ライフサイエンスコーパス: closed state

1 product release (open state), or catalysis (closed state).

2 open state is energetically higher than the closed state.

3 luded ground state and a low population of a closed state.

4 a T4P molecular machine in the open and the closed state.

5 cleavage to fold efficiently into the mature closed state.

6 from an immature uncleaved state to a mature closed state.

7 cture that traps the channel in a presumably closed state.

8 MP-PNP was only observed when trapped in the closed state.

9 ion and the L1 stalk is positioned in a half-closed state.

10 robability of the channel by stabilizing its closed state.

11 scopy indicated these to resemble the mature closed state.

12 lecular chaperone, in a catalytically active closed state.

13 nactivated state then slowly deactivate to a closed state.

14 he two other beta subunits in the completely closed state.

15 channels, and their formation stabilized the closed state.

16 d by an inhibitor that traps HSP70-1A in its closed state.

17 usly shown to cross between protomers in the closed state.

18 y base-pairing dNTP, it re-equilibrates to a closed state.

19 ate and rewinds during the transition to the closed state.

20 s Ac in the position that corresponds to the closed state.

21 ibitor, NS2B complexes with NS3pro to form a closed state.

22 d radicals, demonstrating the existence of a closed state.

23 the formation of the catalytically competent closed state.

24 tion, indicating propofol stabilizes a novel closed state.

25 nfiguration of syntaxin 1a is dominated by a closed state.

26 r charge distribution as that of the high-pH closed state.

27 it from a high-water-permeability state to a closed state.

28 dominant GAP, biasing TRPM1 channels to the closed state.

29 nown zebrafish P2X4 crystal structure in the closed state.

30 bilizes Env in the vaccine-desired prefusion-closed state.

31 ying a dynamic entity trapped in an unstable closed state.

32 ional transition into a catalytically viable closed state.

33 side can bind anions that may stabilize the closed state.

34 he channel, is important for stabilizing the closed state.

35 change in the inhibitor-induced shift to the closed state.

36 ndicating inappropriate rearrangement to the closed state.

37 r end all the way to the middle of M2 in the closed state.

38 lly ICD2, show a much faster HDX than in the closed state.

39 milar conformation as in the aspartate-bound closed state.

40 in the open state and is pulled apart in the closed state.

41 at barbiturates preferentially stabilize the closed state.

42 e dynamics and shorten the dwell time in the closed state.

43 tRNAi, mRNA, or 18S rRNA exclusively in the closed state.

44 face of the plasma membrane and stabilizes a closed state.

45 gating via stability of a novel inactivated closed state.

46 en state at the expense of a substrate-bound closed state.

47 al and internal dynamics properties of Hsp90 closed state.

48 lution models of the channel in the open and closed states.

49 analyses indicate one open and two distinct closed states.

50 py structures of human TRPV6 in the open and closed states.

51 the channel is able to open from all (five) closed states.

52 on the partitioning of PICs between open and closed states.

53 icant energy barrier separating the open and closed states.

54 d by switching the tweezers between open and closed states.

55 osite F290 from open through the three first closed states.

56 e phosphorylated state, and on toward ligand-closed states.

57 maripaludis chaperonin in a mix of open and closed states.

58 free-energy difference between the open and closed states.

59 l homolog K-Shaw2 by stabilizing the resting/closed states.

60 d on structural transitions between open and closed states.

61 The structures correspond to two distinct closed states.

62 dues to the ion channel pore in the open and closed states.

63 t that gates may in fact contain two or more closed states.

64 e transition state between the activated and closed states.

65 losed-pore/desensitized and antagonist-bound/closed states.

66 erminal bundles equilibrate between open and closed states.

67 ements as they switch between their open and closed states.

68 C conformation resembling the active, "fully closed" state.

69 which the enzyme is in either an "open" or "closed" state.

70 t domains that move Env from a functionally "closed" State 1 to more "open" conformations, but the mo

71 isms for stabilization of Slo2 channels in a closed state: (1) dewetting and collapse of the inner po

72 MYO1C(C) favored the actomyosin closed state (AM(C)), MYO1C(16) populated the actomyosin

73 that MYO1C(35) populated the actomyosin.ADP closed state (AMD(C)) 5-fold more than the actomyosin.AD

74 transition between a single 5-fold symmetric closed state and an ensemble of low Mg(2+), open, asymme

75 y two of three distinct structural states, a closed state and an open state, that are adopted by the

76 um channel form an occlusion for ions in the closed state and are splayed open on activation.

77 tension-induced gating, both stabilizing the closed state and coupling the channel to the membrane.

78 gate operates between the open state and the closed state and exhibits a residual conductance.

79 he Arg327 residue in stabilizing the channel closed state and explicate for the first time the struct

80 n, the enzyme is unable to achieve the fully closed state and is rendered inactive despite possessing

81 nce that strongly support the existence of a closed state and its analogue-dependent transition to th

82 channel function by locking channels into a closed state and that endogenous CFTR in HBEs is affecte

83 8 channel, resulting in stabilization of its closed state and thus reducing both its cold sensitivity

84 ed that NPA binding stabilized NMDA receptor closed states and increased the energy barriers toward o

85 eling suggests concurrent destabilization of closed states and low-affinity open channel block.

86 e, the coupled relationship of both open and closed states and their role in recapitulating macroscop

87 The absence of FHF2 accelerates the rate of closed-state and open-state sodium channel inactivation,

88 ML1: a 3.72-A apo structure at pH 7.0 in the closed state, and a 3.49-A agonist-bound structure at pH

89 te is antigenically distinct from the mature closed state, and cleavage has been reported to be essen

90 rable gate that fills and seals pores in the closed state, and creates a non-fouling, liquid-lined po

91 or Escherichia coli show the channel in its closed state, and indicate that ribosome binding per se

92 oscillating between active/open and inactive/closed states, and is regulated in part by phosphorylati

93 We describe stable wetted/open and dewetted/closed states, and uncover conformational changes in the

94 mmed PRE complexes, which sampled the hybrid/closed state approximately once before undergoing transl

95 t single-channel data sets, several open and closed states are required for accurately representing t

96 ion of the HIV-1 Env trimer to its prefusion-closed state as this state is recognized by most broadly

97 to its redox partner, putidaredoxin, is in a closed state at ambient temperature in solution.

98 IC) from an open, scanning conformation to a closed state at AUG codons, from which Pi is released fr

99 ons of 48S PICs from yeast in these open and closed states, at 6.0 A and 4.9 A, respectively.

100 cted pore; this is likely to correspond to a closed state, because a CaCC with a single Ca(2+) occupa

101 of the thin filament from the blocked to the closed state becomes less responsive to Ca(2+).

102 Glu167 and Arg290 when the channel is in the closed state, but not in the ATP-bound open state.

103 The pores are locked in a closed state by a hydrogen bond network at the C terminu

104 t the inhibitors stabilize the AMPA receptor closed state by acting as wedges between the transmembra

105 for an HIV-1 Env trimer captured in a mature closed state by antibodies PGT122 and 35O22.

106 eta3alpha3 turn is effectively locked in the closed state by the formation of salt bridges between th

107 optically determined conformational open and closed states by FRET, and binding-unbinding states of t

108 contrast, blocking palmitoylation increases closed-state channel inactivation and reduces myocyte ex

109 pt for Ca(V)3.3 channels) and targets mainly closed-state channels, although a small use-dependent co

110 perturbing uS7-eIF2alpha interaction in the closed state, confer the opposite phenotypes of hyperacc

111 pocket and promoting the stabilization of a closed state conformation.

112 this vestibule hairpin is consistent with a closed-state conformation of the Kv channel in the plasm

113 intracellular [Au(CN)2](-) in both open and closed states, corroborating the conclusion that the int

114 A closed-state crystal structure is not available.

115 DEER measurements in the closed state demonstrate that eTRPV1 reports distances i

116 open state than the bent-closed and extended-closed states demonstrates profound regulation of affini

117 a high degree of selectivity, coupled with a closed-state dependent mechanism of action is required f

118 luded that BK channel C-type inactivation is closed state-dependent and that its extents and rates in

119 rtion of the riboswitch may adopt an open or closed state depending on the presence of metabolite.

120 1 kinase at cell poles converts Cdc15 to its closed state, destabilizes the actomyosin ring, and thus

121 , conformational change between the open and closed states did not affect stimulation of ATP hydrolys

122 The cross-linking thus favors a unique closed state distinct from the resting and longest-lived

123 gest that LBDs are semiclosed in the channel-closed state during stationary gating.

124 ormational status of the LBDs in the channel-closed state during stationary gating.

125 resolution structures of the human PIC in a closed state (engaged with duplex DNA), an open state (e

126 th inhibited enzyme function, whereas in the closed state, enzyme is activated by the close proximity

127 formations intermediate between the open and closed state extremes create an ensemble of binding site

128 with the open state facing inwardly and the closed state facing outwardly.

129 a flip in the asymmetry while remaining in a closed state for the second hydrolysis.

130 are conducive for sliding, and the populated closed state has stronger interactions with the phosphat

131 es of detergent-solubilized rat TRPV6 in the closed state have previously been solved.

132 inding correlates with the stability of the 'closed-state' helicase core, a complex with nucleotide a

133 tein Rps5/uS7 and eIF2alpha between open and closed states; however, its importance was unknown.

134 allosteric modulator, and in a desensitized/closed state in complex with fluorowilliardiine.

135 ce in open probability is caused by one long closed state in KcvS.

136 flexible, semiopen state and a rigid, fully closed state in situ and reversibly.

137 open state is unstable and reverts toward a closed state in the absence of the pEF Ca(2+) ion.

138 f nucleotide substrates to a ternary complex closed state in which the reactive groups are aligned fo

139 t flickers rapidly between multiple open and closed states in non-deactivating bursts at positive mem

140 Sampling both open and closed states in their respective pH range, where they a

141 rmational transition between an ultra-stable closed state (in the free hormone) and an active open st

142 intact GluA2 AMPA receptor in an apo resting/closed state, in an activated/pre-open state bound with

143 the kinetics and structural determinants of closed-state inactivation (CSI) in Kv4.2 channels, consi

144 at this gate is additionally responsible for closed-state inactivation (CSI) in Kv4.x channels.

145 induces a significant enhancement of channel closed-state inactivation and ablates sensitivity to dep

146 We conclude that Kv4.1 closed-state inactivation modulates pore blockade by QA

147 Further, the effect of the mutation on closed-state inactivation was evident in the presence of

148 g depolarized steady-state fast-, slow-, and closed-state inactivation, faster repriming, and larger

149 y depolarizes steady-state fast-, slow-, and closed-state inactivation.

150 en state and a more fibrillar pattern in the closed state, indicating that cellulose microfibrils und

151 the proteins occurs only when Gal3p is in a "closed" state induced by ligand binding.

152 successfully refined its conformation from a closed-state initial model to an open-state final model

153 transition between fully open and (multiple) closed states involves global changes in structure of th

154 In the presence of GTP, a closed state is adopted by the SRP-FtsY complex.

155 table conformational states, of which an apo-closed state is dominant, consistent with previous exper

156 sition of release channels from an open to a closed state is identical to the phase transition associ

157 We propose that the transition to the closed state is initiated by voltage-driven disruption o

158 e that the probability of ELIC occupying the closed state is much lower for the ligand-bound mutants

159 contrast to the wild-type enzyme, where the closed state is significantly more stable than the open

160 The closed state is stabilized by a tripartite salt bridge i

161 Although the transition between the open and closed states is critical for the switching process, its

162 e ability of RbmA to switch between open and closed states is important for V. cholerae biofilm forma

163 occurring between activated-open and resting-closed states is required to explain experimental values

164 suggests that transition to a hypothetical "closed"-state is required to bring the cofactors adenosy

165 active site is similar between the open and closed states, it is unexpectedly different at the regul

166 openings reflected a destabilization of the closed state, leading to an apparent increase in the sen

167 411-S4 interactions destabilizes these early closed states, leaving hERG channels able to activate at

168 If this closed state model is correct, these residues are availa

169 The results give strong support to the closed state model of the K(V) channel and a clear expla

170 conformational distribution across open and closed states must exist in the drug-bound enzyme and th

171 d JNJ63955918 as a potent, highly selective, closed-state Nav1.7 blocking peptide.

172 atomistic molecular dynamics studies of the closed-state, non-conducting C1C2 structure and protonat

173 of the S4-S5 linker in both the open and the closed state of a prokaryotic Kv channel (KvAP) in a lip

174 sequestrin2 is a protein that stabilizes the closed state of calcium release channels, i.e. the ryano

175 In particular, the closed state of E295K has a more distorted active site t

176 losely mimicked the vaccine-preferred mature closed state of Env could be obtained.

177 mperature stabilized the open state over the closed state of Kv11.1a/1b channels and exerted the oppo

178 eract strongly with the lipid bilayer in the closed state of MscS, but do not face the bilayer direct

179 t critical lipid interacting residues in the closed state of MscS.

180 It has been proposed that the closed state of RCIIs is responsible for the quenching.

181 disrupts the characteristic long interburst closed state of reconstituted KirBac1.1 in giant liposom

182 12.6) is an RyR2 subunit that stabilizes the closed state of RyR2 and prevents a Ca2+ leak through th

183 The Rycal drug S107 stabilizes the closed state of RyR2 by inhibiting the oxidation/phospho

184 otif domain interface likely destabilize the closed state of RyR2, resulting in enhanced basal channe

185 iological solution conditions, we identify a closed state of the ATP-binding pocket that correlates w

186 lly through a mechanism involving mainly the closed state of the channel and suggest a negative allos

187 dicate that Hi1a binds to and stabilizes the closed state of the channel, thereby impeding the transi

188 ydrated around a central Phe residue, to the closed state of the channel.

189 if of RyR2 are important for stabilizing the closed state of the channel.

190 sfer (smFRET) method to observe the open and closed state of the DNA gate and to measure dwell times

191 the lid domain in the formation of the fully closed state of the enzyme that is required for catalyti

192 The closed state of the fingers domain traps the variant pol

193 supported by homology models of the open and closed state of the HCN2 channel pore.

194 rs to stabilize first the open, and then the closed state of the PIC to promote accurate AUG selectio

195 ATP fulfills a dual role: to destabilize the closed state of the receptor and to promote the ionic co

196 to form the fully collapsed metabolite-bound closed state of the SAM-I riboswitch.

197 cohols and inhaled anesthetics stabilize the closed state of the Shaw2 voltage-gated (Kv) channel (K-

198 in the absence of uracil, and resulted in a closed state of the transporter, due to relative movemen

199 (and thus, conceivably corresponding to the closed state of this channel) has been previously genera

200 Equally represented open and closed states of a back door channel, associated with al

201 led conformational exchange between open and closed states of an engineered mutant of staphylococcal

202 Transitions between open and closed states of CFTR are regulated by ATP binding and h

203 conformational equilibrium between open and closed states of CYP3A4 that involves a pronounced chang

204 The combined studies reveal the open/closed states of GCGR and suggest that glucagon binds to

205 Homology models of the open and closed states of P2X2 indicate that pore opening is asso

206 high-resolution reconstructions of open and closed states of RyR1 were obtained from the same sample

207 o generate structural models of the open and closed states of RyR1.

208 D411 with lower S4 residues stabilizes early closed states of the channel, and that disruption of the

209 in cAMP binding energy between the open and closed states of the channel.

210 not significantly different in the open and closed states of the channel.

211 ate, high-resolution models of both open and closed states of the channel.

212 cated in the transition between the open and closed states of the Cys-loop receptors.

213 vation accompanies transitions through early closed states of the hERG activation pathway, and that t

214 nformational transition between the open and closed states of the Hsp90 dimer.

215 nds to both the activated closed and resting closed states of the Hv1 channel, thereby inhibiting bot

216 gh atomic resolution models of both open and closed states of the proteasome have been elucidated, th

217 These data suggest there are at least two closed states of the thin filament, and that Tm provides

218 pathway is presented to bridge the open and closed states of the TL.

219 conformational sampling between the open and closed states of Tiam1 contributes to Rac1 dissociation.

220 lie the fluctuations between the "open" and "closed" states of the lid-like NCT with respect to a hyd

221 nsitions between active (open) and inactive (closed) states of the hMGL lid domain in controlling sub

222 iT from P. mirabilis in the outward-open and closed states on the corresponding structures of the rel

223 n the PA translocase, gates as either a more closed state or a more dilated state.

224 lanking the M2 channel-lining segment in the closed state (pH 7.5) and in a submaximally activated st

225 r-mediated interactions, absent in the fully closed state, play an important role in formation of the

226 Substrate misalignment in the closed state plays a fundamental part in preventing non-

227 lays in blocking myosin tight binding in the closed-state position.

228 This ATP-bound 'closed' state promotes binding to DNA, tethering DNA end

229 atic interactions between TM segments in the closed state pull hydrophobic residues together to form

230 ns in the pore-lining helix to stabilize the closed state (Q4947N, Q4947T, and Q4947S), which we also

231 photoswitched between its ring-open and ring-closed states quantitatively with excellent fatigue resi

232 crystal forms, and that may suggest open and closed states relevant for substrate binding.

233 ations between the classical/open and hybrid/closed states, respectively, in the presence of EF-G bef

234 g behavior with Hom and WT favoring open and closed states, respectively, whereas Het exhibited heter

235 d F57Bpa KCNE1 were cross-linked in open and closed states, respectively, which suggests that their a

236 B conformation of the labeled UvrD to a more closed state resulting in activation of helicase activit

237 nt X-ray structure of BetP in a sodium-bound closed state revealed that one of these sites, equivalen

238 The cryo-EM structure of the closed state reveals an ordered SRP RNA and SRP M domain

239 ds to the GPCR; the second conformation, the closed state, shows no interaction with the receptor.

240 nt accessibility to the amide oxygen with a "closed state" steric barrier compared to an "open state"

241 ts for molecular dynamics simulations of the closed state structure.

242 Comparison of this structure with the closed-state structure in complex with competitive antag

243 Here we report the closed-state structure of the 2.3-megadalton complex of

244 Molecular dynamics simulations of the closed-state structure suggest this second sodium site i

245 We compare open- and closed-state structures developed previously with a rece

246 onsistent with those inferred from open- and closed-state structures of prokaryotic sodium channels.

247 sodium ions stabilize the TRPV1 channel in a closed state, such that removing the external ion leads

248 mt6 is unable to transition between open and closed states, suggesting that the regulation of RNA or

249 The closed state supports a model of catalysis in which the

250 re that less active mutants have less stable closed states than their open states, in marked contrast

251 trasubunit interactions were observed in the closed state that are weakened upon desensitization and

252 ves toward the active site, where it forms a closed state that orients the C-As bond for dioxygen add

253 ed with formin homology 2 domains toward the closed state that precludes polymerization, but that pro

254 The periplasmic domain of BamA was in a closed state that prevents access to the barrel lumen, w

255 pen state that permits ion conductance and a closed state that prevents permeation.

256 s in a minor ( approximately 10 %) partially closed state that rapidly exchanges with a predominantly

257 s a conformational change to an intermediate closed state that shows increased effectiveness of pyrim

258 zyme I which exists in a variety of open and closed states that are sampled at various points in the

259 where c1 and c2 are initial-closed and deep-closed states that both close the channel fully, whereas

260 rin can bind a number of ligands, but in the closed state the ligand-binding sites are inaccessible.

261 ecular-dynamics simulations show that in the closed state, the channel conductance is approximately 1

262 For the KcsA channel in the closed state, the distribution of water is peaked in the

263 In the closed state, the lagging strand does not pass through t

264 When extrapolated to the closed state, the two outermost negatively charged resid

265 This protein, FKBP12, promotes the RyR1 closed state, thereby inhibiting Ca(2+) leakage in resti

266 nal domains observed in the structure of the closed state, thereby promoting the resulting conformati

267 In the rigid, fully closed state, these interactions are prevented by steric

268 an autoinhibitory domain that maintains the closed state through electrostatic interactions, and adj

269 The strap stabilizes the closed state through trans-protomer interactions.

270 , can be switched in situ from a rigid fully closed state to a flexible semiopen state via Cl(-) indu

271 ch of Rpn11's Insert-1 loop from an inactive closed state to an active beta hairpin.

272 e begins with transitions from a ligand-free closed state to glutamate-bound active and desensitized

273 e of a transition directly from the proximal closed state to the inactivated state.

274 changes to switch between distinct open and closed states to tighten the active site and avail catal

275 te of syntaxin-1 during its transition from "closed" state to the SNARE complex formation.

276 ransition shifts the structure from a tense (closed) state toward a more relaxed (open) state.

277 -activated Slo2 potassium channels are in a closed state under normal physiological conditions, alth

278 -activated Slo2 potassium channels are in a closed state under normal physiological conditions, alth

279 ility to "gate" between an open and several "closed" states under applied voltage.

280 tance K(+) -selective Slo2 channels are in a closed state unless activated by elevated [Na(+) ]i .

281 tance K(+) -selective Slo2 channels are in a closed state unless activated by elevated [Na(+) ]i .

282 m that normally holds the transporter in the closed state when cellular Mg(2+) levels are high.

283 which bonds formed was extremely low in the closed state, when a bond did form it took significantly

284 s of the actin-tropomyosin interface in the "closed state" where tropomyosin binds to actin in the ab

285 we provide a snapshot of GRK5 in a partially closed state, where structural elements of the kinase do

286 inding, correct dNTPs are transported to the closed state, whereas incorrect dNTPs are delivered to t

287 odel could correspond to a commonly occupied closed state, whereas the McjD-based model could represe

288 These regions associate to produce a closed state, which is generally thought to suppress ass

289 upled with the analogue-based radical in the closed state while odd-numbered analogues could trigger

290 ) channel activity by destabilizing the long closed states while facilitating closed-to-open state tr

291 alyze a Friedel-Crafts reaction in the fully closed state, while the semiopen state shows no reactivi

292 occurrence and the dwelling time of the long closed states whilst increasing the frequency of channel

293 Simulations of the closed state with PIP(2) revealed an intermediate state

294 Locking the IgE-Fc into the closed state with the Cys-335 mutation does not affect b

295 emichannel but rather promoted gating to the closed state with transitions characteristic of the intr

296 ly switched between its ring-opened and ring-closed states with high fidelity over multiple cycles.

297 bstrates by isomerizing between the open and closed states with nucleotide bound.

298 n which the two core domains join to form a 'closed state' with an ATPase active site, conserved moti

299 he open conformation, and indicates that the closed state, with a high ( approximately 13 kcal/mol) f

300 otides can bind to the N-terminally open and closed state without strictly forcing the protein into a