ライフサイエンスコーパス: clonic

1 ximately half of patients, and include tonic-clonic, absence, and myoclonic seizures, including statu

2 also associated with more prehospital tonic-clonic activity (22.7% vs 4.2%; P < .001) and cardiopulm

3 physiological sparse and pathological tonic-clonic activity may coexist in the same cortical network

4 how that the highest synchrony occurs during clonic ADs, consistent with the idea that specific circu

5 sent study examined the neuronal network for clonic AGS in GEPR-3s by microinjecting a competitive NM

6 upport a critical role for NMDA receptors in clonic AGS modulation.

7 The brainstem nuclei of the clonic AGS network are identical to those subserving ton

8 re implicated as requisite components of the clonic AGS network, and these data support a critical ro

9 ver, the requisite involvement of AMG in the clonic AGS network, which is not seen in tonic AGS, is s

10 The neuronal network for clonic AGS remains to be investigated.

11 xhibiting tonic AGS, and GEPR-3s, exhibiting clonic AGS.

12 enetetrazole (PTZ)-induced generalized tonic-clonic and myoclonic seizure incidence and severity.

13 izure approximately 20 s after injection was clonic and showed no EEG changes.

14 ts important mechanistic differences between clonic and tonic forms of AGS.

15 e-like seizures but decreased propensity for clonic and tonic seizures.

16 Susceptibility to clonic and tonic-clonic flurothyl-induced seizures posit

17 llenged with flurothyl and the threshold for clonic and tonic-clonic seizures was determined.

18 Thresholds for flurothyl-induced clonic and tonic-clonic seizures were determined.

19 loped seizures (primarily generalized, tonic-clonic, and atonic) that began on average at 6.8 months

20 types, including absence, generalised tonic-clonic, and complex partial seizures, converge on the sa

21 ure began 3-4 min after injection, was tonic-clonic, and had EEG spike-wave activity.

22 haracterized by myoclonic, generalized tonic-clonic, and in 30% of patients, absence seizures.

23 ralised tonic-clonic, complex partial, focal clonic, and infantile spasms.

24 ne rats (GEPR-3s) exhibits generalized onset clonic audiogenic seizures (AGS), but following repetiti

25 clonic but decreases susceptibility to tonic-clonic bicuculline seizures in intact male rats.

26 he model and in humans, the time between two clonic bursts increased exponentially from the start of

27 t prenatal morphine exposure does not affect clonic but decreases susceptibility to tonic-clonic bicu

28 ultiple forms of epilepsy (generalized tonic-clonic, complex partial, absence seizures), including re

29 TBC1D24 mutations included generalised tonic-clonic, complex partial, focal clonic, and infantile spa

30 -47 sec), seizure-like bursts with tonic and clonic components occurred spontaneously (53%) or in res

31 perhaps contributing to the limbic and tonic-clonic components of the observed epileptic phenotype.

32 e first stage 6 seizure or generalized tonic-clonic convulsion (GTC).

33 eceptor antagonist CGP 35348 prevented tonic-clonic convulsions and significantly enhanced survival o

34 This compound did not cause tonic-clonic convulsions in mice, had a good pharmacokinetic p

35 ugh mice toxicity studies, we observed tonic-clonic convulsions in several mice at high doses.

36 This was manifested by (1) generalized tonic-clonic convulsions with multiple failings, which were el

37 ion between oral automatisms and generalized clonic convulsions.

38 -18 years with partial and generalised tonic-clonic epilepsy were identified by population screening.

39 Susceptibility to clonic and tonic-clonic flurothyl-induced seizures positively correlated

40 terminal value of the log-linear fit of the clonic frequency decrease was correlated with the presen

41 rile seizures consisted of generalized tonic-clonic, generalized tonic, generalized atonic, simple pa

42 ized by a combination of myoclonic and tonic-clonic (GTC) seizures.

43 Thresholds for minimal clonic, maximal tonic, or psychomotor (partial) seizures

44 ularis oculi (OO) spasms and 18 patients had clonic OO spasms) and 8 patients with IB were included i

45 titive, rhythmic burst discharges, either as clonic or spike-wave activity, again mediated both by in

46 activation of PV(+) interneurons during the clonic phase generated excitatory GABAergic responses in

47 logical network hyperexcitability during the clonic phase of seizures.

48 ncreased exponentially from the start of the clonic phase of the seizure.

49 an initial tonic phase, followed by a longer clonic phase that is characterized by rhythmic bouts of

50 ons reduced the occurrence of ADs during the clonic phase.

51 seizure (1.3 [1.1 to 1.6]), and first tonic-clonic seizure (1.5 [1.2 to 1.8]).

52 th new-onset seizure was a generalized tonic-clonic seizure (72 [33%]).

53 lete and reversible blockade of only the F&F clonic seizure behavior was induced by AP7 (1 and 7.5 nm

54 Only 17 of these had a tonic-clonic seizure during follow-up.

55 ere was an increase in the flurothyl-induced clonic seizure threshold (anticonvulsant effect) in the

56 ere was an increase in the flurothyl-induced clonic seizure threshold after an E injection alone whil

57 ction alone while there was a reduced tonic--clonic seizure threshold in the presence of both hormone

58 ctrical stimulation until the first forelimb clonic seizure was induced.

59 can provide notification of an ongoing tonic-clonic seizure, or peace of mind in the absence of notif

60 our institution, she had a generalized tonic-clonic seizure.

61 to first seizure of any type and first tonic-clonic seizure.

62 urring during, or immediately after, a tonic-clonic seizure.

63 f eclampsia, as defined by a witnessed tonic-clonic seizure.

64 on phase of the experiment, only generalized clonic seizures ("forebrain seizures") were expressed.

65 10 suppressed minimal clonic seizures (6 Hz mouse model) without typical rotar

66 myoclonus (all patients), generalized tonic-clonic seizures (all patients) and complex partial seizu

67 n to sound stimuli-induced generalized tonic-clonic seizures (audiogenic reflex seizures) and is a va

68 y (JAE), and epilepsy with generalized tonic clonic seizures (EGTCS).

69 (JME), one predisposing to generalized tonic-clonic seizures (GTCS) and a second to myoclonic seizure

70 zed with the algorithm: 25 generalized tonic-clonic seizures (GTCSs) from 11 patients, and 19 episode

71 le childhood epilepsy with generalized tonic-clonic seizures (ICEGTC), which bears similarity to SMEI

72 ice) exhibited spontaneous generalized tonic-clonic seizures (which occurred in the absence of cardia

73 prefrontal cortex are associated with tonic-clonic seizures and a normal survival rate.

74 res, and 1 had 4 witnessed generalized tonic-clonic seizures and approximately 30 suspected generaliz

75 ers manifesting with action myoclonus, tonic-clonic seizures and ataxia.

76 Moreover, incidence of tonic clonic seizures and hindlimb extension were reduced in w

77 epilepsy with early onset, generalized tonic-clonic seizures and juvenile lethality by 3 weeks of age

78 hildhood absence epilepsy, generalized tonic clonic seizures and the epileptic encephalopathy, Dravet

79 frequent myoclonic jerks, generalized tonic-clonic seizures and, less commonly, absences.

80 Generalized tonic-clonic seizures are among the most dramatic physiologica

81 mes in which generalized myoclonic and tonic-clonic seizures are expressed.

82 Generalised tonic-clonic seizures are the greatest risk factor for SUDEP;

83 s of GABA metabolism, and one in which tonic-clonic seizures associate with increased central nervous

84 , neurological insult, total number of tonic-clonic seizures before randomisation, seizure type and t

85 g the networks involved in generalized tonic-clonic seizures can provide insights into mechanisms of

86 ed early onset spontaneous generalized tonic-clonic seizures concurrent with a significant reduction

87 Tonic-clonic seizures developed spontaneously after 5 months o

88 e with EEG abnormality were at risk of tonic-clonic seizures during follow-up compared with 16% of th

89 ining three had infrequent generalized tonic-clonic seizures during nocturnal sleep.

90 ted with afebrile focal or generalized tonic-clonic seizures during the first to second year of life;

91 Fewer generalized clonic seizures failed to reliably produce changes in se

92 ltered if (1) a minimum of eight generalized clonic seizures had been expressed, and (2) a minimum of

93 ic hyperactivity immediately following tonic-clonic seizures in DS mice, which leads to lethal bradyc

94 astic behaviors and eventually induces tonic-clonic seizures in rodents.

95 seizures are at low risk of subsequent tonic-clonic seizures in the period of time to which therapeut

96 fects of treatment on the frequency of tonic-clonic seizures in those patients with such pre-randomis

97 pothalamic brain sites following generalized clonic seizures induced by kainic acid.

98 greater latency and lower incidence of tonic-clonic seizures induced by pentylenetetrazol (PTZ; 70 mg

99 SPECT from 59 secondarily generalized tonic-clonic seizures obtained during epilepsy surgery evaluat

100 (JME), epilepsy with only generalized tonic-clonic seizures occurring either randomly during the day

101 e absence epilepsy, five patients with tonic-clonic seizures on awakening and 30 control subjects had

102 epsy and two out of five patients with tonic-clonic seizures on awakening, but in none of the 30 cont

103 le absence epilepsy, and epilepsy with tonic clonic seizures only under the sole heading of idiopathi

104 Because generalised tonic-clonic seizures precede most cases of SUDEP, patients mu

105 Daily flurothyl-induced generalized clonic seizures resulted in a progressive decrease in bo

106 rter latencies to onset of generalized tonic-clonic seizures than controls.

107 used in the MESS study are greater for tonic-clonic seizures than they are for partial seizures.

108 h the remaining 7-12% comprising generalized clonic seizures that transition into brainstem seizures.

109 ine, and he continued to have frequent tonic-clonic seizures throughout his life.

110 in is unusually sensitive to recurrent tonic-clonic seizures upon routine handling and to seizures in

111 othyl and the threshold for clonic and tonic-clonic seizures was determined.

112 holds for flurothyl-induced clonic and tonic-clonic seizures were determined.

113 es conferring a low threshold to ECT minimal clonic seizures were mapped to the telomeric region of m

114 Tonic-clonic seizures were observed in HAGS animals, while LAG

115 of aged apoE4 TR mice had more severe tonic-clonic seizures which occasionally progressed to tonic e

116 All had generalized tonic-clonic seizures with onset associated with fever, consis

117 normal early development, generalized tonic-clonic seizures with onset at 5-10 years of age, and pro

118 e of the normoglycemic rats, developed tonic-clonic seizures within 12h after ischemia.

119 its acoustically triggered generalized tonic-clonic seizures, and often times the EEG, recorded with

120 died prematurely following generalized tonic-clonic seizures, and they were equally susceptible to th

121 caused low seizure threshold, sporadic tonic-clonic seizures, brain enlargement and ectopic neurons i

122 age between oral automatisms and generalized clonic seizures, by measuring changes in mRNA expression

123 t paradigm, pentylenetetrazole-induced tonic-clonic seizures, exclude the possibility that the geneti

124 ncreased latencies to forelimb clonus, tonic clonic seizures, hindlimb extension, and death compared

125 icate that the higher the frequency of tonic-clonic seizures, the higher the risk of SUDEP; furthermo

126 zures recorded, the majority are generalized clonic seizures, with the remaining 7-12% comprising gen

127 nique capacity to initiate generalized tonic-clonic seizures.

128 at a mean age of 42 days from massive tonic-clonic seizures.

129 notype consisting of 3/sec absence and tonic-clonic seizures.

130 approximately 30 suspected generalized tonic-clonic seizures.

131 rred immediately following generalized tonic-clonic seizures.

132 d with the tonic phases of generalized tonic-clonic seizures.

133 rogressively severe myoclonus and rare tonic-clonic seizures.

134 le childhood epilepsy with generalized tonic-clonic seizures.

135 ly involved in secondarily generalized tonic-clonic seizures.

136 ions and for impaired consciousness in tonic-clonic seizures.

137 seizures, required ASIC1a to interrupt tonic-clonic seizures.

138 ced threshold to electrically evoked minimal clonic seizures.

139 used by kainic acid, in the absence of tonic-clonic seizures.

140 havioral endpoints of epileptogenesis, tonic-clonic seizures.

141 t week 3 to 4 of life from generalized tonic-clonic seizures.

142 ing hemiclonic, hemitonic, generalized tonic-clonic, simple partial (stereotyped episodes of epigastr

143 in patients with IB and in BSP patients with clonic spasms but not in BSP patients with tonic spasms.

144 BR in patients with IB and in patients with clonic spasms, but not in patients with tonic spasms.

145 ed by multiple transitions between tonic and clonic states.

146 The treatment of tonic-clonic status epilepticus is usually divided into three

147 , the addictive component of tobacco, induce clonic-tonic seizures in animals.