ライフサイエンスコーパス: co-repressor

1 cription whereas GRIP1 acts negatively as a (co)repressor.

2 transcription factor by displacement of SMRT co-repressor.

3 TRIM28, a well-characterized transcriptional co-repressor.

4 to act as a transcriptional co-activator or co-repressor.

5 ty interaction with the RBCC domain of KAP-1 co-repressor.

6 forms a well-defined structure covering the co-repressor.

7 (ER)-alpha by AHR/ARNT as a transcriptional co-repressor.

8 y inhibits activators by recruiting the CtBP co-repressor.

9 d by Hr (HR) functions as a nuclear receptor co-repressor.

10 factors (TCF) and kept silent by Groucho/TLE co-repressors.

11 questering TLE proteins that function as PRH co-repressors.

12 an atypical member of the Gro-TLE family of co-repressors.

13 at mediates interaction with transcriptional co-repressors.

14 ere identified that require tetracyclines as co-repressors.

15 t with GATA4 and function as transcriptional co-repressors.

16 a) resulted in a higher binding affinity for co-repressors.

17 e heterodimers, but was unable to dissociate co-repressors.

18 tide that still binds chromatin and recruits co-repressors.

19 anced RARA interactions with transcriptional co-repressors.

20 pathway initiated by degradation of Aux/IAA co-repressors.

21 tion with the Groucho family transcriptional co-repressors.

22 th proteins that function as transcriptional co-repressors.

23 s transcription, whereas the toxins serve as co-repressors.

24 at the specific deletion of nuclear receptor co-repressor 1 (NCoR1) in T cells causes excessive negat

25 that suppression of NCoR1 (nuclear receptor co-repressor 1), a co-repressor of PPARalpha, reactivate

26 in which the Ski/Sno family transcriptional co-repressor 2 (Skor2) gene is deleted.

27 SMRT (also known as NCoR2, nuclear receptor co-repressor 2) and NCoR in a variety of developmental s

28 ether with SIM synergistically regulates the co-repressor activity of MTA1 on PS2 transcription, prob

29 this interaction is essential for human SIX3 co-repressor activity; we infer, in turn, that this func

30 etic modifiers, histones, or transcriptional co-repressors, along with immune escape via T-cell-media

31 activation domain (DAD) from the human SMRT co-repressor (also known as NCOR2).

32 Knockdown of Atrophin, a Tll co-repressor, also increases aggression, and both protei

33 rystal structure of BirA in complex with the co-repressor analog biotinol-5'-AMP.

34 ervations show that TPL is a transcriptional co-repressor and further our understanding of how auxin

35 n is elevated, BsFur may now use Mn(II) as a co-repressor and inappropriately repress iron uptake.

36 nding protein 1 (CtBP1) is a transcriptional co-repressor and metabolic sensory protein, which often

37 at the Hippo component TAZ can function as a co-repressor and regulate biological functions by negati

38 by lncRNA-dependent displacement of the Cyc8 co-repressor and subsequent gene looping, suggesting tha

39 the antagonistic activities of the Tup1-Cyc8 co-repressor and Swi-Snf co-activator complexes.

40 ction mutations in BCORL1, a transcriptional co-repressor and tumour suppressor.

41 of the MeCP2 'bridge' between the NCoR/SMRT co-repressors and chromatin.

42 icity of RA/T3 action by testing the role of co-repressors and co-activators in regulation of epiderm

43 Binding of hormone dissociates co-repressors and facilitates recruitment of co-activato

44 Conversely, co-repressors and HDAC become co-activators of unligande

45 ncodes a member of the Groucho/TLE family of co-repressors and its function in various cell contexts

46 ene expression by recruiting transcriptional co-repressors and/or by preventing DNA binding of activa

47 ng with its cofactors NCoR (nuclear receptor co-repressor) and SMRT (silencing mediator of retinoid a

48 This C-terminus binds to the Groucho/TLE co-repressor, and also to the Chip/LDB1-SSDP enhanceosom

49 involve DNA response elements, co-activators/co-repressors, and histone modifying enzymes.

50 A polymerase II (RNA pol II), co-activators, co-repressors, and more.

51 Although transcriptional co-repressors are known to contact other repression doma

52 Atx3 is a transcriptional co-repressor, as well as a deubiquitinating enzyme that

53 involves: 1) an interaction with the Groucho co-repressor at the Eh-1 motif in the C-terminus; and 2)

54 Intriguingly, KorA and KorB can act as co-repressors at varying distances between their operato

55 iption factor as co-activator (ATF3-JunB) or co-repressor (ATF3-NFkappaB).

56 the TNFalpha promoter, while recruiting the co-repressor BCL6.

57 ant PRC1 complex that also contains the BCL6 co-repressor BCOR and the histone demethylase KDM2B.

58 The X-linked BCL-6 co-repressor (BCOR) gene encodes a key constituent of a

59 h is known to be caused by mutations in BCL6 co-repressor (BCOR) gene.

60 e entire MeCP2 protein sequence, the DNA and co-repressor binding domains alone are sufficient to avo

61 ther TA systems, MqsR is not a transcription co-repressor but instead functions to destabilize the Mq

62 toxin does not function as a transcriptional co-repressor, but instead functions to destabilize the a

63 ent (Eya) co-activator and the Groucho (Gro) co-repressor, but the relative contribution that each co

64 The co-repressor buttresses the dimer interface, resulting i

65 functions as an unconventional transcription co-repressor by modulating RNA polymerase II at the elon

66 cer of split (TLE) proteins that function as co-repressors by interacting with histone deacetylases w

67 uitment of transcriptional co-activators and co-repressors by Pax6.

68 The transcriptional co-repressor C-terminal binding protein (CtBP) interacts

69 t mechanism that probably uses the canonical co-repressor C-terminal Binding Protein (CtBP).

70 aled that TGF-beta signaling Smads and their co-repressor C-terminal binding protein 1 (CtBP1) transc

71 We also show that E2F7 recruits the co-repressor C-terminal-binding protein (CtBP) and that

72 egulating degradation of the transcriptional co-repressor C-terminal-binding protein-1 (CtBP1) throug

73 educed by overexpressing a dominant-negative co-repressor (c-SMRT), a constitutively active RAR (VP16

74 Genetic knock out of the transcriptional co-repressor carboxyl-terminal-binding protein (CtBP) in

75 ast to the traditional 'passenger' role of a co-repressor, CBFA2T2 functions synergistically with tra

76 main and a conserved N-terminal co-activator/co-repressor (COAR) domain consisting of A1, B1, B2 sub-

77 lysine-specific histone demethylase 1 (LSD1) co-repressor complex associates with the hTERT promoter

78 ression mediated by the unliganded RARgamma2-co-repressor complex constitutes a novel mechanism to re

79 y ESET (also known as SETDB1 or KMT1E) and a co-repressor complex containing KRAB-associated protein

80 LF14 represses the TGFbetaRII promoter via a co-repressor complex containing mSin3A and HDAC2.

81 ssociation of ER with the core promoter in a co-repressor complex containing SMRT and/or NCoR; this r

82 echanistic studies demonstrate that the NuRD co-repressor complex interacts with EWS/FLI, and that it

83 The Sin3a/HDAC co-repressor complex is a critical regulator of transcri

84 The structure of the co-repressor complex is also a dimer, clearly related to

85 /enhancer-binding protein alpha (c/EBPalpha) co-repressor complex onto human RNF144A promoter.

86 and AtCZS represent two main components of a co-repressor complex that fine tunes flowering and is un

87 matopoietic factor GATA-1, binds to the NuRD co-repressor complex through a conserved N-terminal moti

88 critical for recruitment of the HDAC1/Sin3a co-repressor complex to either the Ncx1 or Bnp promoter.

89 S (SEU) that function together in a putative co-repressor complex to prevent ectopic AGAMOUS (AG) tra

90 an active transcription mark and recruits a co-repressor complex to regulate gluconeogenic gene expr

91 ess HO and recruit the Tup1-Cyc8 (Tup1-Ssn6) co-repressor complex to the HO promoter.

92 eosome Remodeling and Histone Deacetylation) co-repressor complex, and NuRD-mediated silencing has be

93 cruitment of the LSD1-containing CoREST-CtBP co-repressor complex, causing repression of an additiona

94 RF2BP2 axis, interacting with the NCOR1/SMRT co-repressor complex, suppresses the expression of the v

95 hylase, LSD1--a component of the CoREST-CtBP co-repressor complex--is required for late cell-lineage

96 ulate genes by passively dissociating the ER co-repressor complex.

97 also exist in a latent state, maintained by co-repressor complexes containing class I histone deacet

98 me remodeling and deacetylase complex (NuRD) co-repressor complexes in mice.

99 s, information about the composition of such co-repressor complexes is just beginning to emerge.

100 of expression levels by chromatin-modifying, co-repressor complexes provides transcriptional fine-tun

101 HDAC5 may function as a scaffold to recruit co-repressor complexes to promoters.

102 ion often depends on the action of recruited co-repressor complexes with intrinsic enzymatic activiti

103 red for the interaction of the HDAC1/2/Sin3a co-repressor complexes with the Nkx2.5 and YY1 transcrip

104 DACs requires recruitment into multi-subunit co-repressor complexes, which are in turn recruited to c

105 catalytic core of the Sin3A, NuRD and CoREST co-repressor complexes.

106 proteins which in turn recruit multiprotein co-repressor complexes.

107 permiogenesis to regulation of transcription co-repressor complexes.

108 through aberrant recruitment of multiprotein co-repressor complexes.

109 of distinct LSD1-containing co-activator or co-repressor complexes.

110 lators of gene expression in transcriptional co-repressor complexes.

111 interaction between MeCP2 and the NCoR/SMRT co-repressor complexes.

112 factor NRSF, which recruits the NADH-binding co-repressor CtBP to generate a repressive chromatin env

113 tio and the NAD(H) sensitive transcriptional co-repressor CtBP.

114 ratio and the NAD(H)-sensitive transcription co-repressor CtBP.

115 with Drosophila Brinker (Brk) recruiting the co-repressors CtBP and Groucho (Gro), in addition to pos

116 Our observations suggest that the co-repressor CtBP1 and HDAC3 are part of transcription s

117 at lysine 670 is required for recruiting the co-repressor CtBP1 and transcriptional repression.

118 1(-/-) cells binding of Mll1/2, Bmi1 and the co-repressor Ctbp1 at Hox loci are all abrogated and Hox

119 n is dependent on GI, which interacts with a CO repressor, CYCLING DOF FACTOR 1 (CDF1), and controls

120 This regulation is also dependent on the co-repressor, Dichaete.

121 ors differentiate into neurons, REST and its co-repressors dissociate from the RE1 site, triggering a

122 Dissociation of the CAPERalpha/TBX3 co-repressor during oncogenic stress activates UCA1, rev

123 tive interactions with the co-activators and co-repressors during erythroid development, the activato

124 n was abrogated by expression of SHP and its co-repressor EID1 in hepatoma cells Huh7, Hepa1, and ste

125 the nucleus and functions as a transcription co-repressor for E2F-1.

126 Overexpression of NAB2, a co-repressor for EGRs, attenuated the EGF-induced increa

127 uggest that Ajuba selectively functions as a co-repressor for Gfi1 autoregulation.

128 d the Polycomb-like protein hPCL3 as a novel co-repressor for HIC1.

129 , small heterodimer partner (SHP), acts as a co-repressor for many transcriptional factors and has be

130 Ajuba functions as a co-repressor for synthetic Gfi1 SNAG-repressor domain-co

131 al attributes with Drosophila Insensitive, a co-repressor for the Drosophila CSL factor.

132 ed co-repressor KAP1 is an essential nuclear co-repressor for the KRAB zinc finger protein superfamil

133 entral components of SWI/SNF, act instead as co-repressors for E2F-mediated transcriptional repressio

134 binding partners, including transcriptional co-repressors (for example, the NCoR/SMRT complex), tran

135 molecular mechanism for the displacement of co-repressors from DNA-bound CSL by NICD.

136 We hypothesize that the inability to release co-repressors from RXRalpha/RARalpha is responsible for

137 roviding important mechanistic insights into co-repressor function in plants.

138 ZBTB family members and broaden the scope of co-repressor functions for the MTG family, suggesting co

139 tion acts as a signal for recruitment of the co-repressor G9a.

140 We show that PRDM1 co-repressors, G9a and HDAC2, are recruited to CIITApI,

141 sed the pancreatic expression of the Groucho co-repressors, Grg1, Grg2, Grg3 and Grg4 (Tle1-Tle4), wh

142 e show that Cux1 directly interacts with the co-repressor Grg4 (Groucho 4), a known effector of Notch

143 ver, we found that the Groucho family member co-repressor Grg6 contributes to Pax6-mediated suppressi

144 ave identified a sea urchin homologue of the co-repressor Groucho (LvGroucho) that has been shown to

145 e binding sites for both the transcriptional co-repressor groucho, and the co-activator beta-catenin.

146 f the X signal element sisA and the maternal co-repressor groucho.

147 al represses transcription by recruiting the co-repressor Groucho.

148 les for the adaptor protein Hairless and the co-repressors Groucho and CtBP in conferring repressive

149 The co-repressor, Groucho, enhances Vnd repression, and thes

150 which vertebrate NKx6-type proteins bind the co-repressor, Groucho.

151 was no difference in the recruitment of the co-repressor HDAC1 (histone deacetylase 1).

152 oter and are required for association of the co-repressor HDAC1.

153 r nfkb1 operating via p50:p50 dimers and the co-repressor HDAC1.

154 Transcriptional co-repressors HDAC1 and HDAC2 compete with beta-catenin

155 cetylases (HDACs) are normally considered as co-repressors, HDAC1 has been identified as a coactivato

156 e have demonstrated that the transcriptional co-repressor HDAC5 can interact with GEF in the absence

157 The interaction of the co-repressors histone deacetylases 1 and 2 as well as ly

158 modeling ATPases in addition to recruiting a co-repressor/histone deacetylase complex.

159 ere we provide evidence that transcriptional co repressor homeodomain interacting protein kinase 2 (H

160 ike 4 (Vgll4) functions as a transcriptional co-repressor in the Hippo-Yes-associated protein (YAP) p

161 These data reveal a novel mammalian CSL co-repressor in the nervous system, and show that the No

162 e mutants utilize Mn(II) but not Fe(II) as a co-repressor in vivo.

163 d that Shn proteins recruit coactivators and co-repressors in a context-dependent manner, rather than

164 ene regulation is mediated by recruitment of co-repressors in the absence of T3 and coactivators in i

165 of Runx2 is determined by associations with co-repressors including histone deacetylase 7 (HDAC7).

166 g aberrant transcription factor/co-activator/co-repressor interactions and histone-modifying activiti

167 ind Groucho and that binding of Nkx6 to this co-repressor is modulated intra-molecularly.

168 This helps explain why the binding of the co-repressor is necessary to optimize the binding of Bir

169 hat the Groucho-related gene (GRG) family of co-repressors is expressed in a model cell line for the

170 set, Tcf7l2 interacts with a transcriptional co-repressor Kaiso/Zbtb33 to block beta-catenin signalli

171 The Kruppel-associated box (KRAB)-associated co-repressor KAP1 is an essential nuclear co-repressor f

172 eover, D53 can interact with transcriptional co-repressors known as TOPLESS-RELATED PROTEINS.

173 is dependent upon the phosphorylation of the co-repressor, Kruppel-associated box (KRAB) domain-assoc

174 Upon binding of the co-repressor L-arginine there is a approximately 15 degr

175 may play a common role as a transcriptional co-repressor leading to human disease.

176 d and isolated two Arabidopsis transcription co-repressors LEUNIG (LUG) and SEUSS (SEU) that function

177 r could function by recruiting just a single co-repressor, many can recruit more than one, with Droso

178 a negative regulator of EAAT1 with HDACs as co-repressors, mediating the inhibitory effects of manga

179 elium and revealing how this transcriptional co-repressor modulates this crucial step of beta-cell de

180 ween its proline/serine/threonine domain and co-repressor molecules such as histone deacetylase (HDAC

181 es presented here identifies known and novel co-repressors, most notably the ETO2 and IRF2BP2 protein

182 e function is mediated through an ETO-family co-repressor Mtgr1, which tightly binds to the pre-SET/S

183 nt with CTNNB1 mutations, and in the nuclear co-repressor (N-CoR) complex genes GPS2, BCOR and LDB1.

184 s by intercepting the degradation of nuclear co-repressor (N-CoR) protein which has a key role in the

185 structure of a complex between an HDAC and a co-repressor, namely, human HDAC3 with the deacetylase a

186 ene repression is mediated by recruitment of co-repressors NCoR and HDAC3.

187 hown to be modulated by interaction with the co-repressors NCoR and SMRT.

188 or domain of MeCP2 with the nuclear receptor co-repressor (NCoR) complex and suppresses the ability o

189 HDAC3, the catalytic subunit of the nuclear co-repressor (NCoR) complex, and recruits HDAC3 to the n

190 de-repression step in which nuclear receptor co-repressor (NCoR) complexes are actively removed from

191 rotein (CBP) and release of nuclear receptor co-repressor (NCoR) on a TRE but had no significant effe

192 al repressors by recruiting nuclear receptor co-repressor (NCoR)-HDAC3 complexes to Rev-Erb response

193 es its interaction with the nuclear receptor co-repressor (NCoR1), resulting in repression of Rev-erb

194 The ZIM protein domain recruits the co-repressors NINJA and TOPLESS to JAZ-bound transcripti

195 via Rad53-dependent inactivation of the MBF co-repressor Nrm1.

196 CDK whereas MBF targets are repressed by the co-repressor, Nrm1.

197 PA28gamma acts as a co-repressor of HTLV-1 p30 to suppress virus replication

198 KEY POINTS: PA28gamma acts as a co-repressor of HTLV-1 p30 to suppress virus replication

199 ific demethylase 1 (LSD1), a transcriptional co-repressor of nuclear receptor TLX, is a downstream ta

200 f NCoR1 (nuclear receptor co-repressor 1), a co-repressor of PPARalpha, reactivates ketogenesis in ce

201 PBX1 interacting protein (PBXIP1/HPIP) is a co-repressor of pre-B-cell leukemia homeobox 1 (PBX1) an

202 found that this protein is a transcriptional co-repressor of STAT1.

203 ded by Rorc, by acting as a co-activator and co-repressor of STAT3, respectively.

204 w that in breast cancer MCF-7 cells, TLE3, a co-repressor of the Groucho/Grg/TLE family, interacts wi

205 ion of FoxG1 with TLE2, a Xenopus tropicalis co-repressor of the Groucho/TLE family, is crucial for r

206 ETO has also been found to act as a co-repressor of the promyelocytic zinc finger and Bcl-6

207 sociated protein 6 (Daxx) is a transcription co-repressor of the RelB-responsive gene promoters.

208 ospero-related homeobox 1 (Prox1) as a novel co-repressor of the retinoic acid-related orphan recepto

209 rginine methyltransferase (CARM-1) acting as co-repressors of glucocorticoid receptor monomers.

210 However, co-repressors of OPN have not been identified.

211 Transcriptional co-repressors of the Groucho/TLE family are important re

212 , co-activators and histone acetylase become co-repressors of the RA/T3 receptors in the presence of

213 fiers histone deacetylases (HDACs) served as co-repressors of YY1 to further decrease EAAT1 promoter

214 X1 and RFX5, associate with distinct sets of co-repressors on the collagen transcription start site i

215 llows it to differentially serve as either a co-repressor or a co-activator of transcription at the s

216 ntrol gene expression through recruitment of co-repressors or co-activators, depending on their hormo

217 The network is linked to multiple co-repressor pathways and is composed of numerous protei

218 this report, we show that recruitment of the co-repressor protein Grg4 to a Pax DNA-binding site disp

219 Here, we demonstrate that the co-repressor protein Sin3a is crucial for lung endoderm

220 tructures in the presence and absence of the co-repressor protein Tup1.

221 Here we identify a novel co-repressor protein, CBFA2T2, that regulates pluripoten

222 ivator binding and promoted interaction with co-repressor protein.

223 uired for interaction with the TOPLESS (TPL) co-repressor protein.

224 ple mechanisms, including the recruitment of co-repressor proteins belonging to the TLE family of chr

225 r, the molecular mechanism of recruitment to co-repressor proteins has yet to be established.

226 By contrast, numerous CSL co-repressor proteins have been identified, and these ar

227 by the loss of either one of the downstream co-repressor proteins Rgt1p or Mth1p.

228 eins, or other transcription co-activator or co-repressor proteins.

229 in a pocket sandwiched between the HDAC and co-repressor proteins.

230 tivator interacting with the transcriptional co-repressor pyrimidine tract-binding protein-associated

231 Repression by GR involves co-repressor recruitment, because treatment of transfect

232 (methyl CpG binding protein 2) and HP-1alpha co-repressor recruitments to Ppargamma promoter and enha

233 These transcriptional co-repressors regulate diverse cell phenotypes depending

234 that direct interaction between Otx2 and Grg co-repressors regulates GnRH gene expression in hypothal

235 ated Sp1 phosphorylation, and HDAC1/2/mSin3A co-repressor release indicating its role as linker coact

236 e show that the LEUNIG (LUG) and SEUSS (SEU) co-repressors repress miR172 expression in the outer who

237 for co-activators and increased affinity for co-repressors, resulting in suppression of the receptors

238 ong the affected transcriptional targets are co-repressor SHP (small heterodimer partner) as well as

239 REL2 encodes a transcriptional co-repressor similar to the TOPLESS protein of Arabidops

240 and YY1 co-sediment with the transcriptional co-repressor Sin3a and its functional partner histone de

241 inhibitory domain that can interact with the co-repressor Sin3A.

242 he pathway, Smad6 and Smad7, and the nuclear co-repressors Ski and Skil (SnoN).

243 oes not utilize the TGF-beta transcriptional co-repressors Ski or SnoN in mesangial cells.

244 constitutively interacted with another Smad co-repressor, Ski, and they formed ternary complex with

245 HGF is shown to induce Smad co-repressor Sloan-Kettering Institute proto-oncogene-re

246 show that knock-in mutations of the nuclear co-repressor SMRT (silencing mediator of retinoid and th

247 und that non-polar peptides derived from the co-repressors SMRT and NCoR bind to a hydrophobic patch

248 Smad transcriptional co-repressor SnoN acts as an antagonist that tightly con

249 action via upregulating Smad transcriptional co-repressor SnoN expression.

250 ors such as p300 and CREB-binding protein or co-repressors such as HDAC3.

251 Co-repressors, such as KAP-1, function to regulate the r

252 hosphorylation, induced Smad transcriptional co-repressor TG-interacting factor expression, and block

253 duced expression of the Smad transcriptional co-repressor TGIF in mesangial cells.

254 ow that SHARP, which interacts with the SMRT co-repressor that activates HDAC3, is not only essential

255 absence of apo-BCCP, biotin-5'-AMP acts as a co-repressor that induces BirA dimerization and binding

256 in A-ribosylated substrate), a transcription co-repressor that is implicated in dynamin-independent e

257 ucleus and cytoplasm and serves as a nuclear co-repressor that regulates bone and muscle development.

258 Groucho (Gro) is a Drosophila co-repressor that regulates the expression of a large nu

259 tBP) is a well-characterized transcriptional co-repressor that requires homo-dimerization for its act

260 ylation in vitro, suggesting that DMAP1 is a co-repressor that supports the maintenance and de novo a

261 n as over-induction is prevented by a second co-repressor that the model yeast Saccharomyces cerevisi

262 Hdac9 are activity-regulated transcriptional co-repressors that are highly expressed in innervated mu

263 Tgif1 and Tgif2 are transcriptional co-repressors that limit the response to TGFbeta signali

264 To identify potential co-activators or co-repressors that mediate these actions of Glis2, we pe

265 ber of the Groucho family of transcriptional co-repressors that we identified as a Hex target in embr

266 he methionine repressor protein MetJ and its co-repressor, the methionine derivative S-adenosylmethio

267 cetylase activity and their interaction with co-repressors, these enzymes are also found in the cytop

268 hat REL2 also functions as a transcriptional co-repressor throughout development.

269 CRMs during cleavage stages and recruits the co-repressor Tle/Groucho in the early blastula.

270 tivator into a repressor by recruitment of a co-repressor to Bicoid-dependent promoters.

271 t G9a functions both as a co-activator and a co-repressor to enhance cellular proliferation and inhib

272 of CtBP1 direct the assembly of a functional co-repressor to influence gene expression is not well un

273 olic genes primarily by recruiting the HDAC3 co-repressor to sites to which it is tethered by cell ty

274 Consequently, recruitment of the YAP co-repressor to subnuclear domains is abrogated and expr

275 r that acts in concert with co-activators or co-repressors to control the activity of associated targ

276 omb complexes, methyltransferases, and other co-repressors to gene promoters.

277 romatin-bound complexes with transcriptional co-repressors to repress transcription.

278 itment on the viral genome of KAP1, a master co-repressor, together with HP1 and the SETDB1 histone m

279 es are direct targets of the transcriptional co-repressor TOPLESS (TPL) and that PLT1/2 are necessary

280 ts target genes by physically recruiting the co-repressor TOPLESS and the histone deacetylase HDA19.

281 h the bHLH transcription factor MYC2 and the co-repressor TOPLESS but, consistent with the absence of

282 as suggested that the AFPs interact with the co-repressor TOPLESS to inhibit ABA-regulated gene expre

283 teractions with histone deacetylases and the co-repressor TOPLESS.

284 teractions with histone deacetylases and the co-repressor TOPLESS.

285 interaction partner CtBP2, a transcriptional co-repressor, was in a complex with beta-catenin.

286 understand how NICD displaces CSL-associated co-repressors, we have quantified the binding of differe

287 recruitment of co-activators and release of co-repressors when ERRalpha and AP1 bind and ERalpha is

288 t should need to recruit CtBP, a short-range co-repressor, when Gro is known to be able to function o

289 -box, essential for interaction with TPL/TPR co-repressors, whereas the repressive EAR domain is disp

290 repressors function primarily by recruiting co-repressors, which are accessory proteins that antagon

291 deacetylase (HDAC) family of transcriptional co-repressors, which induce apoptosis of neoplastic cell

292 PPARgamma requires various co-activators or co-repressors, which may dynamically associate with and

293 (novel INHAT repressor) is a transcriptional co-repressor with inhibitor of histone acetyltransferase

294 k1 translocates to the nucleus and acts as a co-repressor with p53 to down-regulate PKD1 transcriptio

295 ticipate in the interaction of the Ssn6-Tup1 co-repressor with the Gcn5-containing SAGA chromatin-rem

296 h recruitment of co-activators or release of co-repressors with unique roles in elongation.

297 transcribes the gene, whereas repressors and co-repressors work to achieve the opposite goal.

298 conditions; production is further boosted by co-repressor Zac1 or pharmacologic agents that enhance R

299 terminus and a specific interaction with the co-repressor ZMYND11 (BS69).

300 cells' metal sensors of other types: Zn(II) co-repressor Zur, Co(II) activator CoaR, and Zn(II) dere