of clonal deletion by cross-presenting antigen captured fro
89 ve thymocytes were prevented from undergoing clonal deletion by either a lack of CD28 costimulation o
90 a B cell tolerance mechanism in addition to clonal deletion, clonal anergy, and receptor editing.
91 her molecule thought to be a key mediator of clonal deletion, could be responsible for Bim-independen
92 of P1A antigen in the thymus induces T cell clonal deletion demonstrates that normal hematopoietic c
93 olerance induction by impairing BCR-mediated clonal deletion, deregulating receptor editing, and decr
95 lls are positively selected in K14 mice, but clonal deletion does not ocur in K14 mice or in relB-neg
96 ence, P1A-specific T cells must have escaped clonal deletion due to low expression of P1A in the thym
99 Autoreactive thymocytes can be eliminated by clonal deletion during their development in the thymus.
100 ombined deficiency in Bim and Nur77 impaired clonal deletion efficiency and significantly increased p
102 sHEL in this model system in order to block clonal deletion fails to rescue survival of mature B cel
104 latory mechanisms in addition to intrathymic clonal deletion for the maintenance of tolerance to reci
105 reactivity in the B-cell compartment include clonal deletion, functional inactivation and receptor ed
106 populations, (2) the physiologic process of clonal deletion functions to remove clones that have rea
108 und T-cell tolerance most likely mediated by clonal deletion, (ii) T-cell clonal ignorance, and (iii)
109 pression can be used as a specific marker of clonal deletion in an unmanipulated thymus and directly
110 t's lymphoma, is a model for antigen-induced clonal deletion in germinal center B-lymphocytes, with a
113 However, the significance of B7-mediated clonal deletion in preventing autoimmune diseases has no
114 tion, Bim has been shown to be important for clonal deletion in several model systems, whereas Nur77
116 conventional alphabetaT cells are subject to clonal deletion in the medulla, entry into the thymus me
118 accepted that developing T cells can undergo clonal deletion in the thymus in response to a high affi
122 8 absence did not impair TCR-V beta-specific clonal deletion induced by neonatal exposure to MMTV.
123 n has, however, remained controversial, with clonal deletion, induction of suppressor cells or of typ
132 ough there is evidence that they can support clonal deletion, it is not clear whether they do so dire
134 The critical role of B7-1 and B7-2 in T cell clonal deletion may explain, at least in part, the parad
135 self-reactive T cells by altering the thymic clonal deletion mechanism, or reduce the production of C
138 ur77 deficiency did not substantially impact clonal deletion nor did it exacerbate the defect in clon
139 etic (NOD) genetic variation impairs neither clonal deletion nor downstream transcriptional programs.
142 The precise developmental stage(s) at which clonal deletion occurs in a normal thymus has been diffi
146 nd degree of humoral tolerance was caused by clonal deletion of alloreactive specificities from the p
147 nce in experimental models, which implicates clonal deletion of alloreactive T and B cells, induction
150 s receptor signaling is not the mechanism of clonal deletion of antigen-reactive cells after antibody
152 reveal that costimulatory molecules enhance clonal deletion of autoreactive T cells as well as gener
155 ining 20-30 copies of the transgene, massive clonal deletion of B cells was observed in the bone marr
158 e fact that VIP and PACAP prevent Ag-induced clonal deletion of CD4+ T cells, but not that of CD8+ T
159 PTAs) in thymic stromal cells, promoting the clonal deletion of differentiating T cells that recogniz
160 but maintained to third-party antigens, and clonal deletion of donor-reactive host Vbeta T cells.
161 ipients, demonstrating a role for peripheral clonal deletion of donor-reactive T cells after allogene
162 Long-term mixed hematopoietic chimerism, clonal deletion of donor-reactive T cells, and bidirecti
166 at bind specifically to foreign antigens and clonal deletion of equivalent B cells that bind self-ant
167 failed to abrogate the process of peripheral clonal deletion of H(+)/K(+) ATPase-specific CD4 T cells
170 men despite the development of chimerism and clonal deletion of host T cells to donor MHC-Ags in the
171 trathymic and extrathymic chimerism, and for clonal deletion of host-type thymocytes with TCR recogni
175 Therefore, miR-181a helps to guarantee the clonal deletion of particular moderate-affinity clones b
176 etition with mTg-derived peptides may impede clonal deletion of pathogenic, mTg-specific T cells in t
177 on, induction of HO-1 expression accelerates clonal deletion of peripheral alloreactive CD4+ T cells
181 gative selection, primarily mediated through clonal deletion of self-reactive thymocytes, is critical
182 -antigens (UbA), Bim is not required for the clonal deletion of self-reactive thymocytes, suggesting
183 The absence of Aire results in impaired clonal deletion of self-reactive thymocytes, which escap
186 IEk bound to the MCC variant caused the clonal deletion of some T cells specific for the IEk + M
188 of B7-1 and B7-2 substantially inhibits the clonal deletion of T cells in the thymus and leads to an
189 , and is most likely mediated by intrathymic clonal deletion of T cells that recognize antigens expre
192 ht be an important checkpoint leading to the clonal deletion of the majority of effector T cells, pos
193 duced apoptosis has been used as a model for clonal deletion of thymocytes or peripheral T cells.
197 lymphocyte reaction responses, showing that clonal deletion or anergy did not occur, but that graft
198 that tolerance was not secondary to general clonal deletion or anergy of donor-reactive T cells.
199 ction, suggesting that neither chimerism nor clonal deletion or anergy of recipient T cells to alloan
200 absence of inflammatory signals resulted in clonal deletion or anergy of the T cell, respectively.
202 controlling both intrathymic and extrathymic clonal deletion or inactivation of T cells, this objecti
203 ce induced to these Ags, ranging from T cell clonal deletion or inactivation to clonal "ignorance" of
204 nresponsive state is specific and not due to clonal deletion or irreversible functional inactivation
205 onses; virus-specific T cells either undergo clonal deletion or lose their ability to display the ful
206 Thus, bystander suppression does not reflect clonal deletion or reduced clonal expansion of the bysta
209 tral hypothesis in immunology, which is that clonal deletion plays an important role in preventing au
212 eceived living-donor kidney transplants with clonal deletion protocol (total lymphoid irradiation or
214 ssue of Immunity, Yu et al. (2015) show that clonal deletion prunes the T cell repertoire but does no
215 hat, despite being dispensable for thymocyte clonal deletion, RasGRP1 is critical for agonist selecti
216 id not abolish tolerance, suggesting central clonal deletion rather than anergy as the likely toleran
217 at H + L transgenic B cells are regulated by clonal deletion, receptor editing via secondary rearrang
218 otoxin beta receptor (LTbetaRIg) interrupted clonal deletion, reduced the size of the primary cancer,
219 ment, allowing self-reactive cells to escape clonal deletion; reducing transgenic TCR-mediated positi
220 eted Ag-specific thymocytes, and this thymic clonal deletion required CCR9-mediated homing and was pr
221 on status of the stimulatory APC, peripheral clonal deletion requires persistent Ag and is not determ
223 that these mechanisms represent two distinct clonal deletion strategies that are differentially imple
224 hree orders of magnitude, to agonist-induced clonal deletion, such that their proportion increased, g
225 ctivity (mixed lymphocyte coculture assays), clonal deletion (T-cell receptor Vbeta11 assay), periphe
231 of thymic peripheral antigen expression and clonal deletion to self-tolerance is demonstrated in the
235 downstream of the T-cell receptor (TCR) for clonal deletion to UbA versus TRA and highlight the prof
236 his family of DNA-binding proteins in thymic clonal deletion, transgenic (Tg) mice bearing a dominant
242 T cell receptor-Vbeta5.(1/2) and TCR-Vbeta11 clonal deletion was detected in host T cells in chimeras
243 nt in PG490-88-treated mice, suggesting that clonal deletion was not responsible for the observed tol
246 relative utilization of receptor editing vs clonal deletion, we determined the frequency of in-frame
249 c antigen-presenting cells were tolerated by clonal deletion, whereas peptides excluded from the thym
250 fferentiation (positive selection) or death (clonal deletion), which is dictated in large part by the
251 in the number of developing 1B2+ thymocytes (clonal deletion), which occurred primarily at the CD4+ C
252 ly recognize fetal/placental antigen undergo clonal deletion without priming for cytotoxic effector f
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