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1                                        Using clustered regularly interspaced short palindromic repeat
2                                  The CRISPR (clustered regularly interspaced short palindromic repeat
3 ds-especially those that utilize the CRISPR (clustered regularly interspaced short palindromic repeat
4                                              Clustered regularly interspaced short palindromic repeat
5                                     Based on clustered regularly interspaced short palindromic repeat
6 rate that targeting MUC1-C with silencing by clustered regularly interspaced short palindromic repeat
7 r-like (TAL) effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeat
8 fragments of foreign DNA are integrated into Clustered Regularly Interspaced Short Palindromic Repeat
9             Recently, the RNA-guided CRISPR (clustered regularly interspaced short palindromic repeat
10             We name the tool CRISPR-ERA, for clustered regularly interspaced short palindromic repeat
11 ine the role of XIRP2 in hearing, we applied clustered regularly interspaced short palindromic repeat
12 olve inducible defense using the CRISPR-Cas (clustered regularly interspaced short palindromic repeat
13 wn for its role in the bacterial and archeal clustered regularly interspaced short palindromic repeat
14  In addition, we compared RNAi technology to clustered regularly interspaced short palindromic repeat
15 vents did not affect virus antigenicity, and clustered regularly interspaced short palindromic repeat
16                                          The clustered regularly interspaced short palindromic repeat
17 DNA of specific 30-40-base-pair lengths into clustered regularly interspaced short palindromic repeat
18                                              Clustered regularly interspaced short palindromic repeat
19 oreign (viral or plasmid) DNA fragments into clustered regularly interspaced short palindromic repeat
20                                              Clustered regularly interspaced short palindromic repeat
21 rectly into the intestine, a Cryptosporidium clustered regularly interspaced short palindromic repeat
22 NA (shRNA) or functionally ablated using the clustered regularly interspaced short palindromic repeat
23 ll line generated by genome editing with the clustered regularly interspaced short palindromic repeat
24                                              Clustered regularly interspaced short palindromic repeat
25 osomally integrated synthetic constructs and clustered regularly interspaced short palindromic repeat
26 fector complex of the Cmr/type III-B CRISPR (clustered regularly interspaced short palindromic repeat
27                                      We used clustered regularly interspaced short palindromic repeat
28                      The recently discovered clustered regularly interspaced short palindromic repeat
29                The prokaryotic immune system clustered regularly interspaced short palindromic repeat
30 ted as such harbored an insertion in the 3rd clustered regularly interspaced short palindromic repeat
31 guided DNA endonuclease from the CRISPR-Cas (clustered regularly interspaced short palindromic repeat
32 FGE), multilocus sequence typing (MLST), and clustered regularly interspaced short palindromic repeat
33 scription activator-like effector nucleases, clustered regularly interspaced short palindromic repeat
34                                          The clustered regularly interspaced short palindromic repeat
35                                  The CRISPR (clustered regularly interspaced short palindromic repeat
36 or-like effectors (TALEs) and the RNA-guided clustered regularly interspaced short palindromic repeat
37 activator-like effector nuclease (TALEN) and clustered regularly interspaced short palindromic repeat
38                                              Clustered regularly interspaced short palindromic repeat
39 us in the host chromosome known as a CRISPR (clustered regularly interspaced short palindromic repeat
40        METHODS AND Here, we packaged SaCas9 (clustered regularly interspaced short palindromic repeat
41      This proof-of-principle work shows that clustered regularly interspaced short palindromic repeat
42                       Bacterial and archaeal clustered regularly interspaced short palindromic repeat
43                                          The clustered regularly interspaced short palindromic repeat
44 es make use of small RNAs encoded by CRISPR (clustered regularly interspaced short palindromic repeat
45                          Using the bacterial clustered regularly interspaced short palindromic repeat
46                                              Clustered regularly interspaced short palindromic repeat
47 otide polymorphisms (SNPs) and an indel in a clustered regularly interspaced short palindromic repeat
48 hia, Neisseria, Thermotoga, and Mycobacteria clustered regularly interspaced short palindromic repeat
49                                  Prokaryotic clustered regularly interspaced short palindromic repeat
50 nsecutive spacer-repeat units within a novel clustered regularly interspaced short palindromic repeat
51 nsporters for carbohydrates and peptides and clustered regularly interspaced short palindromic repeat
52                                          Two clustered regularly interspaced short palindromic repeat
53          Meanwhile, new technologies such as clustered regularly interspaced short palindromic repeat
54              In the present study, we used a clustered regularly interspaced short palindromic repeat
55 natal and adult-onset diabetes using CRISPR (clustered regularly interspaced short palindromic repeat
56 glycan (HSPG)-knockout (KO) cells by using a clustered regularly interspaced short palindromic repeat
57  of STING expression in endothelial cells by clustered regularly interspaced short palindromic repeat
58                                  Prokaryotic clustered regularly interspaced short palindromic repeat
59                             Here, we develop clustered regularly interspaced short palindromic repeat
60                                          The clustered regularly interspaced short palindromic repeat
61                              The prokaryotic clustered regularly interspaced short palindromic repeat
62 y small interfering RNA (siRNA) knockdown or clustered regularly interspaced short palindromic repeat
63                                          The clustered regularly interspaced short palindromic repeat
64                          We used two CRISPR (clustered regularly interspaced short palindromic repeat
65                In many prokaryotes, type III clustered regularly interspaced short palindromic repeat
66 tagged Rab5c or Rab7a or lacking Cdc42 using clustered regularly interspaced short palindromic repeat
67  and A549 cells were genetically modified by clustered regularly interspaced short palindromic repeat
68                   TPCN2 knockout by means of clustered regularly interspaced short palindromic repeat
69                                              Clustered regularly interspaced short palindromic repeat
70 ned by a combination of analysis of cellular clustered regularly interspaced short palindromic repeat
71 nal genomic technologies in combination with clustered regularly-interspaced short palindromic repeat
72                                  The CRISPR (clustered regularly interspaced short palindromic repeat
73 mprinted genes during seed development using Clustered Regularly Interspaced Short Palindromic Repeat
74                                          The clustered regularly interspaced short palindromic repeat
75                                              Clustered regularly interspaced short palindromic repeat
76  Delivery by adeno-associated virus (AAV) of clustered regularly interspaced short palindromic repeat
77                   By taking advantage of the clustered regularly interspaced short palindromic repeat
78 ted protein 9), derived from type II CRISPR (clustered regularly interspaced short palindromic repeat
79 cterial adaptive immune systems use CRISPRs (clustered regularly interspaced short palindromic repeat
80                                          The clustered regularly interspaced short palindromic repeat
81       Unique among these are the CRISPR-Cas (clustered regularly interspaced short palindromic repeat
82 d that Argonautes encoded within CRISPR-cas [clustered regularly interspaced short palindromic repeat
83 rating fragments of foreign DNA into CRISPR (clustered regularly interspaced short palindromic repeat
84 present a high-throughput approach that uses clustered regularly interspaced short palindromic repeat
85 genic differentiation from a high-efficiency Clustered regularly interspaced short palindromic repeat
86                                              Clustered regularly interspaced short palindromic repeat
87                                        Using clustered regularly interspaced short palindromic repeat
88 terspaced short palindromic repeats (CRISPR)/clustered regularly interspaced short palindromic repeat
89                                          The Clustered Regularly Interspaced Short Palindromic Repeat
90                                      We used clustered regularly interspaced short palindromic repeat
91            We show that the type I-E CRISPR (clustered regularly interspaced short palindromic repeat
92                                              Clustered regularly interspaced short palindromic repeat
93 ing single-cell RNA sequencing (RNA-seq) and clustered regularly interspaced short palindromic repeat
94 ith the discovery of RNA-guided CRISPR-Cas9 (clustered regularly interspaced short palindromic repeat
95 idine deaminase (AID) with nuclease-inactive clustered regularly interspaced short palindromic repeat
96 ase allele-corrected intestinal tissue using clustered regularly interspaced short palindromic repeat
97                     The barcode, an array of clustered regularly interspaced short palindromic repeat
98 endonuclease Cas9 from the microbial CRISPR (clustered regularly interspaced short palindromic repeat
99 nome-editing methods, especially the CRISPR (clustered regularly interspaced short palindromic repeat
100                      The recently discovered clustered regularly interspaced short palindromic repeat
101                                              Clustered regularly interspaced short palindromic repeat
102                            Nix knockout with clustered regularly interspaced short palindromic repeat
103 and harness these capabilities, we developed clustered regularly interspaced short palindromic repeat
104 tivator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeat
105 of prokaryotic adaptive immunity mediated by clustered regularly interspaced short palindromic repeat
106 sing patients' mutations were generated with clustered regularly interspaced short palindromic repeat
107 use temperate phages to deliver a functional clustered regularly interspaced short palindromic repeat
108 ided surveillance complexes that use CRISPR (clustered regularly interspaced short palindromic repeat
109                                  CRISPR-Cas (clustered regularly interspaced short palindromic repeat
110                   We used engineered CRISPR (clustered regularly interspaced short palindromic repeat
111         Bacteria and archaea rely on CRISPR (clustered regularly interspaced short palindromic repeat
112   We developed a highly effective autonomous Clustered Regularly Interspaced Short Palindromic Repeat
113 s knocked out from the recipient cells using clustered regularly interspaced short palindromic repeat
114                                      We used clustered regularly interspaced short palindromic repeat
115    The prokaryotic immune system CRISPR-Cas (clustered regularly interspaced short palindromic repeat
116                                       Use of clustered regularly interspaced short palindromic repeat
117                              The presence of clustered regularly interspaced short palindromic repeat
118                                              Clustered regularly interspaced short palindromic repeat
119  tandem-repeat (VNTR) analysis (MLVA), (iii) clustered regularly interspaced short palindromic repeat
120                                      CRISPR (clustered regularly interspaced short palindromic repeat
121                           Genome editing via clustered regularly interspaced short palindromic repeat
122                                  Analysis of clustered regularly interspaced short palindromic repeat
123                                      We used clustered regularly interspaced short palindromic repeat
124     Bacterial adaptive immunity uses CRISPR (clustered regularly interspaced short palindromic repeat
125 archaea adaptive immune system consisting of clustered regularly interspaced short palindromic repeat
126 as9, an RNA-guided DNA endonuclease found in clustered regularly interspaced short palindromic repeat
127                        Recently, the CRISPR (clustered regularly interspaced short palindromic repeat
128                          Using the bacterial clustered regularly interspaced short palindromic repeat
129  elongation factor 2 (eEF-2) gene] using the Clustered Regularly Interspaced Short Palindromic Repeat
130 bacterial adaptive immune system mediated by clustered regularly interspaced short palindromic repeat
131  and integration of invader DNA into CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat
132           Tal-effector nucleases (TALEN) and clustered regularly interspaced short palindromic repeat
133 CRISPR/Cas9-mediated (where CRISPR indicates clustered regularly interspaced short palindromic repeat
134 ns as well as single-cell gene editing using clustered regularly interspaced short palindromic repeat
135 i), Argonaute-based interference, as well as clustered regularly interspaced short palindromic repeat
136  unique antiviral defense system composed of clustered regularly interspaced short palindromic repeat
137                                              Clustered regularly interspaced short palindromic repeat
138 uses in vitro constituted nuclease-deficient clustered regularly interspaced short palindromic repeat
139      The discovery that the machinery of the Clustered Regularly Interspaced Short Palindromic Repeat
140 RNA) is one of the two key components of the clustered regularly interspaced short palindromic repeat
141                                          The clustered regularly interspaced short palindromic repeat
142 ite-specific insertion of a trait gene using clustered regularly interspaced short palindromic repeat
143                                              Clustered regularly interspaced short palindromic repeat
144                             In bacteria, the clustered regularly interspaced short palindromic repeat
145 ke effector nucleases (TALENs) or RNA-guided clustered regularly interspaced short palindromic repeat
146  RNA regulatory element activity (GenERA), a clustered regularly interspaced short palindromic repeat
147                                    The term 'clustered regularly interspaced short palindromic repeat
148    The simplicity of programming the CRISPR (clustered regularly interspaced short palindromic repeat
149 ucleases constitute a core family of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat
150 rom RNA interference to gene knockouts using Clustered Regularly Interspaced Short Palindromic Repeat
151                                              Clustered regularly interspaced short palindromic repeat
152                                              Clustered regularly interspaced short palindromic repeat
153  adaptive immune systems, called CRISPR-Cas (clustered regularly interspaced short palindromic repeat
154                                  The type II clustered regularly interspaced short palindromic repeat
155                                          The clustered regularly interspaced short palindromic repeat
156                                              Clustered regularly interspaced short palindromic repeat
157 nterference (Swarts et al, 2014), as well as clustered regularly interspaced short palindromic repeat
158  This activity is in contrast to that of the clustered regularly interspaced short palindromic repeat
159 ing technologies-including in particular the clustered regularly interspaced short palindromic repeat
160 was to assess whether genome editing using a clustered regularly interspaced short palindromic repeat
161 n activator-like effector protein (TALE) and clustered regularly interspaced short palindromic repeat
162                                              Clustered Regularly Interspaced Short Palindromic Repeat
163                                              Clustered regularly interspaced short palindromic repeat
164 ancer model generation using the CRISPR/Cas (clustered regularly interspaced short palindromic repeat
165 tudy, we have applied the recently developed clustered regularly interspaced short palindromic repeat
166                                              Clustered regularly interspaced short palindromic repeat
167 s including zinc finger nucleases (ZFNs) and clustered regularly interspaced short palindromic repeat
168                                          The clustered regularly interspaced short palindromic repeat
169 acteria and archaea, small RNAs derived from clustered regularly interspaced short palindromic repeat
170                                The bacterial clustered regularly interspaced short palindromic repeat
171       RNA-guided Cas9 nucleases derived from clustered regularly interspaced short palindromic repeat
172                                              Clustered regularly interspaced short palindromic repeat
173             Recently the type II prokaryotic clustered regularly interspaced short palindromic repeat
174                                              Clustered Regularly Interspaced Short Palindromic Repeat
175 ave evolved adaptive immune defenses, termed clustered regularly interspaced short palindromic repeat
176              The type II prokaryotic CRISPR (clustered regularly interspaced short palindromic repeat
177  RNA-guided Cas9 nuclease from the microbial clustered regularly interspaced short palindromic repeat
178 possess an adaptive immune system encoded by clustered regularly interspaced short palindromic repeat
179 al adaptive immune system is the CRISPR/Cas (clustered regularly interspaced short palindromic repeat
180 e-stranded DNA nuclease that participates in clustered regularly interspaced short palindromic repeat
181  hypervariable nature of virulence genes and clustered regularly interspaced short palindromic repeat
182                                              Clustered regularly interspaced short palindromic repeat
183 or-like (TAL) effector nuclease (TALEN)- and clustered regularly interspaced short palindromic repeat
184 ficiently and accurately using an engineered clustered regularly interspaced short palindromic repeat
185 ng capacity is 75% devoted to three distinct clustered regularly interspaced short palindromic repeat
186                                     CRISPRs (clustered regularly interspaced short palindromic repeat
187 y-generating retroelements and virus-encoded Clustered Regularly Interspaced Short Palindromic Repeat
188 t-deficient LEW.1WR1 rats using CRISPR-Cas9 (clustered regularly interspaced short palindromic repeat
189 DGCC7710 with phage 2972 and tracked CRISPR (clustered regularly interspaced short palindromic repeat
190 gical studies and disease treatment, and the clustered regularly interspaced short palindromic repeat
191  The main focus of this review is on CRISPR (clustered regularly interspaced short palindromic repeat
192                                              Clustered regularly interspaced short palindromic repeat
193                                  The CRISPR (clustered regularly interspaced short palindromic repeat
194                                              Clustered regularly interspaced short palindromic repeat
195 ing an adaptive immune response based on the clustered regularly interspaced short palindromic repeat
196 ated by a cassette-like genomic locus termed Clustered Regularly Interspaced Short Palindromic Repeat
197                                  CRISPR/Cas (Clustered Regularly Interspaced Short Palindromic Repeat
198                                              Clustered regularly interspaced short palindromic repeat
199 gments of virus-derived DNA into loci called clustered regularly interspaced short palindromic repeat
200                         RNA transcribed from clustered regularly interspaced short palindromic repeat
201 egrating short fragments of foreign DNA into clustered regularly interspaced short palindromic repeat
202       In each case, transcripts derived from clustered regularly interspaced short palindromic repeat
203                                              Clustered regularly interspaced short palindromic repeat
204                  Matches between S. enterica clustered regularly interspaced short palindromic repeat
205 egion of its genome that is distinguished by clustered regularly interspaced short palindromic repeat
206                              The prokaryotic clustered regularly interspaced short palindromic repeat
207                                              Clustered regularly interspaced short palindromic repeat
208 ents of invader-derived DNA into loci called clustered regularly interspaced short palindromic repeat
209            Many bacteria and archaea contain clustered regularly interspaced short palindromic repeat
210 ve prokaryotic immune system arises from the clustered regularly interspaced short palindromic repeat
211  of FoxM1 to the cyclin B1 gene promoter via clustered regularly interspaced short palindromic repeat
212 dels with similar variants using the CRISPR (clustered regularly interspaced short palindromic repeat
213 We generated a human cell model of CHS using Clustered Regularly Interspaced Short Palindromic Repeat
214                               Many bacterial clustered regularly interspaced short palindromic repeat
215                The RNA-guided, RNA-targeting clustered regularly interspaced short palindromic repeat
216 tem of adeno-associated virus (AAV)-mediated clustered regularly interspaced short palindromic repeat
217 tor-like effector nucleases (TALENs) and the clustered regularly interspaced short palindromic repeat
218 enome-wide small interfering RNA (siRNA) and clustered regularly interspaced short palindromic repeat
219                              Using a CRISPR (clustered regularly interspaced short palindromic repeat
220 bining transposon-based transgenesis and the clustered regularly interspaced short palindromic repeat
221                           From a genome-wide clustered regularly interspaced short palindromic repeat
222                                              Clustered regularly interspaced short palindromic repeat
223                                  Here we use clustered regularly interspaced short palindromic repeat
224                                      CRISPR (clustered regularly interspaced short palindromic repeat
225  of genome editing based on the CRISPR-Cas9 (clustered regularly interspaced short palindromic repeat
226                                  CRISPR-Cas (Clustered regularly interspaced short palindromic repeat
227 ciples of genome editing, recent advances in clustered regularly interspaced short palindromic repeat
228 ly interspaced short palindromic repeats and clustered regularly interspaced short palindromic repeat
229                                  The CRISPR (clustered regularly interspaced short palindromic repeat
230          Targeted gene disruption induced by Clustered Regularly Interspaced Short Palindromic Repeat
231 ls in which the PKD1 gene was knocked out by clustered regularly interspaced short palindromic repeat
232     Transcriptome analyses revealed that the clustered regularly interspaced short palindromic repeat
233 assessed the therapeutic efficacy of CRISPR (clustered regularly interspaced short palindromic repeat
234                                              Clustered regularly interspaced short palindromic repeat
235                                      Using a clustered regularly interspaced short palindromic repeat
236                       The high efficiency of clustered regularly interspaced short palindromic repeat
237                                              Clustered regularly interspaced short palindromic repeat
238 tations associated with S-HSCR, and used the clustered regularly interspaced short palindromic repeat
239 e bacterial immune system, which is based on clustered regularly interspaced short palindromic repeat
240             However, the nuclear dynamics of clustered regularly interspaced short palindromic repeat
241 and genome engineering involving the CRISPR (clustered regularly interspaced short palindromic repeat
242                                     Applying clustered regularly interspaced short palindromic repeat
243                                              Clustered regularly interspaced short palindromic repeat
244 bacterial host also has two complete CRISPR (clustered regularly interspaced short palindromic repeat
245                                              Clustered regularly interspaced short palindromic repeat
246 activator-like effector nuclease and CRISPR (clustered regularly interspaced short palindromic repeat
247 nt tRNA-based vectors for producing multiple clustered regularly interspaced short palindromic repeat
248 ent method for gene disruption using CRISPR (clustered regularly interspaced short palindromic repeat
249 uence using integrative cotransformation and clustered regularly interspaced short palindromic repeat
250 kdown techniques, and the recently developed clustered regularly interspaced short palindromic repeat
251 eno-associated virus was used to deliver the clustered regularly interspaced short palindromic repeat
252 iption activator-like effector nucleases and clustered regularly interspaced short palindromic repeat
253 nd by TLR4 ablation in macrophages using the clustered regularly interspaced short palindromic repeat
254 iption activator-like effector nucleases, or clustered regularly interspaced short palindromic repeat
255 tivator-like effector nucleases (TALENs) and clustered regularly interspaced short palindromic repeat
256        We report here the use of the CRISPR (clustered regularly interspaced short palindromic repeat
257                                      We used clustered regularly interspaced short palindromic repeat
258 ngle-cell labeling of endogenous proteins by clustered regularly interspaced short palindromic repeat
259 itope tagging of the genomic MARCH6 locus by clustered regularly interspaced short palindromic repeat
260                         We used CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat
261 ning genome-wide epigenetic information with clustered regularly-interspaced short palindromic repeat
262 th enhancer activity, Enhancer L Strikingly, clustered regularly-interspaced short palindromic repeat
263                            Among these, only clustered, regularly interspaced short palindromic repea
264  of most bacteria and archaea is an array of clustered, regularly interspaced short palindromic repea
265 een expanded to include the CRISPR system of clustered, regularly interspaced short palindromic repea
266 ion activator-like effectors (TALEs) and the clustered, regularly interspaced, short palindromic repe
267 loy surveillance complexes guided by CRISPR (clustered, regularly interspaced, short palindromic repe
268        Evidence from flies mutated using the clustered, regularly interspaced, short palindromic repe
269           Epigenome editing with the CRISPR (clustered, regularly interspaced, short palindromic repe
270                      Genome editing with the clustered, regularly interspaced, short palindromic repe
271                                          The clustered, regularly interspaced, short palindromic repe
272                                              Clustered, regularly interspaced, short palindromic repe
273                Components of the prokaryotic clustered, regularly interspaced, short palindromic repe
274 roughput of genome editing based on type II, clustered, regularly interspaced, short palindromic repe
275                                              Clustered, regularly interspaced, short palindromic repe
276                                              Clustered, regularly interspaced, short palindromic repe
277                                              Clustered, regularly interspaced, short palindromic repe
278                                              Clustered, regularly interspaced, short palindromic repe
279  been largely fueled by the emergence of the clustered, regularly interspaced, short palindromic repe
280 n activator-like effector nucleases, and the clustered, regularly interspaced, short palindromic repe
281                         We report the use of clustered, regularly interspaced, short palindromic repe
282                                              Clustered, regularly interspaced, short palindromic repe
283 teria, foreign nucleic acids are silenced by clustered, regularly interspaced, short palindromic repe
284                              Here we use the clustered, regularly interspaced, short palindromic repe
285 erference pathway from bacteria [the type II clustered, regularly interspaced, short palindromic repe
286 y Island 1 (SPI-1), ste fimbrial operon, and Clustered, Regularly Interspaced, Short Palindromic Repe
287 okaryotes utilize small RNA transcribed from clustered, regularly interspaced, short palindromic repe
288                                              Clustered, regularly interspaced, short palindromic repe
289                                              Clustered, regularly interspaced, short palindromic repe
290                              In prokaryotes, clustered, regularly interspaced, short palindromic repe
291               We initially used dual-CRISPR (clustered, regularly interspaced, short palindromic repe
292                                              Clustered, regularly interspaced, short palindromic repe
293                                              Clustered, regularly interspaced, short palindromic repe
294                                          The clustered, regularly interspaced, short palindromic repe
295 of site-specific genome targeting by type II clustered, regularly interspaced, short palindromic repe
296 ctivator-like effector nucleases (TALENs) or clustered, regularly interspaced, short palindromic repe
297                                 Discovery of clustered, regularly interspaced, short palindromic repe
298                                              Clustered, regularly interspaced, short palindromic repe
299                                          The clustered, regularly interspaced, short palindromic repe
300      We developed a method that uses CRISPR (clustered, regularly interspaced, short palindromic repe

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