ライフサイエンスコーパス: clostridial

1 Bacteroides spp., and a species of the order Clostridiales.

2 hment of a protective microbiota enriched in Clostridiales.

3 Breast-fed infants had lower proportions of Clostridiales.

4 and expansion of Lactobacillales and loss of Clostridiales.

5 Depletion of Clostridiales also abolished colonization resistance in

6 S] clusters compared with the well described clostridial and chromatium types.

7 Sequences were aligned to SILVA database and Clostridiales and Erysipelotrichales orders were more ab

8 d that deworming treatment reduced levels of Clostridiales and increased Bacteroidales.

9 0.06, and produced communities dominated by Clostridiales and Lactobacillales.

10 otomaculum and Bacteroidetes, enrichments of Clostridiales and Psychrosinus species, and a temporal s

11 eased proportions of two orders of Bacteria: Clostridiales and Syntrophobacterales, with Desulfotomac

12 erococcaceae and Streptococcaceae, decreased Clostridiales) and taxa associated with gastrointestinal

13 ecies, and three novel bacteria in the order Clostridiales are among the bacterial species significan

14 toward AADC, along with previously reported clostridial asRNAs, were examined for structural feature

15 el, Clostridia (44%) at the Class level, and Clostridiales at the Order level (41%).

16 f either a Megasphaera species or one of the Clostridiales bacteria yielded a sensitivity of 99% and

17 higher in women with baseline detection of 3 Clostridiales bacteria, designated as BVAB1 (risk ratio,

18 , the role of these putative drug targets in clostridial biological pathways was studied while subcel

19 Clostridial botulinum neurotoxin (BoNT) causes a neuropa

20 The clostridial botulinum neurotoxins (BoNTs) are the most p

21 Clostridial botulinum neurotoxins (BoNTs) cause neuropar

22 Clostridial botulinum neurotoxins (BoNTs) exert their ne

23 Administration of Clostridiales, but not Bacteroidales, protected neonatal

24 n, many members of the orders Bacillales and Clostridiales can sporulate, generating dormant and resi

25 ically deduced structure of the A-Cluster in clostridial carbon monoxide dehydrogenase.

26 feature might be common to all cellulosomal clostridial CBM4 modules.

27 We propose that clostridial CBM4s have possibly evolved to bind the free

28 They are adjacent on the Clostridial chromosome and encode polypeptides of 57.3 a

29 egration of multiple functional genes into a clostridial chromosome--here, the C. acetobutylicum chro

30 m human feces that represent three different clostridial clusters (IV, XIVa, and XVI).

31 icially synthesized NTR gene using optimized clostridial codons (sNTR).

32 A mouse model of antibiotic-associated clostridial colitis was established to examine the role

33 A mouse model of antibiotic-associated clostridial colitis was set up.

34 Western blot analysis showed that Clostridial collagenase degraded various collagens but s

35 However, the instability of clostridial collagenase I (Col G) results in a degraded

36 rystal structures of the peptidases of three clostridial collagenase isoforms (ColG, ColH, and ColT).

37 Clostridial collagenases are among the most efficient en

38 critically affects the enzymatic activity of clostridial collagenases.

39 ce in Erysipelotrichales, Bacteroidales, and Clostridiales, correlates strongly with disease status.

40 lethal toxins, A and B, members of the large clostridial cytotoxin family.

41 The tpeL gene encoding the large clostridial cytotoxin was localized to the cpb plasmids

42 proteins with significant homology to large clostridial cytotoxins.

43 logy with the catalytic domains of the large clostridial cytotoxins.

44 lap that appear to be unique among the large clostridial cytotoxins.

45 The current clostridial-derived vaccines against BoNT intoxication h

46 ortant implications for human and veterinary clostridial disease epidemiology and provides important

47 e observations lead to the conclusion that a clostridial endopeptidase conjugate that can be used to

48 ngens is recognized as an important cause of clostridial enteric diseases, only limited knowledge exi

49 d phosphonates that takes advantage of (i) a Clostridial enzyme to set the absolute stereochemistry a

50 orted for the analogous radical bound to the clostridial enzyme.

51 eoxyadenosyl radical as in the action of the clostridial enzyme.

52 tate of E. coli LAM, as in the action of the clostridial enzyme.

53 obium, Desulfovibrio and four members of the Clostridiales family.

54 eates a methodology to combine solventogenic clostridial fermentation and chemical catalysis via extr

55 SKO1 cells never achieved the swollen clostridial form typical of the parental strain and did

56 rved extended time between the appearance of clostridial forms and endospore formation.

57 gas embolism, severe decompression sickness, clostridial gas gangrene, necrotizing fasciitis, and acu

58 The clostridial gene encoded a basic 14.5-kDa protein (TcbC)

59 In Clostridial genomes, only the Spo0A protein was found, s

60 ing CPB2 (cpb2) are strongly associated with clostridial GI diseases in domestic animals, including n

61 TpeL is a member of the family of clostridial glucosylating toxins produced by Clostridium

62 hin the RTX toxin that is conserved in large clostridial glucosylating toxins TcdB, TcdA, TcnA, and T

63 phospholipase, neuraminidase, and two large clostridial glucosylating toxins, TcsL and TcsH.

64 a process that is conserved across the large clostridial glucosylating toxins.

65 lights the profound clinical significance of clostridial glucosylating toxins.

66 es of bacterial toxins, including all of the clostridial glucosyltransferase toxins and various MARTX

67 CROP-independent receptor-binding domain in clostridial glycosylating toxins and suggest a two-recep

68 RBD-like regions are conserved in all other clostridial glycosylating toxins preceding their CROP do

69 wo-receptor model for the cellular uptake of clostridial glycosylating toxins.

70 Here, we present the crystal structure of a clostridial hemagglutinin (HA) complex of serotype BoNT/

71 rotein in the E. coli host compared with the clostridial host, which we hypothesized could be the res

72 n the development of therapies for arresting clostridial infections by enabling the isolation of indi

73 dence supporting a role for any QS system in clostridial infections.

74 Clostridial isolates were typed and toxin genes detected

75 estinal microbiota, including members of the Clostridiales, Lachnospiraceae and Ruminococcaceae, from

76 radicals at the active sites of E. coli and clostridial LAM are different.

77 The radical in the reaction of clostridial LAM has the (S)-configuration, whereas that

78 on different from that at the active site of clostridial LAM.

79 . coli is 5.0 min(-1), 0.1% of the value for clostridial LAM.

80 he iron-sulfur cluster at the active site of Clostridial lysine 2,3-aminomutase.

81 ociated monosaccharides and identify several Clostridiales members that utilize intestinal mucins.

82 mework advances our understanding of complex clostridial metabolism and physiology and also facilitat

83 r electron transfer (e.g., Bacteroidales and Clostridiales) might indirectly contribute to bioelectro

84 dium perfringens is the most common cause of clostridial myonecrosis (gas gangrene).

85 ase, including food poisoning, gas gangrene (clostridial myonecrosis), enteritis necroticans, and non

86 eral human diseases, including gas gangrene (clostridial myonecrosis), enteritis necroticans, antibio

87 h buprenorphine and morphine do not die from clostridial myonecrosis.

88 vel therapies to reduce tissue damage during clostridial myonecrosis.

89 Cleavage of syb by a clostridial neurotoxin resulted in significant defects i

90 The clostridial neurotoxins (CNTs) are the most toxic protei

91 The potency of the clostridial neurotoxins (CNTs) relies primarily on their

92 n (TeNT) and botulinum neurotoxin (BoNT) are clostridial neurotoxins (CNTs) responsible for the paral

93 The clostridial neurotoxins (CNTs), comprised of tetanus neu

94 Clostridial neurotoxins are bacterial endopeptidases tha

95 Clostridial neurotoxins are the causative agents of the

96 Clostridial neurotoxins are zinc endopeptidases that blo

97 Clostridial neurotoxins are zinc endopeptidases, and eac

98 First, clostridial neurotoxins block neurotransmission to or fr

99 Clostridial neurotoxins comprising the seven serotypes o

100 The catalytic component of the clostridial neurotoxins is their light chain (LC), a Zn2

101 Clostridial neurotoxins potently and specifically inhibi

102 se studies provide new insights into how the clostridial neurotoxins recognize their substrates.

103 Binding of the clostridial neurotoxins to receptors on neuronal cells i

104 Clostridial neurotoxins' metalloprotease domain selectiv

105 urotoxin type A is the most potent among the clostridial neurotoxins, and to date there is no post-ex

106 other data for inhibitors of the proteolytic clostridial neurotoxins.

107 T/G and BoNT/B subtypes, but varies in other clostridial neurotoxins.

108 es, and were sensitive to Ca2+ depletion and clostridial neurotoxins.

109 rystal structure of a BoNT in complex with a clostridial nontoxic nonhemagglutinin (NTNHA) protein at

110 f methanogens, and enterotypes enriched with Clostridiales or Prevotella species.

111 zed species, including three bacteria in the Clostridiales order that were highly specific for bacter

112 s is associated with several bacteria in the Clostridiales order, Megasphaera phylotype 2, and P. lac

113 rtium of commensal bacteria belonging to the Clostridiales order, which exerts in vitro antilisterial

114 f germination proteins in the Bacillales and Clostridiales orders are discussed and models for the ge

115 spore-forming members of the Bacillales and Clostridiales orders, although SpoVAEa's amino acid sequ

116 spore forming members of the Bacillales and Clostridiales orders.

117 This was the first report of a clostridial organism containing more than two neurotoxin

118 A clostridial OTU was overabundant in prediagnosis samples

119 elothrix, Atopostipes, Bacteroides, and many Clostridiales OTUs; additional experiments must determin

120 at this enzyme is not the well-characterized clostridial p-hydroxyphenylacetate decarboxylase (CsdBC)

121 To address this and other questions in clostridial phylogeny, we have compared a phylogenetic t

122 me is (R)-beta-lysine, the enantiomer of the clostridial product.

123 e vector with one of two powerful endogenous clostridial promoters: that of the thiolase gene (thlP)

124 The predominance of spore-forming Clostridiales provided evidence for the resilience of th

125 mpared with control mice, with enrichment of Clostridiales (Ruminococcaceae, Lachnospiraceae) and dep

126 fatty acid effects in bacteria belonging to Clostridiales, Rykenellaceae, and in species of the gene

127 n and has several conserved homologues among clostridial saccharolytic, cellulolytic, and pathogenic

128 bers of the Negativicutes revealed typically clostridial sets of sporulation genes.

129 XDXGXTW motifs and catalytic residues of the clostridial sialidase are conserved in the mycoplasmal g

130 timulate the hydrolysis of NeuAc from GM2 by clostridial sialidase, but not the hydrolysis of GalNAc

131 the external NeuAc from this ganglioside by clostridial sialidase.

132 ase the number of noncommensal/nonpathogenic clostridial species and provide a key foundation for fut

133 . difficile spore proteome to those of other clostridial species defined 88 proteins as the clostridi

134 To expand the knowledge base for clostridial species relevant to current biofuel producti

135 were determined to high resolution from the clostridial species Thermoanaerobacterium thermosaccharo

136 Clostridial species were regarded as classic examples.

137 reconstruction of Rex regulons in 11 diverse clostridial species with detailed experimental character

138 Ts) are produced by at least four pathogenic clostridial species, and several LCTs are proven pivotal

139 ts of nGRs from spores of all Bacillales and Clostridiales species and defines two highly conserved s

140 us, although they are apparently absent from Clostridiales species.

141 ostridial species defined 88 proteins as the clostridial spore "core" and 29 proteins as C. difficile

142 The endogenous compounds that regulate clostridial spore germination are not fully understood.

143 Clostridial spore germination requires degradation of th

144 Clostridial spore-formers lack, among others, spoIIB, sd

145 present a key regulatory protein controlling clostridial sporulation.

146 ously shown that spores of the nonpathogenic clostridial strain C. sporogenes genetically engineered

147 es higher than that produced by the original clostridial strain.

148 ass conversion, cellulosome composition, and clostridial systems biology.

149 idetes, as well as a peculiar arrangement of Clostridiales taxa, may enhance the Hadza's ability to d

150 Our studies revealed that the clostridial TcbC protein activated the transcription of

151 ria to one dominated by Bacteroidales and/or Clostridiales that poorly stimulate TLR4.

152 rst dominated by Firmicutes (Lachnospiraceae/Clostridiales), the second by Proteobacteria (Klebsiella

153 bacteria enhanced the ability of protective Clostridiales to colonize the gut.

154 cytotoxin active site shared with the large clostridial toxin (LCT) family and proteins such as ToxA

155 ium sordellii lethal toxin (TcsL) is a large clostridial toxin (LCT) that glucosylates Ras, Rac, and

156 ogy to only the enzymatically active site of clostridial toxin B.

157 are indistinguishable from those mediated by clostridial toxin B.

158 related toxins that are members of the large clostridial toxin family.

159 omain required for enzymatic activity of the clostridial toxin homologs, suggesting a role in urogeni

160 The sensitivity to the action of clostridial toxin indicates the docking-fusion complex i

161 Neutralization of PLC activity in the clostridial toxin preparation completely abrogated human

162 Intramuscular injection of a clostridial toxin preparation containing both phospholip

163 Pretreatment with clostridial toxin resulted in reduced co-immunoprecipita

164 homologous CPD is also present in the large clostridial toxin TcdB and recent studies showed that in

165 Large clostridial toxins (LCTs) are produced by at least four

166 lethal toxin (TcsL) is distinct among large clostridial toxins (LCTs), as it is markedly reduced in

167 nt class of virulence factors known as large clostridial toxins (LCTs).

168 e pathogenicity locus (PaLoc), which encodes clostridial toxins A and B.

169 sion, we have identified six CPPs from large clostridial toxins and have demonstrated the ability of

170 colitis through the elaboration of two large clostridial toxins and other virulence factors.

171 The most powerful clostridial toxins are tetanus and botulinum neurotoxins

172 However, pretreating cells with clostridial toxins blocked the cellular translocation of

173 quence is strictly conserved among all large clostridial toxins is shown to be functionally important

174 g exocytosis and to determine the effects of clostridial toxins on SNARE-mediated trafficking of H(+)

175 Flow cytometry confirmed that these clostridial toxins or recombinant PLC induced formation

176 Research is underway to use clostridial toxins or toxin domains for drug delivery, p

177 on of GR activity also occurs with the large clostridial toxins produced by Clostridium sordellii and

178 vations represent a unique property of these clostridial toxins whereby they can associate into large

179 ing of peptides derived from two other large clostridial toxins, TcdA and TcsL, uncovered two new Tcd

180 ology with the catalytic domain of the large clostridial toxins, which are retaining glycosyltransfer

181 tivity to KB-R7943, and resistance to native Clostridial toxins.

182 been prepared for use in our studies of the clostridial toxins.

183 of the thiolase gene (thlP) and that for the clostridial transcription factor abrB310 (abrBP).

184 says and Western blots of cell extracts from clostridial transformants harboring plasmid constructs o

185 esults suggest that C. reinhardtii employs a clostridial type H(2) production pathway in the dark, es

186 that the C. tepidum Fds are chimeras of both clostridial-type and chromatium-type Fds, suggesting tha

187 In clostridial-type ferredoxins, each of the two [4Fe-4S]2+

188 Fe azotobacter-type ferredoxins from the 8Fe clostridial-type ferredoxins, one of the two motifs pres

189 The "clostridial-type" ferredoxins have two Cys-Xaa-Xaa-Cys-X

190 ack of colonization resistance occurred when Clostridiales were absent in the neonatal microbiota.

191 nd in U(VI)-free incubations, members of the Clostridiales were dominant with sulfate-reducing phylot

192 We examined members of the Clostridiales, which included the families Clostridiacea

193 methanogens: all but two were members of the Clostridiales, with several being, or related to, known

194 Stool Bacteroidaceaeae and Clostridiales XIV predicted 90-day hospitalizations inde

195 Specifically, lower stool Bacteroidaceae, Clostridiales XIV, Lachnospiraceae, Ruminococcacae and h

196 nt prediction using stool Bacteroidaceae and Clostridiales XIV.

197 bligate and facultative anaerobes, including Clostridiales year round, suggests that anaerobic bacter