ライフサイエンスコーパス: clonogenicity

1 gnificantly inhibit glioma cell survival and clonogenicity.

2 ells' proliferation, migration, invasion and clonogenicity.

3 assays for intracellular ROS, apoptosis, and clonogenicity.

4 ssing cells and induced a pronounced loss of clonogenicity.

5 mitochondrial injury, cell death, or loss of clonogenicity.

6 cterization of colony forming efficiency and clonogenicity.

7 hondrial dysfunction, apoptosis, and loss of clonogenicity.

8 le causing only small decreases in long term clonogenicity.

9 e more sensitive than KB in terms of loss of clonogenicity.

10 ns with recombinant DPT protein improved HSC clonogenicity.

11 aling and inhibited Jurkat proliferation and clonogenicity.

12 inhibition and 4-fold higher with respect to clonogenicity.

13 ed by a substantial decline in leukemic cell clonogenicity.

14 end, however, cause a loss of suppression of clonogenicity.

15 growth retardation, cell death and decreased clonogenicity.

16 orrelated with growth inhibition and loss of clonogenicity.

17 ny formation, a measure of LTC-IC number and clonogenicity.

18 tion and is strongly correlated with loss of clonogenicity.

19 emature chromosome condensation, and loss of clonogenicity.

20 and 22Rv1 resulted in significantly reduced clonogenicity.

21 cterized by Kdr/Flk1, Cdh5, CD31 and lack of clonogenicity.

22 nticancer drug-induced apoptosis and greater clonogenicity.

23 enhancing Slug nuclear accumulation and MaSC clonogenicity.

24 lymphoid progenitors exhibit enhanced serial clonogenicity.

25 ell invasiveness, and in OPCN2-enhanced cell clonogenicity.

26 poxia is paralleled by a twofold increase in clonogenicity.

27 a reduction in tumor cell proliferation and clonogenicity.

28 ncided with a dramatic increase in soft-agar clonogenicity.

29 In the epidermis, the highest clonogenicity, a feature of stem cells (SCs), is found i

30 shed cell size that correlated with a higher clonogenicity, a longer-term proliferative potential, an

31 bsence of drug treatment caused some loss of clonogenicity, although the magnitude of this cytotoxic

32 Compound 2 irreversibly inhibited clonogenicity, although this required at least 4 h of ex

33 y, siRNA targeting FGFR3 and kdFGFR3 reduced clonogenicity, anchorage-independent growth, and disinte

34 N-Cadherin and vimentin expressions, higher clonogenicity and ALDH positive expression of cancer cel

35 sfection resulted in reduced cell growth and clonogenicity and an approximately 2.0-fold increase in

36 -mediated in vitro suppression of tumor cell clonogenicity and analyzed the sequence of the gene clon

37 f aberrant progenitors with unlimited serial clonogenicity and blocked differentiation.

38 SP status predicts clonogenicity and cardiogenic gene expression (Gata4/6,

39 a progressive proliferation defect, loss of clonogenicity and diminished tissue regenerative ability

40 or of BMP type I receptor kinases, represses clonogenicity and diminishes the cancer stem cell-enrich

41 ation resulted in increased survival, higher clonogenicity and enhanced invasiveness of these cells.

42 Lymphoma SP cells exhibited autonomous clonogenicity and exported Wnt3a via exosomes to neighbo

43 MECs also showed increased invasiveness and clonogenicity and formed more free-floating spheroids an

44 Analysis of the viability, differentiation, clonogenicity and function of human stem/progenitor cell

45 methacin, and PB alone or in combination] on clonogenicity and HCCs recovery from 5-fluorouracil (FUr

46 enicity, whereas miR-215 knockdown increases clonogenicity and impairs differentiation in CDX1-high c

47 Knockdown of IL1RAP decreased clonogenicity and increased cell death of AML cells.

48 patients with AML-inhibited cell growth and clonogenicity and induced apoptosis.

49 d AR activity as well as increased survival, clonogenicity and invasiveness.

50 ion-mediated drug resistance, and suppressed clonogenicity and lymphoma growth ex vivo and in vivo.

51 ratoma formation by Lu-iPSCs, and diminished clonogenicity and malignant growth of SCLC cells in vivo

52 ndent effects upon growth factor dependence, clonogenicity and migration.

53 Clonogenicity and multipotentiality of normal bovine SF

54 xpression of CDX1 in HCT116 leads to reduced clonogenicity and production of differentiating crypt-co

55 an lung SCC cell lines suppressed tumor cell clonogenicity and proliferation in culture and in vivo A

56 g cancer cell viability, Ki-67 intensity and clonogenicity and promoted lung cancer cell migration.

57 45 treated cells counteracted the effects on clonogenicity and replicative senescence.

58 scavengers in CSCs markedly decreases their clonogenicity and results in radiosensitization.

59 that EGR2 knockdown inhibited proliferation, clonogenicity and spheroidal growth in vitro and induced

60 nockdown decreases proliferation, migration, clonogenicity and the size of the metastasis-initiating

61 lial to mesenchymal transition and inhibited clonogenicity and tumor initiation.

62 l expression concomitant with a reduction in clonogenicity and tumorigenesis accompanied by an increa

63 nhibition, and suppression of both soft agar clonogenicity and tumorigenicity in nude mice.

64 Serine355, is required for maintaining both clonogenicity and tumorigenicity.

65 perties: decreased doubling times, increased clonogenicity and viability, facilitated S-phase entry,

66 ression, leading to increased proliferation, clonogenicity, and anchorage-independent growth.

67 lular activities for inhibiting cell growth, clonogenicity, and cellular glutamate production, (2) ex

68 as associated with decreased MaSC expansion, clonogenicity, and expression of Slug, a master regulato

69 properties of cell adhesion, cell migration, clonogenicity, and in vitro life span.

70 phoma stromal cells confers drug resistance, clonogenicity, and induction of histone deacetylase 6 (H

71 h shRNA slows leukemia cell growth, inhibits clonogenicity, and leads to increased sensitivity to ima

72 ell lysates and inhibited the proliferation, clonogenicity, and motility of U251 cells in a PTP-zeta-

73 d demonstrate long-term self-renewal, serial clonogenicity, and multigerm layer differentiation poten

74 ances spontaneous differentiation, decreases clonogenicity, and reduces in vivo tumor growth.

75 r, such as increased cell growth, migration, clonogenicity, and self-renewal capacity.

76 ASXL3 silencing inhibited proliferation, clonogenicity, and teratoma formation by Lu-iPSCs, and d

77 the regulation of NSCLC cell proliferation, clonogenicity, and tumor growth, suggesting that IGFBP-3

78 ML significantly suppressed the growth rate, clonogenicity, and tumorigenicity of breast cancer cells

79 The effect of vitamin C on viability, clonogenicity, apoptosis, P-glycoprotein, reactive oxyge

80 Induction of apoptosis and loss of clonogenicity are 3-5-fold lower under pulse treatment c

81 ridol and imatinib synergistically decreased clonogenicity as evaluated by the median-effect method.

82 ermined by an apoptosis assay at 72 h, and a clonogenicity assay at 12 days, after the initial treatm

83 In an anchorage-independent clonogenicity assay, MCF7/caspase-3 cells stably express

84 In vitro clonogenicity assays have demonstrated that the CD34(+)A

85 termined by peripheral blood cell counts and clonogenicity assays of hematopoietic progenitors, did n

86 used cell contact-dependent cell growth and clonogenicity assays, which showed that knockdown of TGF

87 al 6 beta-OOH, producing a 50% loss of L1210 clonogenicity at approximately 1/5 the concentration of

88 deleted for the two genes possess increased clonogenicity at late stages of stationary phase surviva

89 radiation dose sufficient to reduce cellular clonogenicity by 1 log in cells expressing functional p5

90 Inhibition of cancer cell clonogenicity by Chk1 inhibition could be rescued in vit

91 ereas prior exposure decreased inhibition of clonogenicity by paclitaxel.

92 cells in vitro for proliferation, survival, clonogenicity, cell cycle, and p53 expression.

93 tumorigenic properties of MPM cells, such as clonogenicity, cell migration and resistance to pemetrex

94 the cell cycle, and dramatically increasing clonogenicity, colony size and motility.

95 xerted greater inhibition of cell growth and clonogenicity compared to a single gene.

96 ockdown of HIF1-alpha abolished the enhanced clonogenicity during hypoxia.

97 rvivin mRNA and protein levels, reduced cell clonogenicity, enhanced paclitaxel activity), but lost i

98 tures of bone marrow-derived MSCs, including clonogenicity, expression of certain markers, and follow

99 ligand HGF further sustained proliferation, clonogenicity, expression of self-renewal markers, migra

100 F decreased pancreatic cancer cell survival, clonogenicity, formation of pancreatospheres, invasive c

101 2 in the AML cell line U937 leads to loss of clonogenicity, G1 arrest and partial differentiation.

102 e transferred to adherent dishes to evaluate clonogenicity; growth-controlled spheroids also failed t

103 addition to growth arrest and suppression of clonogenicity, HMBA induces apoptosis both in freshly is

104 isplays long-term colony-forming efficiency, clonogenicity, immunosuppression, and panmesodermal pote

105 fragmentation and condensation, and loss of clonogenicity in 3 MM cell lines (U266, RPMI-8266, and N

106 type gene, this mutant has no effect on cell clonogenicity in agar.

107 + cells from PNH patients had markedly lower clonogenicity in both primary colony cultures and in the

108 estinal crypts, as well as stemness and high clonogenicity in colon cancer cells, depend on Wnt signa

109 genous EPHB6 resulted in inhibition of their clonogenicity in culture.

110 d migratory capacity in transwell assays and clonogenicity in limiting dilution analyses.

111 decreased cell proliferation, viability and clonogenicity in mutant p53 cell lines.

112 They also showed reduced growth and clonogenicity in plating efficiency and soft agarose ass

113 asis suppression correlated with a decreased clonogenicity in soft (0.3%) and hard (0.9%) agar.

114 m cell marker, CD44, and displayed increased clonogenicity in soft agar and broad drug-resistance in

115 CF or the MyCF proteins exhibited decreased clonogenicity in soft agar and increased sensitivity to

116 with decreased rates of cell proliferation, clonogenicity in soft agar, changes in the actin cytoske

117 reduced rate of tumor growth and a decreased clonogenicity in soft agar.

118 Menin overexpression reduced the RAS-induced clonogenicity in soft agar.

119 heir anoikis susceptibility and blocks their clonogenicity in the absence of adhesion to the ECM.

120 ed its ability to inhibit tumor cell-induced clonogenicity in vitro, to induce apoptosis in lung tumo

121 logeneic HSCs in vivo and do not enhance HSC clonogenicity in vitro.

122 first time that FC significantly enhance HSC clonogenicity, increase the proportion of multipotent pr

123 fter a dose of PDT producing a 99.9% loss of clonogenicity, LY-R cells responded by an increased prod

124 onal studies, depletion of YY1 inhibited the clonogenicity, migration, invasion, and tumor formation

125 ed to significantly decreased proliferation, clonogenicity, migration, spheroid formation, and G1 cel

126 formation, including attenuated cell growth, clonogenicity, mobility, and anchorage-independent growt

127 f H460 cells greater than PMX; PMX inhibited clonogenicity more than C1 or C2 at pH 7.2, which favors

128 universal stem cell characteristics such as clonogenicity, multipotency and self-renewal capacity.

129 significant impairment of proliferation and clonogenicity occurs.

130 O1 inhibited the long-term proliferation and clonogenicity of AE cells and t(8;21) AML cell lines.

131 fering (si)RNA, decreased cell viability and clonogenicity of ALK+ ALCL cells.

132 Further, GANT61 treatment abolished the clonogenicity of all six human colon carcinoma cell line

133 iRNA-knockdown of Nrf2 significantly reduced clonogenicity of AML patient cells and improved their ch

134 osure, these NPs more efficiently reduce the clonogenicity of bone marrow cancer cells from patients

135 , this treatment combination yielded reduced clonogenicity of bone marrow-resident 5TGM1 cells, reduc

136 ing units/cell) resulted in 100% loss of the clonogenicity of breast tumor cells.

137 antisense LDH-A expression reduces soft agar clonogenicity of c-Myc-transformed Rat1a fibroblasts, c-

138 r to c-Myc, JPO1 overexpression enhances the clonogenicity of CB33 human lymphoblastoid cells in meth

139 Furthermore, hypoxia enhanced the clonogenicity of CML cells, as well as their efficiency

140 -terminally truncated version can rescue the clonogenicity of CRD-BP knockdown breast cancer cells, s

141 that, compared with controls, frequency, and clonogenicity of DBA, EEP and LEP are significantly decr

142 ng unit assays further demonstrate decreased clonogenicity of FLT3/ITD(+) cells upon treatment with A

143 GA was a potent inhibitor of the clonogenicity of four glioma cells lines with IC(50)s ra

144 reversible growth inhibition and decrease in clonogenicity of FUra-treated HCC are prolonged by subse

145 less potent derivative of GA, inhibited the clonogenicity of glioma cells with IC(50) values of 13 n

146 We also found that the clonogenicity of H1299 cells in soft agar was markedly r

147 hich favors PCFT uptake, C1 and C2 inhibited clonogenicity of H460 cells greater than PMX; PMX inhibi

148 human colon cancer cells leads to increased clonogenicity of HCA-7, but not HCT-116 cells.

149 elped preserve the HSC/MPP pools and promote clonogenicity of hematopoietic progenitor cells.

150 CREB regulates hematopoietic engraftment and clonogenicity of hematopoietic progenitors, and is depen

151 hannel inhibitor glibenclamide decreased the clonogenicity of HepG2 cells without inducing cytotoxici

152 PB than on BM CD34+ cells, do not affect the clonogenicity of human and murine HSPCs, and increase ad

153 aling molecule Smoothened (Smo) promoted the clonogenicity of human SCLC in vitro and the initiation

154 te that FTY720 induces apoptosis and impairs clonogenicity of imatinib/dasatinib-sensitive and -resis

155 Inhibition of HLX reduces proliferation and clonogenicity of leukemia cells, overcomes the different

156 These agents abrogate the clonogenicity of leukemic cells but have minimal effects

157 ry CFC numbers after 5 weeks of culture, and clonogenicity of LTC-ICs was determined by limiting dilu

158 trate that erlotinib treatment increases the clonogenicity of lung cancer cells in a sphere-forming a

159 and ATRA were synergistic in inhibiting the clonogenicity of MCF-7 and T-47D cells that expressed es

160 ibit proliferation, migration, invasion, and clonogenicity of MM cells.

161 1R levels and inhibits the proliferation and clonogenicity of neuroblastoma cells in vitro but not th

162 breast cancer cells, but did not affect the clonogenicity of nontumorigenic cells.

163 kdown by RNA interference (RNAi) reduced the clonogenicity of Panc1 pancreatic cancer cells 4-fold an

164 In this study, we show that the clonogenicity of several human tumor cell lines and prim

165 y, lenalidomide decreased the percentage and clonogenicity of SP cells, and also induced phosphorylat

166 GR overexpression led to a reduction in the clonogenicity of the follicular epithelial SCs.

167 e marrow-derived CD34+ cells to maintain the clonogenicity of the primitive progenitors.

168 in soft agar were performed to evaluate the clonogenicity of the sorted cells.

169 a specific pSTAT3 inhibitor, suppressed the clonogenicity of the stem-like cells in patients with hi

170 at5 on either the developmental potential or clonogenicity of this population.

171 1 per 11 cells on PA6, thus showing the high clonogenicity of this primitive stem cell population.

172 Our findings that self-renewal and clonogenicity of TICs were suppressed by pharmacological

173 s was demonstrated by inhibiting the loss in clonogenicity of TS(-) cells by anti-FasL and in enhance

174 vivo as well as the self-renewal ability and clonogenicity of tumor-derived stem cells.

175 exosomes that increase the proliferation and clonogenicity of tumor-initiating glioma stem-like cells

176 For each passage, clonogenicity on 3T3 fibroblasts feeder layers was compa

177 ng, decreased cell proliferation and reduced clonogenicity on plastic and in soft agar.

178 ot accompanied by an increased inhibition of clonogenicity over that induced by SN-38 alone.

179 damage, as shown by enhanced cell survival, clonogenicity, proliferation, and differentiation.

180 ession stimulated in vitro proliferation and clonogenicity properties and favored tumor development i

181 s, hypoxia enhances tumor cell viability and clonogenicity relative to normoxia.

182 enchymal stem cells (GMSCs), which exhibited clonogenicity, self-renewal, and multipotent differentia

183 Clonogenicity significantly declined from P1 to P3 for t

184 TBD-BMSCs exhibited reduced clonogenicity, spontaneous differentiation into adipocyt

185 of p17 variants (vp17s) endowed with B-cell clonogenicity, suggesting a role of vp17s in lymphomagen

186 limited replicative expansion and maintained clonogenicity, suggests certain advantages for their use

187 markedly less cell adhesion, spreading, and clonogenicity than did control cells.

188 radiation resulted in a greater reduction of clonogenicity than either treatment alone in cells with

189 nes, CPA-LLP resulted in significantly lower clonogenicity than free CPA (p<0.05).

190 to apoptosis, DNA fragmentation, and loss of clonogenicity than HL-60/pCEP4 cells.

191 A also caused a reduction in both growth and clonogenicity that was associated with restoration of re

192 (-/-) NPCs results in reduced glycolysis and clonogenicity, thus depleting the embryonic NPC pool and

193 ro proliferation assays, direct cell counts, clonogenicity under anchorage-dependent and anchorage-in

194 This clonogenicity was higher in lesion-free ApoE(-/-) mice a

195 IC(50) of 3.59 +/- 1.23 micromol/L although clonogenicity was inhibited at concentrations of 75 to 1

196 These data suggest that the reduced clonogenicity was predominantly due to intrinsic deficie

197 er cell lines by Ad-IGF-Ir/as, the soft agar clonogenicity was reduced by 84%.

198 chondria after 18 hours of IL-3 deprivation, clonogenicity was unaffected when IL-3 was replenished a

199 mage processing, cell-cycle progression, and clonogenicity were unique to cells transformed by mutant

200 osis), and colony formation in 0.2% agarose (clonogenicity) were measured.

201 L1210 cells exhibited a progressive loss of clonogenicity when irradiated with broad-band visible li

202 fferentiated cell lines causes a decrease in clonogenicity, whereas miR-215 knockdown increases clono

203 hich is essential for cell proliferation and clonogenicity, with immediate therapeutic implications.

204 akaryocyte-erythroid progenitors show higher clonogenicity, with increased megakaryocyte, megakaryocy