ライフサイエンスコーパス: clonal selection

1 level from the same parental source without clonal selection.

2 -gal) was generated by gene transfection and clonal selection.

3 ent and the interaction of this process with clonal selection.

4 through the process of clonal variation and clonal selection.

5 revealed a focused repertoire suggestive of clonal selection.

6 tolerance is receptor selection rather than clonal selection.

7 genic cycles of mutation, proliferation, and clonal selection.

8 affinity and stability are optimized during clonal selection.

9 asts then mature into centrocytes to undergo clonal selection.

10 mportance of apoptosis in GC homeostasis and clonal selection.

11 a deterministic, clone-size-based model for clonal selection.

12 multiple cycles of mutation acquisition and clonal selection.

13 c cell death in the regulation of CD4 T cell clonal selection.

14 ather than to random methylation followed by clonal selection.

15 c factors in the microenvironment may foster clonal selection.

16 Cx43 were generated by gene transfection and clonal selection.

17 cells as a source of genetic plasticity and clonal selection.

18 ifferentiated CD4(+) effector T cells during clonal selection.

19 al composition), most probably the result of clonal selection.

20 structure, 2) alterations in cell number, 3) clonal selection, 4) metabolic differentiation, and 5) h

21 drogen-independent cells that are poised for clonal selection after androgen-deprivation therapy.

22 es two subsequent rounds of transfection and clonal selection after each transfection.

23 well as for effective strategies to improve clonal selection against age related deterioration.

24 ion, leading to the conclusion that negative clonal selection against mutator clones is unlikely to b

25 , genetic diversity provides a substrate for clonal selection and a source of therapeutic escape.

26 Display of antigen on FDCs is critical for clonal selection and affinity maturation of activated B

27 hese results suggest a revised vision of how clonal selection and affinity maturation operate in resp

28 FRA-1 perspective supporting the notion that clonal selection and cell plasticity represent two sides

29 cytes that respond rapidly to stress without clonal selection and differentiation.

30 in the absence of a better understanding of clonal selection and evolution.

31 -resident and migratory DCs was required for clonal selection and expansion of CD4(+) T cells after s

32 ent and natural antibody are interdependent: clonal selection and expansion of CD5+ B-1 cells is depe

33 products of inflammation, may play a role in clonal selection and expansion of CLL B cells.

34 of the T-cell line, suggesting a non-random clonal selection and expansion of T-cell clones that rec

35 xpress acquired antigen receptors or undergo clonal selection and expansion when stimulated.

36 cell stressors are a recognized mechanism of clonal selection and leukemogenesis in bone marrow failu

37 Whole-exome sequencing detected clonal selection and outgrowth of the acquired resistant

38 o 25 mmol/l glucose for 35 days induces both clonal selection and reversible dinucleotide repeat expa

39 e lymphocytes and may frame new questions of clonal selection and self tolerance.

40 Proteins of the BCL-2 family regulate clonal selection and survival of lymphocytes, and are fr

41 ry immune response when somatic mutation and clonal selection are still in progress.

42 develops as a result of somatic mutation and clonal selection, but quantitative measures of selection

43 tent with a model where JAK2(V617F) promotes clonal selection by conferring TNFalpha resistance to a

44 reagents using the miniaturized platform for clonal selection by destructive assay versus conventiona

45 eneity in real-time gene expression, enables clonal selection by flow cytometry, and forms a basis fo

46 ce that luminal cell translocation may drive clonal selection by promoting either the death or the ex

47 e acidity induced by glycolysis reveals that clonal selection can stabilize glycolysis even when ener

48 Whereas clonal selection controls cell death or survival in resp

49 er, our results suggest that therapy-induced clonal selection could be already present at the MRD sta

50 f random, stochastic methylation followed by clonal selection due to a proliferative advantage caused

51 Although these may in part be due to clonal selection during adaptation to tissue culture, ou

52 This phenomenon may be critical in clonal selection during carcinogenesis.

53 The forces that govern clonal selection during the genesis and maintenance of s

54 Current models attribute T cell clonal selection during the immune response to T-cell re

55 AR mutations exhibited clonal selection during treatment, including an increase

56 f cancer that is not subject to the blunting clonal selection effects that reduce the efficacy of oth

57 cal memory imply that Ab diversification and clonal selection exist in cartilaginous fish.

58 ssion resulted in chromosomal aberration and clonal selection for cells with c-myc amplification and

59 cells that escaped senescence had undergone clonal selection for faster proliferation and extensive

60 of heterozygosity at defined regions during clonal selection for growth advantage define the minimal

61 of TCR usage, which indicates strong T-cell clonal selection for peptide recognition.

62 e suppressive micro-environments and elicits clonal selection for survival and proliferative expansio

63 ype patterns of newborn twins suggested that clonal selection for TCRDV is independent of genetic bac

64 d that point mutations, indel formation, and clonal selection form a robust tripartite system for ant

65 This regulation compartmentalizes clonal selection from receptor selection.

66 2 and IFN-gamma production is independent of clonal selection, functional avidity maturation, and the

67 Clonal selection has been proposed as a pathogenetic mec

68 onses to abnormal environmental signals, and clonal selection have all been hypothesized to play a ro

69 ced-fitness" mutations may mediate "negative clonal selection," i.e., selective elimination of premal

70 This suggests a lack of strong clonal selection in Barrett's and that the malignant pot

71 Our results suggest the importance of clonal selection in endocrine therapy resistance of brea

72 Many B cells undergo apoptosis during B cell clonal selection in GCs.

73 ty depends on rapid B cell proliferation and clonal selection in germinal centers (GCs) and declines

74 gest that this mechanism is also critical to clonal selection in MPN.

75 The data suggest a nonrandom clonal selection in T-LGL, possibly driven by a common a

76 Most models of clonal selection in the Th cell compartment favor TCR af

77 examine how B cell receptor affinity affects clonal selection in thymus-independent type 2 (TI-2) imm

78 models results from an iterative process of clonal selection in vitro and/or in vivo.

79 ide experimental access to the mechanisms of clonal selection in vivo.

80 en that somatic hypermutation and subsequent clonal selection increase antigen-antibody specificity a

81 Following these checkpoints, clonal selection induces a host-specific DH reading fram

82 Clonal selection initially is promiscuous, activating ce

83 The process of clonal selection is a central feature of the immune syst

84 Clonal selection is central to immune function, but it i

85 among epithelium and stroma, but subsequent clonal selection is driven by factors, which appear to b

86 Somatic hypermutation and clonal selection lead to B cells expressing high-affinit

87 after radiotherapy could be associated with clonal selection leading to tumor regrowth at the treatm

88 mathematical analysis is applied to negative clonal selection, leading to the conclusion that negativ

89 strating that Bcl-xL and apoptosis influence clonal selection/maintenance for affinity maturation.

90 induced changes in gene expression, and that clonal selection may partially explain the change in mes

91 Here, we investigate whether clonal selection might contribute to this phenotype chan

92 tic and not determined by a distinct step of clonal selection necessary for survival from the acute r

93 Tetrachimeric mice show clonal selection occurs during development with further

94 e dominant clone at recurrence arose through clonal selection of a pre-existing minor clone present a

95 Clonal selection of a T cell for use in the immune respo

96 cancers is a stochastic process resulting in clonal selection of aggressively expanding cells with al

97 e Ab responses to DNA are dependent upon the clonal selection of B cells expressing particular H and

98 Here, we report that clonal selection of CD4(+) T cells is also extrinsically

99 stability in the absence of ATM function and clonal selection of cells harboring alterations within t

100 of CpG island methylation could result from clonal selection of cells having growth advantages due t

101 Since replicational stress leads to clonal selection of cells with p53 mutations, our result

102 cellular origin of high affinity IgE and the clonal selection of high affinity memory B cells into th

103 We conclude that clonal selection of INS-1 cells allows isolation of cell

104 No evidence of clonal selection of lentiviral vector-transduced T cells

105 daptive immunity by providing the ground for clonal selection of lymphocytes with the appropriate ant

106 when concepts of neonatal immune tolerance, clonal selection of lymphocytes, and "forbidden clones"

107 ignant lesion and the features that underpin clonal selection of one particular integrant remain poor

108 ent and mesenchymal phenotype may arise from clonal selection of tumor cells that have acquired the p

109 In all 15 cases examined, clonal selection on engraftment was observed in both pri

110 This may be a result of either clonal selection or selective activation in the pathogen

111 bly through a role in somatic hypermutation, clonal selection, or both.

112 tudies characterize a BCR-dependent negative clonal selection pathway that has been co-opted by a com

113 esults, the fitness function of the previous clonal selection phase is inferred to be directional and

114 ion is critical to the development of T-cell clonal selection, possibly from immune competition secon

115 A candidate mechanism for the apparent clonal selection pressure exerted by the sulfone against

116 T cells surviving the clonal selection process emigrate from the thymus to the

117 The nature of the clonal selection process is unclear, and to address this

118 Ultimately, this reconceptualization of the clonal selection process suggests a quantitative, testab

119 autoantibodies are derived from a restricted clonal selection process.

120 bled from microarray-eluted material without clonal selection produced only 30% less protein than seq

121 The immunological process of clonal selection requires a rapid burst in lymphocyte pr

122 e not the only sites for the affinity-driven clonal selection responsible for the maturation of humor

123 ancies identified as evolving neutrally, all clonal selection seemingly occurred before the onset of

124 t arose from the application of mutagenesis, clonal selection techniques, and media optimization to s

125 ronment is an important driving force in the clonal selection that leads to invasive and metastatic d

126 This phenomenon is reflected by the clonal selection that occurs during Ab-MLV-mediated tran

127 Clonal selection theories postulate that lymphocyte fate

128 The clonal selection theory first proposed by Macfarlane Bur

129 tion originated as a critical element of the clonal selection theory of antibody formation in order t

130 The clonal selection theory states that B lymphocytes produc

131 e implications of these new findings for the clonal selection theory, self-tolerance, and immunodomin

132 Contrary to the general precepts of the clonal selection theory, several recent studies have pro

133 cells undergo class switch recombination and clonal selection to generate high affinity neutralizing

134 acteristic of T cells that was eliminated by clonal selection to protect the host from autoimmune pat

135 e conditions favoring overgrowth resulted in clonal selection, which with added Ras or MEK oncogenes

136 FDCs) is essential for B cell activation and clonal selection within germinal centers.

137 lonal expansion, genetic diversification and clonal selection within the adaptive landscapes of tissu