ライフサイエンスコーパス: clonality

1 e for these tests in a new R package called 'Clonality'.

2 ected clones and a decline in overall T-cell clonality.

3 arC allele combination, supporting its tight clonality.

4 ne assay (HUMARA) has been used to determine clonality.

5 are such genomic profiles for an evidence of clonality.

6 ld gel electrophoresis was used to determine clonality.

7 as previously thought, from a difference in clonality.

8 ulated multinomial distribution based on IBC clonality.

9 meter, the oligoclonality index, to quantify clonality.

10 lthy subjects and patients showed restricted clonality.

11 cterize genetic relatedness and hence assess clonality.

12 on CDR3 length polymorphisms, have a limited clonality.

13 e of the desired mutation and to demonstrate clonality.

14 th America, where it is also associated with clonality.

15 f this subspecies and its apparent long-term clonality.

16 adicting widely held perceptions of obligate clonality.

17 nd the PIG-A gene was sequenced to determine clonality.

18 amples, whereas all PB plasma samples showed clonality.

19 the reproductive system tends toward strict clonality.

20 hematopoietic stem-cell transplants to show clonality.

21 izontal transfer of genes on a background of clonality.

22 lated strains to investigate epidemiological clonality.

23 re reliable than mutations for demonstrating clonality.

24 of naive T cells unmasking underlying memory clonality.

25 nal, quantitative definition for determining clonality.

26 sequence-based PCR (rep-PCR) assessments of clonality.

27 uence typing (MLST) were performed to assess clonality.

28 ivity despite equivalent measures of overall clonality.

29 g to determine their resistance profiles and clonality.

30 ulted in a high discrimination rate of tumor clonality (77.3%; 75/97) in metachronous multiple lung c

31 However, clonality also results in the spatial expansion of the g

32 Evidence of clonality also was assessed with antibodies to T cell re

33 NA, or, more likely, a reflection of limited clonality among hematopoietic stem cells in this bone ma

34 Tumor clonality, an important issue in tumor biology, has been

35 matopoiesis in 5 of 8 studied cases based on clonality analysis and presence of somatic genetic aberr

36 lymphoma from uveitis remains difficult, and clonality analysis may be either unsuccessful or mislead

37 Therefore, the reliability of the PCR-based clonality analysis may require further evaluation.

38 ion, we performed whole-exome sequencing and clonality analysis of 72 urothelial carcinoma samples, i

39 Clonality analysis of array CGH data suggested that mult

40 Clonality analysis of this large data set further enable

41 nt a novel system and standards for accurate clonality analysis using 454 pyrosequencing.

42 Clonality analysis using X-chromosome inactivation patte

43 sequencing technology enable high-throughput clonality analysis via vector integration site (VIS) seq

44 Clonality analysis was performed using human androgen re

45 -associated mutations, exome sequencing, and clonality analysis, we demonstrate that JAK2V617I is lik

46 and TSC2, promoter methylation of TSC2, and clonality analysis.

47 into one with infrequent genetic changes/low clonality and another with relatively higher clonality a

48 of high-avidity peripheral CTL with limited clonality and are able to contain acute and chronic infe

49 row, MC should be analysed for their number, clonality and c-Kit mutation.

50 Here, we investigate the clonality and cells of origin of regenerative nodules in

51 To determine the clonality and cellular origin of the monotypic plasmabla

52 g deep sequencing; this allowed us to define clonality and clonal evolution patterns precisely at rel

53 No correlation was found between clonality and disease severity but in patients treated w

54 loss of heterozygosity (LOH), could evaluate clonality and distinguish second primary breast cancer f

55 characterize them and identify trends in DNA clonality and divergence.

56 A correlation between clonality and JAK2V617F allelic ratio was demonstrated f

57 stigate the relationship between granulocyte clonality and JAK2V617F allelic ratio.

58 ni-Urbani and Buser overlap index), relative clonality and Morisita's overlap index, as well as the i

59 We aimed to assess the clonality and mutation burden of individual crypts in co

60 clonality and another with relatively higher clonality and mutations impacting TpT dinucleotide.

61 ification of an HES subset with T lymphocyte clonality and production of cytokines, particularly IL-5

62 a means of comparing the relative impact of clonality and recombination on fungal populations.

63 mor ploidy, allele-specific copy number, and clonality and represents this in an intuitive graph.

64 ion patterns while controlling for cell line clonality and sex.

65 he diffuse-type GCs show significantly lower clonality and smaller numbers of somatic and structural

66 the utility of RNA-seq for assessing T-cell clonality and T-cell antigen receptor (TCR) repertoire o

67 kinetics, and the relationships between cell clonality and their functional phenotypes.

68 toimmune disease, the finding of CD8+ T cell clonality and trafficking implies participation in a dis

69 Strict fungal clonality and vertical transmission evidently have not p

70 ciency virus (HIV) infection and explore the clonality and viral specificity of the autoinvasive T ce

71 . anthracis virulence is associated with the clonality and virulence of plasmids pXO1 and pXO2.

72 across a range of mosaic event sizes, types, clonalities, and sequencing depths.

73 tion between immunoglobulin (Ig) gene usage, clonality, and antigen specificity.

74 We describe the phenotype, clonality, and carbapenemase-encoding genes present in C

75 d on including information on strains, tumor clonality, and examination for genetic mutation or alter

76 In this study, the origin, clonality, and function of these cells were investigated

77 lities in terms of proliferation, apoptosis, clonality, and immunophenotype prior to the onset of a f

78 The distribution, clonality, and intrafamilial transmission of highly leuk

79 asmid transfers, and previous reports of its clonality are artifacts from the use of geographically a

80 In the long run, however, the effects of clonality are countered by recombination.

81 wo decades shows that both recombination and clonality are likely to contribute to the reproduction o

82 CAs) have been developed, their kinetics and clonality are virtually unknown.

83 nd significantly greater increases in T-cell clonality as measured by T-cell receptor (TCR) sequencin

84 erent expressions of whole-animal vertebrate clonality (asexual organismal-level reproduction), both

85 f 190 female patients were informative for a clonality assay at the HUMARA locus; 80% of MMM, 75% of

86 We used a clonality assay based on quantitative expression of poly

87 sing a quantitative, transcriptionally based clonality assay, we reported X-chromosome-transcribed al

88 merase chain reaction (qPCR) transcriptional clonality assay.

89 reported 3 X-chromosome transcription-based clonality assays (TCAs) involving the G6PD, IDS, and MPP

90 hat the transcriptionally based X-chromosome clonality assays are suitable for evaluation of clonal h

91 Thus, these novel clonality assays are useful in the diagnosis and follow-

92 Transcriptional clonality assays of the engrafted human IM cells demonst

93 Clonality assays, based on X-chromosome inactivation, di

94 stologic type have different clonal origins, clonality assessment is essential to differentiate MPLCs

95 e entire workflow of IG/TR NGS assays for 1) clonality assessment, 2) minimal residual disease detect

96 Thus, T cell clonality at a site of inflammation may reflect enrichme

97 cers in this cohort arose in persons who had clonality at the time of DNA sampling, more than 6 month

98 Pretreatment peripheral blood TCR clonality below the median was associated with improved

99 after serial transplantation, demonstrating clonality between each primary and passaged leukemia.

100 The results indicated evidence of clonality both within and between these two geographical

101 , EBV-encoded RNA in situ hybridization, and clonality by PCR of T-cell receptor gamma and immunoglob

102 Isolates were analyzed for clonality by pulsed-field gel electrophoresis.

103 T-1080 human fibrosarcoma cells to determine clonality by simple fluorescence visualization of metast

104 ere analyzed for their T cell receptor (TCR) clonality by using anchored RT-PCR of all the TCRbeta lo

105 male patients were additionally assessed for clonality by X-chromosome inactivation analysis.

106 Clonality can be established by a lack of mosaicism in a

107 The signal of clonality can be interrupted by gene uptake and exchange

108 s of SHM, Ag selection (including BASELINe), clonality (Change-O), and CSR.

109 emonstrated BubbleTree's utility in tracking clonality changes from patients' primary to metastatic t

110 Furthermore, T(FH) cells exhibited increased clonality compared with non-T(FH) cells from the same ly

111 5-fold greater density of T cells and higher clonality compared with normal breast.

112 ologic atypia is minimal, studies for T-cell clonality confirm the diagnosis.

113 rall T-cell infiltrate, but not the level of clonality, correlated with mRNA levels of key inflammato

114 analysis of peripheral T-cell phenotypes and clonality, cytokine production in mixed lymphocyte react

115 having the same clonality (SC) and different clonality (DC), respectively.

116 se of the "semiclonal model" or of "epidemic clonality," demonstrating occasional bouts of clonal pro

117 well as providing a clinical useful tool for clonality detection and minimal residual disease monitor

118 Clonality detection based on X-chromosome inactivation p

119 ion of CD5(+)B220(dull) cells (judged by BCR clonality) did not seem to be accelerated by APRIL; both

120 acter isolates to determine epidemiology and clonality during infectious outbreaks.

121 n addition, to maximize the detection of low-clonality events in probands, we applied a trio-based mo

122 re features with Th17 cells, with shared TCR clonality, expression of RORC2 and CCR6 and response to

123 (i) the proposed way to distinguish epidemic clonality from PCE may be faulty and (ii) the evidence o

124 In this model, occasional clonality generates linkage disequilibrium in the short

125 and gene rearrangement studies to determine clonality, have led to more frequent diagnosis of CTCL a

126 mbined analyses of two signatures for mutant clonality, HPRT mutation, and T-cell receptor beta CDR3

127 variable numbers of T lymphocytes of limited clonality, hypereosinophilia, and high IgE levels with a

128 Phenotypic clonality identifies the clonal population by the expres

129 ts for three markers of B-cell activation or clonality: immunoglobulin free light chains (FLCs), solu

130 purpose of the present study was to analyze clonality in 20 sporadic gastrinomas from eight patients

131 The 5 TCAs were used to examine clonality in 46 female patients along with assays for er

132 Th1 clonality in AA, investigated by high-throughput sequenc

133 e, rapid, and efficient method for assessing clonality in conjunction with IgH and specific transloca

134 ysregulation, we reinvestigated the issue of clonality in elderly women.

135 Sexual reproduction and clonality in eukaryotes are mostly seen as exclusive, th

136 bate on the relative significance of sex and clonality in eukaryotes is confounded by not appropriate

137 s, serum erythropoietin levels, establishing clonality in female subjects using assays employing X-ch

138 te their cell type, receptor expression, and clonality in individual mice.

139 ctious virions, providing a viral measure of clonality in infected cells.

140 tificial nuclear transfer; intergenerational clonality in nature via parthenogenesis and gynogenesis;

141 ic because of the difficulty in establishing clonality in paraffin-embedded tissue.

142 eral processes can produce the appearance of clonality in populations that undergo frequent recombina

143 n acute dengue patients, with higher overall clonality in secondary infection.

144 A study of clonality in these tumors has suggested that the epithel

145 In the present article we examine clonality in virus evolution.

146 A combination of methods was used to assess clonality, including MEN1 gene mutation analysis, loss o

147 Molecular markers of clonality, including unique, genomic fusion gene sequenc

148 through a novel combinatorial method, named clonality inference in tumors using phylogeny (CITUP), t

149 present there is no compelling evidence that clonality influences the position or function of interne

150 l and peripheral blood T cell receptor (TCR) clonality inform clinical outcomes in urothelial carcino

151 Clonality is a pervasive feature of sessile organisms, b

152 Clonality is associated with the recent emergence of a m

153 Clonality is assumed in many fingerprinting studies, alt

154 rophilia particularly if evidence of myeloid clonality is lacking.

155 In this review, we address how tumor clonality is measured using next-generation sequencing (

156 knowledge concerning tumor heterogeneity and clonality is needed to determine the impact of targeted

157 This finding demonstrated that clonality is not predictive of an interneuron's ultimate

158 ng, it is not always clear how evaluation of clonality is performed, and is it not known what the rel

159 Thus, clonality is the standard evolutionary mode for viruses

160 y potential applications such as analysis of clonality, isolation of immunogenic antigens and antigen

161 is contribution to the prognosis of sFLCr or clonality, it was found that the sFLCr does not identify

162 t a variably dynamic process of shifting CTL clonality lagging in tandem with viral evolution and sug

163 ulations are highly clonal and that the high clonality likely resulted from epidemic expansion of imp

164 n can stabilise these hybrids, but pervasive clonality may have a profound impact on the distribution

165 Thus, EBV clonality may reflect selection for a TR number that opt

166 The most commonly used phenotypic clonality methods are based on the X-chromosome inactiva

167 'Trailer-end clonality' occurs despite predictions of host immunologi

168 The clonality of 41 highly leukotoxic A. actinomycetemcomita

169 United States were also analyzed to examine clonality of a specific MLVA type.

170 This procedure tests for the clonality of a tissue specimen, a hallmark of neoplasia.

171 Affinity and clonality of allergen-specific IgE antibodies are import

172 An analysis of the clonality of cardiac progenitor cells (CPCs) and myocyte

173 To explore this issue, we have examined the clonality of CD4(+) T cells in simian immunodeficiency v

174 ion 3 sequencing) were used to determine the clonality of CD8(+) T lymphocytes taking part in the rec

175 chromosomal relatedness of strains suggests clonality of chromosomal markers and a limited transfer

176 The clonality of colitis-associated neoplasia has not been f

177 Extreme clonality of CTL expansions seen in LGL leukemia makes i

178 The specificity of recombination and the clonality of each mutant were confirmed by PCR, sequenci

179 The presence or absence of mutations and the clonality of each mutation were determined for each mark

180 determining region 3) sequence to assess the clonality of epitope-specific CD8(+) T lymphocytes gener

181 ompared the peripheral-blood CD34 count, the clonality of granulocytes and platelets in peripheral bl

182 Here we analyzed the clonality of HIV-1-infected cells using high-throughput

183 ion in severe combined immunodeficient mice, clonality of lung metastasis was dependent on cell numbe

184 heterozygosity analysis, we investigated the clonality of mature teratoma and its relationship to oth

185 he simple fluorescence method of determining clonality of metastases described here can allow large-s

186 Previous methods to determine clonality of metastasis used karyotype or molecular anal

187 al, such as the divergence times and genetic clonality of metastatic lineages.

188 esolution analysis allowed us to measure the clonality of methylation in individual tumors and gain i

189 However, to date no study assessing clonality of multiple primaries has been conducted in me

190 Mutation significance and estimated clonality of mutations determined the most likely MSI ta

191 clonal populations and emphasize the lack of clonality of nontypable (NT) H. influenzae isolates.

192 challenging previously held views about the clonality of obligate intracellular bacteria.

193 T-cell clonality of peripheral T-cell lymphoma (PTCL) is routin

194 We studied the clonality of phyllodes tumors from six patients who unde

195 We also analyzed transcript clonality of rat TCR-Valpha5, an ortholog of the dominan

196 We confirmed the clonality of selected transformants by Southern blot hyb

197 ed genomic DNA cannot be used to analyze the clonality of some streptococci containing Phi10394.4 and

198 nique allows for a direct examination of the clonality of sparse cell populations such as HSCs.

199 Little is known about the clonality of Staphylococcus epidermidis in the United St

200 if next-generation sequencing (NGS) revealed clonality of strains.

201 While screening the clonality of Streptococcus pyogenes isolates from an out

202 (Ig) gene rearrangements are used to define clonality of suspected B-lineage malignancy in tissue sa

203 tekeeping founder mutations, and explore the clonality of synchronous lesions to look for field effec

204 pectrotyping of TCR beta-chain to assess the clonality of T cells at different anatomic sites.

205 Clonality of T cells was examined in the lymphoid tissue

206 orbicula to test the hypothesis of long-term clonality of the androgenetic species.

207 dy was aimed at disclosing the diversity and clonality of the anti-Dsg3 response, as well as whether

208 To investigate the clonality of the bcl-2(+) follicles, we performed laser

209 The clonality of the experimental metastasis model depended

210 tations as a marker of clonal expansion, the clonality of the gastric unit and show how mutations exp

211 Spectratyping analysis showed restricted clonality of the identified TCR Vbetas.

212 The extensive somatic mutations and clonality of the IgD(+)Strictly-IgM(-)CD38(+) human tons

213 er their evolutionary landscape by inferring clonality of the individual mutation events.

214 To assess clonality of the MRSA isolates causing SSTI and BSI duri

215 The sudden emergence and clonality of the outbreak suggest that this strain may b

216 After confirming the clonality of the progressively differentiating cells, an

217 and serotype HS:1,8, further indicating the clonality of the related isolates from different host sp

218 ells share a similar phenotypic specificity, clonality of the response in humans has not been determi

219 The clonality of the T-cell repertoire from p53 knockout and

220 was found in peripheral lymphoid organs, the clonality of the TCR-BV8 and BV14 T cells that migrate t

221 To determine clonality of the thymocytes, we used degenerate RT-PCR t

222 PFGE showed marked clonality of the U.S. isolates, with differences between

223 ism for the selective pressure that leads to clonality of these B-cell clusters and opens the possibi

224 We have now examined the clonality of this IgA response in vascular tissue from t

225 To study the clonality of this response, we analyzed 22 MOG35-55-spec

226 The presence and extent (clonality) of genomic instability, as assessed by mutati

227 vantage on standard vertebrate reproduction, clonality offers fresh perspectives on the evolutionary

228 Clonality often defines the diseased state in hematology

229 The impact of bacterial clonality on infections caused by Staphylococcus aureus

230 on provides no insight into the influence of clonality on interneuron development because the entire

231 The extent to which any negative effects of clonality on mating success might be offset by the posit

232 sis predicts the long latent periods and the clonality on the basis of the following two-stage mechan

233 ood but these do not necessarily reflect the clonality or differentiation of cells within tissue.

234 clusive evidence to reject any hypothesis of clonality or low rate of meiotic recombination in P. fal

235 nalyses of the T-cell receptor Vbetas showed clonality or the presence of a very restricted number of

236 combining these methods, we detected either clonality or translocation in 117 of 137 cases (85%) in

237 xpansion of stem cells, but determination of clonality over many decades is restricted by epigenetic

238 (0)/G(1) apoptosis and in ACAs regardless of clonality pattern and presence of G(0)/G(1) apoptosis.

239 Resistant tumors displayed a complex clonality pattern suggesting the emergence of several re

240 d the 11q13 loss of heterozygosity (LOH) and clonality patterns in 15 leiomyomata of the esophagus, l

241 Deep digital sequencing revealed diverse clonality patterns in both never-smokers and smokers.

242 The results demonstrated different clonality patterns in multiple tumors in the same organ

243 udy, we conducted a longitudinal analysis of clonality, phenotype, and function to define the charact

244 s of the Colombian Pacific coast to evaluate clonality, population structure and linkage disequilibri

245 Increased TCR clonality positively correlated with increased CD8(+) PB

246 in otherwise disease-free BM, and whether BM clonality predicted higher risk of progression.

247 ted, in vitro stimulation did not select for clonality; rather, the TCRDV repertoires were similar be

248 Genotypic clonality relies on somatic mutations to mark the clonal

249 T cells, T-cell functional response, and TCR clonality, represents possible additional mechanisms of

250 ses (66.7%) were assessed as having the same clonality (SC) and different clonality (DC), respectivel

251 s estimated by a modified Gini-Simpson index clonality score.

252 Our results indicate that clonality serves to increase sexual fitness when it is a

253 After adjusting for the effect of clonality, seven determinants (fnbA, cna, sdrE, sej, eta

254 ive allelic systems to recombination genes ("clonality/sexuality machinery") to escape recombinationa

255 Analysis of clonality showed that all of these cases represented the

256 Potentially, clonality simplifies efforts to understand social evolut

257 ini Index and cluster sizes quantify the BCR clonality status and are robust to sampling and sequenci

258 gen receptor gene, was used to determine the clonality status of 11 ACF from eight female patients.

259 files in the populations and to describe the clonality structure within populations.

260 Modern clonality studies have confirmed the multipotent stem-ce

261 skewing has recently been suggested by XCIP clonality studies in aging hematopoietic cells.

262 Observed Microviridae clonality suggests recovery of bloom-terminating viruses

263 pients of the same donor and reflected donor clonality, supporting a deterministic, clone-size-based

264 ombining XCIP clonality testing with genetic clonality testing to identify clonal populations with ye

265 research applications include combining XCIP clonality testing with genetic clonality testing to iden

266 Errors in interpreting clonality tests arise from stochastic, genetic, and cell

267 newly activated naive cells of considerable clonality that persisted in the circulation for several

268 Despite clonality, the Sca-1 outliers had distinct transcriptome

269 nsions can serve as surrogate markers of CTL clonality to assess clonal kinetics in T-LGLL.

270 ght chain ratio (sFLCr) and bone marrow (BM) clonality to define more sCR.

271 Using mutation clonality to infer time of onset, we find that while age

272 ell populations include cellular conditions, clonality, transcriptional circuitry and chromatin modif

273 Self-incompatibility, clonality, tree size and proximity to the mother tree we

274 ework, BubbleTree, to characterize the tumor clonality using next generation sequencing (NGS) data.

275 Analysis of tumor clonality using X-linked inactivation assays in a patien

276 genesis and kleptogenesis; intragenerational clonality via polyembryony; and what in effect qualifies

277 Plasma cell clonality was analyzed by flow cytometry, immunohistoche

278 Tumor clonality was assessed by analyses of mitochondrial DNA.

279 Clonality was assessed by laser capture of multiple cell

280 Clonality was assessed by repetitive sequence-based PCR

281 Clonality was demonstrated by eBURST analysis and standa

282 Clonality was demonstrated by following cytochrome c oxi

283 Using X-chromosome inactivation, clonality was detectable in 19 (73%) of 26 BM samples, w

284 Finally, clonality was detected in 21 of 58 atypical B-cell proli

285 abeta, but its expression level was high and clonality was detected in a TCRgammadelta expressing tum

286 Among those tested, Clonality was identified for its robustness as a key met

287 e ability to form colonies, an indication of clonality, was restricted to the aldehyde dehydrogenase

288 data on survival, plasmid copy numbers, and clonality, we developed a model predicting virulence.

289 To increase our ability to detect clonality, we developed simple TCA for detecting the tra

290 Regardless of clonality, we found that MCPyV status was concordant for

291 orrelations between granulocyte and monocyte clonalities were greatest, followed by correlations betw

292 ons, endogenous erythroid colony growth, and clonality were investigated in 51 children.

293 on of high pretreatment peripheral blood TCR clonality with elevated PD-L1 IC staining in tumor tissu

294 e inflamed joint share T-cell receptor (TCR) clonality with Th17 cells, suggesting a shared clonal or

295 and breast, confounding assessment of tumor clonality with traditional X-inactivation studies.

296 and clinical significance by virtue of their clonality within a tumor cell population, their distinct

297 TS from reinfection, despite a high level of clonality within and among individuals, giving insights

298 Additionally, we observed evidence of clonality within the EAC cases; specifically, 22 of 25 E

299 Clonality within the T-cell compartment was identified b

300 ticolor Cre-dependent marker system to trace clonality within the tumor microenvironment to show that