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1 also show that SWI-SNF is able to remodel a closed circular array in the absence of topoisomerase I,
7 and is sustained by the episomal covalently closed circular (CCC) DNA in the nuclei of infected hepa
9 nthesis of hepadnaviral RNAs is a covalently closed circular (ccc) DNA located in the nucleus of the
10 TANCE The hepatitis B virus (HBV) covalently closed circular (CCC) DNA, by serving as the viral trans
11 ell nucleus for conversion to the covalently closed circular (CCC) DNA, the template for viral transc
12 incoming RC-DNA is converted into covalently closed circular (ccc) DNA, which serves as a viral persi
13 c mature nucleocapsid (NC) to the covalently closed circular (CCC) DNA, which serves as the template
14 RC DNA needs to be converted to covalently closed circular (CCC) DNA, which serves as the template
15 the host cell nucleus to form the covalently closed circular (CCC) DNA, which sustains viral replicat
17 regular or synthetic AP site on a covalently closed circular (ccc) duplex plasmid molecule or a long
18 be because it fails to eliminate covalently closed circular (CCC) HBV DNA from the nuclei of infecte
19 lly active at this time or if the covalently closed circular (CCC) replicative intermediate of HBV DN
20 The highly structured (64% GC) covalently closed circular (CCC) RNA (220 nt) of the virusoid assoc
21 pregenome, are transcribed from a covalently closed circular (ccc) viral DNA that is found in the nuc
23 tions of intrahepatic WHV RNA and covalently closed circular (ccc)WHV-DNA levels also were observed.
26 in which the protein induces nearly the same closed circular configuration point to the statistical a
27 atin, which might account for the covalently closed circular conformation of quiescent HCMV genomes.
30 f the conversion of nicked plasmids from the closed circular damaged plasmid substrate; the inhibitio
31 itro results in the generation of covalently closed circular daughter molecules, indicating that the
33 licative intermediates, including covalently closed circular DNA (cccDNA) and Dane particles, were de
36 treatment does not affect initial covalently closed circular DNA (cccDNA) conversion but inhibits the
39 pies, lies in the accumulation of covalently closed circular DNA (cccDNA) in nuclei of infected cells
41 ) and subgenomic RNA from the HBV covalently closed circular DNA (cccDNA) minichromosome, both in cul
42 criptional template, a long-lived covalently closed circular DNA (cccDNA) molecule, is degraded noncy
43 k hepatitis virus (WHV) contained covalently closed circular DNA (cccDNA) molecules with deletions an
46 control the nuclear pool of viral covalently closed circular DNA (cccDNA) transcriptional template of
47 ed that both encapsidated DNA and covalently closed circular DNA (cccDNA) were turned over independen
48 e of the hepatitis B virus (HBV), covalently closed circular DNA (cccDNA), has been difficult to stud
49 orms a stable minichromosome, the covalently closed circular DNA (cccDNA), in the nucleus of infected
50 in the intranuclear pool of viral covalently closed circular DNA (cccDNA), resulting in a transient e
51 ause it does not directly affect nuclear HBV closed circular DNA (cccDNA), the genomic form that temp
53 replication and formation of new covalently closed circular DNA (cccDNA), the viral transcriptional
54 eradicate or inactivate the viral covalently closed circular DNA (cccDNA), which is a stable episomal
58 number of episomal viral genomes [covalently closed circular DNA (cccDNA)] in the nuclei of infected
60 ifically target hepatitis B virus covalently closed circular DNA (HBV cccDNA), the episomal form of t
61 eplication is due to a less rapid covalently closed circular DNA amplification, leading to lower vire
62 nctional cure are the presence of covalently closed circular DNA and ineffective/exhaustive immune sy
63 strains as both low-copy-number, covalently closed circular DNA and tandemly duplicated, chromosomal
66 f significantly higher amounts of covalently closed circular DNA compared with wild-type HBV replicat
70 us, chemotherapeutic clearance of covalently closed circular DNA did not involve the replacement of t
73 ed without amplification by using covalently closed circular DNA extracted from the liver of an infec
74 binding, taurocholate uptake, HBV covalently closed circular DNA formation, and expression of all HBV
76 ee 3' end, which would nevertheless preserve closed circular DNA in either single-stranded (SS) or do
77 could generate a small amount of covalently closed circular DNA in LMH cells, a chicken hepatoma cel
78 able to introduce positive supercoils into a closed circular DNA in the presence of bacterial or euka
79 and the resulting apparent unwinding of the closed circular DNA is used to calculate both ligand unw
82 tion of virus entry since initial covalently closed circular DNA levels were not decreased in IFN-tre
85 diates, no effect on the level of covalently closed circular DNA or HBV transcripts was observed at l
87 inding assays, and topological analyses with closed circular DNA show that the properties of multipro
90 on histone-DNA interactions were studied on closed circular DNA that was either moderately or positi
91 cation (LDA), for selective amplification of closed circular DNA using sequence-specific primers.
92 cation (LDA), for selective amplification of closed circular DNA using sequence-specific primers.
93 complete cure (ie, eradication of covalently closed circular DNA) of CHB, several challenges in basic
94 igated using plasmid DNA, relaxed covalently closed circular DNA, and linear duplex DNA as substrates
95 ed RNAs associated primarily with covalently closed circular DNA, consistent with this structure bein
96 molar input ratio) in supercoiling relaxed, closed circular DNA, in inducing ligase-mediated circula
97 as replicative intermediate DNA, covalently closed circular DNA, pregenomic RNA, and the percentage
98 levels and impaired production of covalently closed circular DNA, the template for DHBV gene expressi
99 for reversibly binding DNA ligands that uses closed circular DNA, topoisomerase I (Topo I), and two-d
100 ses the transcriptional template, covalently closed circular DNA, was formed by circularization of li
101 ) and surface (HBs) antigens, and covalently closed circular DNA, was observed in HUHEP and HIS-HUHEP
108 ed with foreign, single-stranded, covalently closed, circular DNA molecules identical in length to th
112 the presence of DNA nicks, and can occur on closed-circular DNAs in the absence of topoisomerases.
113 l spectrum generated during transcription of closed circular double-stranded DNA indicates that wild
116 ng linear RecA-ssDNA filament and covalently closed circular duplex DNAs is promoted by supercoiling
117 e lesion during bidirectional replication of closed circular duplex molecules carrying the SV40 origi
118 turbations induced when echinomycin binds to closed circular duplex pBR322 DNA were also investigated
119 convert its linear genome to the covalently closed circular episomal form in which it persists in pr
121 conversion of nicked circular plasmid to the closed circular form by cell extracts filling the repair
122 or each HBV DNA species, with the covalently closed circular form of HBV DNA being the most resistant
123 ote limited excision to produce a covalently closed circular form of the transposon, showing that Tn
124 competent form of many DNA molecules is the closed circular form, it would be adventitious to amplif
125 competent form of many DNA molecules is the closed circular form, it would be adventitious to amplif
126 inant form of VS RNA observed in vivo is the closed circular form, though minimal VS ribozyme self-cl
127 eplication and causes a complete loss of the closed-circular form of EBV episomes in latently infecte
129 lopment of treatment to eradicate covalently closed circular HBV DNA, and development of immunotherap
133 Helraiser transposition generates covalently closed circular intermediates, suggestive of a replicati
135 synthesis products, i.e., newly synthesized closed circular molecules carrying the photoproduct, wer
138 lly all the plastid DNA comprises covalently closed circular monomers, together with a tiny minority
139 terations cause changes in the topology of a closed circular nucleosomal array that persist after rem
143 troduce superhelical tension into covalently closed circular plasmid DNA is stimulated by Rad51.
144 oth orientations, DpnI-resistant, replicated closed circular plasmid DNA was sensitive to nicking by
145 ive ligand PIPER can unwind double-stranded, closed circular plasmid DNA, as determined by a topoisom
152 econd, we measured the change in topology of closed circular relaxed DNA following binding of HU.
153 mants with extrachromosomal plasmid DNA when closed circular, replicative plasmid carrying an uptake
154 PO(4) single-strand RNA to form a covalently closed circular RNA molecule through ligase-adenylylate
156 ar ligation of single-stranded RNA to form a closed circular RNA via covalent ligase-AMP and RNA-aden
158 C are defective phages that contain a novel closed circular single-stranded DNA and that this DNA wa
159 indicated that pyocin C particles contained closed circular single-stranded DNA, approximately 4.0 k
160 , it exists as a protein capsid to protect a closed circular, single-stranded DNA (ssDNA) genome.
161 where the linear dsDNA is used to mimic the closed circular, ssDNA in M13 phage, upon removal of the
162 of LH1 complexes thought to exist as a large closed circular structure only in the latter strain.
163 erent sites, and loading PCNA onto a nicked, closed circular substrate with a unique Hx residue enhan
164 ear non-homologous DNA ends repaired to form closed-circular supercoiled monomers, are joined without
165 rom Anabaena was used to generate covalently closed circular trans-acting ribozymes in Escherichia co
167 ermediates from the cytoplasm and covalently closed circular viral DNA from the nucleus of infected c
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