ライフサイエンスコーパス: closely mimic

1 on in the crystal structure 1TW7 is found to closely mimic a key intermediate in the flap-opening pat

2 amino acid R820X, to produce an allele that closely mimics a point mutation (E827X) in human SPINK5.

3 is a progressive, lethal disease which very closely mimics active human disease.

4 al structures and found that these compounds closely mimic all key interactions of MLL with menin.

5 Asp-128 --> Ala (D128A) streptavidin mutant closely mimics an intermediate on a well-defined dissoci

6 ibodies (mAbs), which, in vitro and in vivo, closely mimic antibodies that cause thrombocytopenia in

7 ed a clinically relevant cardiomyopathy that closely mimics ARVC in humans.

8 have developed a transgenic mouse model that closely mimics atherosclerosis in humans with type 1 dia

9 This construct closely mimics blimp1/krox1b expression during early sta

10 nsport gene can produce an animal model that closely mimics both the biochemical and histopathologica

11 are capable of inducing a skin disease that closely mimics bullous pemphigoid, supporting the hypoth

12 mmatory subepidermal blistering disease that closely mimics bullous pemphigoid.

13 e genetic circuits in environments that more closely mimic cells' natural 3D settings, to better expl

14 In an attempt to more closely mimic challenge with HIV, we administered repeat

15 It is concluded that FCH closely mimics choline uptake by normal tissues and pros

16 of "adequate relief," allows researchers to closely mimic clinical situations and use a cutoff point

17 th skeletal myopathy and cardiomyopathy that closely mimics clinical DMD were studied.

18 Our second-generation test more closely mimics clinical scenarios by applying force to a

19 g an approach to target validation that more closely mimics clinical trials.

20 hored three-dimensional collagen lattices to closely mimic conditions in vivo.

21 n that are missed on larger pillars and more closely mimic continuous surfaces.

22 nt preclinical models of addiction that more closely mimic diagnostic criteria of addiction.

23 s following p21 overexpression in PC12 cells closely mimic distinctive events previously shown to occ

24 We conclude that hESC-derived erythropoiesis closely mimics early human development because the first

25 Hirudo verbana a sequence of behaviors that closely mimic elements of spontaneous reproductive behav

26 ogic changes using radiopharmaceuticals that closely mimic endogenous molecules.

27 erial artificial chromosome (BAC) constructs closely mimics endogenous LRRK2 distribution in the mous

28 We find that organic thin-film growth closely mimics epitaxial growth of inorganic materials,

29 ss forming liquid using a methodology, which closely mimics experiment.

30 Disease progression closely mimics hallmarks of human CCHF disease, making I

31 n in androgen-independent LNCaP cells, which closely mimic hormone-refractory prostate cancer cells i

32 is study aimed to establish a mouse model to closely mimic human B-cell PIOL and to test the therapeu

33 capable of triggering blisters in mice that closely mimic human BP.

34 ynamic and neurohumoral characteristics that closely mimic human dilated cardiomyopathy.

35 tegies to combat invasive aspergillosis that closely mimic human disease are desirable.

36 onclusion that animal models of disease must closely mimic human disease to produce clinically releva

37 ve elevated levels of IL-1beta and IL-18 and closely mimic human disease.

38 mainly for lack of experimental models that closely mimic human disease.

39 emia) or EL4 (B6 acute T cell leukemia) that closely mimic human GVL.

40 he lack of easily studied animal models that closely mimic human infection.

41 lar development, induces tumors in mice that closely mimic human medulloblastomas.

42 ale fluid channels to create constructs that closely mimic human organs.

43 provide the community with models that more closely mimic human retinitis pigmentosa.

44 thologic information, few animal models that closely mimic human sepsis, and a relative shortage of s

45 iation block at the promyelocytic stage that closely mimics human APL even in its response to retinoi

46 s is the first report of a murine model that closely mimics human B-cell PIOL.

47 t activation and neutrophil infiltration and closely mimics human BP.

48 of triggering a blistering skin disease that closely mimics human BP.

49 53-null mouse mammary gland tumor model that closely mimics human breast cancer, we have identified,

50 ary cancer (RMC), an animal tumor model that closely mimics human breast carcinoma.

51 odel of chemotherapy-induced alopecia, which closely mimics human chemotherapy-induced alopecia, stro

52 However intravenous administration more closely mimics human cocaine abuse during pregnancy.

53 inistration of cocaine in a manner that most closely mimics human cocaine use has long-term effects o

54 In an animal model that closely mimics human development; chronic treatment with

55 cation of the aortic valve, a phenotype that closely mimics human disease caused by NOTCH1 haploinsuf

56 While this animal model closely mimics human disease, rhesus macaques can harbor

57 tly described as a bubonic plague model that closely mimics human disease.

58 MPO) induces a mouse model of ANCA NCGN that closely mimics human disease.

59 This novel pig model of infection closely mimics human gastric pathology and presents a su

60 t of a mouse model of G6Pase deficiency that closely mimics human GSD-Ia.

61 hamsters with ANDV results in a disease that closely mimics human HPS in incubation time, symptoms of

62 , we used a neonatal mouse model, which more closely mimics human infants, to study the role of the i

63 le for studying ZIKV disease because it more closely mimics human infection by mosquito bite than nee

64 es were used to develop an animal model that closely mimics human Mycobacterium tuberculosis infectio

65 developing a murine model for infection that closely mimics human skin infection, we show that the va

66 data describe a novel transgenic mouse that closely mimics human tauopathy and may represent an impo

67 To produce a mouse model that closely mimics human VHL disease and avoids embryonic le

68 An LAL null (lal-/-) mouse model closely mimics human WD/CESD, with hepatocellular, Kupff

69 Since the conditions defined here more closely mimic in vivo ionic concentrations, they may per

70 ured IECs, producing an in vitro system that closely mimics in vivo conditions in the human intestine

71 Thus, the nonhuman primate model closely mimics influenza in humans.

72 the probability of lung involvement and more closely mimics intranasal immunization of humans.

73 triacylglycerol/water interfaces, which more closely mimic lipoprotein surfaces.

74 nucleotide precursors under conditions that closely mimic M13 replication in vivo.

75 f an engineered cytochrome c peroxidase that closely mimics manganese peroxidase (MnP) has been chara

76 ently established a murine model for LF that closely mimics many features of human disease.

77 BL/6 J:129S1/SvImJ mice) model of NAFLD that closely mimics most aspects of human disease.

78 ds and the development of animal models that closely mimic multiple aspects of cerebral microinfarcts

79 from ischemia/reperfusion injury, which more closely mimics myocardial infarction in patients, becaus

80 ug screening process as 3D tissue models can closely mimic native tissues and, in some cases, the phy

81 .c.), and intranasal exposure routes to more closely mimic natural exposure.

82 the factors responsible, animal models that closely mimic natural modes of allergen exposure should

83 The double-stranded stems of these aptamers closely mimic natural substrates near the RNase H domain

84 torial use of different approaches that more closely mimic nature's diverse cues, which may result in

85 volution of neural activities in the network closely mimics neural responses recorded in frontal cort

86 e is associated with clinical syndromes that closely mimic other primary rheumatic diseases.

87 ue 6-base self-complementary sequence, which closely mimics palindromic sequences that mediate functi

88 creatic edema, and acinar cell injury, which closely mimic pancreatitis in humans.

89 lergic disease and a mouse model designed to closely mimic peptide therapy in humans.

90 f these IgGs (i.e., in a situation that more closely mimics physiologic conditions), GE Abs display s

91 ng their function under conditions that more closely mimic physiological conditions.

92 This more closely mimics physiological stimuli and circumvents the

93 iation upon TCR engagement in a process that closely mimics positive selection.

94 cells missing chromosome II in a manner that closely mimics postsegregational killing mediated by pla

95 We conclude that these mice very closely mimic severe human von Willebrand disease and wi

96 or growth and metastatic spread of 4T1 cells closely mimics stage IV breast cancer.

97 e data indicate that growth in 5 mM KCl more closely mimics survival and maturation of granule neuron

98 Although these side effects closely mimic symptoms of mitochondrial dysfunction, the

99 uce second-generation Ab molecules that more closely mimic TCR fine specificity.

100 osition using modified growth medium to more closely mimic that of BL-04 yielded cells that showed in

101 ant allele manifest a retinal phenotype that closely mimics that in humans with RHO mutations.

102 as prostate cancer progression in this model closely mimics that observed in the human disease, and t

103 on of FRP-alphabeta without any FMN addition closely mimics that of a single-component bifunctional m

104 c, ceramic-based scaffold whose architecture closely mimics that of cuttlebone -a structural biomater

105 the shallow F' pocket in a conformation that closely mimics that of the alkyl chain in the CD1a-sulfa

106 d illustrate that, unexpectedly, its 3D fold closely mimics that of the DEDDh family of exonucleases.

107 ther direct expression in other tissues that closely mimics that of the endogenous gene.

108 eling supports a dual C/D RNP structure that closely mimics that recently visualized by electron micr

109 ies revealed that these diiron(II) complexes closely mimic the active site structures of the hydroxyl

110 ated colonic polyps with use of methods that closely mimic the attenuation, noise, and polyp-colon wa

111 it (GPIIb) only when the drug is present and closely mimic the behavior of antibodies found in human

112 Both monoclonals closely mimic the behavior of antibodies from patients w

113 To closely mimic the Cambridge Neuropsychological Test Auto

114 shown by high resolution NMR spectroscopy to closely mimic the CD4 domain 1 CC' surface loop.

115 istologic changes in the kidney of T2DN rats closely mimic the changes seen in the kidney of patients

116 Simulant reference materials, which closely mimic the characteristic chemical structures of

117 physiologic testing methodologies that more closely mimic the chronic intracellular infection usuall

118 when designing large animal studies to most closely mimic the clinical course of MI and enable trans

119 a canine model that has been demonstrated to closely mimic the clinical situation.

120 structural and surface characteristics that closely mimic the DNA phosphate backbone, enabling it to

121 -receptor interactions under conditions that closely mimic the environment in which these encounters

122 rated theoretical VVC inhibition curves that closely mimic the experimental data for the resistant vi

123 selection for the eye-like color pattern to closely mimic the eye or face of any particular predator

124 d NADP+ or with NAD+ and H2NADPH should more closely mimic the ground states for forward and reverse

125 ave been developed and/or characterized that closely mimic the human disease state.

126 media, wherein experimental conditions more closely mimic the in vivo environment than those in prev

127 an be studied in microenvironments that more closely mimic the in vivo environment.

128 ues and comparing these to simulations which closely mimic the inhibitor actions, careful application

129 del of intestinal cells was utilized to more closely mimic the intestinal epithelium.

130 s of miniature all-polymer flow sensors that closely mimic the intricate morphology of the mechanosen

131 ion, allowing formation of biomaterials that closely mimic the material properties of native elastin.

132 ts in diagnosing these cases as these tumors closely mimic the mesenchymal submucosal tumors such as

133 s such as the prototype BG505 SOSIP.664 that closely mimic the native Env spike can induce autologous

134 c or trimeric (gp140) forms of Env that more closely mimic the native proteins on the virion are ofte

135 the number of ticks in the challenge to more closely mimic the natural dose and found a profound defe

136 mall helical spirocyclic molecules that most closely mimic the natural product.

137 SS may more closely mimic the natural route of malaria infection ini

138 To more closely mimic the pattern of NKX3.1 loss that occurs in

139 These features closely mimic the periventricular and cortical pathology

140 pression of PML-RARA in this mouse model may closely mimic the physiologic expression pattern of PML-

141 ents are studied to determine which may most closely mimic the physiological form by comparing stress

142 ers down to two, narrow, curved tunnels that closely mimic the shape of the preferred substrate.

143 ys with a synthetic Zn (2+) complex, to more closely mimic the structure of the active site in proMMP

144 the CaSR, which would be anticipated to more closely mimic the structure of the native CaSR ECD.

145 The UL144 structure was predicted to closely mimic the surface of HVEM, and we also found tha

146 eptide containing a noncanonical residue can closely mimic the tertiary structure of the native seque

147 rget antigenic sites on a tumor antigen must closely mimic the three-dimensional structure of the cor

148 pigs and rabbits, the canine model may more closely mimic the vascular response of humans.

149 ults indicate that growth on vertical plates closely mimics the Adh/GUS expression observed for soil-

150 ion state analogue, ADP.AlFx, bound, that it closely mimics the ATP-bound state.

151 Our model closely mimics the behavior of Metapolybia wasps, demons

152 In model systems, DHE closely mimics the behavior of native cholesterol.

153 ium coatneyi, a simian malaria parasite that closely mimics the biological characteristics of P. falc

154 This model closely mimics the clinical and pathological features of

155 ion of specific mutations, in a context that closely mimics the complexity of cancer.

156 This experimental approach more closely mimics the conditions found in vivo.

157 pho-epitope within the C terminus of LT that closely mimics the consensus Cdc4 phospho-degron found w

158 model is a model of multiple sclerosis that closely mimics the disease characteristics in humans.

159 d an in vitro organotypic culture model that closely mimics the disease.

160 We show here that, unlike IL-2, IL-15 closely mimics the effects of IFN I in causing strong an

161 rentiation and arrested growth in vitro that closely mimics the effects of siRNA-mediated attenuation

162 (TSCs) proliferating in the presence of FGF4 closely mimics the events triggered by FGF4 deprivation:

163 f virus-associated pulmonary B-cell lymphoma closely mimics the full spectrum of human lymphomatoid g

164 ck of an appropriate small animal model that closely mimics the generation of BOOP lesions has been a

165 , which renders cells temperature sensitive, closely mimics the global defects of the Fe-S cluster mu

166 images with results showing performance that closely mimics the gold standard manual process.

167 --> HisPhe-43 --> His, called Cu(B)Mb) that closely mimics the heme-copper center in HCO.

168 arance of the cell cycle events in the mouse closely mimics the human disease progression.

169 A canine model that closely mimics the human disease was used to determine i

170 ies specific for mouse MPO induces NCGN that closely mimics the human disease.

171 A mouse model of total saposin deficiency closely mimics the human disease.

172 imens, we have developed a murine model that closely mimics the human lung disease process.

173 n orthotopic murine mammary tumor model that closely mimics the human pathology, including pDC and re

174 the authors characterized a mouse model that closely mimics the human phenotype and tested the feasib

175 This biological model closely mimics the human setting and permits transient s

176 ouse model of vascular graft infections that closely mimics the human situation.

177 tep in developing an in vivo model that more closely mimics the IgE-mediated responses in man, we use

178 chlamydial-specific Th1-biased response that closely mimics the immune response produced after chlamy

179 mall molecules tested in a setting that more closely mimics the in vivo cancer microenvironment so as

180 Whole blood perfusion more closely mimics the in vivo situation, but extracorporeal

181 t overexpression of the HU-induced SAR1 gene closely mimics the known effects of HU on K562 and CD34(

182 arning in smooth eye movements in a way that closely mimics the learning instructed by real visual mo

183 +) for its effects: removal of this tyrosine closely mimics the loss of sli-1 but not of another nega

184 of a bottle-brush polymer whose architecture closely mimics the lubricating protein lubricin.

185 ary, we have identified a novel peptide that closely mimics the MAb 2D7 epitope on CCR5.

186 iabetic Fatty Rat (ZDF/Drt-fa), a model that closely mimics the metabolic abnormalities of NIDDM.

187 d a biomimetic modular polymer that not only closely mimics the modular multidomain structure of titi

188 ished an ex vivo 3D Ewing sarcoma model that closely mimics the morphology, growth kinetics, and prot

189 he structure of a model membrane system that closely mimics the myelin sheath.

190 he structure of the partially unfolded forms closely mimics the native organization, four residues in

191 he design and fabrication of a scaffold that closely mimics the native skeletal-muscle extracellular

192 ct HR1 redesigns confirm that redesigned Env closely mimics the native, prefusion trimer with a more

193 d by the ACP, indicating that the crypto-ACP closely mimics the natural DH substrate.

194 eadily available protein substrate that more closely mimics the natural substrates of endoproteinases

195 ) may result in optic nerve damage that very closely mimics the pathologic course of primary open ang

196 model lacking both dystrophin and telomerase closely mimics the pathological progression of human DMD

197 The mdx diaphragm muscle closely mimics the pathophysiological changes in DMD mus

198 using an intravenous (IV) rodent model that closely mimics the pharmacokinetics seen in humans after

199 This effect closely mimics the phenotype of APP A673T, a recently di

200 yl is a weak allosteric activator, the ester closely mimics the physiological corepressor in activati

201 e that the structure of the covalent complex closely mimics the physiological electron transfer compl

202 ess fertilin beta in vitro in a fashion that closely mimics the processing pattern observed in vivo d

203 ures an aspartyl-BeF3 covalent adduct, which closely mimics the proposed aspartyl-phosphate intermedi

204 se and eosinophilia after RSV challenge that closely mimics the RSV vaccine-enhanced disease observed

205 oth late-stage chondrocytes and osteoblasts, closely mimics the skeletal phenotype in fro/fro mice.

206 d in cellular prosurvival Bcl-2 proteins and closely mimics the structure of the prosurvival Bcl-2 fa

207 a tert-butyldiarylsilyl (TBDAS) linker that closely mimics the tert-butyldiphenysilyl protecting gro

208 substrate with stochastic surface order that closely mimics the topographic features of native baseme

209 DATMe-ImmH more closely mimics the transition of human PNP than does Imm

210 Our structure closely mimics the wild-type fold of TrkAIg2 in complex

211 ts is necessary to induce, and sufficient to closely mimic, the original mutant phenotypes of Trp(P36

212 s on spontaneous and Ca(2+)-triggered fusion closely mimic those observed in neuronal cultures.

213 kek5 phenotypic effects closely mimic those observed with Short gastrulation (So

214 n chromatin architecture and gene expression closely mimic those of deleting the fetal globin repress

215 nal features of these mouse medulloblastomas closely mimic those of human MYC-subgroup tumors and sig

216 xposed to low-frequency soil vibrations that closely mimic those of rainfall.

217 board, with stimulus parameters designed to closely mimic those of the commercial FDT test.

218 eference of the bacterially expressed enzyme closely mimic those of the enzyme expressed in mammalian

219 oid tissue and other pathologic sequela that closely mimics those observed in HIV infected humans.

220 , the TLS structure is 'two faced': one face closely mimics tRNA and drives aminoacylation, the other

221 el of spontaneous breast carcinogenesis that closely mimics tumor-host interactions seen in humans.

222 imuli by designing novel paradigms that more closely mimic visual behavior in the wild.

223 tings with lower bacterial inocula that more closely mimic what initially occurs in humans.