ライフサイエンスコーパス: closed conformation

1 he transition of the clamp from an open to a closed conformation.

2 ttering analyses show that it locks IDE in a closed conformation.

3 own highly conserved C-terminus, inducing a closed conformation.

4 uces a conformational change from an open to closed conformation.

5 rs that lock the enzyme in the inactive over-closed conformation.

6 l death and Ucn1 maintains this channel in a closed conformation.

7 AS stabilizes integrins in the low-affinity, closed conformation.

8 t with stabilization of the voltage sensor's closed conformation.

9 in solution, but Merlin(S518D) remains in a closed conformation.

10 We found that individual Sed5 adopts a tight closed conformation.

11 y inhibits ligand binding by stabilizing the closed conformation.

12 ite within the central ion channel pore in a closed conformation.

13 y are separated widely (30.4 A apart) in the closed conformation.

14 between an active open state and an inactive closed conformation.

15 This rate enhancement is diminished in the closed conformation.

16 and electron transfer from Pdx occurs in the closed conformation.

17 microtubule-depolymerizing kinesins is in a closed conformation.

18 ATD clamshell transitions from an open to a closed conformation.

19 oplasmic domain stabilizes the pentamer in a closed conformation.

20 oup but stabilizes the CD1d-LPC complex in a closed conformation.

21 t the dystrophin N-ABD binds to F-actin in a closed conformation.

22 atalytic pocket that predominantly assumes a closed conformation.

23 ey hydrogen bonds necessary to stabilize the closed conformation.

24 t isoflurane binding stabilizes LFA-1 in the closed conformation.

25 nonproductive rapid motions or an inactive, closed conformation.

26 obic pocket found in the hinge region of the closed conformation.

27 nositide-bound form obtained previously in a closed conformation.

28 the enzyme, as it converts from an open to a closed conformation.

29 sted that isoflurane stabilized LFA-1 in the closed conformation.

30 igand (namely H32A and Y75A) are both in the closed conformation.

31 autoinducer, provided that they stabilize a closed conformation.

32 DS-SOSIP in the vaccine-preferred prefusion-closed conformation.

33 its potential ability in stabilizing the LBD closed conformation.

34 is highly dynamic but predominantly adopts a closed conformation.

35 ATP analogue, RNA and Yra1-C, Sub2 assumes a closed conformation.

36 s a folding chaperone enabling E4 to adopt a closed conformation.

37 odulates Cascade activity by stabilizing the closed conformation.

38 chain motions that already take place in the closed conformation.

39 sports Fe(III) by binding the metal ion in a closed conformation.

40 oro or bromo substituent engendered a second closed conformation.

41 uced apparent affinity, inducing a partially closed conformation.

42 helix that locks the active site in an over-closed conformation.

43 f the cofactor-binding loop in both open and closed conformations.

44 l structures of human beta4GalT7 in open and closed conformations.

45 kinetic parameters for the enzyme's open and closed conformations.

46 n intermediate energy state between open and closed conformations.

47 se interactions by stabilizing two different closed conformations.

48 ell survival protein that exists in open and closed conformations.

49 ve displacement upon transition from open to closed conformations.

50 the connexons in either orientation adopted closed conformations.

51 tion of the Asp acid/base in the open versus closed conformations.

52 e oscillates between open, intermediate, and closed conformations.

53 serve as alternatives to those in the cleft-closed conformations.

54 escribed the transition between the open and closed conformations.

55 ves approximately 10 A, from an "open" to a "closed" conformation.

56 y crystallography to 3.9 A, revealing a new 'closed' conformation.

57 n be summarized as "open," "semi-open," and "closed" conformations.

58 e antiviral agent DMXAA, leading to similar "closed" conformations.

59 gnificant structural changes from "open" to "closed" conformations.

60 arrier between the apo 'open' and ATP-bound 'closed' conformations.

61 ADP in two distinctly different ('Open' and 'Closed') conformations.

62 (1) a resting state of the apo enzyme with a closed conformation, (2) a first shallow binding mode, f

63 he 99-, 148-, and 220-loop exist in open and closed conformations, allowing or preventing substrate a

64 ion of the intact nNOS-CaM complex reveals a closed conformation and a cross-monomer arrangement with

65 (eco) results in population shift toward the closed conformation and a significant reduction of k(cat

66 at the bulky residues should destabilize the closed conformation and eliminate the approximately 3 kc

67 These interactions may lock the clamp to the closed conformation and enclose the DNA being transcribe

68 vert in solution, with low salt favoring the closed conformation and high salt favoring the open conf

69 the stability of the dimer interfaces in the closed conformation and how clamp dynamics contribute to

70 yo-EM structures of CorA in the Mg(2+)-bound closed conformation and in two open Mg(2+)-free states a

71 d stabilize BG505 SOSIP.664 in its prefusion closed conformation and limit reactivity to weakly neutr

72 mRNA leader, with AUG recognition evoking a closed conformation and more stable P site interaction o

73 prothrombin wild type stabilized 70% in the closed conformation and of the mutant Y93A stabilized 80

74 ctions involving the eIF1A NTT stabilize the closed conformation and promote utilization of suboptima

75 e structure, the cytoplasmic domain adopts a closed conformation and the ion conduction pore is also

76 Sly1 binds to both the closed conformation and the N-peptide of Sed5, suggestin

77 well-established to bind tightly to both the closed conformation and the N-peptide of syntaxin 1a, th

78 hat Munc18c, like Munc18a, binds to both the closed conformation and the N-peptide of Syx4.

79 onformation that is intermediate between the closed conformation and the open conformation of the con

80 fingers domain caused the enzyme to adopt a closed conformation and to become susceptible to the ant

81 sts a mechanism in which the enzyme adopts a closed conformation and two residues, Phe91 and Trp93, d

82 oss-linking actually traps the LBDs in cleft-closed conformations and delineate semiclosed conformati

83 ling the uncoupling between ATP-PRT open and closed conformations and its functional state.

84 ound LBDs also stayed predominantly in cleft-closed conformations and made only infrequent excursions

85 ctive site locked the activated enzyme in a "closed" conformation and revealed the positions of criti

86 elements that block E2 Ub from adopting a 'closed' conformation and (2) participating in contacts t

87 ta6, alphaVbeta8 has a constitutive extended-closed conformation, and binding to pro-TGF-beta1 does n

88 orable for the ligand-free AdK to access the closed conformation, and imply that ligand binding may p

89 However, ATP binding to RAD50 induces a closed conformation, and in this state MRE11 is an endon

90 mmetric, three of the protomers exhibiting a closed conformation, and one an open conformation.

91 ) that captured this permease in the outward-closed conformation, and we identified the extracellular

92 cross-linking immobilized the LBDs in cleft-closed conformations, and consequently concluded that th

93 in a dynamic equilibrium between "open" and "closed" conformations, and the extent to which the open

94 ical, is responsible for the PS1 pathogenic 'closed' conformation, and resulting increase in the Abet

95 itin adopt extended 'open' and more compact 'closed' conformations, and ubiquitin-binding domains and

96 hesive and that the extended-closed and bent-closed conformations are nonadhesive.

97 d crystal structures, but that both open and closed conformations are thermally accessible in the pre

98 tion, and computational analysis support the closed conformation as a myosin V state that is detached

99 lementary dNTPs and highlights the partially closed conformation as a primary checkpoint for nucleoti

100 hermore, the p53/Pol II cocomplex displays a closed conformation as defined by the position of the Po

101 UvrD monomer can rotate between an open and closed conformation as well as two highly populated inte

102 est that apo-GCGR can adopt both an open and closed conformation associated with extensive contacts b

103 ent a cryo-EM structure of mouse Piezo1 in a closed conformation at 3.7A-resolution.

104 ity and histone modifications demonstrated a closed conformation at the human NOS2 locus and an open

105 has been established in its open and locally closed conformations at acidic pH.

106 interactions in one open and four different closed conformations based on metal-ion bridges between

107 ution, both Merlin and Merlin(S518D) adopt a closed conformation, but binding experiments indicate th

108 e Q32 loop in apo-HasA(yp) is already in the closed conformation, but no residue from the Q32 loop bi

109 e apoenzyme shows the C terminus locked in a closed conformation by a disulfide bond between Cys(972)

110 del where mambalgin-2 traps the channel in a closed conformation by precluding the conformational cha

111 Mad2 adopts the closed conformation (C-Mad2) in a Mad1-Mad2 core complex

112 Mad2, in the closed conformation (C-Mad2), stabilizes the complex by

113 ng the actin filaments, that vinculin in its closed conformation cannot bind along the actin filament

114 ly binds a single Ca(2+) and is locked in a "closed" conformation, causing androcam to contact the In

115 en proposed to act as a gate with an open or closed conformation controlling access to the active sit

116 nnel appears to switch between an open and a closed conformation depending on whether the coenzyme NA

117 the pleckstrin homology domain (PHD) from a 'closed' conformation docked near the stalk to an 'open'

118 roved faster than observed for the partially closed conformation due to an effective proton transfer

119 ALIX is normally present in a closed conformation due to an intramolecular interaction

120 ons revealed, switches between an open and a closed conformation due to the flexibility of the surrou

121 er-561 phosphorylation-dependent switch to a closed conformation during synaptic plasticity.

122 uestion is whether the Met(20) loop adopts a closed conformation during the chemical hydride transfer

123 pattern; in other words, E4 adopts the most closed conformation, E2 adopts the most open conformatio

124 The headpiece crystallizes in a closed conformation essentially identical to that seen p

125 are necessary for transition from an open to closed conformation fail to rescue evoked release defect

126 enylate-forming enzyme that does not adopt a closed conformation for catalysis.

127 from the influence of the population of the closed conformation for substrate binding affinity.

128 reased with Ca (systole), suggesting rigidly closed conformations for the E1 (Ca-bound) enzymatic sub

129 he-87, Phe-144, and Phe-153 that support the closed conformation found in the crystal structure.

130 MD simulation of SLADP docked in the closed conformation gave a probe mobility comparable to

131 l domain) could induce a tendency toward the closed conformation greater than that for UL30 and expla

132 he activities are mutually exclusive, as the closed conformation has GTP binding/GTPase activity, and

133 ious reports showing that trapping P-gp in a closed conformation highly activated ATPase activity, he

134 sphorylated smHMM is not compatible with the closed conformation if the blocked head is phosphorylate

135 of ATP to MalK2 promotes an asymmetric, semi-closed conformation in accordance with the low ATPase ac

136 mplex with the CTR in an open apo form and a closed conformation in complex with a cofactor and a pse

137 but collapses to a lower-energy periplasmic-closed conformation in DDM after purification.

138 annel is hindered by N139's preference for a closed conformation in situations with protonated E286.

139 nked DENV protease exists predominantly in a closed conformation in solution.

140 dify the (364)KRRK(367) tail of hFPPS in the closed conformation in the absence of IPP.

141 , thereby forcing the C subunit into a fully closed conformation in the absence of nucleotide.

142 icant orientational bias of Ub toward a more closed conformation in the E3/E2~Ub complex.

143 W43-F183) result in a high population of the closed conformation in the mutant.

144 7 and D211N beta4GalT7 mutant enzymes in the closed conformation in the presence of the acceptor subs

145 ail of eIF1 in blocking rearrangement to the closed conformation in the scanning preinitiation comple

146 protein is a monomer in solution and is in a closed conformation in which the two CH domains seem to

147 pen conformation emerges from an ensemble of closed conformations in a highly Na(+)-dependent manner,

148 Evidence of equilibrium between open and closed conformations in solution was gleaned from distan

149 trate a dynamic equilibrium between open and closed conformations in solution.

150 (A653T) mutation stabilizes the channel in a closed conformation, in contrast to Lurcher.

151 ereas the nucleotide-bound form shows a half-closed conformation, in contrast to the inositide-bound

152 Vinculin can assume a closed conformation, in which the head and tail domains

153 The EBD crystallizes in a "closed" conformation, in contrast to the "open" structur

154 (TC), rearrangement of the 40 S subunit to a closed conformation incompatible with scanning, and stab

155 trate that LNAs which block formation of the closed conformation inhibit genome translation.

156 es four auxiliary domains that stabilize the closed conformation, inhibiting release of membrane-inse

157 However, the closed conformation is likely destabilized by various mu

158 l structure to determine whether the open or closed conformation is more consistent with the FRET dat

159 The same closed conformation is observed by NMR and crystallograp

160 Furthermore, we show that the closed conformation is promoted by a matched incoming dN

161 al and EPR analysis suggests that this fully closed conformation is the major conformation for the AT

162 with excited normal modes confirmed that the closed conformation is the most stable for the CDK2/cycl

163 RET state, which we attribute to a partially closed conformation, is also predominant in ternary comp

164 K and show that MCAK in solution exists in a closed conformation mediated by an interaction between t

165 The closed conformation minimized TCR dwell times and thereb

166 s various open and closed conformations, the closed conformation observed experimentally for HMBPP-bo

167 at the mammalian SC D2 domain stabilizes the closed conformation observed for hSC D1-D5.

168 ded PLC-beta exists in equilibrium between a closed conformation observed in crystal structures and a

169 The closed conformation, observed in a trapped phosphoryl tr

170 The structure representing a dormant and closed conformation of an ERM protein has previously bee

171 portin alpha5 like a "clip," stabilizing the closed conformation of ARM 10.

172 , PLpro translationally samples the open and closed conformation of BL2 loop on a picosecond-nanoseco

173 induced changes consistent with the active, closed conformation of both kinases and confirmed that B

174 IFN-alpha/beta treatment led to a closed conformation of CNS-1, as assessed by DNase I hyp

175 The closed conformation of CYP2B35 contained two molecules o

176 larger molecules in the catalytically active closed conformation of Ddl.

177 rmonomer interaction, which induces a firmly closed conformation of dimers and crucially involves the

178 mational dynamics in the DXPS mechanism: The closed conformation of DXPS is critical for stabilizatio

179 h slow unfolding, favoring the autoinhibited closed conformation of filamin's force-sensing domain pa

180 hobic core clusters to further stabilize the closed conformation of flaps, and the hydrogen bonding i

181 The prefusion-closed conformation of HIV-1 Env has been identified as

182 4) play an important role in maintaining the closed conformation of HIV-1 protease.

183 es in the kinetics for both the open and the closed conformation of Hsp90 in dependence on the number

184 the present study we have modeled the inward-closed conformation of LdNT1.1 using the crystal structu

185 g to 'gene end' RNA sequences stabilized the closed conformation of M2-1 leading to a drastic shift i

186 Here, we present a closed conformation of NaVAe1p, a pore-only BacNaV deriv

187 conditions, our simulations revealed a fully closed conformation of NS5B that may facilitate de novo

188 d may be broadly applicable to stabilize the closed conformation of other kinases many of which may a

189 the nucleotide-binding site to stabilize the closed conformation of PKAc, thus preventing catalysis f

190 A low-resolution solution structure of the closed conformation of PKCbetaII was derived from small-

191 tes SNARE complex formation by loosening the closed conformation of Sed5.

192 e global structure, in which Munc18a binds a closed conformation of Syx1a.

193 Here, we present a catalytically relevant, closed conformation of taxadiene synthase (TXS), the mod

194 sponding to the previously reported open and closed conformation of the A-B and G-H loops.

195 A-CTT from the P-site and rearrangement to a closed conformation of the entry channel with reduced mo

196 bridging sheet region further stabilized the closed conformation of the Env.

197 We also describe a novel closed conformation of the enzyme that may represent an

198 the mutation V478W in helix N to promote the closed conformation of the enzyme to make it susceptible

199 conformations, corresponding to an open and closed conformation of the finger domain as well as a co

200 ce, respectively, inhibit, and stabilize the closed conformation of the headpiece.

201 binding but involves destabilization of the closed conformation of the ion conduction gate.

202 events within the cell can induce a stable, closed conformation of the MsbA homodimer that does not

203 In the fully closed conformation of the NADH complex, the catalytic t

204 s that stabilize the catalytically competent closed conformation of the polymerase.

205 ains play key roles, both in stabilizing the closed conformation of the protomers and in driving the

206 he neuronal protein Munc18a interacts with a closed conformation of the SNARE protein syntaxin1a (Syx

207 Binding of Ecm29 to the proteasome induces a closed conformation of the substrate entry channel of th

208 se PrP aggregates inhibit by stabilising the closed conformation of the substrate entry channel.

209 Mg(2+) to the protein surface stabilizes the closed conformation of the ternary enzyme complex and re

210 Mutations designed to destabilize the closed conformation of the V domain opened the V domain,

211 d TSR1 domains for proMIC2 and MIC2 reveal a closed conformation of the VWA domain and how it associa

212 cates that the substrate does not affect the closed conformation of this gate.

213 ed by a pre-equilibrium between the open and closed conformations of helix alpha2 at the active site.

214 , shifting the partitioning between open and closed conformations of IDE toward the open form.

215 brane-associated lid domain of MGL to favour closed conformations of the enzyme that do not permit th

216 inal domain reveal several distinct open and closed conformations of the peptide linking N- and C-ter

217 te that the equilibrium between the open and closed conformations of the protein translocation channe

218 d effect on the balance between the open and closed conformations of the TnC molecule, which provides

219 pect to one another compared with the X-ray "closed" conformation of MMP-1.

220 n" conformation, which is distinct from the "closed" conformation of postfusion trimers.

221 active site of the enzyme and requires the "closed" conformation of the zinc-binding loop on the sur

222 Electron microscopy demonstrated a "closed" conformation of WT ADAMTS13 and suggested a more

223 ly demonstrate that not only the "open" and "closed" conformations of the GT-B enzyme are largely pre

224 ctural studies have defined the Ca(2+)-free, closed, conformation of the gating ring, but the Ca(2+)-

225 rystal form that show alternative, yet still closed, conformations of active site loops.

226 the secretory SM protein Munc18 binds to the closed conformation" of syntaxin 1, the ER-Golgi SM prot

227 ed that tTG adopts either a nucleotide-bound closed conformation or a transamidation-competent open c

228 its dwell time in an intrinsically occurring closed conformation or desensitized state.

229 stabilizes the assembly in either the active closed conformation or the inactive open conformation.

230 id residues 123-170), which exhibits open or closed conformations or structural disorder, depending o

231 he 150-loop, with the aim of maintaining the closed conformation, or by designing inhibitors that can

232 in N-terminal extension that, by promoting a closed conformation, plays an autoinhibitory function an

233 ith shifts of a Phe residue between open and closed conformations plus an Asp residue carboxylate shi

234 that SL9266/PK is dynamic, with 'open' and 'closed' conformations predicted to have distinct functio

235 The closed conformation predominates (70%) and features an u

236 PfRad50 complexes show that the ATP-induced 'closed' conformation promotes DNA end binding and end te

237 al analysis implied a mechanism in which the closed conformation recruits a cellular factor that woul

238 tion of the CAT and HPX domains to the X-ray closed conformation releases one chain out of the triple

239 quilibrium may exist in CDK4/cyclin D1, with closed conformations resembling that captured for CDK2/c

240 ly resembles the inhibited L-histidine-bound closed conformation, revealing the uncoupling between AT

241 fully model this loop in either its open or closed conformations, revealing the roles of specific re

242 aptured RT bound to the NNRTI efavirenz in a closed conformation similar to that of the apo enzyme, s

243 In the closed conformation state, polbeta appears to allow only

244 is in the ground state and the other in the closed conformation state.

245 The closed conformation structure is highly similar to the b

246 omain, which can adopt two conformations: a "closed" conformation, suitable for internal electron tra

247 The closed conformation supports catalysis by orienting the

248 y affected by Dvl mutants unable to form the closed conformation than by wild-type Dvl.

249 with Syntaxin-1 folded into a self-inhibited closed conformation that binds to Munc18-1.

250 e structure captures in an atomic detail the closed conformation that cN-III adopts upon substrate bi

251 The major intracellular form is the closed conformation that functions as a GTP-binding GTPa

252 Unphosphorylated VraR exists in a closed conformation that inhibits dimer formation.

253 rature and in a lipid bilayer, Aqy1 adopts a closed conformation that is globally better described by

254 dinator for holding the RNAP II complex in a closed conformation that is highly competent for transcr

255 te, thus attenuating the ATP binding-induced closed conformation that is required for phosphorylation

256 Kinase inhibited FAK is in a closed conformation that prevents VE-cadherin associatio

257 ubstituted phenylimidazoles give rise to two closed conformations that depend on the size of the para

258 to single-stranded DNA can exist in open and closed conformations that differ in the orientation of t

259 veloped, which was in equilibrium between a "closed" conformation that forms an intramolecular pi-sta

260 ls, forcing PDE6D to assume a predominantly "closed" conformation that impedes binding of lipids.

261 ps2PD(D24N)-T6P complex structures reveal a "closed" conformation that is effected by extensive inter

262 remarkable because even in the functionally closed conformation the pore constriction remains wide e

263 Our results show that even in the closed conformation, the His-E7 gate does not create a l

264 substrate-free IspH samples various open and closed conformations, the closed conformation observed e

265 Ca(2+) ions per monomer and its pore is in a closed conformation; this probably reflects channel rund

266 In its inactive conformation, Shot adopts a "closed" conformation through interactions between its NH

267 complex, in which syntaxin-1 still adopts a closed conformation tightly bound to Munc18-1, whereas t

268 rolysis, P-gp transitions through a complete closed conformation to a complete open conformation in t

269 ransition of the FH2 ring from an inhibitory closed conformation to a permissive open conformation, s

270 The Hsp40 co-chaperone converts this fully closed conformation to an open conformation to initiate

271 duces a quaternary structural switch from a "closed" conformation to a more "open" conformation, redu

272 depends on its transition from an inactive, "closed" conformation to a potentially active, "open" con

273 utations at the ATPase site bias Get3 toward closed conformations, uncouple TA binding from induced G

274 We showed that apo-Pol lambda exists in the closed conformation, unprecedentedly with a preformed Mg

275 lymerase fingers subdomain from an open to a closed conformation upon binding of a complementary nucl

276 We show that human hSTING(H232) adopts a "closed" conformation upon binding c[G(2',5')pA(3',5')p]

277 on involves interconversion between open and closed conformations was further confirmed by the dampen

278 To stabilize the trimer in its prefusion closed conformation, we complexed trimeric BG505 SOSIP.6

279 In contrast, the enzyme favored a closed conformation when bound to ADP in solution, consi

280 receptor (SNARE) protein syntaxin-1 adopts a closed conformation when bound to Munc18-1, preventing b

281 ontrast, however, the enzyme remained in the closed conformation when ferrous-CO P450cam was titrated

282 tion when bound to the ribosome but are in a closed conformation when not bound to the ribosome.

283 At pH 5.5 NP4 is in a closed conformation where NO is tightly bound, while at

284 ith complementary dNTPs adopt mainly a fully closed conformation, whereas a conformation with a FRET

285 by Src homology 3 (SH3) domain, leading to a closed conformation, whereas a non-phosphorylatable S561

286 he polymerase to the catalytically competent closed conformation, whereas incorrect nucleotides block

287 meric in solution and predominantly occur in closed conformation, whereas their actin-bound conformat

288 the fingers domain to more readily adopt the closed conformation whether or not the drug is bound.

289 We propose that ADAMTS13 circulates in a closed conformation, which is maintained by a CUB-spacer

290 We find that Slo2.2 exists in multiple closed conformations whose relative occupancies are inde

291 Dephosphorylated, inactive smHMM assumes a closed conformation with asymmetric intramolecular head-

292 es at up to 3.4 A resolution, which reveal a closed conformation with base flipping and base-specific

293 The N-lobe consists of EF1 and EF2 in a closed conformation with either Mg(2+) or Ca(2+) bound a

294 onsistent with a model in which CFTR is in a closed conformation with two ATPs bound.

295 inding biases dynamic E2~Ub ensembles toward closed conformations with enhanced reactivity for substr

296 rimer variants were indeed stabilized in the closed conformation, with a reduced ability to undergo r

297 n tail domain (Vt), with all residues in its closed conformation, with all residues in an open I conf

298 ately 50% population of one or a few related closed conformations, with the other 50% populating a co

299 d cytoplasmic orientations from "open" into "closed" conformations within several minutes.

300 y causing accumulation of the complex in the closed conformation without release of Nrf2.