ライフサイエンスコーパス: clonal expansion

1 s of cancer cells during the early stages of clonal expansion.

2 mphocytes either remain tolerized or undergo clonal expansion.

3 ed to be a secondary consequence of leukemic clonal expansion.

4 adipogenesis, during the process of mitotic clonal expansion.

5 69, CD25, CD154, NUR77), IL-2 production, or clonal expansion.

6 very closely related, consistent with recent clonal expansion.

7 low-affinity B cell clones for proliferative clonal expansion.

8 pheral blood lymphocytes solely by measuring clonal expansion.

9 clude auto-antigens involved in the original clonal expansion.

10 tations that accumulate in a cell before its clonal expansion.

11 n biochemical dysfunction-a process known as clonal expansion.

12 NH argue that there are intrinsic drivers of clonal expansion.

13 hat additional lesions are needed to sustain clonal expansion.

14 muscle fibres by means of a greater rate of clonal expansion.

15 years that are associated with premalignant clonal expansion.

16 smission in the new host species, leading to clonal expansion.

17 through all mouse generations with only mild clonal expansion.

18 bclones that were the result of recent rapid clonal expansion.

19 y safely tolerated but also advantageous for clonal expansion.

20 late to the efficiency of T cell priming and clonal expansion.

21 mphocyte development, facilitating leukaemic clonal expansion.

22 erotypes 1, 3, 7F, 19A, 22F, and 33F through clonal expansion.

23 equilibrium between immune surveillance and clonal expansion.

24 st of melanocytic nevi in vivo termed stable clonal expansion.

25 er progenitors is further proposed to impact clonal expansion.

26 d perturbed EC function without the need for clonal expansion.

27 onfers a growth advantage to tumor cells for clonal expansion.

28 and loss of progenitor function, leading to clonal expansion.

29 lignant transformation and peripheral T cell clonal expansion.

30 ctions as an essential regulator of neoblast clonal expansion.

31 f Ag affinity selection in Ab maturation and clonal expansion.

32 reintroductions due to human migration, and clonal expansions.

33 cile RT017 that contain multiple independent clonal expansions.

34 tant IDH1 and 2HG are not required for later clonal expansions.

35 s evaluated, and evidence for antigen-driven clonal expansions.

36 /44-MAPK signaling and inhibition of mitotic clonal expansion, a process essential for adipocyte diff

37 enced preadipocytes exhibit enhanced mitotic clonal expansion accompanied by reduced levels of p27 as

38 individuals and variability in the sizes of clonal expansions across genes.

39 eral tolerance checkpoint that aborts T-cell clonal expansion against allergens and autoantigens and

40 TORC1-haploinsufficient B cells have reduced clonal expansion, AID expression, and capacities to yiel

41 d their capacity to efficiently suppress the clonal expansion along with their ability to hamper TrxR

42 repertoire directed toward these antigens by clonal expansion, alterations in clonal dominance, and i

43 d to better understand genetic diversity and clonal expansion among L. pneumophila bacteria.

44 In addition to increased clonal expansion and acquisition of effector functions,

45 s assess adequate nutrient supply to support clonal expansion and adaptive immune responses.

46 This BCR profile is indicative of clonal expansion and affinity maturation.

47 are also attractive tools for understanding clonal expansion and clonal competition in cancer.

48 , GPR56(+) TEMRA cells have higher levels of clonal expansion and contain the majority of virus-speci

49 adaptive immune response, which is based on clonal expansion and contraction, can be monitored in re

50 We found that medial SMCs can undergo clonal expansion and convert to macrophage-like cells th

51 owed that individual survivors undergo rapid clonal expansion and daughter cell dispersal.

52 contact, naive mouse CD8(+) T cells undergo clonal expansion and differentiate into effector T cells

53 ntigenic stimulation, CD8(+) T cells undergo clonal expansion and differentiation into CTLs that can

54 esult, over periods of hours, in activation, clonal expansion and differentiation of antigen-specific

55 We show that LN FDC networks arise from the clonal expansion and differentiation of marginal reticul

56 ition of JAK2V617F alone is insufficient for clonal expansion and disease progression and causes even

57 T cells are known to scale their clonal expansion and effector cytokine response accordin

58 e are hindered by the biological coupling of clonal expansion and effector differentiation.

59 ns and the factors that influence subsequent clonal expansion and emergence of disease.

60 compartments in which B cells undergo rapid clonal expansion and express activation-induced cytidine

61 e infected cells that persist have undergone clonal expansion and frequently have proviruses integrat

62 on by exiting from quiescence and initiating clonal expansion and functional differentiation, but the

63 ta) is abolished, thereby inhibiting mitotic clonal expansion and further adipocyte differentiation.

64 memory CD8 T cells was coupled with impaired clonal expansion and higher PD-1 re-expression upon seco

65 nt reporter to examine whether the extent of clonal expansion and hypermutation are regulated during

66 We found that Runx3 deficiency limited clonal expansion and impaired upregulation of cytotoxic

67 ve immune response, lymphocytes must undergo clonal expansion and induce a survival program that enab

68 -L1 adipocyte differentiation during mitotic clonal expansion and is critical for maintenance of DNA

69 In addition, we report the clonal expansion and isolation of human LGR5(+ve) cells

70 ET2-deficient cells was sufficient for their clonal expansion and led to a marked increase in atheros

71 CCR6 appears be nonessential for the initial clonal expansion and maintenance of B(mem), CCR6 is esse

72 class II-restricted CD8(+) T cells underwent clonal expansion and mediated killing of HIV-infected ce

73 gulated to respond to environmental cues for clonal expansion and memory cell differentiation.

74 vectors, which are sometimes associated with clonal expansion and oncogenesis.

75 an advantage to mutant cells, driving their clonal expansion and potentially leading to leukemia.

76 tion of the NLRP3 inflammasome, which drives clonal expansion and pyroptotic cell death.

77 ion or amplification of IDH1 was followed by clonal expansion and recurrence at a higher grade.

78 n, suggesting extensive and serial rounds of clonal expansion and selection.

79 y cells and plasmablasts in combination with clonal expansion and signs of somatic hypermutation sugg

80 that acquire preleukemic mutations, allowing clonal expansion and subsequent acquisition of mutations

81 -17-92-deficient CD4 T cells showed impaired clonal expansion and subsequent memory formation.

82 member OX40 (CD134) is critical for optimal clonal expansion and survival of T cells.

83 omb repressive complex 2 deficiency impaired clonal expansion and TE cell differentiation, but minima

84 om a single introduction through the farm by clonal expansion and that contamination of the environme

85 t-7 expression in activated T cells enhances clonal expansion and the acquisition of effector functio

86 t, subsets of CD62L(lo) eTregs showed higher clonal expansion and were more highly interrelated than

87 These MAbs were the result of clonal expansions and had significant levels of somatic

88 ng the mechanism(s) of JAK2V617F subclinical clonal expansions and the transition to overt MPNs will

89 B-cell responses result in clonal expansion, and can occur in a variety of tissues.

90 ndergo somatic hypermutation, affinity-based clonal expansion, and differentiation to produce plasma

91 virus (MCMV), MCMV-specific NK cells undergo clonal expansion, and display increased effector functio

92 ssion supports bursal follicle colonization, clonal expansion, and Ig V gene diversification.

93 processes of tumor initiation, premalignant clonal expansion, and malignant transformation, and even

94 s, their connection to T cell activation and clonal expansion, and their variability across patients.

95 hat GATA1 mutations alone are sufficient for clonal expansions, and additional driver mutations at th

96 l tissue distant from the cancer, reflecting clonal expansions, and the underlying mutational process

97 determining factors for the fate of B cells: clonal expansion, anergy, or apoptosis.

98 mutations in hematopoietic cells leading to clonal expansion are commonly acquired during human agin

99 How long-lasting T-B interactions and B cell clonal expansion are regulated by antigen presentation r

100 Compartment shrinkage and clonal expansions are challenges for naive CD8 T cells.

101 Clonal expansions are rare, being detected once every 36

102 These clonal expansions are statistically significant.

103 g in-vivo lineage tracing data we quantified clonal expansion as well as proliferation and differenti

104 introductions into the hospital followed by clonal expansion associated with transmission.

105 tly, in East Asia and the USA, but underwent clonal expansion at different times.

106 can be present at diagnosis with subsequent clonal expansion at relapse.

107 rom cell lines generated by a barrier bypass-clonal expansion (BBCE) protocol.

108 red information on the kinetics of malignant clonal expansion before clinical detection, including tu

109 o display unpredictable differences in their clonal expansion capacities after transplantation.

110 ere were marked differences in the degree of clonal expansion (CE) between patients (median 0.74, int

111 ETAA1 deficiency decreased clonal expansion cell autonomously within the responding

112 exhibited biased VH use, V(D)J mutation, and clonal expansion comparable to antigen-binding cells.

113 possess traits of adaptive immunity, such as clonal expansion, contraction, and generation of long-li

114 We show that drift-driven clonal expansions cooperate with faster HSC cycling in y

115 The magnitude of B cell clonal expansions correlates with an individual's secret

116 able after passaging for more than one year, clonal expansion, differentiation into neurons, cardiomy

117 hoinositide 3-kinase (PI3K) is essential for clonal expansion, differentiation, and effector function

118 ds on effector CD8(+) T cells, whose optimal clonal expansion, differentiation, and memory properties

119 retinoic acid receptor (RAR) isoforms in the clonal expansion, differentiation, and survival of patho

120 identified in different subjects, suggesting clonal expansion driven by a common antigen.

121 mutations may persist after therapy, lead to clonal expansion during hematologic remission, and event

122 14 patients); most, however, did not undergo clonal expansion during ponatinib treatment and, moreove

123 nable to blast, which resulted in attenuated clonal expansion during viral infection.

124 adoptive cell transfer approaches to profile clonal expansion, effector function, and recruitment of

125 Clonal expansion following high-LET radiation exposure w

126 Developing B lymphocytes undergo clonal expansion following successful immunoglobulin hea

127 a computational method called the multistage clonal expansion for EAC (MSCE-EAC) screening model that

128 ntigen-specific T cells that undergo massive clonal expansion for host protection against pathogen in

129 Clonal expansions have differentiated from a naive to ef

130 et the extraordinary biosynthetic demands of clonal expansion; however, the signals that mediate meta

131 and that the KDM5s are necessary for mitotic clonal expansion in 3T3-L1 cells, indicating that KDM5 K

132 ssion of the CXCL10 receptor CXCR3 for their clonal expansion in a CD27/CD70-dependent peptide-immuni

133 The hiEndoPCs show clonal expansion in culture and give rise to hepatocytes

134 for the female germline, which arrests after clonal expansion in early development, variance in the m

135 igh-affinity, antibody-producing B cells for clonal expansion in germinal centers (GCs), but the natu

136 possibly representing the earliest stages of clonal expansion in hematopoietic stem cells.

137 imes in L1 and L2, but only once followed by clonal expansion in L3.

138 copy in the blood also revealed an increased clonal expansion in patients with steroid-refractory dis

139 acquisition of somatic mutations that drive clonal expansion in the absence of cytopenias and dyspla

140 ry cell fate without significantly affecting clonal expansion in the germinal center (GC).

141 , we show that UNG deficiency reduces B cell clonal expansion in the germinal center in mice and bloc

142 nd the processes of selection, mutation, and clonal expansion in the germinal center.

143 ies are required to characterize the role of clonal expansion in the persistence of replication-compe

144 Anti-insulin B cells undergo clonal expansion in vivo and emerge as IgM(+) and IgM(-)

145 ts with AAA have undergone proliferation and clonal expansion in vivo at the site of the aneurysmal l

146 proliferation, and the inability to undergo clonal expansion in vivo.

147 distribution or the underlying mechanism of clonal expansion in vivo.

148 Despite finding no evidence of clonal expansions in an aged, epitope-specific TCR reper

149 clustered in 42,670 clones, revealing major clonal expansions in each of these subsets.

150 of CD8(+) Tem diversity due to CMV-specific clonal expansions in reactivating patients.

151 We studied the B-cell repertoires and clonal expansions in response to attenuated varicella-zo

152 This review discusses the age-related clonal expansions in the human HSPC pool, which was term

153 The PLCOm2012, Bach, and Two-Stage Clonal Expansion incidence models had the best overall p

154 B cell clonal expansion is a hallmark of host-defense and vacci

155 ivers within the same tumour and reveal that clonal expansion is an early event of tumorigenesis.

156 The observed LC facilitation of mutant p53 clonal expansion is completely alphabeta and gammadelta

157 es were genetically diverse, suggesting that clonal expansion is involved in dissemination of FQ(R) C

158 once a T cell is engaged in antigen-specific clonal expansion, its retention no longer depends on FRC

159 rating CD8(+) T-cell immunity despite normal clonal expansion, likely due to impaired IL-10 productio

160 lso exhibit adaptive characteristics such as clonal expansion, longevity, self-renewal, and robust re

161 We propose that CD8 T-cell clonal expansion may be a correlative biomarker to enabl

162 inhibited the second division of the mitotic clonal expansion (MCE), and inhibited the expression of

163 In turn, increased NSPC migration and clonal expansion might be a consequence of growth in the

164 ther reveal that the main fitness benefit of clonal expansion might occur through the dispersal of of

165 The two-stage clonal expansion model we propose is based on the thesis

166 iability of the two-, three-, and four-stage clonal expansion models given age-specific cancer incide

167 Detectable clonal expansions most frequently involved somatic mutat

168 l and pancreatic cancer using the multistage clonal expansion (MSCE) model have identified two phases

169 Multistage clonal expansion (MSCE) models are a class of continuous

170 The reduced clonal expansion observed in the absence of SLAT resulte

171 he M. tuberculosis complex (MTBC) arose from clonal expansion of a single common ancestor [7] with a

172 d as largely monotypic entities arising from clonal expansion of a single transformed progenitor.

173 rols and found that PSA immunization induced clonal expansion of a small subset of suppressive CD4(+)

174 more, exposure to high-LET radiation induced clonal expansion of a subset of progenitor cells in the

175 events from the Americas but not from local clonal expansion of a successful clone.

176 ed strong infiltration of CD8(+) T cells and clonal expansion of activated CD8(+) effector T cells wi

177 y production of naive T cells in the thymus, clonal expansion of activated cells, cellular self-renew

178 (CD94/NKG2C), a response that resembles the clonal expansion of adaptive immune cells.

179 LPS induced a rapid and specific clonal expansion of alphabetaTh17 cells in the lung, as

180 is a plasma cell neoplasm that results from clonal expansion of an Ig-secreting terminally different

181 Pathogen exposure induces the clonal expansion of B cells expressing antibodies that c

182 lammatory process, as well as activation and clonal expansion of B cells.

183 f infancy display a dramatic, non-neoplastic clonal expansion of beta cells that have undergone mitot

184 Although miR-17-92 deficiency impaired the clonal expansion of both Th1 and TFH cells, the expansio

185 hat miR-17-92 expression is required for the clonal expansion of both virus-specific Th1 and TFH cell

186 t were completely identical, consistent with clonal expansion of CD4+ T cells harboring intact HIV-1.

187 L), the most common leukemia in adults, is a clonal expansion of CD5(+)CD19(+) B lymphocytes.

188 cytic leukemia (CLL) is characterized by the clonal expansion of CD5(+)CD23(+) B cells in blood, marr

189 ramework for understanding the regulation of clonal expansion of CD8 T cells by subthreshold TCR sign

190 tor beta-chains in purified T cells revealed clonal expansion of CD8 T cells, which occurred in blood

191 ituted CD8+ T cell repertoire was created by clonal expansion of cells present before treatment.

192 Clonal expansion of cells with ALV integrations driving

193 mits may not only prevent cancer by aborting clonal expansion of cells, but also by influencing the f

194 Moreover, the compliant matrix potentiated clonal expansion of CMs that involves multiple cell divi

195 -mediated cytopenias and is characterised by clonal expansion of cytotoxic CD3+ CD8+ lymphocytes.

196 mphocytic (LGL) leukemia is characterized by clonal expansion of cytotoxic T cells or natural killer

197 ipid A (MPLA), another TLR4 ligand, enhanced clonal expansion of effector CD8(+) T cells, but it also

198 hat antibiotic selection pressure results in clonal expansion of existing resistant strains.

199 ncrease in fusidic acid (FA) resistance, and clonal expansion of FA-resistant Staphylococcus aureus.

200 -leukaemic' mutations are thought to promote clonal expansion of haematopoietic stem cells (HSCs) by

201 be mutated in elderly individuals along with clonal expansion of hematopoiesis that confers an increa

202 y classical haploinsufficiency underlies the clonal expansion of hematopoietic progenitors in a large

203 nd genes in blood that may contribute to the clonal expansion of hematopoietic stem/progenitor cells.

204 Infections due to clonal expansion of highly virulent bacterial strains ar

205 Clonal expansion of HIV-1-infected cells in peripheral b

206 These results identify potential drivers of clonal expansion of HIV-1-infected cells in vivo.

207 at integration may influence persistence and clonal expansion of HIV-infected cells after cART is int

208 It has been suggested that clonal expansion of HIV-infected cells is an important m

209 mory T cells, and most recently appreciated, clonal expansion of HIV-infected cells.

210 ARCH is defined as the gradual, clonal expansion of HSPCs carrying specific, disruptive,

211 auses mixed cryoglobulinemia (MC) by driving clonal expansion of IgM(+)CD27(+) B cells.

212 Clonal expansion of individually sorted cells re-establi

213 uman genome is thought to play a role in the clonal expansion of infected cells and HIV persistence.

214 Thus, HIV replication in lymphoid tissue, clonal expansion of infected cells, and recirculation of

215 tance are proliferative processes that drive clonal expansion of infected cells.

216 B cell-specific Fcmr(-/-) mice lacked robust clonal expansion of influenza hemagglutinin-specific B c

217 us type I (HTLV-1) replication relies on the clonal expansion of its host CD4(+) and CD8(+) T cells,

218 hese parasites relies on a stem cell-driven, clonal expansion of larvae inside a molluscan intermedia

219 ed that homeostatic T cell proliferation and clonal expansion of latently infected T cells due to vir

220 ng and immunohistochemical analyses revealed clonal expansion of Lkb1-deficient myofibroblast-like ce

221 disease and aging, will partly be due to the clonal expansion of low-level inherited variants.

222 Clonal expansion of lower-avidity T-cell clonotypes depe

223 Here, we extend the MSCE model to include clonal expansion of malignant cells, an advance that per

224 Multiple myeloma (MM) is characterized by clonal expansion of malignant plasma cells in the bone m

225 s a heterogeneous disease characterized by a clonal expansion of mast cells in various organs.

226 ot impact humoral memory survival, Ag-driven clonal expansion of memory B cells and Ab-secreting cell

227 LFA-1 blockade significantly suppressed the clonal expansion of minor histocompatibility antigen-spe

228 n in patient fibroblasts associated with the clonal expansion of mitochondrial DNA mutations.

229 number of hypotheses have been proposed for clonal expansion of mtDNA deletions, including a replica

230 ther hand, no explanation exists yet for the clonal expansion of mtDNA mutants that is compatible wit

231 y damage accumulation, but rather are due to clonal expansion of mtDNA replication errors that occur

232 a hematopoietic malignancy characterized by clonal expansion of myeloid progenitor cells.

233 mic instability and provide an advantage for clonal expansion of neoplastic cells.

234 ve neoplasms (MPNs) are characterized by the clonal expansion of one or more myeloid cell lineage.

235 Interestingly, we find that in vivo clonal expansion of P. gingivalis-specific Th cells and

236 t chain AL amyloidosis, are characterized by clonal expansion of plasma cells which produce a vast am

237 icate that PKCdeltaI is required for mitotic clonal expansion of preadipocytes.

238 e hypothesis that antibiotic use selects for clonal expansion of preexisting resistant bacterial stra

239 wo rare rate-limiting mutations occur before clonal expansion of premalignant cells.

240 a very early event, likely essential for the clonal expansion of preneoplastic hepatocytes to HCC, wh

241 Moreover, our results show that clonal expansion of progenitor cells provides a window i

242 ological phenotype is likely a result of the clonal expansion of secondary mitochondrial DNA mutation

243 This approach is effective for the clonal expansion of single human cells and for basal cel

244 trate that the resulting tumors arise from a clonal expansion of switched cells.

245 eporter revealed continued proliferation and clonal expansion of terminally differentiated acinar cel

246 ctly with TH17 cells in situ and revived the clonal expansion of TH17 cells both ex vivo and in vivo,

247 the integrated viral DNA contributes to the clonal expansion of the infected cells.

248 ral replication cycle, but not in inhibiting clonal expansion of the infected host cells.

249 forded a glimpse into these processes by the clonal expansion of the malignant cell.

250 that mimicked mild sunburn in humans induced clonal expansion of the melanocytes, and repeated doses

251 ethylation profiling, demonstrated nonlinear clonal expansion of the original tumors and identified o

252 that disease flares were associated with the clonal expansion of the S. aureus population, occurring

253 s after sublethal irradiation results in the clonal expansion of the surviving stem cells and the eve

254 restricting the proliferation and consequent clonal expansion of these cells.

255 genome duplications allowing replication and clonal expansion of these complex rearranged molecules.

256 cted c-MYC+ B cells from apoptosis, allowing clonal expansion of this population, providing an explan

257 study whether ipilimumab treatment leads to clonal expansion of tissue-reactive T cells.

258 sion of BRAF(V600E) in mouse EMPs results in clonal expansion of tissue-resident macrophages and a se

259 sms may undergo directional selection during clonal expansion of tumors.

260 We observed clonal expansion of Valpha5(+) transcripts in prediabeti

261 Mice developed marked clonal expansions of B cells; half of the IgVH sequences

262 Lymphomas arise from clonal expansions of B, T, or NK cells at different stag

263 l analysis during regeneration reveals local clonal expansions of hepatocyte stem/progenitors at inju

264 tricted expression of ROR1 and could develop clonal expansions of ROR1(bright)CD5(+)B220(low) B cells

265 Comparison of clonal expansions of TET2 mutations in MDS, MPN, and CMM

266 mly integrating vectors, which may result in clonal expansion, oncogenic transformation, variegated t

267 m in response to antigen and did not undergo clonal expansion or effector differentiation.

268 meric mice, FoxO1 deficiency did not perturb clonal expansion or effector differentiation.

269 Whether this diversity is programmed before clonal expansion or in later phases as a result of stoch

270 e a characteristic of clonal cell selection, clonal expansion, or both.

271 Finally, we show that similar clonal expansion patterns can emerge in independent graf

272 hat activated CD4(+) T cells, at the peak of clonal expansion, persistently downregulated their TCR e

273 proteins, was upregulated during the T cell clonal-expansion phase, followed by inhibition of the tr

274 sis reveals that both RAS and JAK2 drove sub-clonal expansions primarily initiated by CRLF2 rearrange

275 nam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events

276 uced apoptosis and permits significant B-CLL clonal expansion regardless of the clone's BCR mutation

277 action of T-cell diversity because of uneven clonal expansion, senescent T cells have defects in bala

278 iomass 13-fold, seed production 32-fold, and clonal expansion seven-fold, while warming had little ef

279 ead of interfering with sexual reproduction, clonal expansion should often serve to enhance sexual fi

280 LPS boosted clonal expansion similar to the other adjuvants, but few

281 beta-catenin in DCs or blocking IL-10 after clonal expansion similarly led to reduced CD8(+) T cells

282 spent in a germinal center and thus time for clonal expansion, somatic hypermutation, affinity matura

283 mechanisms by which proviral integration and clonal expansion sustain the HIV reservoir.

284 agnostic specimens, consistent with dramatic clonal expansions that came to dominate the transformati

285 short punctuated bursts, followed by stable clonal expansions that form the tumor mass.

286 Thus no difference existed in the rate of clonal expansion throughout muscle fibres between mtDNA

287 early private alterations and not from later clonal expansions, thus exposing the profile of the prim

288 vated T cells, which allows the magnitude of clonal expansion to determine LN egress.

289 of transcription 3 (STAT3) mutations in LGL clonal expansions to test, using sensitive methods, for

290 b as a repressor of Rag transcription during clonal expansion using Abelson murine leukemia virus-tra

291 Clonal expansion via reprogramming also enables the disc

292 h this arises as a consequence of stochastic clonal expansion vs. active selection of particular clon

293 estingly, adjuvant effects on initial T cell clonal expansion were selective for CD4 T cells.

294 Clonal expansions were also present in each donor, stron

295 Blocking mTORC1 prior to growth prevented clonal expansion, whereas blockade after cells reached p

296 + T cells require continuous stimulation for clonal expansion, whereas CD8+ T cells can divide follow

297 e cells provides insight into the process of clonal expansion which is fundamental to our understandi

298 tors (MCp) measured by limiting dilution and clonal expansion with maturation.

299 elayed wound healing accompanied by impaired clonal expansion within the wound area.

300 Krt8(+) mammary luminal cells leads to their clonal expansion without directly affecting their lumina