ライフサイエンスコーパス: clonally

1 Nostoc, and that each appears to be evolving clonally.

2 e is eliminated and the other is transmitted clonally.

3 different modalities are largely segregated clonally.

4 promoter accessibility is tightly linked to clonally active PfRh4 promoters.

5 abundant IgM which, together with SIgM from clonally affiliated PCs, recognized mucus-embedded comme

6 onal spectrum at the whole-genome level of a clonally aged population and uncovered phenotypic variat

7 This cell population can be clonally amplified and maintained for >25 passages (>100

8 monitor B cells in the PB that correspond to clonally amplified populations in the CNS in MS and othe

9 We performed massively parallel clonally amplified sequencing of cDNAs from testes of wi

10 Moreover, clonally amplified virus env genes in milk produced func

11 We established a nuclear transfer method to clonally amplify the genomes of neurons from adult mice

12 A single mutant expands clonally and finally replaces the wild-type population o

13 Some animals reproduce clonally and must therefore require adult somatic mechan

14 Each symplasmatum develops clonally and stochastically from a single bacterium into

15 sands of isolates from a single donor can be clonally archived and taxonomically mapped in multiwell

16 izing libraries of transposon mutant strains clonally arrayed in a multiwell format is provided.

17 Clonally arrayed sequenced collections of bacterial stra

18 Ex vivo, this subpopulation expanded clonally as progenitors but also differentiated toward m

19 Bacteria and archaea reproduce clonally, but sporadically import DNA into their chromos

20 the most abundant clonal genotypes, even in clonally complex and rapidly evolving cases.

21 Single secretory cells clonally dedifferentiated into multipotent stem cells wh

22 ata also show that the CD4+ T cells that are clonally deleted experienced only slightly stronger T-ce

23 cytes at single cell resolution, we isolated clonally derived adipocytes from stromal vascular fracti

24 This fatal cancer is clonally derived and is an allograft transmitted between

25 nt intestinal cellular pool, we transplanted clonally derived BMSCs into fetal sheep.

26 Two distinct and clonally derived CCs, CC1 and CC2, were used for this st

27 Using clonally derived colonic epithelia, we show that toxins

28 tions in vitro or transplantation into mice, clonally derived EP cells differentiate into numerous en

29 t alternative histological phenotypes can be clonally derived from a common cell of origin.

30 pe (WT) UPEC, we discovered that each IBC is clonally derived from a single bacterium.

31 However, through clonally derived help, this population acquired a polyfu

32 Analysis of clonally derived JAK2V617F-positive erythroblasts from M

33 pared with autologous control erythroblasts, clonally derived JAK2V617F-positive erythroblasts from M

34 In addition, clonally derived KO pNSCs and dNSCs displayed impaired p

35 Clonally derived PECAM1(+) tumour cells coalesce to form

36 d drug sensitivity and marker segregation in clonally derived second-generation progeny, and identifi

37 nally, we demonstrate that implantation of a clonally derived spinal cord neurosphere can result in r

38 Karyotype analyses of parental and clonally derived tumor cells expressed many consistent (

39 lodysplastic syndromes and secondary AML are clonally derived.

40 esis, we developed a mathematical model of a clonally descended bacterial population undergoing HDT t

41 aled the frequent within-host coexistence of clonally descended cells that differed in their MGE infe

42 equences, and suggests that the formation of clonally developing clusters may often be the first step

43 ecently formed and long-lived PCs drawn from clonally disparate precursors.

44 ablasts that re-emerge in these subjects are clonally distinct and exhibit enhanced somatic hypermuta

45 hat foreign Ag-specific nTregs and Tconv are clonally distinct and that foreign Ag-specific nTreg pop

46 nity, Plumlee et al. (2013) demonstrate that clonally distinct CD8 T cells have the ability to genera

47 ng microenvironment, and cooperation between clonally distinct cell populations, can contribute to th

48 derived parts of the heart, neck muscles are clonally distinct from these muscles and define a third

49 These clonally distinct MDSC overproduce hematopoietic suppres

50 The activation states are clonally distinct, stable across cell division and devel

51 ILCs lack clonally distributed antigen receptors characteristic of

52 The interaction between clonally distributed inhibitory receptors and their acti

53 compete for binding to TNF, the response is clonally diverse and involves multiple epitopes on adali

54 an intrinsic functional property acquired by clonally diverse B cells.

55 bserve the in vitro numerical expansion of a clonally diverse polyfunctional population of Ag-specifi

56 e-MHC ligand and thereby the generation of a clonally diverse public T cell response to CMV.

57 memory and revealed that M1(58-66)-specific, clonally diverse VB19 T cells express alpha-chains encod

58 ve capacity, allowing aged muscle to mount a clonally diverse, albeit diminished, response to injury.

59 ways; and (iv) APOBEC-induced mutagenesis is clonally enriched in chemotherapy-treated urothelial car

60 During immune responses, B lymphocytes clonally expand and undergo secondary diversification of

61 that became EYFP+ during a primary infection clonally expand as well as all virus-specific CD8+ T cel

62 gland share a common origin, whether glands clonally expand by fission, and determine if such metapl

63 In PM and IBM cytotoxic CD8-positive T-cells clonally expand in situ and invade MHC-I-expressing musc

64 ntracellular lifestyle during which bacteria clonally expand into multicellular bacterial communities

65 colony-stimulating factor and interleukin-3, clonally expand, and differentiate to Ly-6C(high) monocy

66 Autoreactive B cells clonally expand, isotype switch, and mutate--properties

67 in vivo antigen encounter, quiescent B(MEM) clonally expand.

68 ages, this conversion strategy can generate clonally expandable cell populations with a variety of p

69 NSCs are clonally expandable, genetically stable, and easily tran

70 , antigen-specific PD1(+)ICOS(+) cTfh subset clonally expanded after booster immunization whose frequ

71 itat, could, in principle, lead to localized clonally expanded aggregates composed of one or a few ta

72 patients with Goodpasture disease display a clonally expanded alpha3135-145-specific CD4(+) T-cell r

73 T cell-mediated cytotoxicity and persistent, clonally expanded and antigen-driven endomysial T cells,

74 They have a diploid karyotype, can be clonally expanded and genetically manipulated, and are c

75 Furthermore, these PCs were clonally expanded and showed signs of affinity maturatio

76 Patient-specific iPSCs were then generated, clonally expanded and validated.

77 OCBs are locally produced by clonally expanded antigen-experienced B cells and theref

78 FACS-sorted adult human ductal cells clonally expanded as spheres in culture, while retaining

79 evidence that receptor revision may occur in clonally expanded B cell lineages, which supports the hy

80 Clonally expanded CD19(+)CD27(+)CD20(-)CD38(hi) plasmabl

81 These results show that clonally expanded CD4(+)T cells can be a reservoir of in

82 -1 DNA sequences that were derived from such clonally expanded CD4+ T cells constituted 62% of all an

83 y, we showed that trisomy 8 MDS patients had clonally expanded CD8(+) T-cell populations that recogni

84 y dramatically shortening the time to obtain clonally expanded cell colonies.

85 It is not known if any of the clonally expanded cells carry replication-competent prov

86 clouds our assessment of the degree to which clonally expanded cells harbor infectious viruses, and t

87 Clonally expanded cells make up a large and increasing f

88 About 40% of the integrations were in clonally expanded cells.

89 nd BACH2; many of these integrations were in clonally expanded cells.

90 archival origin among highly differentiated, clonally expanded cells.

91 We measured the size of clonally expanded deletions in 62 small and 60 large ind

92 Our data support the concept that clonally expanded EBNA1-specific CD4(+) T cells potentia

93 rganisms depends upon the regulated death of clonally expanded effector cells and the survival of a c

94 , memory lymphocytes self-renew, while their clonally expanded effector progeny differentiate to figh

95 en individual iPSC lines from each tissue or clonally expanded fibroblasts carried an elevated load o

96 n normal esophagus (NE) or BE and were later clonally expanded in BE or in EAC.

97 rring even in histologically NE cells may be clonally expanded in esophageal adenocarcinogenesis.

98 are preferentially enriched and potentially clonally expanded in hepatocellular carcinoma (HCC), and

99 lthough germline TCRs were more abundant and clonally expanded in patients with OS, nongermline seque

100 amples, recombinant antibodies prepared from clonally expanded MS CSF plasma cells did not bind to VZ

101 ry-deficient neurons harbored high levels of clonally expanded mtDNA deletions at a single-cell level

102 ry-deficient neurons harbored high levels of clonally expanded mtDNA deletions at a single-cell level

103 ere isolated from human limbal specimens and clonally expanded on a 3T3 feeder layer, followed by sub

104 a large proportion of HCV(+)MC(+) patients' clonally expanded peripheral B cells is prone to anergy

105 Repertoire analysis revealed a dynamic, clonally expanded plasma cell population with features o

106 idogenic Ig light chain (LC) secreted from a clonally expanded plasma cell.

107 LCs are secreted from clonally expanded plasma cells, generally as disulfide-l

108 her T cells infiltrating AAA lesions contain clonally expanded populations of T cells, we amplified b

109 At time points 1 and 2, such clonally expanded populations were found predominantly i

110 A shortcoming of this model is that clonally expanded precursor lesions do not always belong

111 could be populations of infected cells that clonally expanded prior to and/or during ART, some of wh

112 verse repertoires of healthy individuals and clonally expanded repertoires from individuals with chro

113 clear transfer, Hazen et al. (2016) examined clonally expanded single neurons for mutations and found

114 to that of the host gene, the proportion of clonally expanded sites, and the proportion located with

115 -generation sequencing of the TCRbeta chain, clonally expanded T cells as a hallmark for memory devel

116 The data indicate that dividing clonally expanded T cells contain defective proviruses a

117 often extensive infiltrate of predominantly clonally expanded T cells of CD4 and CD8 lineages.

118 Clonally expanded T cells represented the majority of al

119 iglomerular regions showed a predominance of clonally expanded T cells.

120 ne system has developed mechanisms to delete clonally expanded T cells.

121 The authors identified an enrichment of clonally expanded Th1 cells containing intact HIV-1 prov

122 fresh RCCs showed that EM T cells were more clonally expanded than CM or naive T cells, and the clon

123 also accurately identifies the repertoire of clonally expanded tumor-reactive cells and reveal a dual

124 Sequencing the clonally expanded Vh7 revealed signs of somatic hypermut

125 ve) hERM cells derived by fluorometry can be clonally expanded, can grow organoids, and express the m

126 We hypothesized that clonally expanded, class-switched IgG4-positive B cells

127 Sox10-selected cells could be clonally expanded, cryopreserved, and multiplied for ove

128 ecognition are selectively retained, but not clonally expanded, during aging.

129 Clonally expanded, HIV-1-infected cells were detectable

130 tifiers (UMIs) that allowed for screening of clonally expanded, individually tagged cells.

131 +) T cells from Mtb-infected CBA/J mice were clonally expanded, preferentially expressing T cell rece

132 ppressed, and positively selected thymocytes clonally expanded, resulting in a small thymus with a he

133 nd also at the inflamed site, where they are clonally expanded.

134 remained highly stable as the tumour masses clonally expanded.

135 d genes, rapidly produce cytokines, and have clonally expanded.

136 d cells in patients on long-term therapy are clonally expanded; in some cases the integrated viral DN

137 Some of these CD4(+)T cells are clonally expanded; most of the proviruses are defective.

138 maturation in normal and malignant skin and clonally-expanded antibodies in melanoma, support the in

139 respiratory chain complexes I and IV due to clonally-expanded mitochondrial DNA deletions and a sign

140 ense, so approaches to preferentially target clonally expanding mast cells are needed.

141 These clonally expanding populations of HIV-infected cells may

142 to T and B cells of jawed vertebrates, that clonally express somatically diversified antigen recepto

143 plore the structural features that allow the clonally expressed TCR to functionally engage with multi

144 ues, occasionally caught in the act of being clonally fixed in the adjacent tumors.

145 ocytosis or thrombocytosis, can be initiated clonally from a single cell carrying JAK2-V617F.

146 Most complex multicellular organisms develop clonally from a single cell.

147 d HSCs and analyses of their perpetuation in clonally generated progeny HSCs have now provided defini

148 ephrogenesis demonstrates that Troy(+) cells clonally give rise to tubular structures that persist fo

149 tely in culture; however, present methods to clonally grow them are inefficient and poorly defined fo

150 inizing and modeling microscopically tracked clonally growing populations before and after a semi-let

151 ial to control myeloma and other genetically/clonally heterogeneous cancers.

152 sTR probabilistically classifies isolates as clonally heterogeneous or mixed by using a model of tand

153 Cancers are often clonally heterogeneous, and the detection of subclonal m

154 g rarely, are positively selected and expand clonally in normal testes through a process akin to onco

155 Each of the huge number of clonally independent B cells expresses a unique set of I

156 We confirm that the tumours are clonally independent, having distinct somatic single-nuc

157 utations (SNPs) in aligned pairs distinguish clonally inherited regions from regions where either gen

158 that human Merkel cell polyomavirus (MCV) is clonally integrated in approximately 80% of MCC tumors.

159 olyomavirus, MCPyV, was recently shown to be clonally integrated in several MCC cases.

160 MCV is clonally integrated into MCC tumor cells, which then req

161 eage determination, FoxO1+ Ins(-) cells were clonally isolated and assayed for their capacity to unde

162 op and self-organize into cardiac tissues by clonally isolating and expanding second heart field card

163 be applied to determine cell growth rates in clonally labeled material from a wide range of tissues i

164 In this regime, fit genotypes expand clonally, leading to large fluctuations in the number of

165 c dermatitis are significantly less mutated, clonally less focused, and less indicative of Ag selecti

166 seven housekeeping genes) and four groups of clonally linked (by pulsed-field gel electrophoresis [PF

167 In contrast, clonally marked mature hepatocytes demonstrated the abil

168 X2 and strongly for NANOG, can be propagated clonally on either Matrigel or gelatin, and are morpholo

169 s that single template strands are amplified clonally onto a solid surface prior to the sequencing re

170 ctivating mutation, which is somatically and clonally present in almost all patients through the enti

171 rse, and the complexity of those found to be clonally present in tumors has increasingly made it diff

172 Common lymphoid progenitors (CLPs) clonally produce both B- and T-cell lineages, but have l

173 We show that two morphs clonally produced by the aphid Paracletus cimiciformis d

174 The BCSP clonally produces chondrocytes (cartilage-forming) and o

175 r persistence, but the contribution of these clonally proliferating cells to the rebounding virus is

176 ndividual layers, such as the epidermis, are clonally propagated and structurally maintained by symme

177 As a clonally propagated crop, cassava is especially vulnerab

178 A set of 498 largely unrelated, clonally propagated genotypes were inoculated with F. ci

179 rom grapes (Vitis vinifera ssp. vinifera), a clonally propagated perennial crop, to address three ong

180 rieties in farmers' fields, using cassava, a clonally propagated root crop widely grown in the tropic

181 ommon East Asian tree species introduced and clonally propagated since prehistoric times across the P

182 served in a number of species, especially in clonally propagated species.

183 cp-17-carrying Oceanic paper mulberries are clonally propagated, our data concur with expectations o

184 existence of eukaryotes is best described by clonally propagating cell lines with episodic sex trigge

185 We overcame this problem by clonally propagating males from lineages in a dioecious

186 The majority of sites were clonally pure or composed of clones from a single phylog

187 In this study, we assessed two clonally purified E. chaffeensis mutants with insertions

188 Clonally rearranged Ig DNA was detected in plasma from 7

189 These distinct tumor-initiating cells (TICs) clonally recapitulated the immunophenotypic spectrum of

190 at possess the BCR-ABL1(+) translocation and clonally recombined VDJ regions.

191 cells that propagate rapidly in SCF and can clonally regenerate the mixed population.

192 As a consequence, nestmates are almost clonally related (r = 0.996).

193 nowledge, we found that a restricted pool of clonally related B cells participated in robust bidirect

194 The target antigen or antigens of these clonally related B cells remain unknown; our work contin

195 point to a CSF antigen-driven activation of clonally related B cells that shape the intrathecal immu

196 lusters that might represent the most active clonally related B-cell populations.

197 Cases 2 and 3 were designated as clonally related based on overlapping copy number altera

198 y MLST and were therefore also classified as clonally related by MLST.

199 tionships, typing all isolates classified as clonally related by PFGE with the same type.

200 and greater transcriptional complexity than clonally related cell types in the central and periphera

201 re composed of a dynamic mixture of distinct clonally related complexes.

202 Hence, clonally related composite lymphomas are elegant models

203 ple clones were detected with 16 clusters of clonally related CRAB.

204 For patients with clonally related DLBCL, induction therapy with either an

205 Clonally related enteric neurons exhibit synchronous act

206 Here, we show that clonally related excitatory neurons in the developing hi

207 Clonally related excitatory neurons maintain a coherent

208 terial pathogens, especially at the level of clonally related groups of isolates.

209 is of lineage trees constructed from sets of clonally related Ig sequences.

210 lation, predominantly in the bone marrow, of clonally related IgM-secreting lymphoplasmacytic cells.

211 tools to address this question, finding that clonally related inhibitory interneurons dispersed widel

212 ther analysis of the spatial distribution of clonally related interneurons and demonstrate that inter

213 puter simulation, Sultan et al. suggest that clonally related interneurons are "not randomly disperse

214 ic retroviral barcode labeling, we find that clonally related interneurons can be widely dispersed wh

215 Furthermore, clonally related interneurons did not randomly disperse

216 Moreover, the regional distribution of clonally related interneurons exhibits a clear clusterin

217 As such, it is likely that clonally related interneurons have considerable flexibil

218 Two previous studies suggest that clonally related interneurons originating from individua

219 es and propose a new interpretation, whereby clonally related interneurons would be considered cluste

220 Organisms regenerated from clonally related isogenic founders might a priori have b

221 red to represent the metabolic states of two clonally related lineages of P. aeruginosa isolated from

222 ly by short-lived PCs with repopulation from clonally related memory B cells.

223 Similarly to TG2-specific PCs, clonally related memory IgA B cells of blood showed lowe

224 We analyzed K12 and K7M2 cells, two clonally related murine osteosarcoma cell lines that hav

225 However, a subpopulation of these clonally related neurons also undergoes a short lateral

226 nalling-dependent shift in the allocation of clonally related neurons is essential for the proper ass

227 osits that the ontogenetic columns formed by clonally related neurons migrating along the same radial

228 Mutations common to tumors and clonally related PanIN2 and PanIN3 lesions were identifi

229 transformation and cell-cell killing within clonally related populations, as the consequences of int

230 solates, we were able to investigate whether clonally related Pseudomonas aeruginosa inhabiting diffe

231 oftware on a set of simulated data, a set of clonally related sequences, and a group of randomly sele

232 First, clonally related sets of anti-DSG1 hybridomas characteri

233 ding of RNA polymerase II in these adjacent, clonally related stem cells within intact Drosophila bra

234 that MM composes 4 hierarchically organized, clonally related subpopulations, which, although phenoty

235 ) were more abundant in humans than mice and clonally related to a large repertoire of memory IgM(+)

236 ese phenotypically resembled GCTfh, and were clonally related to a resting PD1(+)ICOS(-) CD4(+) memor

237 evealed an Env-IM cross-reactive Ab that was clonally related to a subsequent vaccine-induced gp41-re

238 ide; and 3) T cells in the d-NALT were often clonally related to cells in the lower respiratory tract

239 revealed that ST459 isolates from Canada are clonally related to colonizing and invasive ST459 organi

240 The sequences clonally related to known antibodies with binding affini

241 monstrate that the trapezius muscle group is clonally related to myocardium at the venous pole of the

242 n environmental clade (ST3, N = 17 isolates) clonally related to the pandemic O3:K6 complex and a cli

243 ed with a very poor outcome, especially when clonally related to the preexisting CLL, the mechanisms

244 The resultant cells were clonally related to the primary leukemic blasts but rese

245 80% of DLBCL cases in patients with CLL are clonally related to the underlying CLL, and the median s

246 eloped acute myeloid leukemia (AML) that was clonally related to their B-ALL, a novel mechanism of CD

247 d that clinical isolates from pigs were more clonally related to those of human origin than the noncl

248 Finally, we show that even clonally related tumors derived from the same immortaliz

249 In clonally related tumors, chromosomal copy number changes

250 Here we report a detailed comparison of clonally related wild-type and RSCV strains isolated fro

251 s M. abscessus subspecies abscessus and were clonally related within each patient.

252 Although not all early US AMP isolates were clonally related, E. faecium CC17 isolates have been cir

253 Deficient and proficient isolates were clonally related, implying evolution from a common ances

254 Abs from these subsets were clonally related, suggesting a common origin.

255 majority of serotype IV isolates (89%) were clonally related, tetracycline-, erythromycin-, and clin

256 of B cells; half of the IgVH sequences were clonally related.

257 atients, different bands comprising OCBs are clonally related.

258 mas and Hodgkin's lymphomas, the tumours are clonally related.

259 suggesting that the individual mAbs are not clonally related.

260 Air and clinical isolates were found to be clonally related.

261 pressing cTfh and tonsillar GCTfh cells were clonally related.

262 Transmission was defined as carriage of a clonally-related ESBL producer with identical bla(ESBL)

263 lls, proliferate to expand a small number of clonally relevant lymphocytes, differentiate to antibody

264 800 individuals clonally replicated and grown on four sites, and genotyp

265 tion of loblolly pine (Pinus taeda) that was clonally replicated at three sites in the southeastern U

266 roach, using an unimproved population of 380 clonally replicated unrelated trees, to test 3,938 singl

267 a quantitative trait mapping experiment in a clonally-replicated full-sibling family of loblolly pine

268 lity, but can be more accurately assessed in clonally-replicated plantings where each genotype is rep

269 ent Bmi1(+) ISCs dramatically proliferate to clonally repopulate multiple contiguous crypts and villi

270 last populations at diagnosis and were fully clonally represented at relapse, identifying these rare

271 ng genome contains, on average, more than 30 clonally represented gene alterations per case.

272 t the typical CLL coding genome contains <20 clonally represented gene alterations/case, including pr

273 enotyping of the diagnostic biopsy to detect clonally represented somatic tumor mutations and is a re

274 antigen-presenting cells in that they have a clonally restricted antigen-specific receptor, the B cel

275 nse to a hapten is impaired when preexisting clonally restricted cells recognizing the hapten are dom

276 The clonally restricted expansion of Th1 cells is most likel

277 eptors (KIRs) are expressed in a variegated, clonally restricted fashion on NK cells and are importan

278 Clonally restricted hematopoiesis is associated with an

279 Differences between 2DL4 and clonally restricted KIR promoters suggest a model that e

280 he lack of any known protective epitopes and clonally restricted T cell subsets with complementary T

281 Unlike GC B cells, which are clonally restricted, T(FH) cells distributed among all G

282 ity promotes structural alterations that are clonally selected to drive tumor development.

283 cogenic mutation could bias this process and clonally spread the mutation throughout the stem cell po

284 ommunity of hundreds of nuclei and reproduce clonally through large multinucleated spores.

285 Clonally transmissible cancers are somatic cell lineages

286 ble cancers, and discuss the implications of clonally transmissible cancers for host-pathogen evoluti

287 highlight the common and unique features of clonally transmissible cancers, and discuss the implicat

288 CTVT) are the only known naturally occurring clonally transmissible cancers.

289 studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the diseas

290 ntrast, the remaining 20% of patients have a clonally unrelated DLBCL and have a prognosis similar to

291 arly, the probability of harboring multiple, clonally unrelated fields at the time of diagnosis was f

292 sequencing confirmed the presence of a STIC clonally unrelated to 1 case of UEC, and NGS of the othe

293 bined B-cell non-Hodgkin lymphomas are often clonally unrelated.

294 malaria parasite Plasmodium falciparum show clonally variant expression regulated at the epigenetic

295 A peculiar case of clonally variant genes are the 2 nearly identical clag3

296 together, our findings support the idea that clonally variant genes facilitate the adaptation of para

297 -infected erythrocytes, is a major family of clonally variant targets of naturally acquired immunity

298 lciparum Ags are extraordinarily diverse and clonally variant, which likely contribute to the ineffic

299 ture, melanin-producing melanocytes expanded clonally within the epidermis before losing their differ

300 later divisions in the DLN could self-renew, clonally yielding a TCF1-silenced daughter cell as well